Download or read book Heterogeneity in Brain Aging written by Jasmine Alexandra Nettiksimmons and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease (AD) is a neurodegenerative disease that appears in the elderly and is characterized by cognitive impairment, specifically in memory. Due to shifting demographics and improving medical technology resulting in longer lifespans, the prevalence of AD and other types of dementia is on the rise. While AD has been recognized for over a century, the scientific understanding of the biological pathways involved is still fragmentary. Definitive diagnosis of AD requires examination of the brain in an autopsy, which complicates studying the disease in living patients. A wide variety of cognitive tests exist, but intra- and inter-person variability in test-taking ability along with overlapping symptomology between different types of dementia makes precise characterization of disease more difficult. In recent years, there has been substantial development in the use of a variety of different types of biomarkers to understand AD. AD biomarkers include regional brain volume measures from MRI, measures of regional metabolism with FDG-PET, protein levels in cerebrospinal fluid (CSF), along with others. The Alzheimer's Disease Neuroimaging Initiative (ADNI) was a large, prospective study of AD biomarkers funded by a public/private partnership. Starting in 2003, ADNI enrolled approximately 800 subjects, 200 with AD, 400 with mild cognitive impairment (MCI), and 200 who were cognitively normal, and followed each group longitudinally over 2-3 years collecting repeated clinical and biological data. Although there are many biomarkers that are associated with AD, none of them is sufficiently sensitive or specific enough to be used as a diagnostic test; for most biomarkers, there is substantial overlap in distribution between the three diagnostic groups. This research focused on examining multivariate structure in AD biomarkers using unsupervised cluster analysis in an effort to understand whether subgroups exist which have clinical implications. The biomarker profiles found in both the cognitively normal controls and MCI subjects were highly informative regarding the degree and type of biological heterogeneity accompanying the relative clinical homogeneity in each diagnostic group. A small subgroup of the ADNI controls had a biomarker profile clearly characteristic of the early stages of AD at baseline, even though they were still cognitively normal. Over time, this group experienced more rapid cognitive decline than the rest of the controls. Another large subgroup of the normal controls demonstrated marked atrophy in multiple brain regions, but lacked the CSF profile characteristic of AD. Vascular damage was examined as a possible explanation, and in fact, this group was consistently associated with a variety of vascular risk factors and also exhibited significantly more cognitive decline than the typical/healthy normal cluster. There was a great deal of biological heterogeneity in the MCI group, with two of the four clusters exhibiting biomarker patterns that are not well described by the prevailing theory of AD. Finally, structurally missing data in ADNI provoked an exploration into the possibilities of using imputation techniques for clustering. Although imputation is very commonly used in regression, there is virtually no literature on its use with other statistical techniques. The simulation performed here indicated that both single and multiple imputation methods have the capacity to perform very well in a clustering context, even when the clusters are not compact and well-separated.
Download or read book Heterogeneity of Alzheimer s Disease written by Francois Boller and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: The term "Alzheimer's disease" is currently used to refer to senile and also presenile dementia, but the heterogeneity of this disorder is demonstrated in many of its aspects. This is of great theoretical interest, and with the appearance of new therapeutic interventions, it may well also start to have very significant practical importance. To shed some light on the debate, the Fondation Ipsen organized an international symposium which took place on April 6, 1992. This volume contains the proceedings of this meeting, which was attended by researchers in epidemiology, clinical neurology and geriatrics, neuropsychology, neuropathology, molecular biology, and genetics.
Download or read book Cognitive Neuroscience of Aging written by Roberto Cabeza and published by Oxford University Press. This book was released on 2017 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: A rapidly growing body of research has consituted a new discipline that may be called cognitive neuroscience of aging. This book offers an introduction to the topic, useful to both professionals & students in cognitive neuroscience, cognitive psychology, neuroscience, neuropsychology & neurology.
Download or read book Neuroimaging in Dementia written by Frederik Barkhof and published by Springer Science & Business Media. This book was released on 2011-02-11 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: This up-to-date, superbly illustrated book is a practical guide to the effective use of neuroimaging in the patient with cognitive decline. It sets out the key clinical and imaging features of the various causes of dementia and directs the reader from clinical presentation to neuroimaging and on to an accurate diagnosis whenever possible. After an introductory chapter on the clinical background, the available "toolbox" of structural and functional neuroimaging techniques is reviewed in detail, including CT, MRI and advanced MR techniques, SPECT and PET, and image analysis methods. The imaging findings in normal ageing are then discussed, followed by a series of chapters that carefully present and analyze the key findings in patients with dementias. Throughout, a practical approach is adopted, geared specifically to the needs of clinicians (neurologists, radiologists, psychiatrists, geriatricians) working in the field of dementia, for whom this book will prove an invaluable resource.
Download or read book Brain Aging written by David R. Riddle and published by CRC Press. This book was released on 2007-04-19 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur
Download or read book Cognitive and Brain Aging Interventions to Promote Well Being in Old Age Roadmap for Interventions Preventing Cognitive Aging written by Pamela M. Greenwood and published by Frontiers Media SA. This book was released on 2020-03-03 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Neurobiology of Aging and Alzheimer Disease in Down Syndrome written by Elizabeth Head and published by Academic Press. This book was released on 2021-08-31 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena. Discusses the complexities involved with aging and Alzheimer’s disease in Down syndrome Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research
Download or read book Cognitive Aging written by Institute of Medicine and published by National Academies Press. This book was released on 2015-07-21 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: For most Americans, staying "mentally sharp" as they age is a very high priority. Declines in memory and decision-making abilities may trigger fears of Alzheimer's disease or other neurodegenerative diseases. However, cognitive aging is a natural process that can have both positive and negative effects on cognitive function in older adults - effects that vary widely among individuals. At this point in time, when the older population is rapidly growing in the United States and across the globe, it is important to examine what is known about cognitive aging and to identify and promote actions that individuals, organizations, communities, and society can take to help older adults maintain and improve their cognitive health. Cognitive Aging assesses the public health dimensions of cognitive aging with an emphasis on definitions and terminology, epidemiology and surveillance, prevention and intervention, education of health professionals, and public awareness and education. This report makes specific recommendations for individuals to reduce the risks of cognitive decline with aging. Aging is inevitable, but there are actions that can be taken by individuals, families, communities, and society that may help to prevent or ameliorate the impact of aging on the brain, understand more about its impact, and help older adults live more fully and independent lives. Cognitive aging is not just an individual or a family or a health care system challenge. It is an issue that affects the fabric of society and requires actions by many and varied stakeholders. Cognitive Aging offers clear steps that individuals, families, communities, health care providers and systems, financial organizations, community groups, public health agencies, and others can take to promote cognitive health and to help older adults live fuller and more independent lives. Ultimately, this report calls for a societal commitment to cognitive aging as a public health issue that requires prompt action across many sectors.
Download or read book Diseases of the Brain Head and Neck Spine 2020 2023 written by Juerg Hodler and published by Springer Nature. This book was released on 2020-02-14 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.
Download or read book Cognitive Changes and the Aging Brain written by Kenneth M. Heilman and published by Cambridge University Press. This book was released on 2019-12-05 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the changes in the brain and in cognitive functions that occur with aging in the absence of a neurological, psychiatric, or medical disease. It discusses aging-related changes in many brain functions, including memory, language, sensory perception, motor function, creativity, attention, executive functions, emotions and mood. The neural mechanisms that may account for specific aging-related changes in cognition, perception and behavior are explored, as well as the means by which aging-related cognitive decrements can be managed and possibly ameliorated. Consequently, this book will be of value to clinicians, including neurologists, psychiatrists, geriatricians, primary care physicians, psychologists and speech-language pathologists. In addition, researchers and graduate students who want to learn about the aging brain will find this an indispensable guide.
Download or read book Neurodegeneration written by Anthony Schapira and published by John Wiley & Sons. This book was released on 2017-02-13 with total page 1078 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject. Presents a clinically oriented guide to the diseases caused by neurodegeneration Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson’s Disease, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases Edited by globally leading authorities on the subject, and written by expert contributing authors
Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Download or read book Sex Differences in the Aging Brain written by Sivaniya Subramaniapillai and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "The mechanisms underlying sex differences in many neurodegenerative conditions have been historically understudied, despite established sex differences in the prevalence of these conditions. For example, men are more likely to be diagnosed with Parkinson's Disease, while women are at greater risk of developing Alzheimer's disease (AD). In the case of AD, two-thirds of clinically diagnosed cases are women, emphasizing the importance of investigating sex-specific biological and gender-specific sociocultural factors that might increase women's AD risk. This thesis aims to characterize brain-aging differences of women and men throughout the adult lifespan, and the factors that differentiate typical aging from atypical cases, such as AD. Understanding individual differences, whether sex, gender, non-modifiable risk factors (e.g., family history of AD), or modifiable factors (e.g., education, physical exercise) can help to clarify the heterogeneity underlying brain-aging differences, and thus inform specialized health interventions based on individual differences. The thesis describes three studies investigating sex differences in the effect of age on brain structure, function, and cognition throughout the adult lifespan. In Study 1, we report sex differences in how age affected memory-related brain activity despite there being no differences in memory performance. Older women showed retrieval-related deficits in frontoparietal and medial temporal areas that was associated with worse memory performance but demonstrated compensatory recruitment of these areas at encoding to support their performance. In men, we found that older individuals were not able to successfully recruit semantic processing brain areas (i.e., ventral lateral prefrontal and ventral visual areas) that younger men were able to recruit for successful memory performance. In Study 2, we demonstrate that cognitively normal women and men may have varied brain-aging differences depending on the presence of non-modifiable risk factors, such as a family history of AD. Despite the negative consequences of AD risk factors to brain aging, we provide preliminary evidence indicating that modifiable factors, such as physical exercise and body mass index, can buffer against AD risk factors to protect against greater brain aging. In Study 3, we conducted a systematic literature review to determine what is known about sex and gender differences in lifestyle and demographic factors, such as education, occupation, and physical activity, in promoting healthy brain aging and reducing AD risk. We found some evidence indicating that these protective factors benefit women and men equally, and in some cases, women benefit more from engaging in these factors to lower their AD risk. Taken together, the findings across these studies highlight the importance of investigating sex and gender differences in healthy aging, and the role of modifiable and non-modifiable factors in contributing to differences in brain aging"--
Download or read book The Cambridge Handbook of Cognitive Aging written by Ayanna K. Thomas and published by Cambridge University Press. This book was released on 2020-05-28 with total page 1019 pages. Available in PDF, EPUB and Kindle. Book excerpt: Decades of research have demonstrated that normal aging is accompanied by cognitive change. Much of this change has been conceptualized as a decline in function. However, age-related changes are not universal, and decrements in older adult performance may be moderated by experience, genetics, and environmental factors. Cognitive aging research to date has also largely emphasized biological changes in the brain, with less evaluation of the range of external contributors to behavioral manifestations of age-related decrements in performance. This handbook provides a comprehensive overview of cutting-edge cognitive aging research through the lens of a life course perspective that takes into account both behavioral and neural changes. Focusing on the fundamental principles that characterize a life course approach - genetics, early life experiences, motivation, emotion, social contexts, and lifestyle interventions - this handbook is an essential resource for researchers in cognition, aging, and gerontology.
Download or read book Aging and Decision Making written by Thomas M. Hess and published by Academic Press. This book was released on 2015-02-17 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Decisions large and small play a fundamental role in shaping life course trajectories of health and well-being: decisions draw upon an individual's capacity for self-regulation and self-control, their ability to keep long-term goals in mind, and their willingness to place appropriate value on their future well-being. Aging and Decision Making addresses the specific cognitive and affective processes that account for age-related changes in decision making, targeting interventions to compensate for vulnerabilities and leverage strengths in the aging individual. This book focuses on four dominant approaches that characterize the current state of decision-making science and aging - neuroscience, behavioral mechanisms, competence models, and applied perspectives. Underscoring that choice is a ubiquitous component of everyday functioning, Aging and Decision Making examines the implications of how we invest our limited social, temporal, psychological, financial, and physical resources, and lays essential groundwork for the design of decision supportive interventions for adaptive aging that take into account individual capacities and context variables. Divided into four dominant approaches that characterize the current state of decision-making science and aging neuroscience Explores the impact of aging on the linkages between cortical structures/functions and the behavioral indices of decision-making Examines the themes associated with behavioral approaches that attempt integrations of methods, models, and theories of general decision-making with those derived from the study of aging Details the changes in underlying competencies in later life and the two prevailing themes that have emerged—one, the general individual differences perspective, and two, a more clinical focus
Download or read book The Wiley Handbook of Cognitive Control written by Tobias Egner and published by John Wiley & Sons. This book was released on 2017-03-20 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering basic theory, new research, and intersections with adjacent fields, this is the first comprehensive reference work on cognitive control – our ability to use internal goals to guide thought and behavior. Draws together expert perspectives from a range of disciplines, including cognitive psychology, neuropsychology, neuroscience, cognitive science, and neurology Covers behavioral phenomena of cognitive control, neuroanatomical and computational models of frontal lobe function, and the interface between cognitive control and other mental processes Explores the ways in which cognitive control research can inform and enhance our understanding of brain development and neurological and psychiatric conditions
Download or read book The Wiley Handbook on the Aging Mind and Brain written by Matthew Rizzo and published by John Wiley & Sons. This book was released on 2018-05-29 with total page 807 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thought-provoking treatise on understanding and treating the aging mind and brain This handbook recognizes the critical issues surrounding mind and brain health by tackling overarching and pragmatic needs so as to better understand these multifaceted issues. This includes summarizing and synthesizing critical evidence, approaches, and strategies from multidisciplinary research—all of which have advanced our understanding of the neural substrates of attention, perception, memory, language, decision-making, motor behavior, social cognition, emotion, and other mental functions. Written by a plethora of health experts from around the world, The Wiley Handbook on the Aging Mind and Brain offers in-depth contributions in 7 sections: Introduction; Methods of Assessment; Brain Functions and Behavior across the Lifespan; Cognition, Behavior and Disease; Optimizing Brain Function in Health and Disease; Forensics, Competence, Legal, Ethics and Policy Issues; and Conclusion and New Directions. Geared toward improving the recognition, diagnosis, and treatment of many brain-based disorders that occur in older adults and that cause disability and death Seeks to advance the care of patients who have perceptual, cognitive, language, memory, emotional, and many other behavioral symptoms associated with these disorders Addresses principles and practice relevant to challenges posed by the US National Academy of Sciences and National Institute of Aging (NIA) Presents materials at a scientific level that is appropriate for a wide variety of providers The Wiley Handbook on the Aging Mind and Brain is an important text for neurologists, psychiatrists, psychologists, physiatrists, geriatricians, nurses, pharmacists, social workers, and other primary caregivers who care for patients in routine and specialty practices as well as students, interns, residents, and fellows.
