Download or read book The Endocrinology of Prostate Tumours written by R. Ghanadian and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumours of the prostate are the commonest types of neoplasm in the male. Whilst the benign form is virtually a universal condition in the ageing male, malignant tumours rank amongst the top causes of cancer death. Despite the fact that the involvement of the testis in the growth of the prostate has been recognised for almost two centuries, it was not until the early 1940s that Charles Huggins' studies on the effect of orchidectomy and oestrogen therapy on prostatic cancer initiated endocrine manipulation in the management of this malignancy. During the 1960s progress in the understanding of the mechanism of hormone action, achieved through advances in molecular biology and the recognition of certain aspects of hormonal control in relation to the genome, introduced a new dimension for approaching endocrine manipulation of prostatic tumours. By the end of that decade a new scientific discipline devoted to prostate research had been born, which brought together investigators in the fields of molecular biology, biochemistry, endocrinology, immunology, urology and pathology to search for the cause and to explore methods for advancing the management of abnormal prostatic growth. Since then a wealth of scientific data has accumulated on the prostate in which endocrinology has manifested itself as the cardinal aspect to which most of the findings can be related.
Download or read book Endocrine Therapies in Breast and Prostate Cancer written by C. Kent Osborne and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been recognized for many years that cancers originating in the breast and prostate gland are frequently 'endocrine-dependent. ' Traditional thera pies included surgical endocrine ablative procedures or pharmacologic hor mone administration, both designed to antagonize the stimulatory effects of sex steroid hormones. In the past decade, several new treatment strategies for these tumors have emerged from basic studies in reproductive biology and mechanisms of action of steroid hormones. In some instances, these new treatments have elimin ated or reduced the need for major surgical ablative procedures or for toxic hormone therapy. The clinical role for other new treatments has not yet been clearly defined, although exciting preliminary data from recent clinical trials are now available. Thus, an objective review of the current status of these new therapeutic approaches is of interest. In this volume we have attempted to provide an in-depth review of both basic and clinical research involving several new treatment strategies for breast and prostate cancer. The first three chapters summarize preclinical and clinical studies of the luteinizing hormone-releasing hormone analogues, which can be used effectively to induce 'medical castration. ' Chapters 4, 5, and 6 review the rationale and clinical use of the compounds known collec tively as the aromatase inhibitors, which can also be used to suppress sex steroid hormone levels. Antiestrogen mechanism of action and its clinical implications for the design of innovative treatment approaches is considered in chapters 7 and 8.
Download or read book The Prostate as an Endocrine Gland written by Richard J. Ablin and published by CRC Press. This book was released on 1989-11-30 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique publication illustrates that the prostate elaborates an array of local hormones or "autocoids" and how these influence prostatic growth, function and oncogenesis. It describes how familiarity with these participants and how they effect the character and direction of prostatic function may suggest diagnostic markers of malfunction and new sites and modes of therapeutic intervention. The catholic scope and authorship of the work seeks to integrate the views of those urologists, reproductive physiologists and endocrinologists who presently work with the prostate. It attempts to show all other biologists the full range of the gland's activities and participating molecules. Included are: oncogenes, mitogens, polyamines, prostaglandins, growth factors, antigens, and the familiar steroid, peptide and protein hormones. This volume is unique in its point of view and in the new concepts it presents. Addressed are actions of spermine-binding protein and osteoblastic mitogens, consequences of inhibin/thyrotropin-releasing hormone balance, and urokinase effects. Covered also are androgen modulation of vasoactive intestinal polypeptides, evidence of a prostatolymphoreticular system, secretion of dihydrotestosterone, and a model of the inter-dependence of prostatic epithelium and stroma. This unique new volume is of great value to those in urology, internal medicine, physiology, endocrinology and pharmacology.
Download or read book Hormones and Cancer Breast and Prostate An Issue of Endocrinology and Metabolism Clinics of North America written by Alice C. Levine and published by Elsevier Health Sciences. This book was released on 2011-09-28 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Endocrinology Clinics brings the reader up to date on the latest information about hormones and cancer of the breast and prostate. The first section focuses on the breast, and topics covered include the following. The role of sex steroids and their receptors in normal breast development; estrogen carcinogenesis in breast cancer; hormonal mechanisms underlying the relationship between obesity and breast cancer; postmenopausal hormone replacement therapy and the risk of breast cancer; aromatase inhibitors, anti-estrogen and SERMS in the treatment of breast cancer; and androgens in breast cancer in men and women. The second section is devoted to the prostate, and topics covered include the following. Overview of prostate anatomy, histology, and pathology; the critical role of sex steroids in normal prostate development; estrogens and androgens in prostate cancer development and the rationale for hormonal chemopreventive therapies; weighing the clinical evidence regarding the timing and extent of androgen ablative therapy for prostate cancer treatment; new hormonal therapies for castration-resistant prostate cancer; and the management of the side effects of castration therapy.
Download or read book Antiandrogens in Prostate Cancer written by Louis Denis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: The European School of Oncology came into existence to respond to a need for information, education and training in the field of the diagnosis and treatment of cancer. There are two main reasons :o/hy such an initiative was considered necessary. Firstly, the teaching of oncology requires a rigorously multidisciplinary approach which is difficult for the Universities to put into practice since their system is mainly disciplinary orientated. Secondly, the rate of technological development that impinges on the diagnosis and treatment of cancer has been so rapid that it is not an easy task for medical faculties to adapt their curricula flexibly. With its residential courses for organ pathologies and the seminars on new techniques (laser, monoclonal antibodies, imaging techniques etc.) or on the principal therapeutic controversies (conservative or mutilating surgery, primary or adjuvant chemotherapy, radiotherapy alone or integrated), it is the ambition of the European School of Oncology to fill a cultural and scientific gap and, thereby, create a bridge between the University and Industry and between these two and daily medical practice. One of the more recent initiatives of ESO has been the institution of permanent study groups, also called task forces, where a limited number of leading experts are invited to meet once a year with the aim of defining the state of the art and possibly reaching a consensus on future developments in specific fields of oncology.
Download or read book Endocrine Management of Prostatic Cancer written by H. Klosterhalfen and published by Walter de Gruyter GmbH & Co KG. This book was released on 2019-06-04 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keine ausführliche Beschreibung für "Endocrine Management of Prostatic Cancer" verfügbar.
Download or read book Endocrine Dependent Tumors written by Klaus-Dieter Voigt and published by Lippincott Williams & Wilkins. This book was released on 1991 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Endocrine Oncology written by Stephen P. Ethier and published by Springer Science & Business Media. This book was released on 2000-06-18 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stephen P. Ethier and a panel of leading investigators comprehensively analyze the cellular, molecular, and endocrine factors in the development of cancers of the breast, prostate, endometrium, and ovary. Concentrating on defining the most important unresolved issues in the field, the authors review how steroid hormones function to regulate normal mammary gland homeostasis in humans, with particular emphasis on the roles of estrogen, progesterone, and growth factors. Comprehensive and up-to-date, Endocrine Oncology offers both basic and clinical researchers not only the latest molecular and cellular findings on endocrine cancers, but also a powerful critical analysis that will prove invaluable to all endocrinologists and oncologists working in the area today.
Download or read book Antiandrogens in Prostate Cancer written by Louis Denis and published by . This book was released on 1996-03-12 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hormones Genes and Cancer written by Brian E. Henderson and published by Oxford University Press. This book was released on 2003-03-13 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormonal carcinogenesis is an important and controversial area of current research. In addition to accelerating existing cancers, can hormones play the role of primary carcinogens? How do genetic factors influence hormone-related cancer risk? Hormones, Genes, and Cancer addresses these questions. Over the past few decades, cancer research has focused on external environmental causes(e.g., tobacco smoke, viruses, asbestos). With the advent of new genetic sequencing techniques, we are just now beginning to understand how the body's internal environment(i.e., the hormones and growth factors that determine normal development) influences cancer etiology and prevention. From molecular insights to clinical analyses, this volume provides state-of-the-art information on the complex interactions between hormones and genes and cancer. The epidemiology and molecular endocrinology of prostate, breast, uterine, ovarian and testicular cancer are detailed in this timely treatise.
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Download or read book Steroid Receptors Metabolism and Prostatic Cancer written by F. H. Schröder and published by . This book was released on 1980 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Progress in Diagnostics and Therapy of Prostatic Cancer written by W.B. Peeling and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is now increasing awareness by the general public in European countries that prostate cancer is a serious threat to health, and this has created higher expectations for improved and more effective methods for detecting and treating the disease. However, urologists are very conscious of the limitations of the diagnostic methods that are available and are even more concerned about the apparent lack of therapeutic advances made during the past 50 years since Huggins discovered the fundamental principles of endocrine treatment for is theo prostate cancer. Recent efforts to detect the disease when it retically "curable" have been successful, certainly in the USA, but this has highlighted our uncertainty about the best treatment for early stage prostate cancer, and there is no doubt that radical pro statectomy is sometimes carried out on men who may not be threa tened by their illness. While it is generally accepted that many men with prostate cancer will die of old age rather than this malignancy, it cannot be ignored that this disease kills many others in a process that is frequently lingering, miserable, and humiliating, not only for the victim but also his family. There are many important issues about prostate cancer that remain unclear at the present time, some of which are addressed by the reviews in this book. The debate about early detection and screening can arouse considerable heat in otherwise placid urological mee tings.
Download or read book The Medical Management of Prostate Cancer II written by Louis Denis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: How to treat advanced prostatic cancer remains controversial, despite intense basic and clinical research investigating the pathogenesis and natural history of this unique cancer highly prevalent in elderly males. Nine experts were asked to meet and discuss the facts. This resulting monograph gives an overview of the available knowledge on all aspects of the subject. The objective evaluation and consensus opinion of the authors presented here set this book apart from other publications with conflicting viewpoints. For readers eager to obtain a comprehensive and balanced view of the thousands of clinical contributions and clear advice on the choices, this book is a must.
Download or read book The Medical Management of Prostate Cancer II written by Louis Denis and published by Springer. This book was released on 1991-04-12 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: How to treat advanced prostatic cancer remains controversial, despite intense basic and clinical research investigating the pathogenesis and natural history of this unique cancer highly prevalent in elderly males. Nine experts were asked to meet and discuss the facts. This resulting monograph gives an overview of the available knowledge on all aspects of the subject. The objective evaluation and consensus opinion of the authors presented here set this book apart from other publications with conflicting viewpoints. For readers eager to obtain a comprehensive and balanced view of the thousands of clinical contributions and clear advice on the choices, this book is a must.
Download or read book Molecular Endocrinology of Target Enzymes in Androgen Metabolism written by Torbjörn Söderström and published by . This book was released on 2001 with total page 79 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Prostate Cancer 2000 written by L. Denis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: All epidemiological data predict an endemic rise of prostate cancer in populations with a high proportion of elderly people, leading to a major health problem. The only way to stem this evolution is early detection in organised random- ised trials. Discussion of this controversial subject is followed by an exhaustive review of the endocrine mechanisms stimulating prostate growth and the promising avenues of future research and treatment. Radical prostatectomy and radiotherapy are presented and analysed. Once patients are past this stage of cure, a wide array of medical treatments are available. Endocrine treatment is the first choice, and the different regimes are reviewed as to their respective advantages and side effects. An entirely new approach to hormone refractory diseases completes this overview.
