Download or read book Tendon Regeneration written by Manuela E. Gomes and published by Academic Press. This book was released on 2015-08-08 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes is the first book to highlight the multi-disciplinary nature of this specialized field and the importance of collaboration between medical and engineering laboratories in the development of tissue-oriented products for tissue engineering and regenerative medicine (TERM) strategies. Beginning with a foundation in developmental biology, the book explores physiology, pathology, and surgical reconstruction, providing guidance on biological approaches that enhances tendon regeneration practices. Contributions from scientists, clinicians, and engineers who are the leading figures in their respective fields present recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field. Provides an overview of tendon biology, disease, and tissue engineering approaches Presents modern, alternative approaches to developing functional tissue solutions discussed Includes valuable information for those interested in tissue engineering, tissue regeneration, tissue physiology, and regenerative medicine Explores physiology, pathology, and surgical reconstruction, building a natural progression that enhances tendon regeneration practices Covers recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field

Download or read book Repair and Regeneration of Ligaments Tendons and Joint Capsule written by William R. Walsh and published by Springer Science & Business Media. This book was released on 2007-10-28 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and authoritative review of the most important scientific and clinically relevant topics today in ligaments, tendons, and capsular biology, including their biomechanics and surgical reconstruction. The authors review the basic science of tendons in the hand and shoulder ligaments, the current clinical status of the shoulder and cruciate ligaments, and the latest advances in research on the healing of ligament and tendon to bone, artificial ligaments, and gene therapy. They also cover the major type 1 collagen soft tissues that are of particular interest to upper extremity surgeons and sports medicine specialists.

Download or read book Biomechanics of Tendons and Ligaments written by Johanna Buschmann and published by Woodhead Publishing. This book was released on 2017-05-10 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomechanics of Tendons and Ligaments: Tissue Reconstruction looks at the structure and function of tendons and ligaments. Biological and synthetic biomaterials for their reconstruction and regeneration are reviewed, and their biomechanical performance is discussed. Regeneration tendons and ligaments are soft connective tissues which are essential for the biomechanical function of the skeletal system. These tissues are often prone to injuries which can range from repetition and overuse, to tears and ruptures. Understanding the biomechanical properties of ligaments and tendons is essential for their repair and regeneration. Contains systematic coverage on how both healthy and injured tendons and ligaments work Includes coverage of repair and regeneration strategies for tendons and ligaments Presents an Interdisciplinary analysis on the topic

Download or read book Tendons written by Hasan Sözen and published by BoD – Books on Demand. This book was released on 2019-12-04 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mankind has reached its present physical form through evolution of the movement system. Muscles, bones, and joints are the most important components of the movement system. Muscles are active elements, while bones and joints are passive elements. But to bring about movement, these three elements must work together. Tendons are round, oval, or flat tissues that connect muscles to bones. Muscle, tendon, or ligament injuries prevent motion so this is an important issue in trauma. If muscle, tendon, or ligament injuries occur together with vessel or nerve injury, it may be life threatening. The cause of injury might differ from a simple sports injury to a serious traffic accident. Muscles, bones, and joints have taken their place in the literature, but it would be wrong to say the same for tendons. This book describes tendons from different perspectives, thus providing the missing information in the literature. I hope that this book will be useful for anyone who wants to read about new perspectives on tendons. I also hope that it will inspire researchers working in this field.

Download or read book Inflammation and tendon healing written by Parmis Blomgran and published by Linköping University Electronic Press. This book was released on 2017-10-30 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tendons heal through three different overlapping phases; the inflammatory, proliferative and remodeling phase. Many studies have investigated what factors influence healing of tendons. However, little was known about inflammation and the immune cells present during Achilles tendon healing by the time this thesis started. We developed a flow cytometry method for our rat model of tendon healing, which enabled us to study different leukocyte subpopulations during Achilles tendon healing. The general aim of this thesis was to understand more about inflammation and the immune cell populations present during tendon healing and how the immune cell composition changes during normal tendon healing. Moreover, we investigated how different factors that are known to influence tendon healing affected the composition of the immune cell population. First, we described the immune cells during the time course of tendon healing focusing on different subpopulations of macrophages and T cells. Then, we studied how these cells were influenced by reduced mechanical loading. Mechanical loading prolonged the presence of M1 macrophages and delayed the switch to regulatory T cells and M2 macrophages compared to reduced mechanical loading. Next, the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on the leukocyte composition revealed that, even though NSAIDs influence the mechanical properties of healing tendon, this effect was not mediated via changes in the leukocyte sub-populations during early and mid-time tendon healing. Further, the effect of corticosteroids during the inflammatory and remodeling phases of tendon healing was an improved healing of tendons and a reduction of CD8a T cells when corticosteroid was administered after the inflammatory phase. Lastly, we investigated if impairment of tendon healing by NSAIDs was related to mechanotransduction or microdamage during mechanical loading and showed that NSAIDs impair tendon healing by reducing the response to microdamage. In conclusion, these studies show that inflammation plays an important role during Achilles tendon healing, and factors that influence healing can also alter the presence or polarization of immune cell populations.

Download or read book Regenerative Medicine and Plastic Surgery written by Dominik Duscher and published by Springer Nature. This book was released on 2019-11-27 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest advances in the field of regenerative medicine in plastic surgery. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner.The first part introduces readers to essential principles of skin and soft tissue regeneration, e.g. the possibility of using mesenchymal stem cells for wound healing. Since bone serves as a supportive tissue in most of the body, bone regeneration is an important aspect of regenerative medicine; accordingly, the second part discusses the novel bone implants, activated bone grafts and bone tissue engineering. The book’s third part, focusing on cartilage regeneration, includes chapters on e.g. stem cells and ear regeneration. In turn, part four addresses muscle and tendon regeneration: from tendon to bone and tendon to muscle, as well as aging in the realm of muscle regeneration. Lastly, part five highlights nerve regeneration, deepening surgeons’ knowledge to help them successfully treat injuries to the peripheral neural system. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties. "With beautiful clinical images and artwork, this book will be a central companion to both practicing plastic surgeons who wish to remain abreast of oncoming technologic advances and regenerative medicine researchers who wish to understand the current state of the art of surgical reconstruction." - Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine

Download or read book Tendon Healing written by Malin Hammerman and published by Linköping University Electronic Press. This book was released on 2018-02-20 with total page 35 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanical loading and the inflammatory response during tendon healing might be important for the healing process. Mechanical loading can improve the healing tendon but the mechanism is not fully understood. The aim of this thesis was to further clarify the effect of mechanical loading on tendon healing and how mechanical loading affects the inflammatory response during the healing process. We used a rat Achilles tendon model to study healing. The rats were exposed to different degrees of loading by unloading methods such as paralysis of the calf muscles with Botox, tail suspension, and an orthosis (a boot). Full loading was achieved by free cage activity or treadmill walking. Microdamage in tendons, unloaded with Botox, was also investigated by needling. The healing tendons were evaluated in a materials testing machine (to analyze the mechanical properties), by gene expression analysis (microarray and PCR), or histology. Our results show that moderate loading (unloading with Botox) improves the mechanical properties of healing tendons compared to minimal loading (unloading with Botox in combination with tail suspension or a boot), especially the material properties. In accordance to these findings, expression of extracellular matrix genes were also increased by moderate compared to minimal loading. Full loading improved all mechanical properties and the expression of extracellular matrix genes was further increased compared to moderate loading. However, structural properties, such as the strength and the size of the healing tendon, were more affected by full loading. Full loading also affected the expression of inflammation-related genes during the early healing phase, 3 and 5 days after tendon injury, and increased the number of immune cells in the healing tendon tissue. Also microdamage of the healing tendon (detected by blood leakage) was increased by full loading compared to moderate loading during the early healing phase. Induced microdamage by repeated needling in the healing tendon tissue increased the structural properties of the healing tendon. The gene expression after needling was similar to the gene expression after full loading. The improvement of mechanical properties by loading in healing tendons was decreased by an anti-inflammatory drug called parecoxib, which decreases the production of prostaglandins by inhibiting COX-2 activity. The effect of parecoxib was reduced when loading was reduced but we could not confirm that the effect of parecoxib was related to the degree of loading. However, parecoxib abolished the stimulatory effect of microdamage. In conclusion, these studies show that moderate loading improves the quality of the healing tendon whereas full loading also increases the quantity of the healing tendon tissue. Full loading creates microdamage and increases inflammation during the early healing phase. The strong effect of full loading on the structural properties might be due to microdamage. Indeed, the anti-inflammatory drug parecoxib seems to impair mechanical stimulation of healing tendons by reducing the response to microdamage.

Download or read book Tendon and Ligament Healing written by William Weintraub and published by Redwing Book Company. This book was released on 2003 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 25 years of practicing structural/osteopathic manual therapy the author has done considerable work with seriously damaged tendons and ligaments, and has achieved results that conventional medicine would rate as improbable. Over time, he has developed a therapeutic model for treating these injuries so that individuals with chronic conditions -- who have exhausted the standard physiotherapy options and are facing surgery -- can have a viable option for recovery. His techniques, based on basic principles of structural healthcare, emphasize the importance of precise anatomical focus and the capacity to work with subtle changes of structure. Of essential importance is combining detailed specific treatment of the small fibers and tissues of the local injury area with an overall approach to improving larger body patterns and tensions. Logically, the responsiveness and self-corrective capacity of body tissues when given proper conditions is also an important factor. The primary techniques used are the osteopathic methods of strain-counterstrain, cranial and visceral osteopathy, and fascial release, as well as body-mind centering, zero balancing, and acupressure. His clinical model, which represents a new approach to serious, chronic tendon and ligament injuries, is based on these techniques, their combinations and specific usage, and the skills and aptitudes necessary for applying these techniques, including certain perceptual skills and a thorough knowledge of anatomy and kinesiology. Weintraub's descriptions are vital, interesting, alive, absorbing, even dramatic. He discusses at great length the nature of the tendons and ligaments, describes his manual therapy model -- comparing it with conventional medical procedures -- and covers processes and tissue changes in tendon/ligament healing as related to manual therapy. Case studies, self-help strategies, and thoughtful words on clinical efficacy and future directions in the field make for a thorough and well-rounded presentation. (Product Description).

Download or read book Biointegration of Medical Implant Materials written by Chandra P. Sharma and published by Elsevier. This book was released on 2010-07-13 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biointegration is essential for the successful performance of implanted materials and devices within the human body. With an increasing number and wide range of implant procedures being performed, it is critical that materials scientists and engineers effectively design implant materials which will create a positive biological and mechanical response with the host tissue. Biointegration of medical implant materials provides a unique and comprehensive review of recent techniques and research into material and tissue interaction and integration. Part one discusses soft tissue biointegration with chapters on the biocompatibility of engineered stem cells, corneal tissue engineering and vascular grafts. Part two then reviews particular techniques in drug delivery including inorganic nanoparticles for targeted drug delivery and alginate based drug delivery devices. Part three covers design considerations with coverage of themes such as biocompatibility of materials and its relevance to drug delivery and tissue engineering, mechanisms of failure of medical implants during long term use and rapid prototyping in biomedical engineering. With its distinguished editor and team of international contributors, Biointegration of medical implant materials: science and design is a standard reference for medical materials scientists and engineers in industry and the academic sector. Provides a unique and comprehensive review of recent techniques and research into material and tissue interaction and integration Discusses soft tissue biointegration with chapters on the biocompatibility of engineered stem cells, corneal tissue engineering, vascular grafts and replacement materials for facial reconstruction Reviews particular techniques in drug delivery featuring inorganic nanoparticles and functionalized nanoparticles for targeted drug delivery

Download or read book Muscle and Tendon Injuries written by Gian Luigi Canata and published by Springer. This book was released on 2017-05-10 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores in a comprehensive manner the causes and symptoms of muscle and tendon pathologies, the available diagnostic procedures, and current treatment approaches. Specific aspects of the anatomy, biomechanics, and function of muscles and tendons are analyzed, and detailed guidance is provided on the most innovative methods – both conservative and surgical – for ensuring that the athlete can make a safe and quick return to sporting activity. Optimal care of tendon and muscle injuries in sportspeople requires effective cooperation of sports scientists and medical practitioners to identify the best ways of preserving muscle and tendon structures and to develop new strategies for their rehabilitation and regeneration. Muscle and Tendon Injuries is an excellent multidisciplinary reference written by the leading experts in the field and published in collaboration with ISAKOS. It will appeal to all specialists in sports medicine and sports traumatology who are seeking a state of the art update on the management of muscle and tendon disorders.

Download or read book Tendon Injury and Repair written by Terry S. Saxby and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tendon problems are a common cause of foot and ankle pathology. In the past decade there has been significant advances in the management of these problems. This has been achieved not only by an improvement of surgical techniques but also through a better understanding of tendon injury and healing. In this issue we will review the recent advances in the diagnosis and treatment of common tendon problems beginning with a review of tendon healing. This issue will provide the reader with an excellent review of all that is new on this topic.

Download or read book Orthocell s Ortho ATI written by Ming Hao Zheng and published by Jerome Waddell. This book was released on 2015-05-14 with total page 43 pages. Available in PDF, EPUB and Kindle. Book excerpt: Orthocell's Ortho-ATI. Tendon regeneration biotechnology. Tendon Injury Intervention.

Download or read book The Achilles Tendon written by James A. Nunley and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disorders of the Achilles tendon are universal, affecting people in a wide range of age groups. Because the Achilles tendon is one of the most pow- ful musculotendinous structures in the body, the impact of an injury to the Achilles tendon becomes magnified. There is a wide range of disorders or problems that can involve the insertional region, where pathology may rest with bone, tendon, or bursae. A completely different set of pathologic entities resides in the noninsertional region, one of which may include the frustrating degenerative tendinopathy. As our growing population ages but remains phy- cally active longer into life, the incidence of these disorders will continue to increase. I am proud to be given the opportunity to write the foreword to this text, which is intended for foot and ankle surgeons worldwide. Seldom does a book on a single entity become a current concepts review, as this work has. Too often, textbooks are not published for several years after the chapters have been written, making them obsolete upon publication. Not so with this book, which deals with timely topics on the Achilles tendon. Dr. James Nunley has compiled this work in slightly over a year, thus providing the reader with sta- of-the-art material. Dr. Nunley had the foresight to create a much needed techniques-oriented book dealing with the complexities of the Achilles tendon. His approach was to develop a comprehensive guide to managing Achilles tendon problems.

Download or read book Regenerative Medicine and Biomaterials for the Repair of Connective Tissues written by Charles Archer and published by Elsevier. This book was released on 2010-01-12 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regenerative medicine for the repair of connective tissues is a fast moving field which generates a lot of interest. Unfortunately the biomaterials and biomechanics for soft tissue repair has been under-represented in the past. Particularly the natural association between cartilage, tendons and ligaments is often not made. Regenerative medicine and biomaterials for the repair of connective tissues addresses this gap in the market by bringing together the natural association of cartilage, tendons and ligaments to provide a review of the different structures, biomechanics and, more importantly, provide a clear discussion of practical techniques and biomaterials which may be used to repair the connective tissues. Part one discusses cartilage repair and regeneration with chapters on such topics as structure, biomechanics and repair of cartilage. Chapters in Part two focus on the repair of tendons on ligaments with particular techniques including cell-based therapies for the repair and regeneration of tendons and ligaments and scaffolds for tendon and ligament tissue engineering. Addresses the natural association between cartilage, tendons and ligaments which is often not made Provides a review of the different structures, biomechanics and practical techniques which are used in the repair of connective tissues Chapters focus on such areas as cartilage repair and regeneration, the repair of tendons and ligaments, investigating techniques including scaffolds and cell-based therapies

Download or read book Musculoskeletal Disorders and the Workplace written by Institute of Medicine and published by National Academies Press. This book was released on 2001-05-24 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every year workers' low-back, hand, and arm problems lead to time away from jobs and reduce the nation's economic productivity. The connection of these problems to workplace activities-from carrying boxes to lifting patients to pounding computer keyboards-is the subject of major disagreements among workers, employers, advocacy groups, and researchers. Musculoskeletal Disorders and the Workplace examines the scientific basis for connecting musculoskeletal disorders with the workplace, considering people, job tasks, and work environments. A multidisciplinary panel draws conclusions about the likelihood of causal links and the effectiveness of various intervention strategies. The panel also offers recommendations for what actions can be considered on the basis of current information and for closing information gaps. This book presents the latest information on the prevalence, incidence, and costs of musculoskeletal disorders and identifies factors that influence injury reporting. It reviews the broad scope of evidence: epidemiological studies of physical and psychosocial variables, basic biology, biomechanics, and physical and behavioral responses to stress. Given the magnitude of the problem-approximately 1 million people miss some work each year-and the current trends in workplace practices, this volume will be a must for advocates for workplace health, policy makers, employers, employees, medical professionals, engineers, lawyers, and labor officials.

Download or read book Tendon Surgery of the Hand E Book written by Jin Bo Tang and published by Elsevier Health Sciences. This book was released on 2012-04-23 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get the best results from the latest procedures with Tendon Surgery of the Hand, the only reference that offers comprehensive coverage of this complex and challenging area. World-renowned experts guide you through all of the newest techniques and technologies, equipping you to restore optimal function in your patients. It's your one-stop source for mastering today's best approaches to treating tendon injuries and disorders of the hand. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Successfully implement hot new repair techniques involving new suture materials, tendon sheath and pulley treatments, vascularized tendon grafts, and recent postoperative rehabilitation methods. Improve your primary flexor tendon repair and rehabilitation treatment planning based on surgical and post-surgical care principles that clearly describe successful global methods and protocols. Benefit from the collective knowledge and experience of an international group of surgeons, investigators, and therapists who offer unique and insightful techniques and advice. See how to perform key techniques with exclusive operative videos online. Access the complete contents online at expertconsult.com.

Download or read book Tendinopathy in Athletes written by Savio L-Y. Woo and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise volume in the Encyclopaedia of Sports Medicine series, published under the auspices of the International Olympic Committee, provides a dependable source of current knowledge available on tendinopathy and covers both the basic science and clinical aspects of the subject. Despite its high incidence, the precise etiopathogenesis and effective treatment of tendinopathy remain elusive. Tendinopathy in Athletes draws on the expertise of an international and prolific collection of contributors, both clinicians and scientists, who provide new insights into this specialized area. This book: provides a comprehensive resource for both clinicians and researchers with information organized logically, with an easy-to-follow progression from the basic scientific findings to clinical applications discusses the full range of treatment modalities, including new molecular and biological approaches, plus surgical and alternative approaches to tendinopath contains “What We Need to Know” sections that suggest future areas of research for young investigators. As tendinopathy remains one of the most common injuries encountered, both in sports and at the workplace, this essential volume is sure to be a source of frequent consultation.