Download or read book DNA Repair and Mutagenesis in Eukaryotes written by W. Generoso and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not many years ago most discussion of mutation induction by physical and chemical agents concentrated on the initial lesions induced in the DNA with the implicit assumption that once the lesions were made they were converted almost automatically to mutations by relatively simple processes associated with DNA replication. The discovery of a variety of enzymatic processes that can repair these lesions, the great increase in our understanding of the molecular steps involved in repair, replication, and recombination, and the increasing availability of cells with genetic defects in these pro cesses have led to the realization that mutation induction is a far more complex process than we originally thought. Repair systems can remove lesions before they can be converted to mutation, they can also convert initial lesions to secondary ones that are them selves mutagenic, and they can remove potentially lethal lesions at the expense of making mutations. The error-avoiding systems asso ciated with replication are themselves complex and may be caused to make mistakes in various ways. These different pathways for mutation production and mutation avoidance are still being worked out in prokaryotes and are less well understood in eukaryotes. This symposium shows, however, that very encouraging progress has been made in the last several years, and the progress is now accelerating.
Download or read book DNA Repair and Mutagenesis written by Errol C. Friedberg and published by American Society for Microbiology Press. This book was released on 2005-11-22 with total page 2587 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential resource for all scientists researching cellular responses to DNA damage. • Introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade. • Discussed the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed. • Provides information on covering sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage.
Download or read book DNA Repair and Mutagenesis in Eukaryotes written by W. M. Generoso and published by . This book was released on 1980 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Symposium on DNA Repair and Mutagenesis in Eukaryotes, sponsored by the National Institute of Environmental Health Sciences, and held in Atlanta, Georgia, June 25-29, 1979.
Download or read book DNA Damage and Repair written by Jac A. Nickoloff and published by Springer Science & Business Media. This book was released on 1998-08-12 with total page 1050 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention. Extensive up-to-date references and rigorous peer-review of each chapter make this volume definitive and bring it to the active frontiers of research.
Download or read book DNA Repair Mutagenesis and Other Responses to DNA Damage written by Errol C. Friedberg and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular DNA is constantly bombarded with environmental and chemical assaults that damage its molecular structure. In addition, the normal process of DNA replication is prone to error and may introduce mutations that can be passed to daughter cells. If left unrepaired, these DNA lesions can have serious consequences, such as cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews the mechanisms that cells use to recognize and repair various types of DNA damage. Contributors discuss base excision repair, nucleotide excision repair, mismatch repair, homologous recombination, nonhomologous end joining, the SOS response, and other pathways in prokaryotes and eukaryotes, and describe how these processes are linked to DNA replication, transcription, and cell cycle controls. The repair of telomeric and mitochondrial DNA is described, as is the influence of chromatin structure on DNA repair. This volume also includes discussion of human genetic diseases that involve defects in DNA damage repair. It is an essential reference for molecular and cell biologists, medical geneticists, cancer biologists, and all who want to understand how cells maintain genomic integrity.
Download or read book Recent Research Development in DNA Repair and Mutagenesis written by Encarna Alejandre-Durán and published by . This book was released on 2002 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book DNA Repair Mechanisms written by Philip Hanawalt and published by Elsevier. This book was released on 2012-12-02 with total page 832 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Repair Mechanisms is an account of the proceedings at a major international conference on DNA Repair Mechanisms held at Keystone, Colorado on February 1978. The conference discusses through plenary sessions the overall standpoint of DNA repair. The papers presented and other important documents, such as short summaries by the workshop session conveners, comprise this book. The compilation describes the opposing views, those that agree and dispute about certain topic areas. This book, divided into 15 parts, is arranged according to the proceedings in the conference. The plenary sessions are grouped with the related workshop and poster manuscripts. The first two parts generally tackle repair in terms of its identification and quantification, as well as the models, systems, and perspectives it utilizes. The following parts discuss the various types of repair including base excision, nucleotide excision repair in bacteria, excision repair in mammalian cells, inducible/error-prone repair in prokaryotes, and strand break repair in mammalian cells among others. This reference material looks into the replicative bypass mechanisms in mammalian cells, viral probes, and hereditary repair defects. It explains repair deficiency and human disease, as well as mutagenesis and carcinogenesis. The last part of this book deals with the consequences and effects of DNA repair. This volume is a helpful source of reference for students, teachers, scientists, and researchers in the different fields of genetics, radiology, biochemistry, and environmental biology.
Download or read book Induced Mutagenesis written by Christopher W. Lawrence and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concern is often expressed that our environment may include an increasingly large variety of mutagens, but the extent of the potential hazard they pose has yet to be fully evaluated. A variety of empirical procedures has been devised with which to estimate the mutagenic potency of suspect agents, and the relative merits of different tests are currently under debate. Although such tests are of great value, and are indeed indispensable, they are not, nevertheless, sufficient. In the long term, accurate estimation of hazard will also require a better understanding of the various mechanisms of mutagenesis, and in many instances these remain remarkably elusive. Our knowledge and appreciation of the problem has increased substantially over the last few years, but the precise way in which many mutagens cause mutations is not yet known. The aims of this conference were therefore two-fold. The first was to survey present information about mutagenic mechanisms, drawing together data from work with various experimental approaches and organisms, in order to discern the principles governing the action of different mutagens. The second was to examine the implications of such principles for the execution and evaluation of test procedures, and critically assess the research areas that need further attention in order to improve the interpretation of test results. Chris Lawrence v ACKNOWLEDGEMENT We gratefully acknowledge the support provided for this Conference by the U.,S. Department of Energy, The Foundation for Microbiology, Exxon Corporation and the University of Rochester.
Download or read book New Research on DNA Repair written by Breehn R. Landseer and published by Nova Publishers. This book was released on 2007 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a major defence against environmental damage to cells DNA repair is present in all organisms including bacteria, yeast, drosophila, fish, amphibians, rodents and humans. DNA repair is involved in processes that minimise cell killing, mutations, replication errors, persistence of DNA damage and genomic instability. Abnormalities in these processes have been implicated in cancer and ageing. This book presents leading-edge research from around the world in this frontal field.
Download or read book DNA Repair Protocols written by Daryl S. Henderson and published by Humana Press. This book was released on 1999-06-21 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book DNA Repair and Replication written by and published by Elsevier. This book was released on 2004-12-24 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Repair and Replication contains an up-to-date review of general principles of DNA replication and an overview of the multiple pathways involved in DNA repair. Specific DNA repair pathways, including base-excision repair, light-dependent direct reversal of UV-damage, nucleotide-excision repair, transcription-coupled repair, double-strand break repair, and mismatch repair, are each discussed in separate chapters.Selected Contents: - Base Excision Repair - Eukaryotic DNA Mismatch Repair - Double Strand Break Repair - Functions of DNA Polymerases - Somatic Hypermutation: A Mutational Panacea
Download or read book DNA Damage and Repair written by Jac A. Nickoloff and published by Springer Science & Business Media. This book was released on 2001-03-13 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jac A. Nickoloff and Merl F. Hoekstra update and expand their two earlier acclaimed volumes (Vol. I: DNA Repair in Prokaryotes and Lower Eukaryotes and Vol. II: DNA Repair in Higher Eurkaryotes) with cutting-edge reviews by leading authorities of primary experimental findings about DNA repair processes in cancer biology. The reviews cover a wide range of topics from viruses and prokaryotes to higher eukaryotes, and include several new topics, among them the role of recombination in replication of damaged DNA, X-ray crystallographic analysis of DNA repair protein structures, DNA repair proteins and teleomere function, and the roles of BRCA1 and BRCA2 in DNA repair. Authoritative and up-to-date, DNA Damage and Repair, Vol. III: Advances from Phage to Humans surveys the rapidly moving research in DNA damage and repair, and explains the important functional relationships among different DNA repair pathways and the relationship between DNA repair pathways, cancer etiology, and cancer therapies.
Download or read book Molecular and Cellular Mechanisms of Mutagenesis written by J. Lemontt and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been nearly 35 years since the peacetime Biology Division of Oak Ridge National Laboratory was started, born of rather inauspicious conditions. Virtually no facilities were available and most of the wartime scientists had left. So, when we started out, it was obvious to me that something had to be done to reestab lish research. Even more, because Oak Ridge was not known at that time for its biological work but rather for the separation of Uranium 235, nuclear reactor development, and radioisotope produc tion, a new tradition had to be promoted. Although good biological work had been done at Oak Ridge during the war to protect the workers and the results of this work were quite excellent, very few installations remained. When we started the work of the Biology Division, it became essential to make it part of the flow of mod~rn biology allover the world. As Director, I had to do more than just attract promising scientists. We created an atmosphere conducive to creative research and nurtured all of the other aspects of a productive laboratory. Of course, we carefully prepared the results of our work in publish able form. We made a sincere effort to invite seminar speakers and lecturers to come to Oak Ridge despite the sacrifices this presented to our early budget. We also had to do something more, and here I "cashed in" on my experience of the previous 15 years.
Download or read book Induced Effects Of Genotoxic Agents In Eukaryotic Cells written by Toby G Rossman and published by CRC Press. This book was released on 2020-07-26 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an understanding of the consequences of induced proteins in the toxicological response of cells to chemical and radiation damage to DNA and will be helpful in creating proper mathematical models for extrapolation to low doses and assessing human exposure or cellular injury.
Download or read book DNA Replication Recombination and Repair written by Fumio Hanaoka and published by Springer. This book was released on 2016-01-22 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1–3), DNA Replication; Part 2 (Chapters 4–6), DNA Recombination; Part 3 (Chapters 7–9), DNA Repair; Part 4 (Chapters 10–13), Genome Instability and Mutagenesis; Part 5 (Chapters 14–15), Chromosome Dynamics and Functions; Part 6 (Chapters 16–18), Cell Cycle and Checkpoints; Part 7 (Chapters 19–21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.
Download or read book DNA Damage and Repair written by Jac A. Nickoloff and published by Springer Science & Business Media. This book was released on 1998-01-21 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuing the tradition of presenting information on DNA damage and repair, this 3rd volume provides the latest reviews by leading researchers. They illuminate key aspects of DNA repair in mammalian systems and its relationship to human disease.
Download or read book DNA Repair and Replication written by Roger J. A. Grand and published by Garland Science. This book was released on 2018-09-03 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Repair and Replication brings together contributions from active researchers. The first part of this book covers most aspects of the DNA damage response, emphasizing the relationship to replication stress. The second part concentrates on the relevance of this to human disease, with particular focus on both the causes and treatments which make use of DNA Damage Repair (DDR) pathways. Key Selling Features: Chapters written by leading researchers Includes description of replication processes, causes of damage, and methods of repair
