Download or read book The Combinatorial Index written by Barry A. Bunin and published by Elsevier. This book was released on 1998-04-15 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis for the generation of molecular diversity. - Organized for rapid retrieval of published information on classes of synthetic transformations, linkers, and analytical methods - Serves as a laboratory manual for bench chemists - Includes a chapter on linkers to assist in choice of linking strategy - Discusses strengths and limitations of the various methods - Contains a structural index showing functional group transformations in solid-phase synthesis
Download or read book Handbook of Combinatorial Chemistry written by K. C. Nicolaou and published by Wiley-VCH. This book was released on 2002-04-29 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: In two volumes, this comprehensive handbook provides coverage of the whole area of combinatorial synthetic chemistry, including compound library design and synthesis.
Download or read book Electronic Combinatorial Index written by Barry A. Bunin and published by . This book was released on 2001-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Combinatorial Chemistry written by Nicholas K. Terrett and published by . This book was released on 1998 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combinatorial chemistry, by accelerating the process of chemical synthesis, is having a profound effect on all branches of chemistry, but especially on drug discovery. This informative text explains the origins of combinatorial chemistry and puts the many diverse library methods into context.It explains why some techniques are generally applicable and others are for specialists only. It also focuses on the renaissance of solid phase chemistry and describes the range of available reactions. This is the first single author book in this important, growing field and it describes thebeneficial impact of combinatorial chemistry, especially for the discovery and optimisation of biologically active molecules. This concise and comprehensive overview of combinatorial techniques is an essential text for final year undergraduates, postgraduates, academics and industrialists inchemistry, bio-orgainc chemistry, medicinal chemistry and drug discovery. It provides an accessible introduction to the area for those new to these methods and a valuable reference text to those experienced in this field.
Download or read book Combinatorial Enumeration written by Ian P. Goulden and published by Courier Corporation. This book was released on 2004-06-23 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: This graduate-level text presents mathematical theory and problem-solving techniques associated with enumeration problems. Subjects include the combinatorics of the ordinary generating function and the exponential generating function, the combinatorics of sequences, and the combinatorics of paths. The text is complemented by approximately 350 exercises with full solutions. 1983 edition. Foreword by Gian-Carlo Rota. References. Index.
Download or read book Analytic Combinatorics written by Philippe Flajolet and published by Cambridge University Press. This book was released on 2009-01-15 with total page 825 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analytic combinatorics aims to enable precise quantitative predictions of the properties of large combinatorial structures. The theory has emerged over recent decades as essential both for the analysis of algorithms and for the study of scientific models in many disciplines, including probability theory, statistical physics, computational biology, and information theory. With a careful combination of symbolic enumeration methods and complex analysis, drawing heavily on generating functions, results of sweeping generality emerge that can be applied in particular to fundamental structures such as permutations, sequences, strings, walks, paths, trees, graphs and maps. This account is the definitive treatment of the topic. The authors give full coverage of the underlying mathematics and a thorough treatment of both classical and modern applications of the theory. The text is complemented with exercises, examples, appendices and notes to aid understanding. The book can be used for an advanced undergraduate or a graduate course, or for self-study.
Download or read book Combinatorial Algorithms written by Donald L. Kreher and published by CRC Press. This book was released on 1998-12-18 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook thoroughly outlines combinatorial algorithms for generation, enumeration, and search. Topics include backtracking and heuristic search methods applied to various combinatorial structures, such as: Combinations Permutations Graphs Designs Many classical areas are covered as well as new research topics not included in most existing texts, such as: Group algorithms Graph isomorphism Hill-climbing Heuristic search algorithms This work serves as an exceptional textbook for a modern course in combinatorial algorithms, providing a unified and focused collection of recent topics of interest in the area. The authors, synthesizing material that can only be found scattered through many different sources, introduce the most important combinatorial algorithmic techniques - thus creating an accessible, comprehensive text that students of mathematics, electrical engineering, and computer science can understand without needing a prior course on combinatorics.
Download or read book Combinatorial Library written by Lisa B. English and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: The continued successes of large- and small-scale genome sequencing projects are increasing the number of genomic targets available for drug d- covery at an exponential rate. In addition, a better understanding of molecular mechanisms—such as apoptosis, signal transduction, telomere control of ch- mosomes, cytoskeletal development, modulation of stress-related proteins, and cell surface display of antigens by the major histocompatibility complex m- ecules—has improved the probability of identifying the most promising genomic targets to counteract disease. As a result, developing and optimizing lead candidates for these targets and rapidly moving them into clinical trials is now a critical juncture in pharmaceutical research. Recent advances in com- natorial library synthesis, purification, and analysis techniques are not only increasing the numbers of compounds that can be tested against each specific genomic target, but are also speeding and improving the overall processes of lead discovery and optimization. There are two main approaches to combinatorial library production: p- allel chemical synthesis and split-and-mix chemical synthesis. These approaches can utilize solid- or solution-based synthetic methods, alone or in combination, although the majority of combinatorial library synthesis is still done on solid support. In a parallel synthesis, all the products are assembled separately in their own reaction vessels or microtiter plates. The array of rows and columns enables researchers to organize the building blocks to be c- bined, and provides an easy way to identify compounds in a particular well.
Download or read book Essays on the combinatorial analysis written by Peter Nicholson and published by . This book was released on 1818 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Course in Combinatorics written by J. H. van Lint and published by Cambridge University Press. This book was released on 2001-11-22 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second edition of a popular book on combinatorics, a subject dealing with ways of arranging and distributing objects, and which involves ideas from geometry, algebra and analysis. The breadth of the theory is matched by that of its applications, which include topics as diverse as codes, circuit design and algorithm complexity. It has thus become essential for workers in many scientific fields to have some familiarity with the subject. The authors have tried to be as comprehensive as possible, dealing in a unified manner with, for example, graph theory, extremal problems, designs, colorings and codes. The depth and breadth of the coverage make the book a unique guide to the whole of the subject. The book is ideal for courses on combinatorical mathematics at the advanced undergraduate or beginning graduate level. Working mathematicians and scientists will also find it a valuable introduction and reference.
Download or read book A Combinatorial Introduction to Topology written by Michael Henle and published by Courier Corporation. This book was released on 1994-01-01 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Excellent text covers vector fields, plane homology and the Jordan Curve Theorem, surfaces, homology of complexes, more. Problems and exercises. Some knowledge of differential equations and multivariate calculus required.Bibliography. 1979 edition.
Download or read book Combinatorial Reciprocity Theorems written by Matthias Beck and published by American Mathematical Soc.. This book was released on 2018-12-12 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combinatorial reciprocity is a very interesting phenomenon, which can be described as follows: A polynomial, whose values at positive integers count combinatorial objects of some sort, may give the number of combinatorial objects of a different sort when evaluated at negative integers (and suitably normalized). Such combinatorial reciprocity theorems occur in connections with graphs, partially ordered sets, polyhedra, and more. Using the combinatorial reciprocity theorems as a leitmotif, this book unfolds central ideas and techniques in enumerative and geometric combinatorics. Written in a friendly writing style, this is an accessible graduate textbook with almost 300 exercises, numerous illustrations, and pointers to the research literature. Topics include concise introductions to partially ordered sets, polyhedral geometry, and rational generating functions, followed by highly original chapters on subdivisions, geometric realizations of partially ordered sets, and hyperplane arrangements.
Download or read book Combinatorial Game Theory written by Aaron N. Siegel and published by American Mathematical Soc.. This book was released on 2013-08-01 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combinatorial game theory is the study of two-player games with no hidden information and no chance elements. The theory assigns algebraic values to positions in such games and seeks to quantify the algebraic and combinatorial structure of their interactions. Its modern form was introduced thirty years ago, with the publication of the classic Winning Ways for Your Mathematical Plays by Berlekamp, Conway, and Guy, and interest has rapidly increased in recent decades. This book is a comprehensive and up-to-date introduction to the subject, tracing its development from first principles and examples through many of its most recent advances. Roughly half the book is devoted to a rigorous treatment of the classical theory; the remaining material is an in-depth presentation of topics that appear for the first time in textbook form, including the theory of misère quotients and Berlekamp's generalized temperature theory. Packed with hundreds of examples and exercises and meticulously cross-referenced, Combinatorial Game Theory will appeal equally to students, instructors, and research professionals. More than forty open problems and conjectures are mentioned in the text, highlighting the many mysteries that still remain in this young and exciting field. Aaron Siegel holds a Ph.D. in mathematics from the University of California, Berkeley and has held positions at the Mathematical Sciences Research Institute and the Institute for Advanced Study. He was a partner at Berkeley Quantitative, a technology-driven hedge fund, and is presently employed by Twitter, Inc.
Download or read book Combinatorial Data Analysis written by Lawrence Hubert and published by SIAM. This book was released on 2001-01-01 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combinatorial data analysis (CDA) refers to a wide class of methods for the study of relevant data sets in which the arrangement of a collection of objects is absolutely central. The focus of this monograph is on the identification of arrangements, which are then further restricted to where the combinatorial search is carried out by a recursive optimization process based on the general principles of dynamic programming (DP).
Download or read book An Introduction to Combinatorial Analysis written by John Riordan and published by Princeton University Press. This book was released on 2014-07-14 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces combinatorial analysis to the beginning student. The author begins with the theory of permutation and combinations and their applications to generating functions. In subsequent chapters, he presents Bell polynomials; the principle of inclusion and exclusion; the enumeration of permutations in cyclic representation; the theory of distributions; partitions, compositions, trees and linear graphs; and the enumeration of restricted permutations. Originally published in 1980. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Download or read book Combinatorial Optimization written by Eugene Lawler and published by Courier Corporation. This book was released on 2012-10-16 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perceptive text examines shortest paths, network flows, bipartite and nonbipartite matching, matroids and the greedy algorithm, matroid intersections, and the matroid parity problems. Suitable for courses in combinatorial computing and concrete computational complexity.
Download or read book Combinatorial Optimization written by Alexander Schrijver and published by Springer Science & Business Media. This book was released on 2003-02-12 with total page 2024 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the reviews: "About 30 years ago, when I was a student, the first book on combinatorial optimization came out referred to as "the Lawler" simply. I think that now, with this volume Springer has landed a coup: "The Schrijver". The box is offered for less than 90.- EURO, which to my opinion is one of the best deals after the introduction of this currency." OR-Spectrum
