Download or read book Drug Discovery written by Robert A. Maxwell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: This treatise had its origins in the authors' strong opinion that the discovery of new drugs, especially of innovative therapeutic agents, really does not happen as a spontaneous sequel to investiga tive research, no matter how penetrating such research may be. Rather, it seemed to us that the discovery of innovative therapeutic agents was a very active process, existing in and of itself, and demanding full attention-it was not simply a passive, dependent by-process of investigative research. And yet, many researchers some close confreres of the authors, others more distant-believed otherwise. We felt that their view reflected unrealistic thinking and that reality probably lay closer to what Beyer" maintained: We are taught to believe that if we can understand a disease it should be easy enough to figure out, say, the molecular configuration of a definitive receptor mechanism somewhere along the line and to design a specific drug . . . . And so we start out to understand the disease but never get around to doing much about therapy. The authors very soon realized that there was essentially no quantitive information available on just where and how innovative therapeutic agents were discovered. There were only anecdotal accounts, and these were able to be selected and presented in ways that could be used to defend any point of view.

Download or read book Molecular Diagnostics written by Lela Buckingham and published by F. A. Davis Company. This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first text on molecular diagnostics specifically designed for clinical laboratory science programs is back! This exceptional resource introduces the fundamentals of nucleic acid, as well as more advanced concepts. With a focus on the application of molecular concepts in the clinical laboratory to diagnosis diseases, the 2nd Edition includes important updates and improvements to keep up with the rapidly developing field. Inside youll find in-depth explanations of the principles of molecular-based assays as well as reference material, trouble-shooting tips for the laboratory, and discussions that emphasize the continuing emergence of new diagnostic technologies.

Download or read book The national period written by Jeannette Rector Hodgdon and published by . This book was released on 1908 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Muse Cells written by Mari Dezawa and published by Springer. This book was released on 2018-11-27 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive account of multilineage-differentiating stress-enduring (Muse) cells, a pluripotent and non-tumorigenic subpopulation of mesenchymal stem cells (MSCs) that have the ability to detect damage signals, migrate to damaged sites, and spontaneously differentiate into cells compatible with the affected tissue, thereby enabling repair of all tissue types. The coverage encompasses everything from the basic properties of Muse cells to their tissue repair effects and potential clinical applications—for example, in acute myocardial infarction, stroke, skin injuries and ulcers, renal failure, and liver disease. An important technical chapter provides a practical and precise protocol for the isolation of Muse cells, which will enable readers to use Muse cells in their own research. In offering fascinating insights into the strategic organization of the body’s reparative function and explaining how full utilization of Muse cells may significantly enhance the effectiveness of MSC treatment, the book will be of high value for Ph.D. students, postdocs, basic researchers, clinical doctors, and industrial developers.

Download or read book Keeping Archives written by and published by . This book was released on 1996 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Hearings Reports and Prints of the Senate Select Committee on Small Business written by United States. Congress. Senate. Select Committee on Small Business and published by . This book was released on 1975 with total page 1776 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Handbook of Signal Processing in Acoustics written by and published by Springer Science & Business Media. This book was released on 2008 with total page 1932 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Save Me from Dangerous Men written by S. A. Lelchuk and published by Flatiron Books. This book was released on 2019-03-19 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: “An outstanding debut...If you’re a fan of Jack Reacher or Lisbeth Salander, you are gonna love Nikki Griffin.” —New York Times bestselling author Douglas Preston “Action packed and razor sharp - Jack Reacher would love Nikki Griffin.” —Lee Child, #1 New York Times bestselling author of Past Tense Nikki Griffin isn't your typical private investigator. In her office above her bookstore’s shelves and stacks, where she luxuriates in books and the comfort they provide, she also tracks certain men. Dangerous men. Men who have hurt the women they claim to love. And Nikki likes to teach those men a lesson, to teach them what it feels like to be hurt and helpless, so she can be sure that their victims are safe from them forever. When a regular PI job tailing Karen, a tech company's disgruntled employee who might be selling secrets, turns ugly and Karen's life is threatened, Nikki has to break cover and intervene. Karen tells Nikki that there are people after her. Dangerous men. She says she'll tell Nikki what's really going on. But then something goes wrong, and suddenly Nikki is no longer just solving a case—she's trying hard to stay alive. Part Lisbeth Salander, part Jack Reacher, part Jessica Jones, Nikki Griffin is a kickass character who readers will root for as she seeks to right the world's wrongs. S.A. Lelchuk’s Save Me From Dangerous Men marks the beginning of a gripping new series and the launch of a fabulous new character.

Download or read book Hybrid Dynamical Systems written by Rafal Goebel and published by Princeton University Press. This book was released on 2012-03-18 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hybrid dynamical systems exhibit continuous and instantaneous changes, having features of continuous-time and discrete-time dynamical systems. Filled with a wealth of examples to illustrate concepts, this book presents a complete theory of robust asymptotic stability for hybrid dynamical systems that is applicable to the design of hybrid control algorithms--algorithms that feature logic, timers, or combinations of digital and analog components. With the tools of modern mathematical analysis, Hybrid Dynamical Systems unifies and generalizes earlier developments in continuous-time and discrete-time nonlinear systems. It presents hybrid system versions of the necessary and sufficient Lyapunov conditions for asymptotic stability, invariance principles, and approximation techniques, and examines the robustness of asymptotic stability, motivated by the goal of designing robust hybrid control algorithms. This self-contained and classroom-tested book requires standard background in mathematical analysis and differential equations or nonlinear systems. It will interest graduate students in engineering as well as students and researchers in control, computer science, and mathematics.

Download or read book Psychological Acoustics written by Earl D. Schubert and published by Hutchinson Ross Publishing Company. This book was released on 1979 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Non Idiopathic Spine Deformities in Young Children written by Muharrem Yazici and published by Springer Science & Business Media. This book was released on 2011-07-21 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-idiopathic early onset scoliosis represents a true challenge to the physician due to the significance of the ongoing growth of the spine, the risk of curve progression, and the risk of pulmonary insufficiency. A comprehensive review of the growth mechanisms of spine in infancy forms the basis of the book. Clinical evaluation and imaging of early onset scoliosis contribute to the diagnostic overview. The main causes of non-idiopathic early onset scoliosis are briefly described in the second part of the book. The last group of chapters presents the conservative and surgical treatments that are available along with their results, chances and challenges. This comprehensive guide is an opportunity for every specialist involved in the treatment of these severe deformities, to obtain an update of the actual trends and knowledge in the field in a one-point reference.

Download or read book World Communication Report written by International Programme for the Development of Communication and published by . This book was released on 1989 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Robust and Optimal Control written by Kemin Zhou and published by Pearson. This book was released on 1996 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Class-tested at major institutions around the world, this work offers complete coverage of robust and H control. It features clear coverage of methodology, and provides detailed treatment of topics including Riccati equations, m theory, H loopshaping and controller reduction.

Download or read book Understanding the City Through Its Margins written by André Chappatte and published by Routledge. This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cover -- Title -- Copyright -- Contents -- List of Illustrations -- Notes on Contributors -- Acknowledgements -- 1 The city and its regulations: Unexpected margins -- Part I Space and state regulation: The urban interstices -- 2 Markets and marginality in Beirut -- 3 The tremendous making and unmaking of the peripheries in current Istanbul -- 4 Resilient forms of urbanity on the margins? Al-Kherba: A vivid market in a damaged section of the medina of Tunis -- 5 Whose margins? Marginality, poverty and the moral geography of pre-Soviet Bukhara -- 6 On the margins of the city: Izmir Prison in the late Ottoman Empire -- Part II Diversity and moral policing: Making claims through marginalisation -- 7 'Texas': An off-centre district at the heart of nightlife in Odienné -- 8 The Manyema in colonial Dar es Salaam (Tanzania) between urban margins and regional connections -- 9 On the margins: Suburban space and religious deviancy in Jakarta and Kuala Lumpur -- 10 Ethnic differentiation and conflict dynamics: Uzbeks' marginalisation and non-marginalisation in southern Kyrgyzstan -- Index

Download or read book Literature for Composition written by Sylvan Barnet and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Previous editions had other title information: essays, stories, poems, and plays.

Download or read book Access to Life written by Desmond Tutu and published by Aperture. This book was released on 2009 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the past 25 years, the AIDS pandemic has inflicted excruciating pain upon humanity, having ravaged the lives of millions of people around the world. Over the past few years, however, a quiet global revolution has enabled millions infected by HIV to live healthy lives through the free antiretroviral treatment program initiated by the Global Fund to Fight AIDS, Tuberculosis and Malaria. In Access to Life, eight of the worlds leading photojournalists, all members of Magnum Photos, follow 30 individuals in nine countries before, and four months after, they began the antiretroviral treatment, documenting the transformative effect on their bodies, their lives, and the lives of their families. Here are the faces, voices, and stories representing millions of people who would otherwise be dead if not for access to free life-saving drugs. But there are also the stories of those individuals for whom treatment came too lateshowing how the fight to bring access to AIDS treatment is still a difficult one.