Download or read book Bone Contact Around Osseointegrated Implants a Histological Study of Implant Surfaces written by Vanessa Coelho Marinho and published by . This book was released on 2003 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Implant Surfaces and their Biological and Clinical Impact written by Ann Wennerberg and published by Springer. This book was released on 2015-01-05 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the reader with the knowledge required in order to understand the chemical, physical, mechanical, and topographical aspects of implant surfaces, as well as their impact on the biological response. Common ways to modify implant surfaces are described, and methods for the evaluation of surface properties are presented in an easy-to-read style. Experimental results that have contributed to surface modifications relevant for commercial available implants are presented, with emphasis on in vivo and clinical studies. While the focus is primarily on surface modifications at the micrometer and nanometer levels, alterations at the millimeter level are also covered, including thread designs and their possible influence on stress distribution. In addition, it is analyzed how surface alterations have changed the clinical long-term results for certain groups of patients.
Download or read book Bone Response to Dental Implant Materials written by Adriano Piattelli and published by Woodhead Publishing. This book was released on 2016-10-27 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Response to Dental Implant Materials examines the oral environment and the challenges associated with dental biomaterials. Understanding different in vivo and in vitro responses is essential for engineers to successfully design and tailor implant materials which will withstand the different challenges of this unique environment. This comprehensive book reviews the fundamentals of bone responses in a variety of implant materials and presents strategies to tailor and control them. Presents a specific focus on the development and use of biomaterials in the oral environment Discusses the basic science of the dental interface and its clinical applications Contains important coverage on the monitoring and analysis of the dental implant interface
Download or read book Bone Implant Interface written by Hugh U. Cameron and published by St. Louis ; Toronto : Moseby. This book was released on 1994 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immediate Loading of Endosseous Implants in the Posterior Mandible written by Georgios Romanos and published by . This book was released on 2005 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Romanos (implant dentistry, University of New York) details the conditions necessary for successful immediate loading of implants in the posterior area of the mandible, so that this therapeutic concept can be implemented in daily practice. An introductory chapter examines the roles of implant material, surface morphology, and implant form in osseoi
Download or read book Osseo Integrated Implants written by Gunther Heimke and published by CRC Press. This book was released on 1990-07-03 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of this two-volume work is osseo integration. It discusses the use of glue to attach bony tissue as well as the use of the absence of biochemical interactions between some oxide ceramics (particularly pure A1203 ceramic) and the adjacent tissue. This book also demonstrates the possibility of controlling the interface remodelling by the stresses and strains created by the insertion of the implant. Written in a concise, easy-to-read format, this text covers the use of implants in orthopedics, maxillo-facial surgery, and dentistry. All those involved with bioengineering, orthopedics, maxillo-facial surgery, dentistry, and biomechanics will find this reference to be of particular interest.
Download or read book Osseo Integrated Implants written by Gunther Heimke and published by CRC Press. This book was released on 1990-07-25 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of this two-volume work is osseo integration. It discusses the use of glue to attach bony tissue as well as the use of the absence of biochemical interactions between some oxide ceramics (particularly pure A1203 ceramic) and the adjacent tissue. This book also demonstrates the possibility of controlling the interface remodelling by the stresses and strains created by the insertion of the implant. Written in a concise, easy-to-read format, this text covers the use of implants in orthopedics, maxillo-facial surgery, and dentistry. All those involved with bioengineering, orthopedics, maxillo-facial surgery, dentistry, and biomechanics will find this reference to be of particular interest.
Download or read book Tissue integrated Prostheses written by Per-Ingvar Brånemark and published by Quintessence Publishing (IL). This book was released on 1985 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: " This book provides the prosthodontist and oral surgeon for the first time with a safe, predictable, and scientifically proven method for permanently anchoring artificial tooth abutments in the jawbones. It combines the osseointegration research results of biologists, physicists, bioengineers, oral surgeons, and prosthodontists to demonstrate step-by-step how to achieve long-term osseointegration of dental implants" -- Amazon.
Download or read book Influence Of Implant Surface Modification On Osseointegrative And Antibacterial Properties In The Setting Of MRSA written by Paul Fortin and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: INTRODUCTION: When periprosthetic infection (PJI) often occurs in patients who have undergone orthopaedic procedures, the complication can substantially increase patient care costs; specifically, PJI may lead to more clinic/hospital visits, multiple revision surgeries, long-term patient disability, and increased mortality. Previous studies have shown that titania nanotube (TiNT) surfaces demonstrate increased bone-implant contact (BIC), enhanced de novo bone formation, and greater implant pull-out forces than non-textured controls. This study evaluated in vitro antibacterial properties of TiNT surfaces, TiNT surfaces integrated with nanosilver (TiNT+Ag), and two current standard-of-care materials (titanium thermal plasma sprayed and titanium alloy surfaces; TPS and Ti, respectively).METHODS: Following Institutional Biosafety Committee and Institutional Animal Care and Use Committee approval, the first in vitro experiment evaluated sterile coupons of TiNT surfaces with diameters of 60nm, 80nm, 110nm, and 150nm submerged in Luria-Bertani (LB) broth and inoculated with 105 colony-forming units (CFU/mL) of methicillin-resistant Staphylococcus aureus (MRSA), quantified at four timepoints (0, 1, 4, 24 hours). A second in vitro experiment quantified viable bacteria by drop-seeding MRSA (105, 106, 108 CFU/mL) suspended in LB directly onto the four sample surfaces, then rinsing and sonicating in culture media at four timepoints (2, 6, 24, 48 hours). In a follow-on in vivo study, New Zealand White rabbits were anesthetized and underwent bilateral antegrade implantation of an intramedullary tibial implant with one of the four sample surfaces (n=12 animals per implant group; 2-week endpoint for all). One tibia received a human clinical isolate of MRSA (105 CFU/mL) suspended in LB broth on the implant surface at the time of implantation (experimental limb), while the contralateral tibia received LB broth (no MRSA) (control limb). At endpoint, six animals per implant group were randomized to sonication analysis and six were randomized to histology (Stevenelu2019s Blue with a van Gieson counterstain and gram staining) and osseointegration imaging [of the proximal tibia via high-resolution microcomputed tomography (u00b5CT)] analyses. At endpoint, implants designated for sonication analysis were removed from each tibiae and sonicated in sterile phosphate buffered saline to quantify viable bacteria from the implant surface. As a small pilot study, an additional u201ctherapeuticu201d cohort (TC) of rabbits (n=12) underwent the same procedure, allowed infection to develop for 4 days, and then received vancomycin treatment (30 mg/kg; subcutaneous, twice per day) for 7 days, until endpoint. Per implant group, two animals were randomized to sonication analysis, while one was randomized to histology and imaging analyses. Histologic analysis of gram-stained sections of tibiae was performed using a custom MatLab program to randomize six regions of interest (ROI) and quantify gram-positive bacteria (GP), focusing on high specificity, at the bone-implant interface. RESULTS: The first in vitro experiment indicated that none of the material surfaces could kill MRSA in surrounding LB broth; however, the direct seeding method showed lower MRSA counts on the TiNT groups at all timepoints and on the TiNT+Ag group at the 24 hr and 48 hr timepoints. TiNT surfaces with 110nm diameters showed the lowest bacteria counts compared to other nanotube diameters, and were subsequently used for all in vivo work. In the in vivo experiment, sonication analysis showed that viable MRSA was greater on the TiNT and TiNT+Ag surfaces (104 CFU/mL, on average) vs. the Ti and TPS surfaces (103 CFU/mL, on average). In the TC, viable bacteria in the sonicant was approximately 102 to 103 CFU/mL for TiNT+Ag and TiNT implants, compared to 104 CFU/mL in the TPS group. u00b5CT analysis of infected limbs showed greatest BIC on TPS implants, followed by TiNT, TiNT+Ag, and Ti. BIC was significantly greater in TiNT+Ag vs. Ti implants (p=0.023) and TPS vs. TiNT+Ag implants (p=0.031). Bone volume fraction (BV/TV) was significantly greater in TPS implants (0.163 u00b1 0.052) than Ti (p=0.016), TiNT (p=0.011), and TiNT+Ag (p=0.015) groups. TPS implants also demonstrated significantly greater tissue mineral density (TMD) than Ti (p=0.001), TiNT (p=0.003), and TiNT+Ag (p=0.003). In the TC, BIC% was greatest in the TPS group (0.277%) and approximately equivalent in the Ti, TiNT, and TiNT+Ag groups (0.15%, 0.1%, and 0.086%, respectively). Analysis of histologic sections demonstrated TiNT+Ag had the greatest BIC%, on average, (41%, range, 18-60), followed by TiNT (33%; range, 12-53), Ti (15%; range, 0-34), and TPS (12%, range, 3-28). In the TC, BIC% was greatest in TiNT+Ag implants (24%), followed by TPS (16%), Ti (15%), and TiNT (8%). On average, Ti had the lowest GP% (6%; range, 2-13), followed by TiNT+Ag (9%, range 3-14), TPS (10%, range 3-21), and TiNT (13%, range 1-26). In the TC, Ti had the lowest GP% (3%), followed by TiNT (5%), TPS (8%), and TiNT+Ag (15%). DISCUSSION: Results from in vitro drop-seeding experiments indicated that TiNT and TiNT+Ag surfaces were more efficacious in resisting MRSA biofilm formation, compared to Ti and TPS. Sonication analysis indicated that TPS and Ti implants had less viable bacteria; however, overnight incubations showed that the implants continued to grow bacteria after sonication, perhaps indicating that differential adhesion of bacteria or decreased biofilm formation of the various surfaces may have interfered with assessment of in vivo antimicrobial efficacy. Specifically, the authors hypothesize that during sonication, bacteria detach more readily from nanotube surfaces, resulting in increased viable MRSA in the sonicant of nanotube implants compared with sonicant from TPS and Ti implants. With a reduction in viable bacteria from nanotube surfaces following antibiotic treatment, MRSA clearance rates may improve with the NT surface modification. Osseointegrative properties, measured by u00b5CT, in the setting of infection were greatest in TPS implants; however histologic analysis showed greatest BIC% in TiNT+Ag implants as well as greater cortical connectivity (contiguous bone between bone-implant interface and cortical shell) in the nanotube cohorts. Ti showed the lowest GP% in both the non-TC and TC cohorts, followed by TiNT+Ag in the non-TC cohort and TiNT in the TC cohort.SIGNIFICANCE/CLINICAL RELEVANCE: Titiania nanotube surfaces may provide improvement over current implant technologies by simultaneously enhancing osseointegration, especially in non-tapered applications (e.g. tibial trays, fusion cages), as well as antibacterial properties. ACKNOWLEDGEMENTS: Work was funded through the University of Michigan MTRAC for Life Sciences Innovation Hub (Subcontract #3004361821).
Download or read book Metabolic Bone Disease and Clinically Related Disorders written by Louis V. Avioli and published by Academic Press. This book was released on 1997-10-08 with total page 843 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic Bone Disease, Third Edition is the new, expanded edition of the classic text, featuring the latest advancements and research information in this fast-moving field. The Third Edition includes the most up-to-date information on molecular mechanisms, basic biology, pathophysiology, and diagnosis and management strategies of metabolic bone disease. Edited by "fathers of the field" An expanded version of a classic AP text Complete coverage of a fast-growing field
Download or read book Osteoconduction of Calcium Phosphate Thin Film on Porous surfaced Implants in Rabbit Tibiae written by Hung Quoc Nguyen and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 1998 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Modelling and Characterization of Mechanically Regulated Tissue Formation Around Bone interfacing Implants written by Craig Alexander Simmons and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In many cases, orthopaedic and dental implants can restore function to diseased or damaged joints and edentulous jaws. However, in several challenging clinical situations, it is difficult to achieve adequate fixation (osseointegration) between the implant and bone. Since osseointegration is necessary for clinical success, implant failure rates in these cases are unacceptably high. Understanding the factors that allow bone-interfacing implants to osseointegrate rapidly and reliably should lead to improvements in their use and design. With this being our goal, we investigated the influence of implant surface geometry and local tissue strains on peri-implant tissue formation. Using a rabbit model, we evaluated the histological and mechanical characteristics of the early healing tissues around nonfunctional implants with Ti6Al4V sintered porous surfaces and Ti plasma-sprayed surfaces. We found that the early healing tissues integrated with the three-dimensional interconnected structure of the sintered porous surface and mineralized more rapidly than the tissues around the irregular geometry of the plasma-sprayed surface. Consequently, the stiffness and strength of attachment was greater for the porous-surfaced implants. These results demonstrate that implant surface geometry influences early peri-implant tissue formation and, as a result, the early mechanical stability of implants. To investigate the relationship between implant surface geometry, the local mechanical environment, and peri-implant tissue formation, we developed a computational micromechanical model based on homogenization methods to describe the effective and local properties of the porous-surfaced and plasma-sprayed peri-implant regions. In validation tests, we showed that the model provided reasonably accurate initial predictions of the properties of the peri-implant regions. Using the computational model, we compared the local mechanical environments around porous-surfaced and plasma-sprayed implants. In cases with minimal implant loading, the model predicted local tissue strains that permitted localized ' and' appositional bone formation around porous-surfaced implants, but only appositional bone formation for plasma-sprayed implants. Based on the model predictions and experimental data from earlier studies, we proposed a quantitative model for the mechanical regulation of peri-implant tissue formation. The mechanoregulatory model is consistent with observations of tissue formation around porous-surfaced and plasma-sprayed implants, and provides initial criteria to evaluate the osseointegration potential of bone-interfacing implants.
Download or read book On the Bone Tissue Response to Titanium Implants written by Lars Sennerby and published by . This book was released on 1991 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book On Surface Roughness and Implant Incorporation written by Ann Wennerberg and published by . This book was released on 1996 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Stem Cells and Biomaterials for Regenerative Medicine written by Marek J. Los and published by Academic Press. This book was released on 2018-11-07 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cells and Biomaterials for Regenerative Medicine addresses the urgent need for a compact source of information on both the cellular and biomaterial aspects of regenerative medicine. By developing a mutual understanding between three separately functioning areas of science—medicine, the latest technology, and clinical economics—the volume encourages interdisciplinary relationships that will lead to solutions for the significant challenges faced by today's regenerative medicine. Users will find sections on the homeostatic balance created by apoptosis and proliferating tissue stem cells, the naturally regenerative capacities of various tissue types, the potential regenerative benefits of iPS-generation, various differentiation protocols, and more. Written in easily accessbile language, this volume is appropriate for any professional or medical staff looking to expand their knowledge with regard to stem cells and regenerative medicine. Arms readers with key information on tissue engineering, artificial organs and biomaterials, while using broadly accessible language Provides broad introduction to, and examples of, various types of stem cells, core concepts of regenerative medicine, biomaterials, nanotechnology and nanomaterials, somatic cell transdyferentiation, and more Edited and authored by researchers with expertise in regenerative medicine, (cancer) stem cells, biomaterials, genetics and nanomaterials
Download or read book Current Concepts in Dental Implantology written by Ilser Turkyilmaz and published by BoD – Books on Demand. This book was released on 2015-02-25 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Implant dentistry has changed and enhanced significantly since the introduction of osseointegration concept with dental implants. Because the benefits of therapy became apparent, implant treatment earned a widespread acceptance. Therefore, the need for dental implants has caused a rapid expansion of the market worldwide. Dental implantology continues to excel with the developments of new surgical and prosthodontic techniques, and armamentarium. The purpose of this book named Current Concepts in Dental Implantology is to present a novel resource for dentists who want to replace missing teeth with dental implants. It is a carefully organized book, which blends basic science, clinical experience, and current and future concepts. This book includes ten chapters and our aim is to provide a valuable source for dental students, post-graduate residents and clinicians who want to know more about dental implants.
Download or read book Osseointegrated Implants in the Treatment of the Edentulous Jaw written by and published by . This book was released on 1977 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
