Download or read book Practical Guide to Hot Melt Extrusion written by Mohammed Maniruzzaman and published by Smithers Rapra. This book was released on 2015-07-22 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past few decades, hot-melt extrusion (HME) techniques have been shown to exhibit remarkable potential for the manufacture of various pharmaceutical products. HME is an emerging processing technology used primarily for the manufacture of pharmaceutical solid dispersions, combining the advantages of a solvent-free process with fewer production steps making it suitable for easy to scale-up and continuous manufacturing applications. A single unit HME based operation, employing heat and mechanical shear, has displayed a significant potential to retain the stability even of thermo-labile therapeutics e.g., proteins. HME has now explicitly been established from a quality-by-design viewpoint for in-line data monitoring as per the recent guidelines issued by the US Food and Drugs Administration (FDA).This book will focus primarily on the foregoing subject areas and will be of significant interest to a broad/interdisciplinary readership across the industries and academia for, (but not limited to) the following reasons:- Emerging HME processes and applications for multiple drug delivery.- Solid-state engineering, solubility enhancement, controlled release, taste masking and sustained release case studies from a continuous manufacturing view-point.- Means to explore the potential of continuous manufacture of co-crystals for promoting solvent free production methods.- Scale-up case study and issue considerations and studies on the regulatory guidelines (FDA) for continuous manufacturing involving emerging HME techniques.
Download or read book Practical Guide to Hot melt Extrusion written by Mohammed Maniruzzaman and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hot Melt Extrusion written by Dennis Douroumis and published by John Wiley & Sons. This book was released on 2012-04-24 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hot-melt extrusion (HME) - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and drug delivery systems, for example granules and sustained release tablets. Hot-Melt Extrusion: Pharmaceutical Applications covers the main instrumentation, operation principles and theoretical background of HME. It then focuses on HME drug delivery systems, dosage forms and clinical studies (including pharmacokinetics and bioavailability) of HME products. Finally, the book includes some recent and novel HME applications, scale -up considerations and regulatory issues. Topics covered include: principles and die design of single screw extrusion twin screw extrusion techniques and practices in the laboratory and on production scale HME developments for the pharmaceutical industry solubility parameters for prediction of drug/polymer miscibility in HME formulations the influence of plasticizers in HME applications of polymethacrylate polymers in HME HME of ethylcellulose, hypromellose, and polyethylene oxide bioadhesion properties of polymeric films produced by HME taste masking using HME clinical studies, bioavailability and pharmacokinetics of HME products injection moulding and HME processing for pharmaceutical materials laminar dispersive & distributive mixing with dissolution and applications to HME technological considerations related to scale-up of HME processes devices and implant systems by HME an FDA perspective on HME product and process understanding improved process understanding and control of an HME process with near-infrared spectroscopy Hot-Melt Extrusion: Pharmaceutical Applications is an essential multidisciplinary guide to the emerging pharmaceutical uses of this processing technology for researchers in academia and industry working in drug formulation and delivery, pharmaceutical engineering and processing, and polymers and materials science. This is the first book from our brand new series Advances in Pharmaceutical Technology. Find out more about the series here.
Download or read book Practical Guide to Blow Moulding written by N. C. Lee and published by iSmithers Rapra Publishing. This book was released on 2006 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Blow moulding is a manufacturing process used to form hollow plastic parts. It evolved from the ancient art of glass blowing and it is used to particular advantage with plastic materials. Celluloid was used first to blow mould baby rattles and novelties in the 1930s, linear low-density polyethylene was used in the 1940s for high production bottles and these days polyethylene terephthalate is used to make anything from soda bottles, to highly sophisticated multilayered containers and automotive fuel tanks in the last decade. When designing a product it is important to consider aspects such as a material's characteristics, the processing methods available, the assembly and finishing procedures, and the life cycle and expected performance of the product. This book presents the basics of blow moulding as well as the latest state-of-the-art and science of the industry. A key feature is the approach of discussing the 'basics' and then taking the reader through the entire process from design development through to final production.
Download or read book Extrusion written by Harold F. Giles Jr and published by William Andrew. This book was released on 2004-12-31 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why is it important to get to equilibrium and how long does it take? Are there problems running polypropylene profiles on a single screw extruder? Does the job involve compounding color concentrates on a corotating twin screw extruder? This unique reference work is designed to aid operators, engineers, and managers in quickly answering such practical day-to-day questions in extrusion processing. This comprehensive volume is divided into 7 Parts. It contains detailed reference data on such important operating conditions as temperatures, start-up procedures, shear rates, pressure drops, and safety. This reference is a practical guide to extrusion bringing together both the equipment and materials processing aspects. It provides basic and advanced topics about the thermoplastics processing in the extruder, for reference and training. Parts 1 û 3, emphasize the fundamentals, for operators and engineers, of polymeric materials extrusion processing in single and twin screw extruders. Parts 4 û 7 treat advanced topics including troubleshooting, auxiliary equipment, and coextrusion for operators, engineers, and managers. Extensive applications in Part 7 cover such contemporary areas as compounding, blown film, extrusion blow molding, coating, foam, and reprocessing. Each chapter includes review topics.
Download or read book Basics of Troubleshooting in Plastics Processing written by Muralisrinivasan Natamai Subramanian and published by John Wiley & Sons. This book was released on 2011-04-20 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Basics of Troubleshooting in Plastics Processing is a condensed practical guide that gives the reader a broad introduction to properties of thermoplastics plastics, additives, the major processes (extrusion, injection molding, rotational molding, blow molding, and thermoforming), as well as troubleshooting. The main goal is to provide the plastics processor with an improved understanding of the basics by explaining the science behind the technology. Machine details are minimized as the emphasis is on processing problems and the defects in an effort to focus on basic root causes to problems and how to solve them. The book’s framework is troubleshooting in plastics processing because of the importance it has to the eventual production of high quality end products. Each chapter contains both practical and detailed technical information. This basic guide provides state-of-the-art information on: Processing problems and defects during manufacturing Plastics materials, their properties and characterization The plastics processing techniques Plastics additives Troubleshooting of the 5 main plastics processes References for further reading
Download or read book Thermo Mechanical Properties of Polymer Composites written by Dr. Inamuddin and published by Trans Tech Publications Ltd. This book was released on 2019-08-07 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains papers describing the results of some research in the area of application diffusion and transport phenomena in polymer composite materials and substances for the industrial and engineering goals. We hope that the presented papers will be interesting and useful for many engineers and researchers.
Download or read book Melt Extrusion written by Michael A. Repka and published by Springer Science & Business Media. This book was released on 2013-10-11 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides readers with the basic principles and fundamentals of extrusion technology and a detailed description of the practical applications of a variety of extrusion processes, including various pharma grade extruders. In addition, the downstream production of films, pellets and tablets, for example, for oral and other delivery routes, are presented and discussed utilizing melt extrusion. This book is the first of its kind that discusses extensively the well-developed science of extrusion technology as applied to pharmaceutical drug product development and manufacturing. By covering a wide range of relevant topics, the text brings together all technical information necessary to develop and market pharmaceutical dosage forms that meet current quality and regulatory requirements. As extrusion technology continues to be refined further, usage of extruder systems and the array of applications will continue to expand, but the core technologies will remain the same.
Download or read book Practical Guide to Water Blown Cellular Polymers written by Chris Defonseka and published by Smithers Rapra. This book was released on 2016-05-10 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular polymers or foamed polymers are an important branch of plastics and are an essential part of daily life. Some of the major sectors of use are bedding, automotive, building construction, furniture, sound/thermal insulation, and packaging.Due to growing global concerns with regard to air pollution, research has led to the fascinating concept of using water as the sole blowing agent to create cellular foams as an alternative to traditional petroleum-based blowing agents (which contribute to air pollution). This strategy has created other possibilities of better and safer foams, and reduced costs are also considerable.With over 45 years of hands-on experience, the author provides in-depth knowledge of water-blown cellular polymers, from their chemistry to formulation and process methodology to produce quality foams. This exciting new phase of the polymer industry is presented in detail with regard to manufacture of standard foams as well as specialty foams. Such descriptions are based on new and emerging technologies, including the challenges and solutions foam producers must face with formulations as well as recommendations for machinery and equipment.This is a comprehensive presentation of all aspects of the technology required to produce water-blown cellular foams with different polymers to meet market demands. This book provides theoretical and practical information as well as guidance, and is an ideal source of information for libraries, students, teachers, foam producers and entrepreneurs.
Download or read book Amorphous Solid Dispersions written by Navnit Shah and published by Springer. This book was released on 2014-11-21 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol®, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems. Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future.
Download or read book Extrusion written by Harold F. Giles Jr and published by William Andrew. This book was released on 2013-09-21 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Extrusion is designed to aid operators, engineers, and managers in extrusion processing in quickly answering practical day-to-day questions. The first part of the book provides the fundamental principles, for operators and engineers, of polymeric materials extrusion processing in single and twin screw extruders. The next section covers advanced topics including troubleshooting, auxiliary equipment, and coextrusion for operators, engineers, and managers. The final part provides applications case studies in key areas for engineers such as compounding, blown film, extrusion blow molding, coating, foam, and reprocessing. This practical guide to extrusion brings together both equipment and materials processing aspects. It covers basic and advanced topics, for reference and training, in thermoplastics processing in the extruder. Detailed reference data are provided on such important operating conditions as temperatures, start-up procedures, shear rates, pressure drops, and safety. A practical guide to the selection, design and optimization of extrusion processes and equipment Designed to improve production efficiency and product quality Focuses on practical fault analysis and troubleshooting techniques
Download or read book Developing Solid Oral Dosage Forms written by Yihong Qiu and published by Academic Press. This book was released on 2009-03-10 with total page 978 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developing Solid Oral Dosage Forms is intended for pharmaceutical professionals engaged in research and development of oral dosage forms. It covers essential principles of physical pharmacy, biopharmaceutics and industrial pharmacy as well as various aspects of state-of-the-art techniques and approaches in pharmaceutical sciences and technologies along with examples and/or case studies in product development. The objective of this book is to offer updated (or current) knowledge and skills required for rational oral product design and development. The specific goals are to provide readers with: Basics of modern theories of physical pharmacy, biopharmaceutics and industrial pharmacy and their applications throughout the entire process of research and development of oral dosage forms Tools and approaches of preformulation investigation, formulation/process design, characterization and scale-up in pharmaceutical sciences and technologies New developments, challenges, trends, opportunities, intellectual property issues and regulations in solid product development The first book (ever) that provides comprehensive and in-depth coverage of what's required for developing high quality pharmaceutical products to meet international standards It covers a broad scope of topics that encompass the entire spectrum of solid dosage form development for the global market, including the most updated science and technologies, practice, applications, regulation, intellectual property protection and new development trends with case studies in every chapter A strong team of more than 50 well-established authors/co-authors of diverse background, knowledge, skills and experience from industry, academia and regulatory agencies
Download or read book Practical Guide to Polypropylene written by Devesh Tripathi and published by iSmithers Rapra Publishing. This book was released on 2002 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polypropylene is now the third largest consumed plastic material after polyethylene and polyvinyl chloride. This book discusses the advantages and disadvantages of working with polypropylene, offering practical comment on the available types of polypropylene, its mechanical properties and in-service performance, and processing. Comparisons with other common plastics are also provided, which highlight the advantages of this polyolefin.
Download or read book Extruding Plastics written by D.V. Rosato and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 791 pages. Available in PDF, EPUB and Kindle. Book excerpt: Worldwide, extrusion lines successfully process more plastics into prod ucts than other processes by consuming at least 36 wt% of all plastics. They continue to find practical solutions for new products and/ or prob lems to meet new product performances. This book, with its practical industry reviews, is a unique handbook (the first of its kind) that covers over a thousand of the potential combina tions of basic variables or problems with solutions that can occur from up-stream to down-stream equipment. Guidelines are provided for maxi mizing processing efficiency and operating at the lowest possible cost. It has been prepared with an awareness that its usefulness will depend greatly upon its simplicity and provision of essential information. It should be useful to: 0) those already extruding and desiring to obtain additional information for their line and/ or prOVide a means of reviewing other lines that can provide their line with operating improvements; (2) those processing or extruding plastics for the first time; (3) those consider ing going into another extrusion process; (4) those desiring additional information about employing the design of various products more effi ciently, with respect to both performance and cost; (5) those contemplat ing entering the business of extrusion; (6) those in new venture groups, materials development, and/ or market development; (7) those in disci plines such as nonplastics manufacturers, engineers, designers, quality control, financial, and management; and (8) those requiring a textbook on extrusion in trade schools and high schools or colleges.
Download or read book Practical Guide to Structures Properties and Applications of Styrenic Polymers written by Norbert Niessner and published by Smithers Rapra. This book was released on 2013-03-18 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Styrenic polymers are among the economically most important plastics. They combine benign processing with a large variety of product properties - from stiff and transparent to tough and durable. The fact that styrene can be polymerized by different reaction mechanisms (radical, ionic and metal catalyzed) makes this line of products unique in regards to the variety of its properties and applications. The primary objective of this book is to provide a detailed understanding of structure and property relationships of styrenic polymers, and their specific use in various applications. By understanding basic chemistry, supermolecular assembly of block- and graft polymers and microscopic fracture mechanisms, the reader will be able to quickly derive macroscopic behavior and hence select the most suitable polymer for a given application. The second objective of this book is to provide a comprehensive overview about unique value propositions of styrenic polymers in different industries and applications. The reader will get an in-depth understanding of why specific styrenic polymers dominate in market segments like computer and printer housings, exterior automotive parts and the food packaging industry, and what the specific customer benefits of using these polymers are. Finally, the third objective is to provide an outlook for future product and application developments. Hence it serves not only as a quick reference guide for downstream industries, but also as a practical guide for students and researchers in this field of material science.
Download or read book Pharmaceutical Microbiological Quality Assurance and Control written by David Roesti and published by John Wiley & Sons. This book was released on 2020-01-02 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Relying on practical examples from the authors’ experience, this book provides a thorough and modern approach to controlling and monitoring microbial contaminations during the manufacturing of non-sterile pharmaceuticals. Offers a comprehensive guidance for non-sterile pharmaceuticals microbiological QA/QC Presents the latest developments in both regulatory expectations and technical advancements Provides guidance on statistical tools for risk assessment and trending of microbiological data Describes strategy and practical examples from the authors’ experience in globalized pharmaceutical companies and expert networks Offers a comprehensive guidance for non-sterile pharmaceuticals microbiological QA/QC Presents the latest developments in both regulatory expectations and technical advancements Provides guidance on statistical tools for risk assessment and trending of microbiological data Describes strategy and practical examples from the authors’ experience in globalized pharmaceutical companies and expert networks
Download or read book Practical Guide To Injection Blow Molding written by Samuel L. Belcher and published by CRC Press. This book was released on 2007-03-05 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taking a straight-forward approach, the Practical Guide to Injection Blow Molding explores the entire industry from conception, design, costing, tooling, and machinery, to trouble-shooting, testing, and daily production. With information for both the novice investor and the plastic industry expert, this concise text is reinforced with pictures, charts, and figures. The author, a highly knowledgeable industry insider, and a member ofThe Plastics Hall of Fame, discusses the history of the industry, as well as its daily workings. He instructs in product and tooling design, as well as material and machine selection, explaining advantages and disadvantages, elaborating on efficiencies that can be realized.
