Download or read book Trophoblast Invasion and Endometrial Receptivity written by H.W. Denker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in mechanisms of embryo implantation is increasing, particularly with the realization that failure of implantation after in vitro fertilization and embryo transfer places significant limits on the success of treatment. In addition, there is a need to provide hypotheses, and ultimately mechanisms, for the high rates of embryonic loss in women in the population at large. Traditionally, implantation research has concentrated on genetics and endocrinology without providing many therapeutic benefits. A new era is now beginning with the application of modem cellular and molecular approaches to the investigation of the relationship between trophoblast and endometrium. At the same time, older data can be reevaluated in the light of current research into cell cell and cell-matrix interactions. The feeling that new avenues of research are open was apparent when an international group of scientists came together at a workshop on "The Cell Biology of Trophoblast Invasion In Vivo and In Vitro" held during the XXIV Annual Meeting of the Cell, Tissue and Organ Culture Study Group (C.T.O.C.) at Heidelberg in 1986. What was unusual about this Conference was the interdisciplinary dialogue between implantation researchers and tumor biologists, highlighting aspects common to invasion of trophoblast and tumor cells.
Download or read book Trophoblast Invasion and Endometrial Receptivity written by Hans-Werner Denker and published by . This book was released on 1990 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular and Cellular Aspects of Periimplantation Processes written by S.K. Dey and published by Springer. This book was released on 1995-12-22 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the proceedings of the Symposium on Molecular and Cellular Aspects of Periimplantation Processes, held July 15 - 18, 1994, in Boston, Massachusetts. Despite considerable research, the molecular and cellular bases of embryo-uterine interactions are still poorly understood. The papers included in this volume address recent advances in several areas in the field of implantation, including uterine receptivity, hormonal regulation, cell-cell interaction, growth factors/cytokines, immunobiology, and trophoblast invasion.
Download or read book Endometrium and Embryo Implantation written by G. Chaouat and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Implantation of the embryo into the maternal endometrium represents a crucial step in the reproductive process. It results from a cascade of finely tuned events. Despite recent progress in the field, many points still require clarification. This special issue offers a broad coverage of the latest findings. New concepts and applications are presented which are based on data strongly suggesting that both embryo implantation and uterine receptivity are controlled, primarily, though not exclusively, by locally acting growth factors and cytokines. Different processes are also studied, such as the MMPs expression regulating the trophoblast invasion, or the possible secretion of sHLA-G molecules by human embryos and its correlation to a successful pregnancy. Further points under discussion are the chromosomal imbalance leading to embryonic mortality, and the potential of the baboon model to study embryo implantation. Finally, a comparative survey is given of the general mechanical, endocrinological and cellular aspects involved in implantation in mammals. Clinicians as well as basic researchers will find this special issue to be a valuable source of new insights.
Download or read book Endocrinology of Embryo Endometrium Interactions written by Stanley R. Glasser and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early embryonic loss is a continuing social and economic global problem. In human populations the estimates of interruptions early in pregnancy range from 35-60%. In animal husbandry (swine, ruminants) fully 30% of pregnancies fail to survive early events of gestation. The futility associated with this persistant high risk is even more unsettling because of advances made in assisted reproductive technology which, although this very selective methodology has added to our knowledge of embryo-endometrial interactions, has resulted in a birth rate of only 14%. These studies have instigated comparisons of the live relative contributions of the embryo and the uterus to the outcome of pregnancy. These analyses have shown that we have learned significantly less about the role of the uterus in deciding the outcome of either natural or assisted pregnancies. In 1979 a quotation by George Corner was used to set the tone of a meeting that was devoted to discussion of the cellular and molecular aspects of implantation. In spite of the proliferation in research activity which occurred in the following 15 years our real understanding of the embryo transfer process has fallen short of our expectations. We use the Corner quotation, once again, to preface this symposium so that we may recall that the fundamental nature of the process which regulates embryo-endometrial interactions still escapes us.
Download or read book The Human Endometrium written by Carlo Bulletti and published by . This book was released on 1994 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structural, biochemical and clinical events related to menstruation, implantation, parturition, endometriosis, abnormal uterine bleeding and endometrial cancer are discussed in this comprehensive volume on the biological functions of the endometrium. New topics, such as the biochemical and molecular mechanisms regulating maternal embryonic interaction, are explored, and gynecologic endoscopy and therapeutic tools are discussed. The proceedings of the first conference is also available from the Academy, as volume 622 of The Annals of The New York Academy of Science.
Download or read book Uterine Endometrial Function written by Hideharu Kanzaki and published by Springer. This book was released on 2016-05-26 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on uterine endometrial function and receptivity from multiple perspectives. The chapters cover a variety of topics including the role of estrogen and progesterone, animal models, parameters for assessing endometrial receptivity, the mechanism of angiogenesis, epigenetic regulation, and stem/progenitor cells. Despite nearly 35 years of experience with in vitro fertilization, the rate of successful implantations remains low. Abnormal endometrial receptivity has been proposed as one of the factors contributing to reduced reproductive potential in women, but our understanding of it is limited. Endometrial receptivity results from an orchestrated interplay between the embryo and the maternal endometrium, and the receptive status, known as the window of implantation, is reached only briefly in the mid-luteal phase. This book provides a comprehensive overview of the latest advances in endometrial function and paves the way for innovative treatments and drug development for infertility. This work will appeal to a wide readership, from researchers on endometrial function and assisted reproductive technology (ART) to clinicians and technicians in the field of gynecology.
Download or read book Emerging Concepts on Human Implantation written by Carlos Simón and published by . This book was released on 1999 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Blastocyst Implantation written by Koji Yoshinaga and published by Adams Publishing Group. This book was released on 1989 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular and Cellular Aspects of Periimplantation Processes written by S. K. Dey and published by . This book was released on 1995-12-01 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Endometrial Gene Expression written by Joanne Kwak-Kim and published by Springer Nature. This book was released on 2019-11-08 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endometrium goes through cyclical changes under the influence of hormones, and immune effectors in the endometrium change their populations cyclically as well. Dynamic changes in immune effectors determine endometrial cytokine and chemokine milieus and, consequently, the endometrial immune response. Endometrial immune responses have been shown to be important for trophoblast invasion and early pregnancy. Indeed, dysregulated endometrial inflammatory immune responses are associated with reproductive failures, such as recurrent pregnancy losses, repeated implantation failure, and gynecological diseases with oncogenic potential. Hence, the investigation of endometrial gene expression may predict infertility, gynecological and oncological conditions. This book presents the state of the art in endometrial gene expression as well as recent developmental findings relating to reproduction and reproductive disorders. It begins with a review of the genetic regulation of urogenital tract formation and molecular mechanism underlying the physiology of menstrual cycle before moving on to the current and emerging technological advances in molecular biology. Endometrial gene expressions of immune inflammatory conditions, viral infection, metabolic and nutritional conditions, and reproductive disorders are then presented in following chapters. Examples of the use and interpretation of gene expression in clinical scenarios including recurrent pregnancy losses, infertility and multiple implantation failures are presented with currently available endometrial gene analysis. Utilizing the latest evidence and clinical guidelines, Endometrial Gene Expression will be a cutting-edge resource for gynecologist, reproductive immunologist, reproductive endocrinologists, obstetrician, maternal fetal medicine specialist and other health care providers in the field of reproductive medicine.
Download or read book The Plasma Membrane of Uterine Epithelial Cells written by Christopher R. Murphy and published by . This book was released on 1993 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Human Implantation written by Ares-Serono Foundation. Workshop and published by . This book was released on 2000 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Implantation and Establishment of Pregnancy in Mammals written by Rodney D. Geisert and published by Springer. This book was released on 2015-10-08 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past few decades technological advances in transcriptomics, proteomics, metabolomics, and glycomics along with the ability to selectively knockout genes of interest has greatly advanced our understanding of maternal-conceptus interactions that are essential for the establishment and maintenance of a successful pregnancy. This knowledge provides a foundation from which to build research endeavors to help resolve infertility, embryonic loss and recurrent abortion in humans, captive wild animals and important farm species. The present volume on “Regulation of Implantation and Establishment of Pregnancy in Mammals” brings together current reviews from leading experts to address the diversity of mechanisms by which species establish and maintain pregnancy. Implantation in rodents, dogs, pigs, cattle, sheep, horses, primates, humans and embryonic diapause in wild species are discussed. Reviews will provide current knowledge on the role of endometrial steroid receptors, adhesion factors, cytokines, interferons, steroids, prostaglandins, growth factors and immune cells involved with regulation of conceptus development.
Download or read book The Primate Endometrium written by Carlo Bulletti and published by . This book was released on 1991 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Placental Bed Disorders written by Robert Pijnenborg and published by Cambridge University Press. This book was released on 2010-06-03 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now recognized that defective placentation in the human is a cause of many pregnancy complications, such as spontaneous abortion, preterm labor and delivery, pre-eclampsia, intrauterine growth restriction, fetal death and abruptio placenta. These clinical disorders can often have long-term consequences into adulthood, causing cardiovascular disease, obesity and diabetes for the newborn as well as an increased risk of premature death in the mother. This is the first book to be entirely focused on the placental bed, bringing together the results of basic and clinical research in cell biology, immunology, endocrinology, pathology, genetics and imaging to consolidate in a single, informative source for investigators and clinicians. Its core aim is to explore new approaches and improve current clinical practice. This is essential reading for clinicians in obstetric, cardiovascular and reproductive medicine.
Download or read book The Endometrium written by Stanley R. Glasser and published by CRC Press. This book was released on 2002-05-16 with total page 1079 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Endometrium is devoted to a comprehensive multi-disciplinary account of the uterine endometrium. This book is the first to define the regulatory biological interrelationships between epithelial and stromal cell phenotypes, endothelial cells, extracellular matrix and immunobiological elements. It highlights their relevance to clinical conditions
