Download or read book Towards the Total Synthesis of RP 66453 written by Scott Twiddy and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Towards the Total Synthesis of RP 66453 written by David James Skinner and published by . This book was released on 2013 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Towards the Total Synthesis of RP 66453 written by David Skinner and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis describes the efforts made towards the total synthesis of RP 66453, a highly strained macrocyclic tetrapeptide. RP 66453 provides an interesting synthetic challenge, not only due to its potential biological activity but also owing to its unusual chemical architecture. The strained bicyclic ring system features a 15-membered macrocycle containing an aryl-aryl bond and a 14-membered meta, para-cyclophane. Herein, several strategies towards the model A-B macrocycle of RP 66453 are presented featuring as a key step, a radical induced transannular ring contraction of a benzyl haloaryl ether and a photochemical transannular cyclisation of cis-stilbene derivatives. Synthetic efforts towards the B-O-C macrocycle are also presented, including copper-mediated and intramolecular SNAr cyclisation strategies. Finally, research into the union of these two fragments is presented followed by a discussion of a proposed end-game strategy.
Download or read book Towards the Synthesis of RP 66453 written by Lana Nanson and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies on the Total Synthesis and Structure Determination of RP 66453 written by Paul John Krenitsky and published by . This book was released on 2003 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurotensin (NT) is a linear tridecapeptide first isolated from bovine hypothalamus shown to have pharmacological properties similar to dopamine antagonists, and as such, analogs of NT may be useful in the treatment of schizophrenia, psychoses, or depression. In the course of a screening program to identify compounds that displace NT from its receptor, RP 66453 was isolated and partially characterized. The connectivity structure was determined through spectroscopic methods and published in 1998, however the relative and absolute stereochemistry remain unsolved. RP 66453 was found to possess a unique and highly strained bicyclic ring system consisting of a 15-membered (AB) ring containing an endo aryl-aryl bond and a 14-membered (BC) ring containing a diaryl ether. This highly strained bicyclic tetrapeptide has never before been prepared synthetically. The S,S -isomer of a fully functionalized BC ring system of RP 66453, which constitutes an unusual reversed 14-membered cycloisodityrosine, was assembled through use of a key diaryl ether macrocyclization reaction enlisting a phenoxide nucleophilic aromatic substitution reaction of an o -fluoro nitroaromatic. The desired stereochemistry was maintained during the course of this synthesis, so it was expected that the conditions used for the cyclization reaction and removal of the nitro group would be suitable to apply to the synthesis of RP 66453. An appropriately functionalized derivative of the (S,S,S )-diastereomer of the 15-membered AB ring system of RP 66453 has been prepared by an unusually effective Suzuki coupling to form the aryl-aryl bond followed by macrolactamization. An optimal site of macrolactamization was identified, and the conformational and atropisomers issues associated with this unusual ring system were established. Two different routes were developed for the synthesis of the unique and highly strained bicyclic ring system of RP 66453. The first route employed diaryl ether formation for the final ring closure reaction, and the second route accomplished the final ring closure through macrolactamization. While not establishing the stereochemistry of RP 66453, these syntheses confirmed the structure of the carbon skeleton of the natural product and confirmed that the natural product does not possess the P,S,S,S,S -configuration.
Download or read book More Dead Ends and Detours written by Miguel A. Sierra and published by John Wiley & Sons. This book was released on 2013-07-11 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Success comes in many forms and in synthesis it can be a failure that results in their ultimate successful solutions. This long-awaited sequel to "Dead Ends and Detours" retains the proven concept while featuring over 20 new case studies of failed strategies and their (successful) solutions in natural product total synthesis. Additionally, computational models are used to discuss the problem in much more detail and to provide readers with additional information not found in the primary literature. The topics range from classic synthetic reactions (e.g. Diels Alder reaction), metal-mediated coupling reactions, metathesis, and asymmetric catalysis to the importance of protecting and activating groups. This book will benefit not only graduate students in organic chemistry but also advanced researchers as they gain knowledge derived from the step-by-step analysis of mistakes made in the past and, thus be able to improve their own chemical reaction planning. With its coverage of the most commonly applied reaction types, the book perfectly complements its predecessor, which focuses on general aspects, such as reactivity and selectivity.
Download or read book The Total Synthesis of Natural Products Volume 1 written by John ApSimon and published by John Wiley & Sons. This book was released on 2009-09-22 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each volume reviews the total synthesis of a set of compounds looking at syntheses reported historically and at the practice current at the time of publication. From volume 1 focusing on carbohydrates, prostagladins, nucleic acids, antibiotics, naturally occurring oxygen ring compounds and pyrrole pigments, the series continues with coverage of aromatic steroids, monoterpenes, triterpenes, sesquiterpenes, cannabinoids, natural inophores, insect pheromones and alkaloids. Volumes revisit the total synthesis of key compounds such as carbohydrates, nucleic acids and pyrrole pigments several times during the series building a picture of the historic development of total synthesis techniques for these major groups. Chapters are edited by experts in their field to give a complete overview of the best in the field at the time.
Download or read book Suzuki Miyaura Cross Coupling Reaction and Potential Applications written by Ioannis D. Kostas and published by MDPI. This book was released on 2018-03-23 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Suzuki–Miyaura Cross-Coupling Reaction and Potential Applications" that was published in Catalysts
Download or read book Natural Product Synthesis I written by Johann H. Mulzer and published by Springer Science & Business Media. This book was released on 2005-01-12 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: B. Basler, S. Brandes, A. Spiegel and T. Bach: Total Synthesis of Kalsoene and Preussin .- R. Bandichhor, B. Nosse and O. Reiser: Paraconic Acids- the Natural Products from Lichen Symbiont .- M. Hiersemann and H. Helmboldt: Recent Progress in the Total Synthesis of Dolabellane and Dolastane Diterpenes .- L. Wessjohann and E. Ruijter: Strategies for Total and Diversity- Oriented Synthesis of Natural Product (-Like) Macrolides .-M. Sefkow: Enantioselectice Synthesis of C(8)-Hydroxylated Lignans: Early Approaches and Recent Advances
Download or read book Practical Medicinal Chemistry with Macrocycles written by Eric Marsault and published by John Wiley & Sons. This book was released on 2017-08-03 with total page 653 pages. Available in PDF, EPUB and Kindle. Book excerpt: Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts Covers design criteria, typical profile of current macrocycles, applications, and limitations
Download or read book Copper Mediated Cross Coupling Reactions written by Gwilherm Evano and published by John Wiley & Sons. This book was released on 2013-09-23 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing comprehensive insight into the use of copper in cross-coupling reactions, Copper-Mediated Cross-Coupling Reactions provides a complete up-to-date collection of the available reactions and catalytic systems for the formation of carbon-heteroatom and carbon-carbon bonds. This essential reference covers a broad scope of copper-mediated reactions, their variations, key advances, improvements, and an array of academic and industrial applications that have revolutionized the field of organic synthesis. The text also discusses the mechanism of these transformations, the use of copper as cost-efficient alternative to palladium, as well as recently developed methods for conducting copper-mediated reactions with supported catalysts.
Download or read book Progress in Total Synthesis written by Sarah Danishefsky and published by . This book was released on 2014-08-15 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Strategic Applications of Named Reactions in Organic Synthesis written by Laszlo Kurti and published by Elsevier. This book was released on 2005-04-29 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist. * The first reference work on named reactions to present colored schemes for easier understanding* 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples* An opening list of abbreviations includes both structures and chemical names * Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works * Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools* Extensive index quickly locates information using words found in text and drawings
Download or read book The Total Synthesis of Natural Products Volume 5 written by John ApSimon and published by John Wiley & Sons. This book was released on 2009-09-22 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each volume reviews the total synthesis of a set of compounds looking at syntheses reported historically and at the practice current at the time of publication. From volume 1 focusing on carbohydrates, prostagladins, nucleic acids, antibiotics, naturally occurring oxygen ring compounds and pyrrole pigments, the series continues with coverage of aromatic steroids, monoterpenes, triterpenes, sesquiterpenes, cannabinoids, natural inophores, insect pheromones and alkaloids. Volumes revisit the total synthesis of key compounds such as carbohydrates, nucleic acids and pyrrole pigments several times during the series building a picture of the historic development of total synthesis techniques for these major groups. Chapters are edited by experts in their field to give a complete overview of the best in the field at the time.
Download or read book The Total Synthesis of Natural Products written by John ApSimon and published by Wiley-Interscience. This book was released on 2009-09-22 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Total Synthesis of Natural Products Volume Seven Edited by John ApSimon This volume contains a chapter updating monoterpene synthesis and reviews the newer areas of leukotrienes and macrocyclic lactones. 1988 (0 471-88076-0) 480 pp. The Total Synthesis of Natural Products Volume Six Edited by John ApSimon Volume Six considers the total synthesis of triterpenes, carbohydrates, aromatic steroids, pyrrole pigments, and genes. 1984 (0 471-09900-7) 304 pp. The Total Synthesis of Natural Products Volume Five Edited by John ApSimon This present volume considers the total syntheses of sesquiterpenes, reflecting, in part, the heightened research activity in this area. 1983 (0 471-09808-6) 560 pp. The Total Synthesis of Natural Products Volume Four Edited by John ApSimon The fourth volume in this successful series offers synthetic approaches to a wide variety of natural products, including the synthesis of cannabinoids, natural inophores, insect pheromones, monoterpenes, and prostaglandins. 1981 (0 471-05460-7) 624 pp. The Total Synthesis of Natural Products Volume Three Edited by John ApSimon 1977 (0 471-02392-2) 576 pp. The Total Synthesis of Natural Products Volume Two Edited by John ApSimon 1973 (0 471-03252-2) 768 pp. The Total Synthesis of Natural Products Volume One Edited by John ApSimon 1973 (0 471-03251-4) 624 pp.
Download or read book Contemporary Aspects of Boron Chemistry and Biological Applications written by Hijazi Abu Ali and published by Elsevier. This book was released on 2005-09-07 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contemporary Aspects of Boron: Chemistry and Biological Applications highlights the biological activity and applications of boron containing compounds. The authors’ specific approach surveys general features of the subject, while exploring new and novel strategies for preparing certain chemical and natural boron products that are of significant substance in medicinal chemistry. For example, cancer treatment is one of the most important issues related to such products. In addition to contributing to the development of new drugs by addressing biological applications in medicinal and industrial fields, the book provides a comprehensive review of the most relevant components that comprise the pharmaceutical, medicinal and environmental applications of boron containing compounds. * Timely and comprehensive * Provides new insights to active researchers in the field * Presents concepts and methods in simple scientific terms
Download or read book Part A Studies Directed Towards the Total Synthesis of A 23187 Part B Formal Total Synthesis of A 23187 written by Eric L. Williams and published by . This book was released on 1980 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:
