Download or read book Part 1 Efforts Towards the Total Synthesis of Scyphostatin Part II Synthetic Studies Towards Peloruside A written by Manomi A. Tennakoon and published by . This book was released on 2001 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards a Total Synthesis of Scyphostatin written by Karen A. Runcie and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Investigations Towards the Total Synthesis of Scyphostatin written by Neil G. Stevenson and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Part 1 Studies on an Approach to the Total Synthesis of pancratistatin Via an Episulfonium Cation Part 2 Synthetic Structural and Thermal Studies of Bisenediyne Macrocycles written by Heather Smith Blanchette and published by . This book was released on 1999 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Part I Total Synthesis and Structural Revision of Tricholomalides A and B Part II Synthetic Studies Towards Cortistatin A written by Zhang Wang and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The first part describes the total synthesis and structural revision of (±)-tricholomalides A and B. The synthetic strategy started from a homo-Robinson annulation, followed by a ketene-olefin [2+2] cycloaddition to introduce the lactone ring. Then a Grignard-type reaction appended the isopropenyl moiety, and the synthesis of tricholomalides A and B was achieved. During the course of synthesis, the structures of tricholomalides A and B were revised. The second part describes the synthetic studies towards (+)-cortistatin A, especially the A ring functionalization. The C3 nitrogen was introduced by azide displacement, and C2 hydroxyl was built up by Luche reduction. The challenging C1 functionalization was achieved with bromine-induced methoxymethyl deprotection, and some interesting chemistry was found in this system. The synthetic endeavor set a promising stage for the total synthesis of cortistatin A.

Download or read book Dissertation Abstracts International written by and published by . This book was released on 2001 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic Studies written by Qiang Han and published by . This book was released on 2005 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Part I Studies Towards the Total Synthesis of Apoptolidin A Part II Hydroxymethylation of Aldehydes and Its Application to Rasfonin written by Douglas J. Tusch and published by . This book was released on 2017 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Part I A Scalable Synthesis of rasfonin Enabled by a Convergent Enantioselective alpha hydroxymethylation Strategy written by Justin Michael Niziol and published by . This book was released on 2020 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Part I. A scalable synthesis of (-)-rasfonin enabled by a convergent enantioselective [alpha]-hydroxymethylation strategy. A scalable total synthesis of (-)-rasfonin, a potent antitumor agent, has been achieved. The synthetic strategy features a highly convergent approach based on a single protocol construction of both molecular hemispheres via catalytic enantioselective a-hydroxymethylation of simple aliphatic aldehydes. The described route has been successful in near-gram quantities of the natural product and serves as the first synthetic strategy to provide sufficient material for broad biological testing. With a keen focus on efficiency, atom economy, cost, and overall yield, the synthetic route described herein is certainly the shortest and most effective way currently described to synthesize significant quantities of (-)-rasfonin. Part II. Studies towards the total synthesis of FK-506. The synthesis of advanced intermediates towards the total synthesis of FK-506 is described herein. FK-506 has been an interesting synthetic target for some time, as it is not only structurally complex, but also a highly potent immunosuppressant. The purpose of the synthesis is to provide FK-506 in its natural form, as well as provide the option for late-stage functionalization in order to manipulate its level of toxicity. Our synthesis towards FK-506 is highly convergent, relying on the synthesis and combination of 4 subunits. Using a modified Julia olefination reaction, the major subunits of FK-506 have been successfully coupled to provide highly advanced structures. The following work also shows the improvement in yield, scalability, and simplicity of numerous reactions in the multiple routes towards the target molecule."--Pages ix-x.

Download or read book Synthetic Studies Toward the Total Synthesis of Sirodesmin A written by Daniel James Conatser and published by . This book was released on 1982 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Part A written by Gabriel Bellavance and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book American Doctoral Dissertations written by and published by . This book was released on 2000 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic Studies Towards a Total Synthesis of Morphine written by Mark David Charles and published by . This book was released on 2003 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Part 1 Studies Toward the Total Synthesis of Myriaporone 3 4 Part II Diisopinocampheyl borane mediated Reductive Aldol Reactions of Allenyl Carboxamides written by Xochina El Hilali and published by . This book was released on 2017 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: The natural product myriaporone 3/4 is structurally related to the pharmacophore of the cytotoxic macrolide tedanolide. Despite only representing a portion of the “parent” compound, myriaporone 3/4 retains much of tedanolide’s biological activity. And while its smaller size makes it a more promising therapeutic lead, the dense functionalization and sensitive structural motifs make it a challenging target for total synthesis. Herein we describe our first and second generation strategies toward an efficient and diastereoselective synthesis of the compound. Both routes incorporate a key silylconjugate addition/aldol sequence for stereoselective construction of the target compound’s carbon skeleton. Late stage epoxidation and Fleming-Tamao oxidations are planned to complete the total synthesis.

Download or read book Synthetic Studies Towards Psychrophilin C and Total Synthesis of Psychrophilin E written by Tack Ngen and published by . This book was released on 2016 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Part I written by Arend Jan te Raa and published by . This book was released on 1972 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Total Synthesis of Natural Products written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.