Download or read book The Exploration and Computations of Mathematical Models of Intermittent Treatment for Prostate Cancer written by Alacia Voth and published by . This book was released on 2012 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comparison Between Mathematical Models of Intermittent Androgen Suppression for Prostate Cancer written by and published by . This book was released on 2013 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Introduction to Mathematical Oncology written by Yang Kuang and published by CRC Press. This book was released on 2016-06-14 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Mathematical Oncology presents biologically well-motivated and mathematically tractable models that facilitate both a deep understanding of cancer biology and better cancer treatment designs. It covers the medical and biological background of the diseases, modeling issues, and existing methods and their limitations. The authors introduce mathematical and programming tools, along with analytical and numerical studies of the models. They also develop new mathematical tools and look to future improvements on dynamical models. After introducing the general theory of medicine and exploring how mathematics can be essential in its understanding, the text describes well-known, practical, and insightful mathematical models of avascular tumor growth and mathematically tractable treatment models based on ordinary differential equations. It continues the topic of avascular tumor growth in the context of partial differential equation models by incorporating the spatial structure and physiological structure, such as cell size. The book then focuses on the recent active multi-scale modeling efforts on prostate cancer growth and treatment dynamics. It also examines more mechanistically formulated models, including cell quota-based population growth models, with applications to real tumors and validation using clinical data. The remainder of the text presents abundant additional historical, biological, and medical background materials for advanced and specific treatment modeling efforts. Extensively classroom-tested in undergraduate and graduate courses, this self-contained book allows instructors to emphasize specific topics relevant to clinical cancer biology and treatment. It can be used in a variety of ways, including a single-semester undergraduate course, a more ambitious graduate course, or a full-year sequence on mathematical oncology.
Download or read book Mathematical Models of Androgen Resistance in Prostate Cancer Patients Under Intermittent Androgen Suppression Therapy written by Javier Baez and published by . This book was released on 2017 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Predicting resistant prostate cancer is critical for lowering medical costs and improving the quality of life of advanced prostate cancer patients. I formulate, compare, and analyze two mathematical models that aim to forecast future levels of prostate-specific antigen (PSA). I accomplish these tasks by employing clinical data of locally advanced prostate cancer patients undergoing androgen deprivation therapy (ADT). I demonstrate that the inverse problem of parameter estimation might be too complicated and simply relying on data fitting can give incorrect conclusions, since there is a large error in parameter values estimated and parameters might be unidentifiable. I provide confidence intervals to give estimate forecasts using data assimilation via an ensemble Kalman Filter. Using the ensemble Kalman Filter, I perform dual estimation of parameters and state variables to test the prediction accuracy of the models. Finally, I present a novel model with time delay and a delay-dependent parameter. I provide a geometric stability result to study the behavior of this model and show that the inclusion of time delay may improve the accuracy of predictions. Also, I demonstrate with clinical data that the inclusion of the delay-dependent parameter facilitates the identification and estimation of parameters.
Download or read book Biomat 2012 International Symposium On Mathematical And Computational Biology written by Rubem P Mondaini and published by World Scientific. This book was released on 2013-06-25 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a book of a series on interdisciplinary topics of the Biological and Mathematical Sciences. The chapters correspond to selected papers on special research themes, which were presented at BIOMAT 2012 International Symposium on Mathematical and Computational Biology, in Tempe, Arizona, USA, November 6-10.This book contains state-of-the art articles on special research topics on mathematical biology, biological physics and mathematical modeling of biosystems; comprehensive reviews on interdisciplinary areas written by prominent leaders of scientific research groups. The treatment is both pedagogical and advanced in order to motivate research students as well as to fulfill the requirements of professional practitioners.
Download or read book Mathematical Modeling and Computational Predictions in Oncoimmunology written by Vladimir A. Kuznetsov and published by Frontiers Media SA. This book was released on 2024-06-06 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a complex adaptive dynamic system that causes both local and systemic failures in the patient. Cancer is caused by a number of gain-of-function and loss-of-function events, that lead to cells proliferating without control by the host organism over time. In cancer, the immune system modulates cancer cell population heterogeneity and plays a crucial role in disease outcomes. The immune system itself also generates multiple clones of different cell types, with some clones proliferating quickly and maturing into effector cells. By creating regulatory signals and their networks, and generating effector cells and molecules, the immune system recognizes and kills abnormal cells. Anti-cancer immune mechanisms are realized as multi-layer, nonlinear cellular and molecular interactions. A number of factors determine the outcome of immune system-tumor interactions, including cancer-associated antigens, immune cells, and host organisms.
Download or read book Mathematical Modelling in Health Social and Applied Sciences written by Hemen Dutta and published by Springer Nature. This book was released on 2020-02-29 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses significant research findings in the field of mathematical modelling, with particular emphasis on important applied-sciences, health, and social issues. It includes topics such as model on viral immunology, stochastic models for the dynamics of influenza, model describing the transmission of dengue, model for human papillomavirus (HPV) infection, prostate cancer model, realization of economic growth by goal programming, modelling of grazing periodic solutions in discontinuous systems, modelling of predation system, fractional epidemiological model for computer viruses, and nonlinear ecological models. A unique addition in the proposed areas of research and education, this book is a valuable resource for graduate students, researchers and educators associated with the study of mathematical modelling of health, social and applied-sciences issues. Readers interested in applied mathematics should also find this book valuable.
Download or read book Advances in Mathematical and Computational Oncology Volume II written by George Bebis and published by Frontiers Media SA. This book was released on 2022-06-27 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metronomic Chemotherapy written by Guido Bocci and published by Springer. This book was released on 2014-09-04 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.
Download or read book Advances in Multiresolution for Geometric Modelling written by Neil Dodgson and published by Springer Science & Business Media. This book was released on 2006-05-24 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiresolution methods in geometric modelling are concerned with the generation, representation, and manipulation of geometric objects at several levels of detail. Applications include fast visualization and rendering as well as coding, compression, and digital transmission of 3D geometric objects. This book marks the culmination of the four-year EU-funded research project, Multiresolution in Geometric Modelling (MINGLE). The book contains seven survey papers, providing a detailed overview of recent advances in the various fields within multiresolution modelling, and sixteen additional research papers. Each of the seven parts of the book starts with a survey paper, followed by the associated research papers in that area. All papers were originally presented at the MINGLE 2003 workshop held at Emmanuel College, Cambridge, UK, 9-11 September 2003.
Download or read book Clinical Case Studies for the Family Nurse Practitioner written by Leslie Neal-Boylan and published by John Wiley & Sons. This book was released on 2011-11-28 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Case Studies for the Family Nurse Practitioner is a key resource for advanced practice nurses and graduate students seeking to test their skills in assessing, diagnosing, and managing cases in family and primary care. Composed of more than 70 cases ranging from common to unique, the book compiles years of experience from experts in the field. It is organized chronologically, presenting cases from neonatal to geriatric care in a standard approach built on the SOAP format. This includes differential diagnosis and a series of critical thinking questions ideal for self-assessment or classroom use.
Download or read book Human Health and Performance Risks of Space Exploration Missions written by Jancy C. McPhee and published by U. S. National Aeronautics & Space Administration. This book was released on 2009 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Epithelial Mesenchymal Plasticity in Cancer Metastasis written by Mohit Kumar Jolly and published by MDPI. This book was released on 2020-12-29 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies have highlighted that epithelial-mesenchymal transition (EMT) is not only about cell migration and invasion, but it can also govern many other important elements such as immunosuppression, metabolic reprogramming, senescence-associated secretory phenotype (SASP), stem cell properties, therapy resistance, and tumor microenvironment interactions. With the on-going debate about the requirement of EMT for cancer metastasis, an emerging focus on intermediate states of EMT and its reverse process mesenchymal-epithelial transition (MET) offer new ideas for metastatic requirements and the dynamics of EMT/MET during the entire metastatic cascade. Therefore, we would like to initiate discussions on viewing EMT and its downstream signaling networks as a fulcrum of cellular plasticity, and a facilitator of the adaptive responses of cancer cells to distant organ microenvironments and various therapeutic assaults. We hereby invite scientists who have prominently contributed to this field, and whose valuable insights have led to the appreciation of epithelial-mesenchymal plasticity as a more comprehensive mediator of the adaptive response of cancer cells, with huge implications in metastasis, drug resistance, tumor relapse, and patient survival.
Download or read book Selected Topics in Cancer Modeling written by Nicola Bellomo and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of selected chapters offers a comprehensive overview of state-of-the-art mathematical methods and tools for modeling and analyzing cancer phenomena. Topics covered include stochastic evolutionary models of cancer initiation and progression, tumor cords and their response to anticancer agents, and immune competition in tumor progression and prevention. The complexity of modeling living matter requires the development of new mathematical methods and ideas. This volume, written by first-rate researchers in the field of mathematical biology, is one of the first steps in that direction.
Download or read book The Physics of Cancer written by Caterina A. M. La Porta and published by Cambridge University Press. This book was released on 2017-04-20 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have witnessed an increasing number of theoretical and experimental contributions to cancer research from different fields of physics, from biomechanics and soft-condensed matter physics to the statistical mechanics of complex systems. Reviewing these contributions and providing a sophisticated overview of the topic, this is the first book devoted to the emerging interdisciplinary field of cancer physics. Systematically integrating approaches from physics and biology, it includes topics such as cancer initiation and progression, metastasis, angiogenesis, cancer stem cells, tumor immunology, cancer cell mechanics and migration. Biological hallmarks of cancer are presented in an intuitive yet comprehensive way, providing graduate-level students and researchers in physics with a thorough introduction to this important subject. The impact of the physical mechanisms of cancer are explained through analytical and computational models, making this an essential reference for cancer biologists interested in cutting-edge quantitative tools and approaches coming from physics.
Download or read book Developing a Protocol for Observational Comparative Effectiveness Research A User s Guide written by Agency for Health Care Research and Quality (U.S.) and published by Government Printing Office. This book was released on 2013-02-21 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)
Download or read book The Chemotherapy Source Book written by Michael Clinton Perry and published by Lippincott Williams & Wilkins. This book was released on 2008 with total page 820 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Chemotherapy Source Book, Fourth Edition pulls together all the current information on the chemotherapeutic management of cancer patients, including choice of chemotherapeutic agents, use of combinations, and toxicity of individual drugs. Organized by disease site, the book brings together pharmacologic and patient management information in one source that clinicians can consult for any question encountered in the delivery of chemotherapy. This updated Fourth Edition includes new drugs as well as new indications for older drugs. Content has been streamlined to provide essential information more quickly for the busy practitioner. Plus, this edition is softcover for greater portability and convenience.
