Download or read book The Effect of Titanium Surface Roughness on the Attachment and Spreading of Bone like Cells written by Rachel E. Rawsterne and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Effect of Titanium Surface Roughness on Growth Differentiation and Protein Synthesis of Cartilage and Bone Cells written by Janet Y. Martin and published by . This book was released on 1996-05-01 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Placement of endosseous dental implants requires the growth and tight opposition of bone tissue to the implant surface. Histomorphological evaluation of various implant systems have shown variable contact between the bone and implant surface. Previous studies have alluded to the fact that various factors probably influence the interactions occurring at the bone-implant interface. These included specific surface characteristics such as chemical composition, surface texture and microgeometry, surface treatments including sterilization methods, presence of surface contaminants, and types of cells interacting at the implant interface. However, the role these factors play in osseointegration is not well known at this time. The object of this study, therefore, was to evaluate the effect of some of these factors on cell response.

Download or read book The Effect of Titanium Surface Roughness on Growth Differentiation and Protein Synthesis of Cartilage and Bone Cells written by Janet Yun-Chieh Martin and published by . This book was released on 1996 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Interface Oral Health Science 2016 written by Keiichi Sasaki and published by . This book was released on 2020-10-08 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume broadens understanding of dentistry and promotes interdisciplinary research across a wide range of related fields, based on the symposium entitled "Innovative Research for Biosis-Abiosis Intelligent Interface 2016". It aims to create highly functional and autonomic intelligent interface by combining highly functional interface science with the technology of an evaluation and a control at the interface, with the various topics of biomaterials, innovation for oral science and application, regenerative oral science, and medical engineering. Since 2002, the Tohoku University Graduate School of Dentistry has hosted "Interface Oral Health Science" several times as the main theme of dental research in the twenty-first century, and this is the sixth proceedings of the symposiums following the ones in 2005, 2007, 2009, 2011, and 2014.This book benefits not only dental scientists but also other health scientists including medical physicians and pharmacologists, material scientists, engineers, and any scientist who is involved in variety of disciplines. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Download or read book The Effects of Titanium Surfaces on the Attachment Proliferation and Morphology of Human Osteoblast like Cells written by Diane Elizabeth Gawronski and published by . This book was released on 1997 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Effects of Surface Modified Titanium Implants on Osseointegration in Irradiated Bone written by Junyuan Li and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Effects of Surface-modified Titanium Implants on Osseointegration in Irradiated Bone" by Junyuan, Li, 黎俊媛, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Radiotherapy is a common treatment for head and neck cancers. However, it compromises bone healing. Titanium implanthas been shown to be a predictable method for replacing missing teeth. Clinical studies revealed that implant failure rate in irradiated regionwas high. Many studies showed that modifications of implant surface could enhance implant osseointegration by improving cell attachment, cell growth and bone formation. Nevertheless, there were few studies investigating the effect of implant surface modification on osseointegration in irradiated bone. In the first experiment, the effect of fluoride-modified (FM) titanium surface on irradiated osteoblast attachment was assessed. The morphology and chemical composition of FM surface was assessed by SEM, AFM and XPS. Osteoblasts received 0Gy, 2Gy, 4Gy, 6Gy, 8Gy, 10Gy radiation. Cell number, fluorescence intensity and cell area of irradiated osteoblasts were assessed. The number of osteoblasts onFM surface was fewer than those on NF surface after 0Gy, 2Gy, 8Gy and 10Gy radiation. Cell area of osteoblasts on FM surface was less at 2Gy radiation but larger at 6Gy radiation than on NF surface. The fluorescence intensity of osteoblasts was also higher on NF surface than on FM surface after receiving 0Gy, 2Gy, 4Gy, 10Gy radiation. In the second experiment, an animal model was established to study the effect of radiation on osseointegration. Rabbits were divided into 15Gy and 30Gy radiation groups. Only the left leg was exposed to radiation, and the right leg was protected from radiation. Totally, 24 implants were inserted. Implant stability quotient (ISQ), bone volume to total volume (BV/TV), bone-to-implant contact (BIC), and bone growth rate were measured. After 15Gy and 30Gy of radiation, ISQ and BV/TV were significantly reduced. At week 3, 15Gy radiation group displayed slower bone growth rate comparing with the control side. Fluorochrome results showed that the 30Gy radiation side had a significantly slower apposition of new bone.In addition, BIC on30Gy radiation side was notablypoorer than that on 15Gy radiation side and on 30Gy control side. Based on the animal model, the third experiment investigated effects of calcium phosphate nanocrystals on implant osseointegration in irradiated bone. Titanium implants treated with nano-scale calcium phosphate (CaP) crystals served as the test group while ones with dual acid-etching only served as the control group. The left leg of rabbits received 15Gy radiation and implants were placed in the irradiated leg. Significant higher ISQ was detected in the nano-CaP group at week 12. The bone growth rate in nano-CaP group was more than doubled than the control group at both week 6 and week 9. The fourth experiment evaluated artifacts on micro-CT images caused by titanium dental implant. Implants were assigned into four groups: (1) implant only; (2) implant with covering screw; (3) implant with resin embedding; and (4) implant with covering screw and resin embedding. Each implant was scanned by micro-CT at 3 angulations. Implant angulation was the most determining factor followed by resin embedding. Minimal metallic artifacts were obtainedin non-embedded implants with its axis paralleling to X-ray. DOI: 10.5353/th_b5312315 Subjects: Osseointegration Dental implants

Download or read book Tailoring Surfaces written by Nicholas D. Spencer and published by World Scientific. This book was released on 2011 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of the book is the modification of surfaces to tailor them for a specific purpose. Using this method of surface modification, materials chosen for their bulk properties (tensile strength, temperature stability, density, price can be optimized for any particular application, which can lead to improved hardness, biological inertness or activity, corrosion resistance, low or high friction or adhesion, water repellency or wettability, or catalytic activity. The works of the author — many of his crucial papers are included — touches upon these surface properties and spans fields including catalysis, analytical surface science, self-assembled monolayers, tribology, biomaterials, superhydrophobicity and polymer coatings.

Download or read book Titanium in Medicine written by D.M. Brunette and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1019 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing scientific and technical in-depth information in a clear format with a homogeneous structure, this text is suited for educational and self-teaching purposes as well as a reference on titanium for biomedical applications. It covers the whole area relevant to the use of titanium for implants, devices and instruments in medicine: material and surface science, physics, chemistry, biology, medicine, quality and regulatory aspects.

Download or read book The Effect of Titanium Implants on the Peripheral Circadian Rhythm of Bone written by Kirstin Ty McCarville and published by . This book was released on 2013 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: BACKGROUND: Endosseous implant osseointegration has been primarily studied from a wound healing-model. The molecular pathway of implant osseointegration is not known. Previous animal studies have shown vitamin D insufficiency impairs the establishment of implant osseointegration. Recent microarray data found an interesting connection between vitamin D receptor and circadian rhythm genes using a vitamin D insufficient animal model (implant failure model). Per1 is one of eight circadian genes that has widely been used as a molecular marker of circadian rhythm. Previous experiments with forskolin-synchronized expression of Per1 in bone marrow mesenchymal stromal cells (BMSCs) in vitro showed vitamin D supplementation significantly and dose dependently increased the baseline expression of Per1::luc, but preserved the circadian rhythm. We have thus postulated that the circadian rhythm of BMSCs may be influenced by titanium dental implants. OBJECTIVES: To determine the effect of titanium implant substrates with different surface characteristics on BMSCs peripheral circadian rhythm. METHODS: In this study, a series of in vitro studies were designed to characterize the peripheral circadian rhythm of BMSCs harvested from Per1::luc transgenic Wistar rats. Per1 transgenic rats genomic locus of Per1 allele were modified by inserting a beetle luciferase reporter gene (Per1::luc). The peripheral circadian rhythms over a 24-hour period were monitored by the real time activation of luciferase-mediated bioluminescence. Lumicycle was the instrument used to record the luciferase activity (Per1 expression) every ten minutes over five days. Data was evaluated both in the raw form (photons/second) Per1 gene expression and baseline subtracted data. The baseline subtracted data provides the peaks, troughs and periods of the BMSCs peripheral circadian rhythm over 5 days. The first experiments were completed on plastic cell culture dishes with and without vitamin D supplementation. In the second project, two titanium substrates with polished (smooth) surface or complex (rough) surface with blasted, acid etched and discrete HA crystalline deposition were characterized. Surface topography: Sa (average surface roughness) and Sdr (hybrid parameter that presents information about the number and height of peaks of a given surface) were determined by a 3D surface profilometry. To ensure BMSC survival and proper attachment a WST-1 assay was completed. To determine the level of osteoblast differentiation capabilities of BMSCs on all three surfaces (plastic, smooth and rough) a calcium mineralization assay was preformed. In the third project, BMSC peripheral circadian rhythm studies were then executed on smooth and rough titanium surfaces with and without vitamin D supplementation. This study was accomplished using Per1:;luc BMSCs and Lumicyle. In the forth project, Taqman- based quantitative reverse transcription polymerase chain reaction (RT-PCR) was used to validate gene expression of 6 circadian rhythm-related molecules (Per1, Per2, Id2, Bmal1, Clock, and NPas2). RESULTS: Bioluminescent raw measurement of Per1 expression on plastic with and without vitamin D showed that vitamin D increased Per1 expression over days 2, 3 and 4. The baseline subtracted data suggested that vitamin D suppressed the amplitude (peak to trough) but maintained the period. The WST-1 assay revealed that over 4 days the three different surfaces had a comparable number of viable cells. The calcium assay also suggested that the different substrate surfaces did not have large influence on osteogenic differentiation of BMSCs. The raw measurement of Per1::luc on titanium implant substrates indicated that the rough titanium surface had a significant reduction in Per1 expression (more than 50%) of photons per second in comparison to the smooth surface. Furthermore, rough titanium with vitamin D had a lower Per1 expression when compared to the rough titanium with no vitamin D. The smooth titanium baseline subtracted data showed a consistent rhythm having developed peaks and troughs. The most dramatic difference was seen in the rough surface baseline subtracted data. The rough surface almost completely eliminated the amplitude and period of the peripheral circadian rhythm. RT-PCR validated that five of the six circadian rhythm genes were downregulated by the rough titanium surface. The only gene upregulated on rough titanium was NPAS2. CONCLUSION: Titanium material had a negative effect on Per1 expression and amplitude of BMSCs peripheral circadian rhythm. Osseointegration pathway is unknown, however, the peripheral circadian rhythm of BMSCs may play a role in the establishment of implant-bone integration. NPAS2 was found to be highly expressed with the rough titanium substrate. Although speculative, the modulation of peripheral circadian rhythm may lead to successful osseointegration.

Download or read book Comprehensive Biomaterials II written by Kevin Healy and published by Elsevier. This book was released on 2017-05-18 with total page 4865 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Biomaterials II, Second Edition, Seven Volume Set brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications

Download or read book Research Into Spinal Deformities 5 written by International Research Society of Spinal Deformities. Meeting and published by IOS Press. This book was released on 2006 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contains papers on the following subjects: Genetics; Etiology and Pathogenesis; Biomechanics and Imaging; Conservative Treatment; Surgical Treatment; and Quality of Life. This publications seeks to serve as a basis for research and as a source of discussion.

Download or read book Joint Replacement Technology written by Peter A. Revell and published by Elsevier. This book was released on 2008-07-09 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: Joint replacement has been one of the major successes of modern medicine. Its continued success depends on effective collaboration between clinicians and researchers across many different areas in science and medicine. This important book brings together the wide range of research in this area and its implications for clinical practice.The book sets the scene with introductory chapters on joint biomechanics and tribology, materials for joint replacement and their interactions with the body, and regulatory issues. Part two reviews the use of metals and ceramics as joint replacement materials, joint design, bone cements and cementless fixation techniques, failure mechanisms and ways of predicting the lifetime of replacement joints. The third part of the book summarises research on how prosthetic joints interact with the body, including biological causes of joint failure, sterilisation techniques and the use of drug delivery systems to enhance joint replacement. The final group of chapters reviews key issues in replacing particular joints including the hip, knee, ankle, shoulder and elbow as well as developments in intervertebral disc and tempero-mandibular joint replacement technology.With its distinguished editor and international team of contributors, Joint replacement technology is a standard reference for the engineering and materials scientific communities, as well as surgeons seeking the best treatment for their patients. - Reviews joint biomechanics and tribology - Considers the use of metals and ceramics as joint replacement materials, joint design and bone cements - Summarises research on prosthetic interaction with the body

Download or read book The International Journal of Oral Maxillofacial Implants written by and published by . This book was released on 2009 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advances in Metallic Biomaterials written by Mitsuo Niinomi and published by Springer. This book was released on 2015-06-11 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the latest advances in processing techniques for producing metallic biomaterial implants. It also discusses recent developments in surface modifications using bioactive ceramics and blood-compatible polymers, as well as the adhesive strength of bioactive surface layers, before introducing the practical applications of metallic biomaterials in the fields of surgery and dentistry. As such, the book provides an essential reference guide for researchers, graduate students and clinicians working in the fields of materials, surgery, dentistry, and mechanics. Mitsuo Niinomi, PhD, D.D.Sc., is a Professor at the Institute for Materials Research, Tohoku University, Japan Takayuki Narushima, PhD, is a Professor at the Department of Materials Processing, Tohoku University, Japan Masaaki Nakai, PhD, is an Associate Professor at the Institute for Materials Research, Tohoku University, Japan

Download or read book Tissue Engineering III Cell Surface Interactions for Tissue Culture written by Cornelia Kasper and published by Springer. This book was released on 2012-04-23 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cell-Surface Interaction, by J. S. Hayes, E. M. Czekanska and R. G. Richards. Studying Cell-Surface Interactions In Vitro: A Survey of Experimental Approaches and Techniques, by Stefanie Michaelis, Rudolf Robelek and Joachim Wegener. Harnessing Cell-Biomaterial Interactions for Osteochondral Tissue Regeneration, by Kyobum Kim, Diana M. Yoon, Antonios G. Mikos and F. Kurtis Kasper. Interaction of Cells with Decellularized Biological Materials, by Mathias Wilhelmi, Bettina Giere and Michael Harder. Evaluation of Biocompatibility Using In Vitro Methods: Interpretation and Limitations, by Arie Bruinink and Reto Luginbuehl. Artificial Scaffolds and Mesenchymal Stem Cells for Hard Tissues, by Margit Schulze and Edda Tobiasch. Bioactive Glass-Based Scaffolds for Bone Tissue Engineering, by Julia Will, Lutz-Christian Gerhardt and Aldo R. Boccaccini. Microenvironment Design for Stem Cell Fate Determination, by Tali Re’em and Smadar Cohen. Stem Cell Differentiation Depending on Different Surfaces, by Sonja Kress, Anne Neumann, Birgit Weyand and Cornelia Kasper. Designing the Biocompatibility of Biohybrids, by Frank Witte, Ivonne Bartsch and Elmar Willbold. Interaction of Cartilage and Ceramic Matrix, by K. Wiegandt, C. Goepfert, R. Pörtner and R. Janssen. Bioresorption and Degradation of Biomaterials, by Debarun Das, Ziyang Zhang, Thomas Winkler, Meenakshi Mour, Christina I. Günter, Michael M. Morlock, Hans-Günther Machens and Arndt F. Schilling.

Download or read book Biomaterials and Engineering for Implantology written by Yoshiki Oshida and published by Walter de Gruyter GmbH & Co KG. This book was released on 2022-02-07 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials are composed of metallic materials, ceramics, polymers, composites and hybrid materials. Biomaterials used in human beings require safety regulations, toxicity, allergic reaction, etc. When used as implantable materials their biological compatibility, biomechanical compatibility, and morphological compatibility must be acessed. This book explores the design and requirements of biomaterials for the use in implantology.

Download or read book Processing and Fabrication of Advanced Materials XVII Part 8 Polymer based composites and nano composites Volume Two written by and published by I. K. International Pvt Ltd. This book was released on 2009 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Papers presented at the Seventeenth International Symposium on Processing and Fabrication of Advanced Material XVII, held at New Delhi during 15-17 December 2008.