Download or read book Clinical Trials in Neurologic Practice written by José Biller and published by Butterworth-Heinemann. This book was released on 2001 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text covers the neurologic areas where trials have become increasingly important, including stroke, epilepsy, head and spinal cord injuries, and movement disorders. By applying the clinical evidence gained from the trials to neurologic practice, clinicians will be better positioned to meet the needs of their patients. * A practical approach to assist neurologists and neurologists in training in the understanding of clinical trials for neurologic disorders * Authors have assembled a distinguished international group of contributors to critically evaluate trials that have been conducted in their areas of expertise * Ideal book for practitioners interested in evidence-based neurologic practice
Download or read book Clinical Trials in Neurology written by Roberto J. Guiloff and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Trials in Neurology comprehensively tackles the methodology and design of clinical trials in neurological disease. A general section deals with the ethical aspects, drug development and regulatory requirements, basic trial designs and the statistics used. A diseases section tackles specific aspects of disorders, focusing on the relevant ethical issues, outcome variables and experience with large multicentre trials.
Download or read book Clinical Trials in Neurology written by Bernard Ravina and published by Cambridge University Press. This book was released on 2012-04-12 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translating laboratory discoveries into successful therapeutics can be difficult. Clinical Trials in Neurology aims to improve the efficiency of clinical trials and the development of interventions in order to enhance the development of new treatments for neurologic diseases. It introduces the reader to the key concepts underpinning trials in the neurosciences. This volume tackles the challenges of developing therapies for neurologic disorders from measurement of agents in the nervous system to the progression of clinical signs and symptoms through illustrating specific study designs and their applications to different therapeutic areas. Clinical Trials in Neurology covers key issues in Phase I, II and III clinical trials, as well as post-marketing safety surveillance. Topics addressed include regulatory and implementation issues, outcome measures and common problems in drug development. Written by a multidisciplinary team, this comprehensive guide is essential reading for neurologists, psychiatrists, neurosurgeons, neuroscientists, statisticians and clinical researchers in the pharmaceutical industry.
Download or read book The Right Therapy for Neurological Disorders written by E. Beghi and published by Karger Medical and Scientific Publishers. This book was released on 2016-07-26 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most neurological disorders are chronic and aging-related. With the increase of life expectancy their incidence and prevalence will grow in the decades to come, which in turn will increase the load on medical and social systems worldwide. There is thus a desperate need for successful preventive and therapeutic measures based on randomized clinical trials (RTCs) conducted by independent organizations. This book provides a compendium relating most of the principles of reliable RTCs to specific neurological diseases. Contributed by specialized neurologists, the articles touch on important aspects of RCTs with a clear critical approach, highlighting their limitations as well as giving recommendations for their planning and conducting to address the variable genotypic and phenotypic aspects of neurological conditions. Consideration is also given to combining the clinical impact of the study results with patients’ values and the interests of pharmaceutical companies. Neurologists involved in clinical trials will certainly benefit from this book, which should become a basic text for all neurological courses dealing with evidence-based neurology.
Download or read book Neuroscience Trials of the Future written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-11-07 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: On March 3-4, 2016, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop in Washington, DC, bringing together key stakeholders to discuss opportunities for improving the integrity, efficiency, and validity of clinical trials for nervous system disorders. Participants in the workshop represented a range of diverse perspectives, including individuals not normally associated with traditional clinical trials. The purpose of this workshop was to generate discussion about not only what is feasible now, but what may be possible with the implementation of cutting-edge technologies in the future.
Download or read book 50 Studies Every Neurologist Should Know written by David Y. Hwang and published by Oxford University Press. This book was released on 2016 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: 50 Studies Every Neurologist Should Know presents summaries and analyses of the fifty clinical trials that have shaped the current practice of neurology. Every subspecialty is covered, with special emphasis on neurocritical care and vascular neurology. This is a must-read for health care professionals and anyone who wants to learn about the data behind clinical practice.
Download or read book Office Practice of Neurology written by Martin A. Samuels and published by . This book was released on 2003 with total page 1572 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive text is the perfect clinical resource, offering quick access to all of the information needed to provide out-patient neurologic care. It focuses on the common and chronic problems that require long-term management, and provides step-by-step guidance on the decision-making process. Readers will find an expanded section on multiple sclerosis as well as updated and revised information in every section, including all of the latest studies and their results. Plus, a table at the beginning of each chapter summarizes the authors' approaches to diagnosis and management. Features contributions from more than 200 authors, representing a wide spectrum of specialists in neurology and related fields. Covers the major problems that any practicing neurologist might encounter, including those that may be rare. Presents a wealth of useful clinical information with enough comprehensive coverage on the difficult, long-term, and complicated disorders. Features an expanded section on multiple sclerosis, with in-depth discussions on the clinical issues surrounding the disease. Discusses the latest molecular genetic studies, including new information on the progressive ataxias · Alzheimer's disease · Huntington's disease · mitochondrial disorders · and familial stroke and headache syndromes. Reports on the results of recent clinical studies on asymptomatic carotid atherosclerosis and symptomatic carotid endarterectomy. Includes the latest methods for treating stroke · seizures · multiple sclerosis · migraine · Parkinson's disease · amyotrophic lateral sclerosis · and Alzheimer's disease. Presents a summary table at the beginning of each chapter, highlighting the authors' approaches to various problems of diagnosis and management.
Download or read book Neurology Evidence written by Kate T. Brizzi and published by Lippincott Williams & Wilkins. This book was released on 2017-07-12 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesizing the vast body of literature available in neurology into one accessible, clinically relevant volume, Neurology Evidence: The Practice-Changing Studies is an invaluable resource for students, residents, and fellows, as well as neurologists at all levels of experience. Featuring the top 100 papers that have had the most significant impact on changing clinical practice, this unique title analyzes the strengths and weaknesses of both seminal and less-noticed studies. Readable commentary is provided for each study by both a senior and junior neurologist in each subspecialty.
Download or read book Clinical Trials in the Neurosciences written by Katherine M. Woodbury-Harris and published by Karger Medical and Scientific Publishers. This book was released on 2009 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: A properly designed and executed clinical trial that addresses an import question and delivers a definitive result can change the practice of medicine worldwide. This book encompasses a bench-to-bedside approach and serves as an excellent guidance for translating preclinical studies to early phase I/II and phase III trials. In the first part, the book covers preclinical science with respect to animal models of various neurological diseases, FDA requirements for preclinical studies, translation of animal to patient studies and scaling up from animal to human studies. In the second part, the design of phase I/II trials and the use of biomarkers as surrogate endpoints are discussed. With regard to phase III trials, FDA and European requirements, specific design issues, relevant clinical endpoints as well as data management and quality are examined. Topics specific to multicenter trials, such as design, recruitment of special populations, monitoring, ethical and consent issues are also covered. Finally, genetics, gene therapy, imaging and surgical devices are reviewed.This publication is highly recommended to clinician researchers, such as neurologists, neurosurgeons, pediatric neurologists and neonatologists, who want to design and conduct clinical trials in the neuroscience, but also to nurses, research coordinators and clinical pharmacologists.
Download or read book Neuroepidemiology written by Lorene M. Nelson and published by Oxford University Press. This book was released on 2004 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fine text provides a comprehensive overview of methods for epidemiologic and clinical research on neurological disorders. The book focuses on classic principles of study design in epidemiologic research, strategies for avoiding study biases, methods for conducting clinical trials and prognostic studies, and principles of evidence-based medicine in neurology. The text gives neurologists, epidemiologists, and their students the foundation for conducting rigorous epidemiologic and clinical research on neurologic disorders.
Download or read book Evidence Based Neurology written by Bart Demaerschalk and published by John Wiley & Sons. This book was released on 2015-09-08 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: From an expert editor team drawn from the Cochrane Neurological Network, Evidence-Based Neurology provides specialists and those in training with the skills and knowledge to apply evidence-based practice in the clinical setting. fills the gap between guidelines and primary studies as well as between primary and secondary scientific medical literature summarizes the most recent and important findings on treatments for neurological patients measures the benefit and, when applicable, the risk of harm inherent in specific neurological interventions now includes new non-clinical topics of interest to neurologists such as education and research
Download or read book Principles and Practice of Clinical Research written by John I. Gallin and published by Elsevier. This book was released on 2011-04-28 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to maximize the safety of research subjects. Complete with sections on the history of clinical research and ethics, copious figures and charts, and sample documents it serves as an excellent companion text for any course on clinical research and as a must-have reference for seasoned researchers. *Incorporates new chapters on Managing Conflicts of Interest in Human Subjects Research, Clinical Research from the Patient's Perspective, The Clinical Researcher and the Media, Data Management in Clinical Research, Evaluation of a Protocol Budget, Clinical Research from the Industry Perspective, and Genetics in Clinical Research *Addresses the vast opportunities for translation of basic science observations to the bedside through clinical research*Delves into data management and addresses how to collect data and use it for discovery*Contains valuable, up-to-date information on how to obtain funding from the federal government
Download or read book Neurology Evidence written by Kate T. Brizzi and published by LWW. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesizing the vast body of literature available in neurology into one accessible, clinically relevant volume, Neurology Evidence: The Practice-Changing Studies is an invaluable resource for students, residents, and fellows, as well as neurologists at all levels of experience. Featuring the top 100 papers that have had the most significant impact on changing clinical practice, this unique title analyzes the strengths and weaknesses of both seminal and less-noticed studies. Readable commentary is provided for each study by both a senior and junior neurologist in each subspecialty. Features: Focuses on those studies that have had the greatest impact on how neurologists care for patients today, explaining the relevance of the information, engaging readers through questions and answers, and offering commentary on future directions. Analyzes the insights gained from both positive and negative trials, with the overall goal of improving clinical outcomes for patients suffering from neurological disease. Provides interpretation by residents and fellows with a particular interest in each clinical topic, as well as the input of accomplished senior neurologists. Includes multiple studies on ischemic stroke, cerebral hemorrhage, traumatic brain injury, neurologic intensive care, neuroinfectious diseases, neuro-oncology, neuromuscular diseases, movement disorders, multiple sclerosis, autoimmune neurology, epilepsy, headache and pain, cognitive neurology, and pediatric neurology. Your book purchase includes a complimentary download of the enhanced eBook for iOS, Android, PC & Mac. Take advantage of these practical features that will improve your eBook experience: The ability to download the eBook on multiple devices at one time -- providing a seamless reading experience online or offline Powerful search tools and smart navigation cross-links that allow you to search within this book, or across your entire library of VitalSource eBooks Multiple viewing options that enable you to scale images and text to any size without losing page clarity as well as responsive design The ability to highlight text and add notes with one click
Download or read book Office Practice of Neurology written by Martin A. Samuels and published by . This book was released on 1996 with total page 1326 pages. Available in PDF, EPUB and Kindle. Book excerpt: A multidisciplinary team offers a definitive and practical source on nervous system dysfunction as it relates to ambulatory patients, and provide concise diagnosis and treatment recommendations.
Download or read book Envisioning a Transformed Clinical Trials Enterprise in the United States written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-13 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is growing recognition that the United States' clinical trials enterprise (CTE) faces great challenges. There is a gap between what is desired - where medical care is provided solely based on high quality evidence - and the reality - where there is limited capacity to generate timely and practical evidence for drug development and to support medical treatment decisions. With the need for transforming the CTE in the U.S. becoming more pressing, the IOM Forum on Drug Discovery, Development, and Translation held a two-day workshop in November 2011, bringing together leaders in research and health care. The workshop focused on how to transform the CTE and discussed a vision to make the enterprise more efficient, effective, and fully integrated into the health care system. Key issue areas addressed at the workshop included: the development of a robust clinical trials workforce, the alignment of cultural and financial incentives for clinical trials, and the creation of a sustainable infrastructure to support a transformed CTE. This document summarizes the workshop.
Download or read book Disease Control Priorities Third Edition Volume 4 written by Vikram Patel and published by World Bank Publications. This book was released on 2016-03-10 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mental, neurological, and substance use disorders are common, highly disabling, and associated with significant premature mortality. The impact of these disorders on the social and economic well-being of individuals, families, and societies is large, growing, and underestimated. Despite this burden, these disorders have been systematically neglected, particularly in low- and middle-income countries, with pitifully small contributions to scaling up cost-effective prevention and treatment strategies. Systematically compiling the substantial existing knowledge to address this inequity is the central goal of this volume. This evidence-base can help policy makers in resource-constrained settings as they prioritize programs and interventions to address these disorders.
Download or read book Critical Thinking in Clinical Research written by Felipe Fregni and published by Oxford University Press. This book was released on 2018 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Critical Thinking in Clinical Research explains the fundamentals of clinical research in a case-based approach. The core concept is to combine a clear and concise transfer of information and knowledge with an engagement of the reader to develop a mastery of learning and critical thinking skills. The book addresses the main concepts of clinical research, basics of biostatistics, advanced topics in applied biostatistics, and practical aspects of clinical research, with emphasis on clinical relevance across all medical specialties.
