Download or read book The Oncogene Handbook written by Robin Hesketh and published by . This book was released on 1994 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years there has been an audible clamour for a comprehensive digest of the vast and exciting literature on the molecular biology of cancer. The Oncogene Handbook fulfills this need, providing a definitive guide to the facts about the genes involved in cancer. This compendium summarizes the clinical association and molecular properties of all known oncogenes and tumour suppressor genes, providing instant access to information on any particular facet of the gene of protein. Data covering gene structure and location, mRNA size and the half-life mass, cellular and tissue location, protein structure and function, sequence, databank file name and accession number is clearly and logically presented. This vital reference work will provide the understanding that will fuel further progress in this field, and will be an invaluable resource for research workers and clinicians as well as senior undergraduates and pre-clinical students with an interest in carcinogenesis. Robin Hesketh is a member if the Department of Biochemistry, University of Cambridge, where his principal research interest is in the control of eukaryotic cell growth. He was previously a staff member of the National Institute for Medical Research, London and has also worked in North America, Australia and at the European Molecular Biology Laboratory at Heidelberg.
Download or read book The Oncogene Handbook written by E. Premkumar Reddy and published by Elsevier Publishing Company. This book was released on 1988 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of Molecular Oncology has emerged in the last decade as an amalgamation of four of the foremost disciplines in cancer research: retrovirology, chemical carcinogenesis, cytogenetics, and cell growth regulation. The subject matter for this book forms the unifying factor for these four areas. Although the field of Molecular Oncology is still comparatively young, the technical vocabulary can be bewildering to the uninitiated. This book is clear in its divisions, grouping oncogenes by biochemical activity or cellular localization; the large group of tyrosine kinases are compared by relevant features. The Oncogene Handbook allows ready access and supplies excellent cross-referencing. An outstanding reference work, giving basic information on each oncogene in a concise and uniform format. The fundamental importance of the subject area and its medical implications, both reflected in The Oncogene Handbook, provide students, scientists in other fields, and clinicians with a very useful manual.
Download or read book Oncogenes written by Geoffrey M. Cooper and published by Jones & Bartlett Learning. This book was released on 1995 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this authoritative text details major advances and developments in the field, such as the identification of many new tumor suppressor genes and the striking progress in understanding signal transduction pathways leading to cell proliferation. Oncogenes, Second Edition, addresses the needs of advanced undergraduates, graduate students, medical students, physicians, and scientists by examining the current state of oncogene study and where future research may lead.
Download or read book The Oncogene and Tumour Suppressor Gene Factsbook written by Robin Hesketh and published by Elsevier. This book was released on 1997-07-11 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of The Oncogene and Tumour Suppressor Gene FactsBook has been completely revised, updated, and expanded by 60%. The book contains more than 80 entries on oncogenes including JUN, MYC, and RAS, as well as DNA tumour viruses, tumour suppressor genes, including p53, retinoblastoma, BRCA1, BRCA2, VHL, F2FL, and essential material on angiogenesis and metastasis, apoptosis, cell cycle control, and gene therapy. - Includes much new data on this fast-moving field, including newly discovered oncogenes - Summarizes the clinical association and molecular properties of all known oncogenes and tumor suppression genes - Contains more than 2000 terms for reference and further research - Revised to included signaling pathways, apoptosis, and metastasis
Download or read book The Oncogene Factsbook written by Robin Hesketh and published by . This book was released on 1995-01-01 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Oncogene FactsBook is a condensed version of the Oncogene Handbook, in the FactsBook Series format. The key information on oncogenes, tumor viruses, and tumor suppressor genes has been selected from the Handbook and arranged in the series style to that the essential information is readily accessible. The introduction summarizes the principal developments in our understanding of oncogenes, the presente position with regard to gene therapy for human cancers, and discusses patterns of oncogene expression in human tumors. Chapter 2 contains tables of the major categories of oncogenes that include a summary of the properties of those oncogenes which do not have individual sections. Chapter 3 covers the individual oncogenes in a constant format for each entry. DNA tumor viruses and tumor suppressor genes are considered separately in two sections. The minimum number of references has been included in order to give the reader rapic access to the literature in the key areas of structure and function of each gene and its product. The emphasis has thus been placed on listing the most up-to-date references, rather than an extensive bibliography. The Oncogene FacsBook contains more that 60 entries on oncogenes including: JUN, MAS, MYC, MAX, and RAS, as well as DNA tomur viruses, tumor suppressor genes, and essential introductory material. * Individual Oncogene Entries include: * Identification * Related genes * Chromosomal Location and Mass * Cellular Location * Tissue Distribution * Protein function * Cancer * Amino acid Sequence * Domain structure * Database accession numbers * Key references
Download or read book The Oncogenomics Handbook written by William J. LaRochelle and published by Springer Science & Business Media. This book was released on 2007-11-09 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.
Download or read book Handbook of Oncogenomics written by Zena Murray and published by American Medical Publishers. This book was released on 2021-11-16 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: The accumulation of DNA mutations and epigenetic variations that leads to uncontrolled cell proliferation and formation of neoplasm refers to cancer. It is a genetic disease. The sub branch of genomics that deals with the study of cancer related genes is known as oncogenomics. The primary goal of the discipline is to recognize new tumor suppressor genes and oncogenes that may lead to new insights in the diagnosis of cancer, help predict the clinical outcome of different cancers and identify new targets for cancer therapies. It uses the techniques of transciptomes, genome sequencing, bioinformatics, functional analysis of oncogenes, etc. The field is also concerned with personalizing cancer treatment by identifying and targeting mutations in an individual patient. The book elucidates the concepts and innovative models around the prospective developments with respect to oncogenomics. The various studies that are constantly contributing towards advancing technologies and evolution of this field are examined in detail. This book, with its detailed analyses and data, will prove immensely beneficial to professionals and students involved in this area at various levels.
Download or read book A SHORT HAND BOOK ON ONCOGENES ONCOGENES AT A GLANCE written by Dr. Noopur Kulkarni and published by Sankalp Publication. This book was released on with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Cancer Handbook written by Malcolm Alison and published by Nature Publishing Group. This book was released on 2002 with total page 928 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a comprehensive overview of all major areas of cancer research and oncology. Bridging the gap between the molecular biology of cancer and clinical diagnosis and treatment, this online reference work provides a resource for medical and life sciences students, as well as all scientists, clinicians and researchers working in the cancer field and related biomedical areas.
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Download or read book Handbook of Growth Factors written by Enrique Pimentel and published by CRC Press. This book was released on 1994-06-02 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume I of this book provides a comprehensive discussion of the factors involved in regulation of the cell cycle, the general biological properties of growth factors, and the receptor and postreceptor mechanisms of action of these signaling agents. It evaluates the possible role of growth factors in the regulation of proto-oncogene and tumor suppressor gene expression, and the development of neoplastic processes is discussed in detail.
Download or read book Targeted Therapies for Solid Tumors written by Antonio Russo and published by Humana. This book was released on 2016-10-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.
Download or read book Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics written by Pandurangan, Ashok Kumar and published by IGI Global. This book was released on 2022-03-18 with total page 643 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many chemotherapeutic agents are available in today’s market that are highly effective against a variety of cancer types; however, the major drawbacks of these chemotherapeutic agents are the many side effects. As an alternative to these chemotherapeutic agents, there are a number of natural agents that are effective against cancer that have been tested in preclinical and clinical models over the years. These natural products must be documented and discussed in order to provide a thorough overview of all the options available for cancer treatment. The Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics emphasizes the list of natural agents against all types of cancers and discusses the current state of research in the fields of natural products and their derivatives against cancer in preclinical and clinical models. This book also provides insight into the applications of meditation and mindfulness-based interventions in clinical and non-clinical conditions. Covering topics such as cancer therapy, antioxidants, and flavonoids, it is ideal for students, research scholars, academicians, professors, scientists, oncologists, doctors, and medical practitioners.
Download or read book Handbook of Growth Factors 1994 written by Enrique Pimentel and published by CRC Press. This book was released on 2017-11-22 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume I of this book provides a comprehensive discussion of the factors involved in regulation of the cell cycle, the general biological properties of growth factors, and the receptor and postreceptor mechanisms of action of these signaling agents. It evaluates the possible role of growth factors in the regulation of proto-oncogene and tumor suppressor gene expression, and the development of neoplastic processes is discussed in detail.
Download or read book Mechanisms in B Cell Neoplasia 1990 written by Michael Potter and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: The eighth workshop in this series on Mechanisms in B-Cell Neoplasia 1990 was held in Wilson Hall at the National Institutes of Health, Bethesda, Maryland on March 28-30. Five major topics formed the basis for the discussions: 1) progress in experimental models of B-cell tumorigenesis, 2) the role of IL-6 in plasma cell tumor formation with particular emphasis on human myeloma, 3) immortaliza tion and regulation of mitosis in B-cells, 4) the mYQ gene in B-cell neoplasia, and 5) the role of EBV and other oncogenes in transforma tion of human B-Iymphocytes. A meeting on the Epidemiology of Myeloma was held at the N. I. H. on the preceding day, and many of those interested in the clinical aspects of myeloma were also participants at the workshop. Experimental Models of B-Cell Tumor Development We have seen in the last eight years the steady growth of model experimental systems, many of which have been designed to be counter parts of the major forms of human B cell tumors, e. g. , follicular lymphomas, Burkitt's lymphomas, acute B-cell leukemia and multiple myeloma. A variety of novel ways of inducing these tumors has been described. Advantage has been taken of the "experiments in nature" to identify critical genes that playa role in tumor pathogenesis. These genes have been identified by being near to viral insertion and chromosomal translocation sites, or by having been incorporated or transduced into a defective transforming retrovirus.
Download or read book Osteosarcoma in Adolescents and Young Adults New Developments and Controversies written by G. Bennett Humphrey and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies is the fifth volume in the series `Cancer Treatment, and Research' devoted to pediatric oncology. Like its immediate predecessor, Hodgkin's Disease in Children: Controversies and Current Practice, this volume also deals with the current state of affairs: where do researchers differ in opinions or firmly held beliefs? What does the future hold for research or for the patients who have benefited from research and are now cured? etc. The first part deals with preclinical and clinical issues that relate to the disease and the second part deals with the results of recent trials and in some cases ongoing trials. It could be argued that section B Pharmacology, Section D Radiotherapy and Section E Surgery of part one belong to part two; however in these sections we have tried to focus on one discipline and in part two, we have tried to focus on the results of multidisciplinary trials. A third part includes a few critiques and editorial comments. This volume was prepared and planned for both basic and clinical oncologists. It is hoped that the basic scientists will gain some insight into the problems of their clinical colleagues and that the clinicians will be willing to read to the more basic articles. It is not a text for students (or for that matter physicians) who want all things to be laid out in `black and white'. But it is a text for those students who want to know how vibrant this field of research is and are willing to stand in awe of how much research needs to be done.
Download or read book Chemical Induction of Cancer written by Joseph C. Arcos and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 748 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the approach to the analysis of disease, including, of course, cancer, two major thrusts may be distinguished. These may be referred to, in shorthand, as agents and processes: the causative agents (chemical, microbial, physical, environmental, and psychosocial) and the organismic processes, initiated and furthered by the agents, culminating in observable pathology (at the macromolecular, cytological, histological, organ function, locomotor, and behavioral levels). The past 25 years, since the appearance of the first volume of the predecessor series (1) authored by the Editors of this present volume, have seen an impressive number of studies on chemicals (and other agents) as etiologic factors in the induction of cancer. The major emphasis has been on the discovery of many chemical carcinogens of widely different structures, their metabolism by various tissues and cells, and, in turn, their molecular-biochemical effects on the cells. This rapidly expanded body of information, as effectively covered in the predecessor volumes, is an excellent entree to the second half of the overall problem of chemical carcinogenesis, the processes. The active agents trigger a large array of molecular-biochemical alterations to which the target cells, target tissues, and target organisms respond in many select and common ways. This second major aspect of the induction of cancer by chemicals (and by other agents)- the sequence of cellular and tissue changes clearly relevant to cancer-remains the challenge for the future.
