Download or read book Development Of Spectrophotometric Methods For Pharmaceutical Analysis written by Kanchan Upadhyay and published by LAP Lambert Academic Publishing. This book was released on 2013 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the present book some simple and sensitive spectrophotometric methods for determination of drugs in pharmaceutical formulations and in biological samples have been described. The methods are based on the use of chromogenic reagents, redox reactions, solvent extraction and solid phase extraction techniques. The methods for validation of developed methods have also been described. The drugs for which methods have been described are -methyldopa, sulphonamide derivatives, lamivudine, nimesulide, nicorandil, olanzapine, and phenothiazine derivatives."
Download or read book Ultraviolet Visible Spectrophotometry in Pharmaceutical Analysis written by S. Gorog and published by CRC Press. This book was released on 2018-01-10 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the state of the art in pharmaceutical applications of UV-VIS spectroscopy. This book presents the fundamentals for the beginner and, for the expert, discusses both qualitative and quantitative analysis problems. Several chapters focus on the determination of drugs in various matrices, the coupling of chromatographic and spectrophotometric methods, and the problems associated with the use of chemical reactions prior to spectrophotometric measurements. The final chapter provides a survey of the spectrophotometric determination of the main families of drugs, emphasizing the achievements of the last decade.
Download or read book Spectroscopic Analyses written by Eram Sharmin and published by BoD – Books on Demand. This book was released on 2017-12-06 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents developments and applications of these methods, such as NMR, mass, and others, including their applications in pharmaceutical and biomedical analyses. The book is divided into two sections. The first section covers spectroscopic methods, their applications, and their significance as characterization tools; the second section is dedicated to the applications of spectrophotometric methods in pharmaceutical and biomedical analyses. This book would be useful for students, scholars, and scientists engaged in synthesis, analyses, and applications of materials/polymers.
Download or read book Ultraviolet Visible Spectrophotometry in Pharmaceutical Analysis written by S. Gorog and published by CRC Press. This book was released on 2017-12-08 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the state of the art in pharmaceutical applications of UV-VIS spectroscopy. This book presents the fundamentals for the beginner and, for the expert, discusses both qualitative and quantitative analysis problems. Several chapters focus on the determination of drugs in various matrices, the coupling of chromatographic and spectrophotometric methods, and the problems associated with the use of chemical reactions prior to spectrophotometric measurements. The final chapter provides a survey of the spectrophotometric determination of the main families of drugs, emphasizing the achievements of the last decade.
Download or read book Compendium of Analytical Nomenclature written by H. M. N. H. Irving and published by Elsevier. This book was released on 2017-05-03 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compendium of Analytical Nomenclature: Definitive Rules 1977 focuses on the recommended nomenclature and symbols to be used in various disciplines of analytical chemistry. The book first offers information on recommendations for the presentation of the results of chemical analysis; recommendations for terminology to be employed with precision balances; and recommendations on nomenclature for contamination phenomena in precipitation from aqueous solution. The text also takes a look at recommended nomenclature for automatic analysis and recommendations for nomenclature of thermal analysis and mass spectrometry, as well as recommended nomenclature for titrimetric analysis. The publication reviews the practical measurements of pH in amphiprotic and mixed solvents. Topics include operational pH scale; selection of a pH unit for amphiprotic solvents; and interpretation of the measured pH. The text also considers the recommendations on nomenclature and presentation of data in gas chromatography and recommendations on nomenclature for chromatography. The book is a valuable source of data for readers wanting to study analytical nomenclature.
Download or read book Spectrophotometry in Pharmaceutical Analysis written by Shabbir Ahmed and published by LAP Lambert Academic Publishing. This book was released on 2011-05 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: A simple spectrophotometric method for determination of cefaclor in raw and dosage forms based on reaction with ninhydrin is developed, optimized and validated. The purple color (Ruhemenn's purple) resulted from the reaction was stabilized and measured at 560 nm.The method optimization was essential as many procedural parameters influenced the accuracy of determination all variables including the reagent concentration, heating time, reaction temperature, color stability period, and cefaclor/ninhydrin ratio were studied in order to optimize the reaction conditions. No interference was observed from common pharmaceutical adjuvant. The developed method is easy to use, accurate and highly cost-effective for routine studies relative to HPLC and other techniques.
Download or read book Handbook of Analytical Quality by Design written by Sarwar Beg and published by Academic Press. This book was released on 2021-01-09 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Analytical Quality by Design addresses the steps involved in analytical method development and validation in an effort to avoid quality crises in later stages. The AQbD approach significantly enhances method performance and robustness which are crucial during inter-laboratory studies and also affect the analytical lifecycle of the developed method. Sections cover sample preparation problems and the usefulness of the QbD concept involving Quality Risk Management (QRM), Design of Experiments (DoE) and Multivariate (MVT) Statistical Approaches to solve by optimizing the developed method, along with validation for different techniques like HPLC, UPLC, UFLC, LC-MS and electrophoresis. This will be an ideal resource for graduate students and professionals working in the pharmaceutical industry, analytical chemistry, regulatory agencies, and those in related academic fields. Concise language for easy understanding of the novel and holistic concept Covers key aspects of analytical development and validation Provides a robust, flexible, operable range for an analytical method with greater excellence and regulatory compliance
Download or read book Development of New Spectrophotometric and HPLC Methods written by Madduri Ramachandra Reddy and published by LAP Lambert Academic Publishing. This book was released on 2014-09-09 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analytical chemistry is playing a vital role in determination of various drugs and pharmaceutical products.The chemical features of selected drug molecules still offer a lot of scope for the development of new UV and visible spectrophotometric and HPCL methods hopefully with better sensitivity, selectiviy, precision and accuracy.The author has made some attempts in this direction and succeeded in developing some new methods having advantages of one or more of the desirable features.
Download or read book Sustainable Approaches in Pharmaceutical Sciences written by Kamal Shah and published by John Wiley & Sons. This book was released on 2024-03-25 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highly comprehensive and detailed text on best possible sustainable approaches associated with the development, design, and origination of pharmaceuticals Sustainable Approaches in Pharmaceutical Sciences enables readers to understand the best possible green approaches associated with the development, design, and origination of pharmaceuticals, including resources that may minimize the adverse effects associated with synthesis, isolation, and extraction. Sustainable Approaches in Pharmaceutical Sciences covers a myriad of current topics, including mechanochemical improvements for API synthesis, as well as the role of artificial intelligence (AI) in the development and discovery of pharmaceuticals, along with recent developments in hydrogels which respond to triggered factors during topical drug delivery. Authored by experienced scientists from institutions across the world, other sample topics covered in Sustainable Approaches in Pharmaceutical Sciences include: Green technologies and benefits associated with them, white biotechnology, green chemistry, and eco-friendly approaches for designing active pharmaceutical ingredients Impact of sustainable approaches in pharmaceutical industries regarding use of solvents, nanoparticles formulations, and antimicrobial bandages Micro-extractive methods capable of generating high recovery values of the analytes and associated techniques, such as dispersive liquid-liquid microextraction Benefits of the exploration of sustainable chemistry on a commercial scale, particularly in relation to bioresources, chemical manufacturing, and organic transformation Discussing both the foundational science and practicality of different approaches regarding human and environmental health, Sustainable Approaches in Pharmaceutical Sciences is an essential resource for scientists, medical professionals, and industrial professionals working in the fields of sustainable technology and synthesis in pharmaceutical sciences, along with advanced level students.
Download or read book Spectrophotometric Determination of Diaveridine and Two Sulfa Drugs written by Abdel-Kader Nora S and published by LAP Lambert Academic Publishing. This book was released on 2015-07-30 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analytical chemistry is very important in pharmaceutical industries, where without quality assurance, the pharmaceutical preparations can't be performed. Thus, the analyst needs a rapid, easy, inexpensive, sensitive, selective and accurate method of analysis, these properties can be achieved by the use of spectrophotometery for quantitative analysis of pharmaceutical compounds. Several spectrophotometric methods are in use in pharmaceutical analysis. For a long time direct UV-measurements have been used as the official and pharmacopoeias methods. Spectrophotometric methods applied in pharmaceutical analysis are numerous; mostly all spectral methods are in use. Among these, is molecular spectrophotometric method using UV and visible radiation.This book contains the development of fast, cheap, accurate and sensitive spectrophotometric techniques for the determination of diaveridine, sulfadimidine and sulfaguanidine in pure forms and in some commercial pharmaceutical preparations.the proposed spectrophotometric techniques have advantages over many of the reported methods due to their sensitivity, wide application and they need inexpensive sophisticated apparatus.
Download or read book Spectrophotometric Methods as Solutions to Pharmaceutical Analysis of Lactam Antibiotics written by Judyta Cielecka-Piontek and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Development and Validation of Differential Spectrophotometric Method for Assay of Enrofloxacin in Bulk and Tablet Formulation written by M. Patel and published by GRIN Verlag. This book was released on 2023-12-12 with total page 19 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research Paper (postgraduate) from the year 2019 in the subject Medicine - Pharmacology, Pharmacy, , course: M pharmacy, language: English, abstract: A simple, precise and accurate spectrophotometric method have been developed and validated for the estimation of Enrofloxacin in bulk as well as tablet formulation. The UV spectra of Enrofloxacin was obtained in 0.1N HCl and 0.1N NaOH, and the overlain spectra showed maximum absorbance at 271.0 nm (maxima) and 276.5 nm (minima) in 0.1N NaOH and HCl respectively. The drug follows linearity in the range of 5-30 μg/ml (R2= 0.988). Both intra- and inter-day precision showed % RSD˂ 2 while LOD and LOQ were 0.320 and 0.971 respectively. The method was validated as per ICH guidelines. Enrofloxacin or [1-cyclopropyl-6-fluoro-7-(4-ethyl-1-piperazinyl)-1,4-dihydro-4-oxo-3 quinoline carboxylic acid]. The chemical structure of the drug is given in. It is a synthetic antibacterial agent from the class of the fluroquinolone carboxylic acid derivatives. It has antibacterial activity against a broad spectrum of Gram negative and Gram positive bacteria. Enrofloxacin is used for the treatment of individual pets and domestic animals. Literature survey shows that several analytical methods for the determination of Enrofloxacin include RP-HPLC, HPLC, RP-LC, LC and dissolution study have been reported. Many pharmaceutical products have been assayed by this method. But Differential UV spectrophotometric method of Enrofloxacin was not reported as so far. So an attempt was made to develop a novel, simple, accurate spectrophotometric method for the determination of Enrofloxacin in tablet formulation.
Download or read book Development and Validation of Anti tussive Drugs in Dosage Form written by Mukesh C. Sharma and published by LAP Lambert Academic Publishing. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analytical methods development and validation play important roles in the discovery, development, and manufacture of pharmaceuticals. The official test methods that result from these processes are used by quality control laboratories to ensure the identity, purity, potency, and performance of drug products. The method is found to be linear and accurate in the specified range. These newer methods for separating and determining chemical species are known collectively as instrumental methods of analysis.
Download or read book Development and Publication of New Spectrophotometric Methods of Analysis written by G.F. Kirkbright and published by . This book was released on 1965 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book HPLC Method Development for Pharmaceuticals written by Satinder Ahuja and published by Elsevier. This book was released on 2011-09-21 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: High pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring changes during scale up or revision of synthetic procedures, evaluating new formulations, and running control/assurance of the final drug product. HPLC Method Development for Pharmaceuticals provides an extensive overview of modern HPLC method development that addresses these unique concerns. Includes a review and update of the current state of the art and science of HPLC, including theory, modes of HPLC, column chemistry, retention mechanisms, chiral separations, modern instrumentation (including ultrahigh-pressure systems), and sample preparation. Emphasis has been placed on implementation in a pharmaceutical setting and on providing a practical perspective. HPLC Method Development for Pharmaceuticals is intended to be particularly useful for both novice and experienced HPLC method development chemists in the pharmaceutical industry and for managers who are seeking to update their knowledge. Covers the requirements for HPLC in a pharmaceutical setting including strategies for software and hardware validation to allow for use in a regulated laboratory Provides an overview of the pharmaceutical development process (clinical phases, chemical and pharmaceutical development activities) Discusses how HPLC is used in each phase of pharmaceutical development and how methods are developed to support activities in each phase
Download or read book Novel Spectrophotometric and HPLC Method Development and Validation written by Pratik Mehta and published by LAP Lambert Academic Publishing. This book was released on 2013-01 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug manufacturing control requires high level and intensive analytical and chemical support of all stages to ensure the drug's quality and safety. Highly specific and sensitive analytical techniques hold the key to the design, development, standardization and quality control of medicinal products. The book is focussed on development and validation of RP-HPLC method for simultaneous estimation of bromhexine HCl, dextromethorphan HBr, and guaiphenesin, colorimetric method for estimation of ferrous fumarate and zinc sulphate, and UV spectrophotometric method for simultaneous estimation of ambroxol HCl, cetirizine HCl, and dextromethorphan HBr, form their combined dosage form. The analysis should be useful to some pharmaceutical companies, students of pharmacy field or anyone else seeking knowledge in the respective field.
Download or read book Method Validation in Pharmaceutical Analysis written by Joachim Ermer and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adopting a practical approach, the authors provide a detailed interpretation of the existing regulations (GMP, ICH), while also discussing the appropriate calculations, parameters and tests. The book thus allows readers to validate the analysis of pharmaceutical compounds while complying with both the regulations as well as the industry demands for robustness and cost effectiveness. Following an introduction to the basic parameters and tests in pharmaceutical validation, including specificity, linearity, range, precision, accuracy, detection and quantitation limits, the text focuses on a life-cycle approach to validation and the integration of validation into the whole analytical quality assurance system. The whole is rounded off with a look at future trends. With its first-hand knowledge of the industry as well as regulating bodies, this is an invaluable reference for analytical chemists, the pharmaceutical industry, pharmaceutists, QA officers, and public authorities.
