Download or read book Collagen Cross linking Using Riboflavin and Ultraviolet a for Corneal Thinning Disorders written by and published by . This book was released on 2011 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The main objectives for this evidence-based analysis were to determine the safety and effectiveness of photochemical corneal collagen cross-linking with riboflavin (vitamin B2) and ultraviolet-A radiation, referred to as CXL, for the management of corneal thinning disease conditions. The comparative safety and effectiveness of corneal cross-linking with other minimally invasive treatments such as intrastromal corneal rings was also reviewed. The Medical Advisory Secretariat (MAS) evidence-based analysis was performed to support public financing decisions"--Page 9.
Download or read book Corneal Collagen Cross Linking written by Mazen M. Sinjab and published by Springer. This book was released on 2016-11-09 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive coverage of corneal collagen cross-linking (CXL), a major management modality for keratoconus and ectatic corneal disorders. All aspects are covered, including refractive and non-refractive surgery indications, models of application, safety, efficacy, performance, outcome measures, evidence of CXL, complications, contraindications, use in children, and controversies. The discussion reflects the considerable progress that has been made in understanding of the modality since its development in the late 1990s. Detailed attention is paid to new concepts, changing surgical techniques and indications, the latest evidence-based science and research, and the future of CXL. Guidance is also provided on the use of CXL in combination with other modalities, such as LASIK, PRK, intracorneal ring implantation and others. The text is accompanied by numerous high-quality color illustrations. Corneal Collagen Cross Linking will provide the reader with a sound grasp of the technique and its use and will hopefully also serve as a stimulus to further research and advances.
Download or read book Corneal Collagen Cross link Therapy for Keratoconus written by Joren Bonderud and published by . This book was released on 2017 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keratoconus is a corneal condition that affects 1 in 2000 people. It causes symptoms including blurry, distorted, and irregular vision that cannot be fully corrected by traditional glasses. Patients with this condition can suffer a decrease in the quality of their life, depending on the severity and progression of the disease. In severe cases, a corneal transplant is needed which can be dangerous, expensive, and ultimately unsuccessful. Corneal Collagen Cross-linking is a procedure that involves treating the eye with topical Riboflavin (Vitamin B2) and Ultraviolet light in order to strengthen the thinning corneal tissue. This procedure has given eye professionals hope for reducing the need for corneal transplants. Also, there is evidence that this procedure can reduce the incidence of severe complications. The information in this literature review is provided by the tireless effort of researchers from 1998 until the present.
Download or read book Photochemical Corneal Collagen Cross linkage Using Riboflavin and Ultraviolet A for Keratoconus written by National Institute for Health and Clinical Excellence (Great Britain) and published by . This book was released on 2009 with total page 2 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Corneal Cross linking with Riboflavin for Keratoconus written by Canadian Agency for Drugs and Technologies in Health and published by . This book was released on 2013 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keratoconus (KC) is a degenerative disorder of the eye in which cornea becomes progressively thinner and bows outward into a more conical shape than its normal gradual curve. KC affects approximately 0.05% of the global population. Patients with KC often experience eye irritation, headaches, light halos, light sensitivity, worsening myopia, and impaired quality of life. KC is usually diagnosed in the adolescent period. Various treatment options for KC include simple correction with glasses, soft or rigid gas permeable contact lenses, surgical implantation of intrastromal corneal ring segments (Intacs), and corneal transplant. In addition, corneal-crosslinking with riboflavin and ultraviolet A (CXL) is increasingly considered as a method for managing KC. The treatment objective for CXL is to stabilize the underlying disease process by strengthening the stromal collagen network in order to delay or defer the need for corneal transplant. In the process of CXL, riboflavin (vitamin B2) works as a photo-mediator to increase the absorption of ultraviolet A light into the corneal stroma. The ultraviolet A (UVA: 370 nm) light increases the degree of molecular bonds of the extracellular matrix of the cornea. Therefore, CXL slows or even stops the progression of KC by increasing the strength and rigidity of the cornea. CXL can be performed with or without removing corneal epithelium. Common reported side-effects of CXL are blurry vision, lacrimation and the sensation of a foreign body for approximately 24 to 48 hours. Serious side effects include corneal haze and keratitis. CXL is only indicated for patients with corneas greater than 400 mcm thick. Corneal cross-linking with riboflavin -- UVA for keratoconus has been increasingly used in some Canadian jurisdictions. However it is currently not covered by any Canadian jurisdiction. Demand for CXL as the standard of care for keratoconus is increasing in some Canadian jurisdictions, although the long-term effectiveness and CXL's impact on the need for corneal transplant is unknown. The objective of this report is to review the clinical effectiveness (such as improved vision and corneal strength/stabilization) and cost-effectiveness on CXL in the treatment of keratoconus.
Download or read book Treatment of Keratoconus written by Michael Litchfield and published by . This book was released on 2012 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keratoconus is characterized bya thinning of the corneal stroma due to non-inflammatory means, and results in conical morphology changes. Because keratoconus is a condition of the cornea -- one of the main refractive surfaces of the eye -- changes in its structure can influence visual acuity. Degradation of visual acuity is one of the main reasons why treating keratoconus is of prime importance. If the condition can be effectively treated, then vision can potentially be preserved. However not all treatments bring about equal results. Some are less invasive like rigid gas permeable contact lenses, which seek to optimize vision through optical means, while other more invasive means such as intrastromal ring segments, lamellar and penetrating keratoplasties seek to replace or change the existing corneal surface so visual acuity can be improved. With each comes a varying degree of efficacy and success. However, one of the most recent treatments, that of riboflavin-UVA collagen cross-linking, has been showing promising results, both in terms of its safety and efficacy. Collagen cross-linking treatment has been found to strengthen thinning corneas and stabilize the histopathological nature of keratoconus. As a result of treatment, both uncorrected and corrected visual acuity has been found consistently to significantly improve, and keratometry values were also found to decrease. These clinical results were seen in both abundant short-term studies, as well as in longer-term studies, which may subsequently allow for its FDA approval in the near future.
Download or read book Mastery of Holcomb C3 R Crosslinking for Keratoconus Other Disorders For Patients and Physicians written by Brian S Boxer Wachler and published by JP Medical Ltd. This book was released on 2013-03-31 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keratoconus is degeneration of the structure of the cornea. The cornea is the clear tissue covering the front of the eye. In keratoconus, the shape of the cornea slowly changes from round to conical (PubMed Health). In the early stages, keratoconus can be corrected with the use of lenses, but in the later stages, surgery is the only option. Holcomb C3-R® is a non-surgical technique that involves placing drops of the vitamin Riboflavin into the eye and using a UV light to activate them. The drops strengthen the fibres of the cornea and over time, preserve sight (American Keratoconus Association). This book is a concise guide to the technique of Holcomb C3-R® to treat keratoconus. Authored by the inventor of the procedure, Brian S Boxer Wachler, the text is based on his first hand clinical experience and explains the history and basic science of cross linking, the development and naming of the technique, its uses and complications, and first patient results. Key points Concise guide to technique of Holcomb C3-R® to treat keratoconus Authored by inventor of the technique and based on clinical experience Includes more than 60 full colour images and illustrations
Download or read book Ocular Imaging written by George Asimellis and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Management of Complications in Refractive Surgery written by Jorge L. Alio and published by Springer. This book was released on 2018-01-02 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: This illustrated guide is written by international opinion leaders with extensive experience in the practice of refractive surgery. It is the first book devoted to refractive complications (with practical hints and case reports on outcomes) to provide ophthalmic surgeons with the most adequate solutions for the most frequent problems. All complications are described and lavishly illustrated. The book provides ophthalmic surgeons with the most adequate solutions for the most frequent problems they face in their daily practice.
Download or read book Controversies in the Management of Keratoconus written by Adel Barbara and published by Springer. This book was released on 2019-02-04 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents new technologies which are available now for the rehabilitation of visual acuity in patients suffering from keratoconusand for arresting the progression of this frustrating disease. All these current treatment options in differing combinations aim to improve the quality of life of the patients and although successful, they are causing confusion for the ophthalmologists; what procedure to do and when? How to perform? Which combination of treatments to choose? Controversies in the Management of Keratoconusprovidesthe widely used treatment options for keratoconus including collagen corneal cross –linking (CXL) covering all the available techniques, intrastromal corneal ring segments (ICRS) , phakic intra-ocular lenses (IOLs), photorefractive keratectomy (PRK) combined or not with CXL penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty ( DALK). Each treatment is addressed by more than one author with different points of view in order to present the various approaches, the logic behind them and the most relevant clinical data available.A chapter by the editor tries to put some light on how to navigate among these controversies. This book will be of interest to trainees as well as the specialized ophthalmologists.
Download or read book Corneal Cross linking with Riboflavin for Keratoconus written by and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keratoconus (KC) is a degenerative disorder of the eye in which cornea becomes progressively thinner and bows outward into a more conical shape than its normal gradual curve. KC affects approximately 0.05% of the global population. Patients with KC often experience eye irritation, headaches, light halos, light sensitivity, worsening myopia, and impaired quality of life. KC is usually diagnosed in the adolescent period. Various treatment options for KC include simple correction with glasses, soft or rigid gas permeable contact lenses, surgical implantation of intrastromal corneal ring segments (Intacs), and corneal transplant. In addition, corneal-crosslinking with riboflavin and ultraviolet A (CXL) is increasingly considered as a method for managing KC. The treatment objective for CXL is to stabilize the underlying disease process by strengthening the stromal collagen network in order to delay or defer the need for corneal transplant. In the process of CXL, riboflavin (vitamin B2) works as a photo-mediator to increase the absorption of ultraviolet A light into the corneal stroma. The ultraviolet A (UVA: 370 nm) light increases the degree of molecular bonds of the extracellular matrix of the cornea. Therefore, CXL slows or even stops the progression of KC by increasing the strength and rigidity of the cornea. CXL can be performed with or without removing corneal epithelium. Common reported side-effects of CXL are blurry vision, lacrimation and the sensation of a foreign body for approximately 24 to 48 hours. Serious side effects include corneal haze and keratitis. CXL is only indicated for patients with corneas greater than 400 mcm thick. Corneal cross-linking with riboflavin -- UVA for keratoconus has been increasingly used in some Canadian jurisdictions. However it is currently not covered by any Canadian jurisdiction. Demand for CXL as the standard of care for keratoconus is increasing in some Canadian jurisdictions, although the long-term effectiveness and CXL's impact on the need for corneal transplant is unk.
Download or read book Corneal Cross Linking written by Lawrence Hopp and published by Addicus Books. This book was released on 2018-07-01 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: Have you been diagnosed with corneal disease? If so, you undoubtedly have questions. How will your eyesight be affected? How can your condition be treated? What are the potential complications of treatment? Dr. Lawrence M. Hopp, M.D., M.S. is a cornea specialist, fellowship-trained in refractive surgery, who has treated thousands of patients with diseases of the cornea. He understands your concerns and offers information that will help ease your anxiety. In Corneal Cross-Linking: Treatment for Cornea Disease, he discusses how cornea diseases develop and how they are best treated. He covers such topics as: signs and symptoms of corneal diseases; corneal disease diagnosis; newest treatments, such as collagen linking, cornea transplants and when they are needed, potential complications of treatment, and more.
Download or read book Corneal Biomechanics written by C.J. Roberts and published by Kugler Publications. This book was released on 2017-05-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: While lecturing in recent months at a number of prominent institutions, I asked some of the residents and fellows whether and how they might benefit from a book on corneal biomechanics. The typical response was the look of a deer caught in the headlights as they tried to intuit the “appropriate” answer, but had little understanding or insight as to why this would be an important and useful knowledge base for them now, or in the future. I then posed the question differently. “Would a book that explained corneal biomechanical principles and testing devices and their application in detecting eyes at risk for developing keratoconus and post-LASIK ectasia, understanding the biomechanical impact of specific types of keratorefractive surgery and riboflavin UV-A corneal collagen cross-linking, and the impact of corneal biomechanics on the fidelity of intraocular pressure measurement and risk for glaucoma progression be of interest?” Framed in this context, the answer I got was a resounding, “Yes!” Therein lies a fundamental disconnect that highlights both the opportunity and need to educate all ophthalmologists about this nascent field. This comprehensive book is strengthened by the breadth of contributions from leading experts around the world and provides an important resource for ophthalmologists at all levels of training and experience. It gives a panoramic snapshot of our understanding of corneal biomechanics today, bridging the gap between theoretical principles, testing devices that are commercially available and in development as well as current and potential future clinical applications. While there has been a long-held appreciation that all types of keratorefractive surgery have an impact and interdependence on corneal biomechanics and wound healing, the initial finite element analyses that were applied to understand radial keratotomy were limited by incorrect assumptions that the cornea was a linear, elastic, homogenous, isotropic material.1 With the advent of excimer laser vision correction, critical observations indicated that Munnerlyn’s theoretic ablation profiles did not account for either lower or higher order (e.g. spherical aberration) refractive outcomes,2 suggesting that there were important components missing from the equation—e.g., corneal biomechanics and wound healing. In a seminal editorial, Roberts3 pointed out that the cornea is not a piece of plastic, but rather a material with viscoelastic qualities. Since that time, much has been learned about spatial and depth- related patterns of collagen orientation and interweaving, as well as the biomechanical response to different keratorefractive surgeries that sever tension-bearing lamellae, as the cornea responds to and redistributes stress induced by IOP, hydration, eye rubbing, blinking and extraocular muscle forces.3-6 The first reports of post-LASIK ectasia7 highlighted the need to identify a biomechanical signature of early keratoconus as well as corneas at high risk of developing ectasia irrespective of their current topography or tomography. The introduction of two instruments into clinical use—the Ocular Response Analyzer (ORA) and the Corneal Visualization Scheimpflug Technology (Corvis ST)—that allow measurement of various biomechanical metrics further catapulted the field. The availability of these instruments in routine clinical settings allowed the systematic study of the effect of age, collagen disorders, collagen cross-linking, corneal rings, flaps of various depths, contour, sidecut angulation, pockets, and flockets, just to name of few. Future application of biomechanics to the sclera may improve our understanding of the development and prevention of myopia, as well as scleral surgeries and treatments under development for presbyopia. It was appreciated by Goldmann and Schmidt that corneal thickness and curvature would influence the measurement of applanation tonometry. The recent ability to measure some corneal biomechanical metrics have led to IOP measurement that may be more immune both to their influence and the impact of central corneal thickness (CCT). Certain chapters in this book explain how a thin cornea could be stiffer than a thick one and that stiffness is also impacted by IOP, thereby precluding simplistic attempts to adjust IOP measurements using nomograms based upon CCT alone. Also highlighted is how corneal hysteresis, the ability of the cornea to absorb and dissipate energy during the bidirectional applanation response to a linear Gaussian air puff, appears to be an independent risk factor for glaucoma progression and rate of progression.9,10 This comprehensive book starts out with a section devoted to outlining basic biomechanical principles and theories, teaching us the language of what Dupps11 has referred to as “mechanospeak”, thus providing a context and common vocabulary to better comprehend the following chapters. By first defining basic concepts such as stress-strain relationships and creep, this theoretical basis is later applied to explain the pathogenesis of corneal diseases, e.g., explaining how a focal abnormality in corneal biomechanical properties precipitates a cycle of decompensation and localized thinning and steepening, clinically expressed as ectasia progression. These early chapters further detail biomechanical differences between in-vivo and ex-vivo testing, between human and animal corneas and sclera, and between methods of testing. The second section provides a thorough description of two FDA-approved devices to measure corneal biomechanics in the clinic (i.e., the ORA and the Corvis ST), as well as an overview of potential future technologies, including OCT with air puff stimulus, ocular pulse elastography, and Brilloiun microscopy. The third and final section of the book is a thorough treatise on how to interpret the metrics derived from the waveform provided by available clinical devices; their adjunct use in ectasia risk screening; the comparative biomechanical impact of various keratorefractive surgeries and corneal procedures such as PRK, LASIK, SMILE, and corneal collagen cross-linking; the impact of corneal biomechanics on IOP measurement; and potential biomechanical markers of enhanced susceptibility to glaucoma progression. This compendium of our current knowledge of corneal biomechanics, its measurement and application, provides a strong foundation to more fully understand advances in keratorefractive and corneal surgery, diseases, and treatments, all of which are interdependent on and influence inherent corneal biomechanical properties and behavior. Both the robust aspects and limitations of our current understanding are presented, including the challenge of creating accurate and predictive finite element models that incorporate the impact of IOP, corneal thickness, geometry, and scleral properties on corneal biomechanics. This book provides a key allowing clinical ophthalmologists and researchers to grasp the basics and nuances of this exciting field and to shape it as it evolves in the future.
Download or read book Astigmatism written by Michael Goggin and published by BoD – Books on Demand. This book was released on 2012-02-29 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the development, optics and physiology of astigmatism and places this knowledge in the context of modern management of this aspect of refractive error. It is written by, and aimed at, the astigmatism practitioner to assist in understanding astigmatism and its amelioration by optical and surgical techniques. It also addresses the integration of astigmatism management into the surgical approach to cataract and corneal disease including corneal transplantation.
Download or read book Femtosecond Laser Assisted Keratoplasty written by Jorge L Alio and published by JP Medical Ltd. This book was released on 2013-07-30 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keratoplasty is the transplantation of all or part of the cornea to repair scarred or damaged tissue. A femtosecond laser is a laser which emits ultrashort pulses, used for minimally invasive corneal surgery. This book is a concise guide to the technique of femtosecond laser-assisted keratoplasty. Beginning with an introduction to the technology, the following chapters discuss its use for different disorders. This practical text is based on the surgical experience of its internationally recognised authors from Spain, Germany, France and the USA. It includes more than 230 full colour clinical photographs and illustrations to enhance learning. Key points Concise guide to the corneal transplantation procedure of femtosecond laser-assisted keratoplasty Covers key technologies and uses for different disorders Internationally recognised author and editor team Includes more than 230 clinical photographs and illustrations
Download or read book Keratoconus written by Ashraf Armia and published by Springer Nature. This book was released on 2021-11-20 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a practical guide to the most recent advances in the diagnostic management of corneal ectasia. Clear, concise chapters address new standardized nomograms of treatment of early progressive ectasia, new epithelium on future crosslinking with and without oxygen supplement, customized protocols, laser assisted corneal regularization protocols and the new femtolaser assisted lamellar corneal transplant. Clinicians and surgeons seeking a go-to guide on the topic of corneal ectasia will find this book to be an essential resource for the latest developments and predicted future trends in the field.
Download or read book Corneal Collagen Crosslinking for Progressive Keratoconus in Pediatric Patients written by Joannie Irizarry Cortes and published by . This book was released on 2016 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the literature review is to examine the efficacy of corneal collagen crosslinking for progressive keratoconus in pediatric patients. Collagen crosslinking (CXL) is a technique that utilizes riboflavin and ultraviolet-A as an effective treatment option for progressive keratoconus in pediatric patients. Several articles have shown topographic results with statistically significant improvement in K readings and visual acuity on the patients. The procedure has proven to be safe on the pediatric population, even do there are studies conducted every day for improvement of it. CXL acts by reducing the mean refractive cylinder nd flatening the cornea, and appears effective in halting the progession of the disease. Ultimately, what is being study in the literature review is that crosslinking stabilizes the condition and, thus, reduces the need for corneal grafting in these young patients for a better and healthy vision.
