Download or read book Understanding Heterogeneity in Alzheimer s Disease written by and published by . This book was released on 2019 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Understanding Heterogeneity in Alzheimer s Disease a Neurophysiological Perspective written by and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Heterogeneity of Alzheimer s Disease written by Francois Boller and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: The term "Alzheimer's disease" is currently used to refer to senile and also presenile dementia, but the heterogeneity of this disorder is demonstrated in many of its aspects. This is of great theoretical interest, and with the appearance of new therapeutic interventions, it may well also start to have very significant practical importance. To shed some light on the debate, the Fondation Ipsen organized an international symposium which took place on April 6, 1992. This volume contains the proceedings of this meeting, which was attended by researchers in epidemiology, clinical neurology and geriatrics, neuropsychology, neuropathology, molecular biology, and genetics.
Download or read book Heterogeneity of Alzheimer s disease written by François Boller and published by Springer Verlag. This book was released on 1992 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New Directions in Understanding Dementia and Alzheimer s Disease written by Taher Zandi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: The management of Alzheimer's Disease and the related dementias is one of the major challenges to health care professionals and American society-at-large for the coming decade and the coming millennium. The rapid growth of the over-eighty-five population, the group which, as recent studies have confirmed and as many of us clinicians have long suspected, has an even higher prevalence than previously quoted of dementing disorders, is the major cause of this. We are thus challenged by, as Bernard Issacs used to call it, "the survival of the unfittest," as well as the oPtimistic approach of "bringing life to years," as John F. Kennedy said. The fact is that we, as a society, tend to confuse "treatment" and "cure" (and "prevention"). As the proceedings of the conference which this book represents emphasize, there is considerable work going on about the potential prevention of, or at least the reduction of, symptomatology in these illnesses by interventions genetically, chemIcally, and so forth. However, the more we find out, the more complicated it becomes, and the more heterogeneous Alzheimer's and the related disorders appear to be, not only in their manifestations (as clinicians have long recognized) but also in the individual initiating and underlying processes. For these reasons, absolute preventive techniques or the likelihood of an intervention which will reverse the process in a high proportion of patients, do not appear to be just around the corner.
Download or read book Heterogeneity of Alzheimer s Disease written by Kaj Blennow and published by . This book was released on 1990 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuroimaging in Dementia written by Frederik Barkhof and published by Springer Science & Business Media. This book was released on 2011-02-11 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: This up-to-date, superbly illustrated book is a practical guide to the effective use of neuroimaging in the patient with cognitive decline. It sets out the key clinical and imaging features of the various causes of dementia and directs the reader from clinical presentation to neuroimaging and on to an accurate diagnosis whenever possible. After an introductory chapter on the clinical background, the available "toolbox" of structural and functional neuroimaging techniques is reviewed in detail, including CT, MRI and advanced MR techniques, SPECT and PET, and image analysis methods. The imaging findings in normal ageing are then discussed, followed by a series of chapters that carefully present and analyze the key findings in patients with dementias. Throughout, a practical approach is adopted, geared specifically to the needs of clinicians (neurologists, radiologists, psychiatrists, geriatricians) working in the field of dementia, for whom this book will prove an invaluable resource.
Download or read book Neuropsychological Heterogeneity in Alzheimer s Disease written by Jason A. King and published by . This book was released on 2004 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Modelling Progression and Heterogeneity in Alzheimer s Disease written by Alexandra Young and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Heterogeneity in Alzheimer s Disease written by and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Key findings: I. Does clinical heterogeneity among individuals with AD and FTD relate to differences in the underlying neurobiological manifestation of the disease? We observed dissociable atrophy patterns among individuals with an atypical AD variant (i.e., PCA), and these are associated with distinct visual processing deficits, e.g., ventral atrophy is associated to object perception. Cognitively-defined subgroups of individuals within the spectrum of typical late-onset AD dementia exhibit differential patterns of regional atrophy, e.g., left-lateralized temporal atrophy in the language subgroup. Cognitively-defined subgroups of individuals with AD dementia display distinct hypometabolic patterns and longitudinal trajectories of brain metabolism, e.g., faster parietal decline in metabolism for the visuospatial subgroup. Individuals with FTD and prominent right-sided anterior temporal atrophy (i.e., rtvFTD) display a clinical phenotype that is most notably characterized by prosopagnosia, and which is distinct from AD and other FTD variants. II. What are the associations between genetics and the clinical/neuroanatomical manifestation of AD? Cognitive subgroup-specific atrophy patterns are related to distinct regional gene expression profiles. By examining biological functions related to these gene expression profiles, we found that some biological pathways are related to atrophy in multiple subgroups (e.g., mitochondrial dysfunction), while other pathways were subgroup-specific (e.g., cell-cycle in the memory subgroup). APOEe2 carriership among individuals with AD dementia is related to a clinical phenotype with more non-amnestic (i.e., language, attention and executive) impairments, and a radiological phenotype with greater vascular involvement (i.e., more microbleeds and white matter hyperintensities) compared to APOEe3 homozygotes and APOEe4 carriers.
Download or read book Modelling Progression and Heterogeneity in Alzheimer s Disease written by A. L. Young and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tischhauser Z ndel Emma Friederike written by and published by . This book was released on 1899 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Phenotypic Heterogeneity and Preclinical Change in Familial Alzheimer s Disease written by Natalie Sarah Ryan and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Deciphering Pathological Heterogeneity in Familial Alzheimer s Disease written by Nanet Willumsen and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Towards an Understanding of Tinnitus Heterogeneity written by Christopher Cederroth and published by Frontiers Media SA. This book was released on 2019-07-19 with total page 832 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tinnitus is the perception of a sound when no external sound is present. The severity of tinnitus varies but it can be debilitating for many patients. With more than 100 million people with chronic tinnitus worldwide, tinnitus is a disorder of high prevalence. The increased knowledge in the neuroscience of tinnitus has led to the emergence of promising treatment approaches, but no uniformly effective treatment for tinnitus has been identified. The large patient heterogeneity is considered to be the major obstacle for the development of effective treatment strategies against tinnitus. This eBook provides an inter- and multi-disciplinary collection of tinnitus research with the aim to better understand tinnitus heterogeneity and improve therapeutic outcomes.
Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Download or read book Alzheimer s Disease written by Zaven S Khachaturian and published by CRC Press. This book was released on 2019-06-04 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published in 1996: Alzheimer's disease is characterized by memory disturbances and changes in personality and is associated with aging, although it can occur in people under 65. It is a progressive disease, painful to witness as the patient's health declines. Alzheimer's Disease: Cause(s), Diagnosis, and Care, with its complete and authoritative discussions, will help you understand all facets of this complex disease. This book addresses a broad spectrum of topics ranging from diagnosis, causes, treatment, epidemiology, genetics, risk factors, and care and management. Alzheimer's Disease: Cause(s), Diagnosis, and Care is intended for a diverse audience, including practitioners and students, family members, and everyone who is concerned about this disease.
