Download or read book Technical Report on Toxicology and Carcinogenesis Studies of Formamide CAS No 75 12 7 in F344 N Rats and B6C3F1 Mice Gavage Studies written by R. D. Irwin and published by DIANE Publishing. This book was released on 2009-02 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Formamide has a variety of uses, including as a softener for paper, gums, and glues. This report details the study of the effects of formamide on male and female rats and mice to identify potential toxic or cancer-related hazards. Solutions containing formamide in deionized water were deposited directly into the stomachs of male and female rats and mice. Groups of 50 animals received 20, 40, or 80 milligrams of formamide per kilogram body weight 5 days per week for 2 years; groups of animals receiving water alone served as the control groups. At the end of the study, tissues from more than 40 sites were examined for every animal. The only effects observed in male and female rats were lower body weight in animals receiving the highest dose of formamide and a slight increase in bone marrow hyperplasia in male rats. The study concludes that exposure to formamide did not cause cancer in male or female rats, but it did produce hemangiosarcomas in the liver of male mice and may have been related to an increase in liver tumors in female mice. Increased incidence of bone marrow hyperplasia in male rats and testicular mineralization in male mice were also associated with formamide exposure. Illus.
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Download or read book Strengthening Forensic Science in the United States written by National Research Council and published by National Academies Press. This book was released on 2009-07-29 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scores of talented and dedicated people serve the forensic science community, performing vitally important work. However, they are often constrained by lack of adequate resources, sound policies, and national support. It is clear that change and advancements, both systematic and scientific, are needed in a number of forensic science disciplines to ensure the reliability of work, establish enforceable standards, and promote best practices with consistent application. Strengthening Forensic Science in the United States: A Path Forward provides a detailed plan for addressing these needs and suggests the creation of a new government entity, the National Institute of Forensic Science, to establish and enforce standards within the forensic science community. The benefits of improving and regulating the forensic science disciplines are clear: assisting law enforcement officials, enhancing homeland security, and reducing the risk of wrongful conviction and exoneration. Strengthening Forensic Science in the United States gives a full account of what is needed to advance the forensic science disciplines, including upgrading of systems and organizational structures, better training, widespread adoption of uniform and enforceable best practices, and mandatory certification and accreditation programs. While this book provides an essential call-to-action for congress and policy makers, it also serves as a vital tool for law enforcement agencies, criminal prosecutors and attorneys, and forensic science educators.
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