Download or read book The Biological Resources of Model Organisms written by Robert L. Jarret and published by CRC Press. This book was released on 2019-07-16 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses 14 model organisms and are used by thousands of researchers, teachers, and students each year in laboratories and classrooms, around the globe. Though acknowledged in innumerable scientific journal articles, little is generally known about the origin of these collections, how the organisms contained within them have been acquired, and how they are maintained and distributed. While some collections such as Drosophila have long histories others, such as the collection of Brachionus, are relatively new. They vary greatly in size. Yet, all have contributed and are continuing to contribute to global research efforts in many areas of scientific research as diverse as tissue regeneration, skin cancer, evolution, water purity, gene function, and hundreds of others. In addition to providing the raw materials for national and international research programs, these collections also provide educational tools used by colleges and high schools. The chapters in this book attempt to provide a brief look at the individual organisms, how they came to be accepted as model organisms, the history of the individual collections, examples of how the organisms have been and are being used in scientific research, and a description of the facilities and procedures used to maintain them. Features: • Provides an in-depth look at the collections of 14 model organisms that have enabled innumerable scientific breakthroughs over decades, and that continue to do so. • Includes detailed descriptions of the operating procedures used for the maintenance of each model organism collection. • Discusses the holdings of the collections of model organisms and its relevance to past, current and future scientific research. • Written by the leaders in the field of the management of model organisms.
Download or read book A Field Guide to the Snakes of Borneo written by Robert B. Stuebing and published by . This book was released on 1999 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Marine Model Organisms in Experimental Biology written by Agnes Boutet and published by CRC Press. This book was released on 2021-12-13 with total page 964 pages. Available in PDF, EPUB and Kindle. Book excerpt: The importance of molecular approaches for comparative biology and the rapid development of new molecular tools is unprecedented. The extraordinary molecular progress belies the need for understanding the development and basic biology of whole organisms. Vigorous international efforts to train the next-generation of experimental biologists must combine both levels – next generation molecular approaches and traditional organismal biology. This book provides cutting-edge chapters regarding the growing list of marine model organisms. Access to and practical advice on these model organisms have become a conditio sine qua non for a modern education of advanced undergraduate students, graduate students and postdocs working on marine model systems. Model organisms are not only tools they are also bridges between fields – from behavior, development and physiology to functional genomics. Key Features Offers deep insights into cutting-edge model system science Provides in-depth overviews of all prominent marine model organisms Illustrates challenging experimental approaches to model system research Serves as a reference book also for next-generation functional genomics applications Fills an urgent need for students Related Titles Jarret, R. L. & K. McCluskey, eds. The Biological Resources of Model Organisms (ISBN 978-1-1382-9461-5) Kim, S.-K. Healthcare Using Marine Organisms (ISBN 978-1-1382-9538-4) Mudher, A. & T. Newman, eds. Drosophila: A Toolbox for the Study of Neurodegenerative Disease (ISBN 978-0-4154-1185-1) Green, S. L. The Laboratory Xenopus sp. (ISBN 978-1-4200-9109-0)
Download or read book Model Organisms written by Rachel A. Ankeny and published by Cambridge University Press. This book was released on 2021-01-28 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Element presents a philosophical exploration of the concept of the 'model organism' in contemporary biology. Thinking about model organisms enables us to examine how living organisms have been brought into the laboratory and used to gain a better understanding of biology, and to explore the research practices, commitments, and norms underlying this understanding. We contend that model organisms are key components of a distinctive way of doing research. We focus on what makes model organisms an important type of model, and how the use of these models has shaped biological knowledge, including how model organisms represent, how they are used as tools for intervention, and how the representational commitments linked to their use as models affect the research practices associated with them. This title is available as Open Access on Cambridge Core.
Download or read book Model Organisms in Drug Discovery written by Pamela M. Carroll and published by John Wiley & Sons. This book was released on 2004-04-21 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fruit flies are "little people with wings" goes the saying in the scientific community, ever since the completion of the Human Genome Project and its revelations about the similarity amongst the genomes of different organisms. It is humbling that most signalling pathways which "define" humans are conserved in Drosophila, the common fruit fly. Feed a fruit fly caffeine and it has trouble falling asleep; feed it antihistamines and it cannot stay awake. A C. elegans worm placed on the antidepressant flouxetine has increased serotonin levels in its tiny brain. Yeast treated with chemotherapeutics stop their cell division. Removal of a single gene from a mouse or zebrafish can cause the animals to develop Alzheimer’s disease or heart disease. These organisms are utilized as surrogates to investigate the function and design of complex human biological systems. Advances in bioinformatics, proteomics, automation technologies and their application to model organism systems now occur on an industrial scale. The integration of model systems into the drug discovery process, the speed of the tools, and the in vivo validation data that these models can provide, will clearly help definition of disease biology and high-quality target validation. Enhanced target selection will lead to the more efficacious and less toxic therapeutic compounds of the future. Leading experts in the field provide detailed accounts of model organism research that have impacted on specific therapeutic areas and they examine state-of-the-art applications of model systems, describing real life applications and their possible impact in the future. This book will be of interest to geneticists, bioinformaticians, pharmacologists, molecular biologists and people working in the pharmaceutical industry, particularly genomics.
Download or read book C Elegans II written by Donald L. Riddle and published by Firefly Books. This book was released on 1997 with total page 1252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Defines the current status of research in the genetics, anatomy, and development of the nematode C. elegans, providing a detailed molecular explanation of how development is regulated and how the nervous system specifies varied aspects of behavior. Contains sections on the genome, development, neural networks and behavior, and life history and evolution. Appendices offer genetic nomenclature, a list of laboratory strain and allele designations, skeleton genetic maps, a list of characterized genes, a table of neurotransmitter assignments for specific neurons, and information on codon usage. Includes bandw photos. For researchers in worm studies, as well as the wider community of researchers in cell and molecular biology. Annotation copyrighted by Book News, Inc., Portland, OR
Download or read book Emerging Model Organisms written by and published by . This book was released on 2009 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nematodes as Model Organisms written by Itamar Glazer and published by Cab International. This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Nematodes, especially Caenorhabditis elegans have been used as a model for research in molecular biology since the 1960's. This is a much-needed update on research on fundamental processes in areas such as genetics, developmental biology, nutrition, toxicology, ecology, pharmacology and medicine"--
Download or read book From Monsoons to Microbes written by National Research Council and published by National Academies Press. This book was released on 1999-05-05 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: What can sharks teach us about our immune system? What can horseshoe crabs show us about eyesight? The more we learn about the ocean, the more we realize how critical these vast bodies of water are to our health and well-being. Sometimes the ocean helps us, as when a marine organism yields a new medical treatment. At other times, the ocean poses the threat of coastal storm surges or toxic algal blooms. From Monsoons to Microbes offers a deeper look into the oceans that surround us, often nurturing yet sometimes harming humankind. This book explores the links among physical oceanography, public health, epidemiology, marine biology, and medicine in understanding what the ocean has to offer. It will help readers grasp such important points as: How the ocean's sweeping physical processes create long-term phenomena such as El Nino and short-term disastrous events such as tsunamisâ€"including what communities can do to prepare. What medicines and nutritional products have come from the ocean and what the prospects are for more such discoveries. How estuaries workâ€"where salt and fresh water meetâ€"and what can go wrong, as in the 7,000 square mile "dead zone" at the out-flow of the Mississippi River. How the growing demand for seafood and the expansion of ocean-going transport has increased our exposure to infectious agentsâ€"and how these agents can be tracked down and fought. Why "red tides" of toxic algae suddenly appear in previously unaffected coastal areas, and what happens when algal toxins find their way into our food supply or the air we breathe. The book recommends ways we can implement exciting new technologies to monitor the physics, chemistry, and biology of the ocean to recognize change as it happens. From the impact of worldwide atmospheric warming to the significance of exotic bacteria from submarine hydrothermal vents, the ocean has many depths left to explore.
Download or read book Sourcebook of Models for Biomedical Research written by P. Michael Conn and published by Springer Science & Business Media. This book was released on 2008-03-07 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.
Download or read book Model Behavior written by Nicole C. Nelson and published by University of Chicago Press. This book was released on 2018-04-04 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mice are used as model organisms across a wide range of fields in science today—but it is far from obvious how studying a mouse in a maze can help us understand human problems like alcoholism or anxiety. How do scientists convince funders, fellow scientists, the general public, and even themselves that animal experiments are a good way of producing knowledge about the genetics of human behavior? In Model Behavior, Nicole C. Nelson takes us inside an animal behavior genetics laboratory to examine how scientists create and manage the foundational knowledge of their field. Behavior genetics is a particularly challenging field for making a clear-cut case that mouse experiments work, because researchers believe that both the phenomena they are studying and the animal models they are using are complex. These assumptions of complexity change the nature of what laboratory work produces. Whereas historical and ethnographic studies traditionally portray the laboratory as a place where scientists control, simplify, and stabilize nature in the service of producing durable facts, the laboratory that emerges from Nelson’s extensive interviews and fieldwork is a place where stable findings are always just out of reach. The ongoing work of managing precarious experimental systems means that researchers learn as much—if not more—about the impact of the environment on behavior as they do about genetics. Model Behavior offers a compelling portrait of life in a twenty-first-century laboratory, where partial, provisional answers to complex scientific questions are increasingly the norm.
Download or read book Collecting Experiments written by Bruno J. Strasser and published by University of Chicago Press. This book was released on 2019-06-07 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Databases have revolutionized nearly every aspect of our lives. Information of all sorts is being collected on a massive scale, from Google to Facebook and well beyond. But as the amount of information in databases explodes, we are forced to reassess our ideas about what knowledge is, how it is produced, to whom it belongs, and who can be credited for producing it. Every scientist working today draws on databases to produce scientific knowledge. Databases have become more common than microscopes, voltmeters, and test tubes, and the increasing amount of data has led to major changes in research practices and profound reflections on the proper professional roles of data producers, collectors, curators, and analysts. Collecting Experiments traces the development and use of data collections, especially in the experimental life sciences, from the early twentieth century to the present. It shows that the current revolution is best understood as the coming together of two older ways of knowing—collecting and experimenting, the museum and the laboratory. Ultimately, Bruno J. Strasser argues that by serving as knowledge repositories, as well as indispensable tools for producing new knowledge, these databases function as digital museums for the twenty-first century.
Download or read book Echinoderms Part B written by and published by Academic Press. This book was released on 2019-04-02 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Echinoderms, Volume 151, the latest release in the Methods in Cell Biology series, highlights advances in the field, with this update presenting chapters on Echinoderm Genome Databases, analysis of gene regulatory networks, using ATAC-seq and RNA-seq to increase resolution in GRN connectivity, multiplex cis-regulatory analysis, experimental approaches GRN/signal pathways, BACs, analysis of chromatin accessibility using ATAC-seq, analysis of sea urchin proteins /Click IT, CRISPR/Cas9-mediated genome editing in sea urchins, super-resolution and in toto imaging of echinoderm embryos, and methods for analysis of intracellular ion signals in sperm, eggs and embryos. Presents clear, concise protocols provided by experts who have established the echinoderms as a model systems Highlights new advances in the field, with this update presenting interesting chapters on echinoderms
Download or read book Emerging Model Organisms written by and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume leading experts provide chapters on 23 emerging model systems, ranging from bat and butterfly to cave fish and choanoflagellates; cricket and finch to quail, snail and tomato.
Download or read book Model Organisms A Precious Resource for Understanding of the Molecular Mechanisms Underlying Human Physiology and Disease written by Maria Grazia Giansanti and published by Frontiers Media SA. This book was released on 2019-11-20 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book WWW Virtual Library written by Gerard Manning and published by . This book was released on 199? with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This site is a catalog of internet resources relating to biological model organisms, and is part of the Biosciences area of the Virtual Library project. Covers main model organisms, including: E. coli, S. cerevisae, Dictyostelium, Celegans, Drosophula, Arabidopsis, ZebraFish, Xenopus, Mouse, and others.
Download or read book Genetics of Adaptation written by Rodney Mauricio and published by Springer Science & Business Media. This book was released on 2005-07-20 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: An enduring controversy in evolutionary biology is the genetic basis of adaptation. Darwin emphasized "many slight differences" as the ultimate source of variation to be acted upon by natural selection. In the early 1900’s, this view was opposed by "Mendelian geneticists", who emphasized the importance of "macromutations" in evolution. The Modern Synthesis resolved this controversy, concluding that mutations in genes of very small effect were responsible for adaptive evolution. A decade ago, Allen Orr and Jerry Coyne reexamined the evidence for this neo-Darwinian view and found that both the theoretical and empirical basis for it were weak. Orr and Coyne encouraged evolutionary biologists to reexamine this neglected question: what is the genetic basis of adaptive evolution? In this volume, a new generation of biologists have taken up this challenge. Using advances in both molecular genetic and statistical techniques, evolutionary geneticists have made considerable progress in this emerging field. In this volume, a diversity of examples from plant and animal studies provides valuable information for those interested in the genetics and evolution of complex traits.
