Download or read book The Catalyst RNA and the Quest to Unlock Life s Deepest Secrets written by Thomas R. Cech and published by W. W. Norton & Company. This book was released on 2024-06-04 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of Literary Hub's Most Anticipated Books of 2024 Exploring the most transformative breakthroughs in biology since the discovery of the double helix, a Nobel Prize–winning scientist unveils the RNA age. For over half a century, DNA has dominated science and the popular imagination as the “secret of life.” But over the last several decades, a quiet revolution has taken place. In a series of breathtaking discoveries, the biochemist Thomas R. Cech and a diverse cast of brilliant scientists have revealed that RNA—long overlooked as the passive servant of DNA—sits at the center of biology’s greatest mysteries: How did life begin? What makes us human? Why do we get sick and grow old? In The Catalyst, Cech finally brings together years of research to demonstrate that RNA is the true key to understanding life on Earth, from its very origins to our future in the twenty-first century. A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA’s spectacular powers, to Cech’s own paradigm-shifting finding that it can catalyze cellular reactions, to the cutting-edge biotechnologies poised to reshape our health. We learn how RNA—once thought merely to transmit DNA’s genetic instructions to the cell’s protein-making machinery—may have jump-started life itself, and how, at the same time, it can cut our individual lives short through viral diseases and cancer. We see how RNA is implicated in the aging process and explore the darker depths of the supposed fountain of youth, telomerase. And we catch a thrilling glimpse into how RNA-powered therapies—from CRISPR, the revolutionary tool that uses RNA to rewrite the code of life, to the groundbreaking mRNA vaccines that have saved millions during the pandemic, and more—may enable us to improve and even extend life beyond nature’s current limits. Written by one of our foremost scientists, The Catalyst is a must-read guide to the present and future of biology and medicine.
Download or read book Buzz Books2024 Spring Summer written by and published by Publishers Lunch. This book was released on 2024-01-16 with total page 1050 pages. Available in PDF, EPUB and Kindle. Book excerpt: Buzz Books 2024: Spring/Summer is the 24th volume in our popular sampler series. This Buzz Books presents passionate readers with an insider’s look at nearly sixty of the buzziest books due out this season. Such major bestselling authors as Ally Condie, Christina Dodd, and Emiko Jean are featured, along with literary figures like Mateo Askaripour, Abi Daré, Alison Espach, Peter Nichols and more. Buzz Books has had a particularly stellar track record with highlighting the most talented, exciting and diverse debut authors, and this edition is no exception. Rita Bullwinkel, editor at large for McSweeney’s and deputy editor of The Believer, offers a novel on women boxer, while Lily Samson’s title has already been preempted by Sony Pictures Television. One YA and two nonfiction authors make their adult fiction debuts: Kristen Perrin, Mary Annaïse Heglar and Kate Young, respectively. Among others are Essie Chambers, Katelyn Doyle, Alejandro Puyana, and Rachel Rueckert. Our robust nonfiction section covers such important subjects as suicide and combating racist biases; several memoirs about harrowing childhoods and illnesses; and a biography of the first Asian-American woman pilot to fly during World War II. Finally, we present early looks at new work from young adult authors, including the New York Times bestselling Tracey Baptiste and Morgan Matson. The YA titles also represent more diversity than ever, with Aboriginal, Chinese, Korean, Japanese, Malaysian and Trinidadian novelists. And be sure to look out for Buzz Books 2024: Fall/Winter, coming in May, for next season’s most talked about books.
Download or read book RNA written by James E. Darnell and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA molecules could function as catalysts. --
Download or read book RNA Worlds New Tools for Deep Exploration written by Thomas R. Cech and published by . This book was released on 2018-12-31 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: "A Subject Collection from Cold Spring Harbor Perspectives in Biology."
Download or read book A Crack In Creation written by Jennifer A. Doudna and published by HarperCollins. This book was released on 2017-06-13 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: BY THE WINNER OF THE 2020 NOBEL PRIZE IN CHEMISTRY | Finalist for the Los Angeles Times Book Prize “A powerful mix of science and ethics . . . This book is required reading for every concerned citizen—the material it covers should be discussed in schools, colleges, and universities throughout the country.”— New York Review of Books Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences, to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans. Writing with fellow researcher Sam Sternberg, Doudna—who has since won the Nobel Prize for her CRISPR research—shares the thrilling story of her discovery and describes the enormous responsibility that comes with the power to rewrite the code of life. “The future is in our hands as never before, and this book explains the stakes like no other.” — George Lucas “An invaluable account . . . We owe Doudna several times over.” — Guardian
Download or read book The Brain in Search of Itself written by Benjamin Ehrlich and published by Farrar, Straus and Giroux. This book was released on 2022-03-15 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Passionate and meticulous . . . [Ehrlich] delivers thought-provoking metaphors, unforgettable scenes and many beautifully worded phrases." —Benjamin Labatut, The New York Times Book Review One of The Telegraph's best books of the year The first major biography of the Nobel Prize–winning scientist who discovered neurons and transformed our understanding of the human mind—illustrated with his extraordinary anatomical drawings Unless you’re a neuroscientist, Santiago Ramón y Cajal is likely the most important figure in the history of biology you’ve never heard of. Along with Charles Darwin and Louis Pasteur, he ranks among the most brilliant and original biologists of the nineteenth century, and his discoveries have done for our understanding of the human brain what the work of Galileo and Sir Isaac Newton did for our conception of the physical universe. He was awarded the Nobel Prize in 1906 for his lifelong investigation of the structure of neurons: “The mysterious butterflies of the soul,” Cajal called them, “whose beating of wings may one day reveal to us the secrets of the mind.” And he produced a dazzling oeuvre of anatomical drawings, whose alien beauty grace the pages of medical textbooks and the walls of museums to this day. Benjamin Ehrlich’s The Brain in Search of Itself is the first major biography in English of this singular figure, whose scientific odyssey mirrored the rocky journey of his beloved homeland of Spain into the twentieth century. Born into relative poverty in a mountaintop hamlet, Cajal was an enterprising and unruly child whose ambitions were both nurtured and thwarted by his father, a country doctor with a flinty disposition. A portrait of a nation as well a biography, The Brain in Search of Itself follows Cajal from the hinterlands to Barcelona and Madrid, where he became an illustrious figure—resisting and ultimately transforming the rigid hierarchies and underdeveloped science that surrounded him. To momentous effect, Cajal devised a theory that was as controversial in his own time as it is universal in ours: that the nervous system is comprised of individual cells with distinctive roles, just like any other organ in the body. In one of the greatest scientific rivalries in history, he argued his case against Camillo Golgi and prevailed. In our age of neuro-imaging and investigations into the neural basis of the mind, Cajal is the artistic and scientific forefather we must get to know. The Brain in Search of Itself is at once the story of how the brain as we know it came into being and a finely wrought portrait of an individual as fantastical and complex as the subject to which he devoted his life.
Download or read book The Quest for a Universal Theory of Life written by Carol E. Cleland and published by Cambridge University Press. This book was released on 2019-09-12 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explores fundamental philosophical and scientific questions about the nature of life, particularly in relation to the search for extraterrestrial life.
Download or read book Phallacy written by Emily Willingham and published by Penguin. This book was released on 2020-09-22 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: A wry look at what the astonishing world of animal penises can tell us about how we use our own. The fallacy sold to many of us is that the penis signals dominance and power. But this wry and penetrating book reveals that in fact nature did not shape the penis--or the human attached to it--to have the upper...hand. Phallacy looks closely at some of nature's more remarkable examples of penises and the many lessons to learn from them. In tracing how we ended up positioning our nondescript penis as a pulsing, awe-inspiring shaft of all masculinity and human dominance, Phallacy also shows what can we do to put that penis back where it belongs. Emphasizing our human capacities for impulse control, Phallacy ultimately challenges the toxic message that the penis makes the man and the man can't control himself. With instructive illustrations of unusual genitalia and tales of animal mating rituals that will make you particularly happy you are not a bedbug, Phallacy shows where humans fit on the continuum from fun to fatal phalli and why the human penis is an implement for intimacy, not intimidation.
Download or read book A Taste for Poison written by Neil Bradbury, Ph.D. and published by St. Martin's Press. This book was released on 2022-02-01 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: “A fascinating tale of poisons and poisonous deeds which both educates and entertains.” --Kathy Reichs A brilliant blend of science and crime, A TASTE FOR POISON reveals how eleven notorious poisons affect the body--through the murders in which they were used. As any reader of murder mysteries can tell you, poison is one of the most enduring—and popular—weapons of choice for a scheming murderer. It can be slipped into a drink, smeared onto the tip of an arrow or the handle of a door, even filtered through the air we breathe. But how exactly do these poisons work to break our bodies down, and what can we learn from the damage they inflict? In a fascinating blend of popular science, medical history, and true crime, Dr. Neil Bradbury explores this most morbidly captivating method of murder from a cellular level. Alongside real-life accounts of murderers and their crimes—some notorious, some forgotten, some still unsolved—are the equally compelling stories of the poisons involved: eleven molecules of death that work their way through the human body and, paradoxically, illuminate the way in which our bodies function. Drawn from historical records and current news headlines, A Taste for Poison weaves together the tales of spurned lovers, shady scientists, medical professionals and political assassins to show how the precise systems of the body can be impaired to lethal effect through the use of poison. From the deadly origins of the gin & tonic cocktail to the arsenic-laced wallpaper in Napoleon’s bedroom, A Taste for Poison leads readers on a riveting tour of the intricate, complex systems that keep us alive—or don’t.
Download or read book The Antidote written by Barry Werth and published by Simon and Schuster. This book was released on 2014-02-04 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Journalist Barry Werth described the company's tumultuous early days during the AIDS crisis in The Billion-Dollar Molecule, a celebrated classic of science and business journalism. Now he returns to tell the story of Vertex's bold endurance and eventual success. The pharmaceutical business is America's toughest and one of its most profitable. It's riskier and more rigorous at just about every stage than any other business, from the towering biological uncertainties inherent in its mission to treat disease; to the 30-to-1 failure rate in bringing out a successful medicine; to the multibillion-dollar cost of ramping up a successful product; to operating in the world's most regulated industry, matched only by nuclear power. Werth captures the full scope of Vertex's 25-year drive to deliver breakthrough medicines.--From publisher description.
Download or read book The Mystery of Life s Origin written by Charles B. Thaxton and published by . This book was released on 2020-01-27 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: The origin of life from non-life remains one of the most enduring mysteries of modern science. This book investigates how close scientists are to solving that mystery and explores what we are learning about the origin of life from current research in chemistry, physics, astrobiology, biochemistry, and more.
Download or read book RNA Methodologies written by Robert E. Farrell Jr. and published by Elsevier. This book was released on 2010-07-22 with total page 794 pages. Available in PDF, EPUB and Kindle. Book excerpt: This laboratory guide represents a growing collection of tried, tested and optimized laboratory protocols for the isolation and characterization of eukaryotic RNA, with lesser emphasis on the characterization of prokaryotic transcripts. Collectively the chapters work together to embellish the RNA story, each presenting clear take-home lessons, liberally incorporating flow charts, tables and graphs to facilitate learning and assist in the planning and implementation phases of a project. RNA Methodologies, 3rd edition includes approximately 30% new material, including chapters on the more recent technologies of RNA interference including: RNAi; Microarrays; Bioinformatics. It also includes new sections on: new and improved RT-PCR techniques; innovative 5’ and 3’ RACE techniques; subtractive PCR methods; methods for improving cDNA synthesis. * Author is a well-recognized expert in the field of RNA experimentation and founded Exon-Intron, a well-known biotechnology educational workshop center * Includes classic and contemporary techniques * Incorporates flow charts, tables, and graphs to facilitate learning and assist in the planning phases of projects
Download or read book Transformer The Deep Chemistry of Life and Death written by Nick Lane and published by W. W. Norton & Company. This book was released on 2022-07-12 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the renowned biochemist and author of The Vital Question, an illuminating inquiry into the Krebs cycle and the origins of life. “Nick Lane’s exploration of the building blocks that underlie life’s big fundamental questions—the origin of life itself, aging, and disease—have shaped my thinking since I first came across his work. He is one of my favorite science writers.”—Bill Gates What brings the Earth to life, and our own lives to an end? For decades, biology has been dominated by the study of genetic information. Information is important, but it is only part of what makes us alive. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight —how the same simple chemistry gives rise to life and causes our demise. Lane is among the vanguard of researchers asking why the Krebs cycle, the “perfect circle” at the heart of metabolism, remains so elusive more than eighty years after its discovery. Transformer is Lane’s voyage, as a biochemist, to find the inner meaning of the Krebs cycle—and its reverse—why it is still spinning at the heart of life and death today. Lane reveals the beautiful, violent world within our cells, where hydrogen atoms are stripped from the carbon skeletons of food and fed to the ravenous beast of oxygen. Yet this same cycle, spinning in reverse, also created the chemical building blocks that enabled the emergence of life on our planet. Now it does both. How can the same pathway create and destroy? What might our study of the Krebs cycle teach us about the mysteries of aging and the hardest problem of all, consciousness? Transformer unites the story of our planet with the story of our cells—what makes us the way we are, and how it connects us to the origin of life. Enlivened by Lane’s talent for distilling and humanizing complex research, Transformer offers an essential read for anyone fascinated by biology’s great mysteries. Life is at root a chemical phenomenon: this is its deep logic.
Download or read book Who We Are and How We Got Here written by David Reich and published by Oxford University Press. This book was released on 2018-03-29 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past few years have witnessed a revolution in our ability to obtain DNA from ancient humans. This important new data has added to our knowledge from archaeology and anthropology, helped resolve long-existing controversies, challenged long-held views, and thrown up remarkable surprises. The emerging picture is one of many waves of ancient human migrations, so that all populations living today are mixes of ancient ones, and often carry a genetic component from archaic humans. David Reich, whose team has been at the forefront of these discoveries, explains what genetics is telling us about ourselves and our complex and often surprising ancestry. Gone are old ideas of any kind of racial âpurity.' Instead, we are finding a rich variety of mixtures. Reich describes the cutting-edge findings from the past few years, and also considers the sensitivities involved in tracing ancestry, with science sometimes jostling with politics and tradition. He brings an important wider message: that we should recognize that every one of us is the result of a long history of migration and intermixing of ancient peoples, which we carry as ghosts in our DNA. What will we discover next?
Download or read book Dictionary of Antibiotics and Related Substances written by Barrie W. Bycroft and published by CRC Press. This book was released on 2013-08-09 with total page 2117 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacterial and parasitic diseases are the second leading cause of death worldwide, according to a report by the London School of Economics. Due to the emergence of drug-resistant "superbugs," like methicillin-resistant Staphylococcus aureus (MRSA), traditional antibiotics such as penicillin and its derivatives are in danger of becoming obsolete. In
Download or read book Brothers on Three written by Abe Streep and published by Celadon Books. This book was released on 2021-09-07 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: **Winner of the 2021 Montana Book Award** **Winner of the 2021 New Mexico-Arizona General Nonfiction Book Award** **Finalist for the Spur Award for Best Contemporary Nonfiction** **A New York Times Editors' Choice Pick** "A heart-stomping, heart-stopping read. Unsentimental. Unforgettable. Astonishing. Brothers on Three captures the roar of a community spirit powered by blood history, loyalty, and ferocious love." —Debra Magpie Earling, author of Perma Red From journalist Abe Streep, a story of coming-of-age on a reservation in the American West and a team uniting a community March 11, 2017, was a night to remember: in front of the hopeful eyes of thousands of friends, family members, and fans, the Arlee Warriors would finally bring the high school basketball state championship title home to the Flathead Indian Reservation. The game would become the stuff of legend, with the boys revered as local heroes. The team’s place in Montana history was now cemented, but for starters Will Mesteth, Jr. and Phillip Malatare, life would keep moving on—senior year was just beginning. In Brothers on Three, we follow Phil and Will, along with their teammates, coaches, and families, as they balance the pressures of adolescence, shoulder the dreams of their community, and chart their own individual courses for the future. Brothers on Three is not simply a story about high school basketball, state championships, and a winning team. It is a book about community, and it is about boys on the cusp of adulthood finding their way through the intersecting worlds they inhabit and forging their own paths to personhood.
Download or read book Red Pill written by Hari Kunzru and published by Vintage. This book was released on 2020-09-01 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: ONE OF THE NEW YORK TIMES'S 100 NOTABLE BOOKS OF 2020 ONE OF NPR's BEST BOOKS OF 2020 ONE OF THE A.V. CLUB'S 15 FAVORITE BOOKS OF 2020 From the widely acclaimed author of White Tears, a bold new novel about searching for order in a world that frames madness as truth. After receiving a prestigious writing fellowship in Germany, the narrator of Red Pill arrives in the Berlin suburb of Wannsee and struggles to accomplish anything at all. Instead of working on the book he has proposed to write, he takes long walks and binge-watches Blue Lives--a violent cop show that becomes weirdly compelling in its bleak, Darwinian view of life--and soon begins to wonder if his writing has any value at all. Wannsee is a place full of ghosts: Across the lake, the narrator can see the villa where the Nazis planned the Final Solution, and in his walks he passes the grave of the Romantic writer Heinrich von Kleist, who killed himself after deciding that "no happiness was possible here on earth." When some friends drag him to a party where he meets Anton, the creator of Blue Lives, the narrator begins to believe that the two of them are involved in a cosmic battle, and that Anton is "red-pilling" his viewers--turning them toward an ugly, alt-rightish worldview--ultimately forcing the narrator to wonder if he is losing his mind.
