Download or read book The Heroin Stimulus written by R. E. Meyer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: The simple fact that the authors were able to give injectable heroin to volunteers for addictive self-administration at a Harvard facility may elude the notice it deserves. On the other hand, resec:irch questions center ing on whether heroin is linked to a craving for pleasure or relief of pain might raise the transplanted hackles of those who simplistically see scien tists as pursuing only transparent trivialities. In truth, this report is about a historical and pioneering step in clinical research on a major unsolved problem of the biological-social-psychological roots of addiction. The research questions posed are clearly relevant both to the design of effec tive treatments (and treatment policy) and to the basic science search that could help our understanding of how addictive drugs capture such power ful control over behavior. Heroin was synthesized and has been available, along with aspirin, for over three-quarters of a century. Yet with all the tools of Western sci ence, and with the enormous and growing social, personal, and economic costs of world-wide heroin use, we-surprisingly--

Download or read book Heroin Stimulus written by R. E Meyer and published by . This book was released on 1979-01-01 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Methods of Assessing the Reinforcing Properties of Abused Drugs written by Michael A. Bozarth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods of Assessing the Reinforcing Properties of Abused Drugs presents a synopsis of the preclinical procedures used to assess drug reinforcement. Researchers using one technique are provided with an overview of the other available methods, and clinicians who wish to evaluate drug abuse research reports can gain the necessary background from this volume. Although emphasis is placed on the methodological aspects of assessing drug reinforcement, some of the scientific conclusions derived from using these techniques are also presented. This edited collection offers a lasting framework for interpreting the results of current experimental findings.

Download or read book Neural Mechanisms of Addiction written by Mary Torregrossa and published by Academic Press. This book was released on 2018-08-24 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Mechanisms of Addiction is the only book available that synthesizes the latest research in the field into a single, accessible resource covering all aspects of how addiction develops and persists in the brain. The book summarizes our most recent understanding on the neural mechanisms underlying addiction. It also examines numerous biobehavioral aspects of addiction disorders, such as reinforcement learning, reward, cognitive dysfunction, stress, and sleep and circadian rhythms that are not covered in any other publication. Readers with find the most up-to-date information on which to build a foundation for their future research in this expanding field. Combining chapters from leading researchers and thought leaders, this book is an indispensable guide for students and investigators engaged in addiction research. Transcends multiple neural, neurochemical and behavioral domains Summarizes advances in the field of addiction research since the advent of optogenetics Discusses the most current, leading theories of addiction, including molecular mechanisms and dopamine mechanisms

Download or read book Methods of Behavior Analysis in Neuroscience written by Jerry J. Buccafusco and published by CRC Press. This book was released on 2000-08-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Download or read book Stimulus Properties of Drugs written by Travis. Thompson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Behavioral pharmacology represents a relatively recent scientific enterprise, the development of which can be followed by plotting the publication of major conceptual papers, review articles, and books. Dews (1955), Sidman (1955), and Brady (1956) published some of the first methodologically significant papers, changing the way both psychologists and pharmacologists viewed the analysis of the behavioral actions of drugs. Dews and Morse (1961), Cook and Kelleher (1963), Gollub and Brady (1965), and Weiss and Laties (1969) kept the field abreast of major developments in the study of behavioral mechanisms of drug action. In 1968, the first textbook in the field was published (Thompson and Schuster), followed by a book of readings covering the preceding 15 years of the field (Thompson, Pickens, and Meisch, 1970). The first attempt to outline a set of generalizations concerning behavioral mechanisms of drug actions was puhlished in 1968 by Kelleher and Morse. As behavioral pharmacology developed, it became clear that demonstrations that drugs affect hehavior were relatively uninteresting. It was the mechanisms by which these effects are hrought about that was of concern. While other aspects of pharmacology have been concerned with biochemical, physiological, and in some cases biophysical accounts of drug actions, behavioral pharmacology has dealt with behavioral mechanisms . . . that is, "any verifiable description of a drug's effects which can he shown to uniquely covary with a specific measured 'response'. Generally, this relation can be subsumed under some more general set of relations or principles" (Thompson, Pickens, and Meisch, 1970, p. I).

Download or read book Pathways of Addiction written by Institute of Medicine and published by National Academies Press. This book was released on 1996-11-01 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug abuse persists as one of the most costly and contentious problems on the nation's agenda. Pathways of Addiction meets the need for a clear and thoughtful national research agenda that will yield the greatest benefit from today's limited resources. The committee makes its recommendations within the public health framework and incorporates diverse fields of inquiry and a range of policy positions. It examines both the demand and supply aspects of drug abuse. Pathways of Addiction offers a fact-filled, highly readable examination of drug abuse issues in the United States, describing findings and outlining research needs in the areas of behavioral and neurobiological foundations of drug abuse. The book covers the epidemiology and etiology of drug abuse and discusses several of its most troubling health and social consequences, including HIV, violence, and harm to children. Pathways of Addiction looks at the efficacy of different prevention interventions and the many advances that have been made in treatment research in the past 20 years. The book also examines drug treatment in the criminal justice setting and the effectiveness of drug treatment under managed care. The committee advocates systematic study of the laws by which the nation attempts to control drug use and identifies the research questions most germane to public policy. Pathways of Addiction provides a strategic outline for wise investment of the nation's research resources in drug abuse. This comprehensive and accessible volume will have widespread relevanceâ€"to policymakers, researchers, research administrators, foundation decisionmakers, healthcare professionals, faculty and students, and concerned individuals.

Download or read book Dopamine Nation written by Dr. Anna Lembke and published by Penguin. This book was released on 2023-01-03 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: INSTANT NEW YORK TIMES and LOS ANGELES TIMES BESTSELLER “Brilliant . . . riveting, scary, cogent, and cleverly argued.”—Beth Macy, author of Dopesick, as heard on Fresh Air This book is about pleasure. It’s also about pain. Most important, it’s about how to find the delicate balance between the two, and why now more than ever finding balance is essential. We’re living in a time of unprecedented access to high-reward, high-dopamine stimuli: drugs, food, news, gambling, shopping, gaming, texting, sexting, Facebooking, Instagramming, YouTubing, tweeting . . . The increased numbers, variety, and potency is staggering. The smartphone is the modern-day hypodermic needle, delivering digital dopamine 24/7 for a wired generation. As such we’ve all become vulnerable to compulsive overconsumption. In Dopamine Nation, Dr. Anna Lembke, psychiatrist and author, explores the exciting new scientific discoveries that explain why the relentless pursuit of pleasure leads to pain . . . and what to do about it. Condensing complex neuroscience into easy-to-understand metaphors, Lembke illustrates how finding contentment and connectedness means keeping dopamine in check. The lived experiences of her patients are the gripping fabric of her narrative. Their riveting stories of suffering and redemption give us all hope for managing our consumption and transforming our lives. In essence, Dopamine Nation shows that the secret to finding balance is combining the science of desire with the wisdom of recovery.

Download or read book Facts Frameworks and Forecasts written by Joan McCord and published by Routledge. This book was released on 2017-09-04 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Facts, Frameworks, and Forecasts calls for rethinking the development of criminological theory. In her introduction, Joan McCord argues that the field is ready for new approaches and that its progress depends on a sound factual base. Examining the discipline's research design, methodology, and quantitative analysis efforts, the contributors identify significant advances in criminological theory. This empirical orientation results in a balanced blend of information and speculation.This book contains a comprehensive review. The first chapter describes biological conditions that have theoretical links with criminal behavior - ending with a discussion of how biological and social conditions may interact to influence criminal behavior. Early chapters discuss general issues related to crime. These are followed by expositions of theoretical orientations not typically found in criminological literature. The second half of the book describes seven longitudinal studies in four countries. The authors interpret their data to expose biological, social, and psychological factors they believe may influence criminal behavior.These contributors include: Guenther Knoblich and Roy King, Daniel Glaser, Robert A. Rosellini and Robin L. Lashley, Robert J. Sampson, Ellen S. Cohn and Susan O. White, Joan McCord, L. Rowell Huesmann and Leonard D. Eron, Robert Cairns and Beverly Cairns, Richard E. Tremblay, Patricia Cohen and Judith S. Brook, David P. Farrington and David Magnussen, Britt af Klinteberg, and Hakan Stattin.Facts, Frameworks, and Forecasts addresses the observation of noted criminologist Marvin Wolfgang that criminological theory had stagnated. This groundbreaking work, available in paperback for the first time, is as relevant now as when first published. It should be read by all concerned with data-related approaches to criminology.

Download or read book NIDA Research Monograph written by and published by . This book was released on 1976 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Research in Biological and Medical Sciences written by Walter Reed Army Institute of Research and published by . This book was released on 1975 with total page 892 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Drug Discrimination written by Richard A. Glennon and published by John Wiley & Sons. This book was released on 2011-08-04 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug discrimination: a practical guide to its contributions to the invention of new chemical entities and evaluations of new or known pharmacological agents Drug discrimination can be described as a "drug detection" procedure that uses a pharmacologically active agent as the subjective stimulus. Although the procedure does require some effort to implement, it can be an extremely important tool for understanding drug action. Whereas medicinal chemists should come to learn the types of information that drug discrimination studies can offer, pharmacologists and psychologists might come to realize how medicinal chemists can apply the types of information that the paradigm routinely provides. Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies provides in-depth analyses of the nature and use of drugs as discriminative stimuli and bridges some of the numerous gaps between medicinal chemistry, pharmacology, and psychology. Stressing the practical aspects of drug discrimination, including types of procedures, study design, data, and interpretation, the book details the advantages and limitations of drug discrimination studies versus other pharmacologic evaluations. Practical information from leading researchers in the field addresses specific topics and techniques that are of interest in drug discovery, evaluation, and development. A groundbreaking new guide to the applications of drug discrimination studies for medicinal chemistry and neuroscience, Drug Discrimination is essential for any scientist, researcher, or student whose interests involve the design, development, and/or action of drugs acting at the level of the central nervous system.

Download or read book Opiate Receptors and Antagonists written by Reginald Dean and published by Springer Science & Business Media. This book was released on 2009-03-12 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive and authoritative, Opioid Receptors and Antagonists: From Bench to Clinic offers neuroscientists, pharmacologists and interested clinicians a unique survey of the extensive and diverse research efforts currently employed with opioid antagonists to develop novel innovative drug therapies. Summarizes the present understanding of the chemistry, pharmacology and molecular biology of opioid receptors and their subtypes Highlights differences and similarities between the opioid pharmacology of animals and human Describes current and potential therapeutic areas for opioid antagonists, including substance abuse, alcohol and ingestive behaviors, behavioral disorders and other medical indications, supported by nonclinical and clinical evidence Focuses on the development of exciting and innovative drug delivery approaches that are being used with opioid antagonists for the above medical indications

Download or read book Problems of Drug Dependence written by College on Problems of Drug Dependence (U.S.). Scientific Meeting and published by . This book was released on 1989 with total page 760 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Problems of Drug Dependence written by Committee on Problems of Drug Dependence (U.S.). Scientific Meeting and published by . This book was released on 1990 with total page 810 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Problems of Drug Dependence 1990 written by Committee on Problems of Drug Dependence (U.S.). Scientific Meeting and published by . This book was released on 1991 with total page 812 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Problems of Drug Dependence written by and published by . This book was released on 1991 with total page 726 pages. Available in PDF, EPUB and Kindle. Book excerpt: