Download or read book Systematic Evaluation of the Mouse Eye written by Richard S. Smith and published by CRC Press. This book was released on 2001-12-20 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completion of the first phase of the Human Genome Project has presented scientists with a mountain of new information. The availability of all human genes and their locations is exciting, but their mechanisms of action and interaction with other genes are often unknown. Certain variations in the environment and characteristics of human genes make i

Download or read book The Mouse in Biomedical Research written by and published by Elsevier. This book was released on 2006-12-15 with total page 829 pages. Available in PDF, EPUB and Kindle. Book excerpt: Normative Biology, Husbandry, and Models, the third volume in the four volume set, The Mouse in Biomedical Research, encompasses 23 chapters whose contents provide a broad overview on the laboratory mouse's normative biology, husbandry, and its use as a model in biomedical research. This consists of chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry. Other chapters cover management, as well as nutrition, gnotobiotics and disease surveillance. There are also individual chapters describing the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases. Chapters on imaging techniques and the use of the mouse in assays of biological products are also included.

Download or read book Comparative Anatomy and Histology written by Piper M. Treuting and published by Academic Press. This book was released on 2012 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. Introduction -- 2. Phenotyping -- 3. Necropsy and histology -- 4. Mammary Gland -- 5. Skeletal System -- 6. Nose, sinus, pharynx and larynx -- 7. Oral cavity and teeth -- 8. Salivary glands -- 9. Respiratory -- 10. Cardiovascular -- 11. Upper GI -- 12. Lower GI -- 13. Liver and gallbladder -- 14. Pancreas -- 15. Endocrine System -- 16. Urinary System -- 17. Female Reproductive System -- 18. Male Reproductive System -- 19. Hematopoietic and Lymphoid Tissues -- 20. Nervous System -- 21. Special senses, eye -- 22. Special senses, ear -- 23. Skin and adnexa -- Index.

Download or read book A Practical Guide to the Histology of the Mouse written by Cheryl L. Scudamore and published by John Wiley & Sons. This book was released on 2014-02-10 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Practical Guide to the Histology of the Mouse provides a full-colour atlas of mouse histology. Mouse models of disease are used extensively in biomedical research with many hundreds of new models being generated each year. Complete phenotypic analysis of all of these models can benefit from histologic review of the tissues. This book is aimed at veterinary and medical pathologists who are unfamiliar with mouse tissues and scientists who wish to evaluate their own mouse models. It provides practical guidance on the collection, sampling and analysis of mouse tissue samples in order to maximize the information that can be gained from these tissues. As well as illustrating the normal microscopic anatomy of the mouse, the book also describes and explains the common anatomic variations, artefacts associated with tissue collection and background lesions to help the scientist to distinguish these changes from experimentally- induced lesions. This will be an essential bench-side companion for researchers and practitioners looking for an accessible and well-illustrated guide to mouse pathology. Written by experienced pathologists and specifically tailored to the needs of scientists and histologists Full colour throughout Provides advice on sampling tissues, necropsy and recording data Includes common anatomic variations, background lesions and artefacts which will help non-experts understand whether histologic variations seen are part of the normal background or related to their experimental manipulation

Download or read book Pathology of Genetically Engineered and Other Mutant Mice written by John P. Sundberg and published by John Wiley & Sons. This book was released on 2022-01-26 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: An updated and comprehensive reference to pathology in every organ system in genetically modified mice The newly revised and thoroughly updated Second Edition of Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice. The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice. Readers will also benefit from: A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice An exploration of concepts related to validating animal models, including the Cinderella Effect Practical discussions of basic necropsy methods and grading lesions for computational analyses Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissues As a one-stop and up to date reference on mouse pathology, Pathology of Genetically Engineered and Other Mutant Mice is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.

Download or read book The Retina and its Disorders written by Joseph Besharse and published by Academic Press. This book was released on 2011-04-19 with total page 929 pages. Available in PDF, EPUB and Kindle. Book excerpt: This selection of articles from the Encyclopedia of the Eye covering retina, optics/optic nerve and comparative topics constitutes the first reference for scientists, post docs, and graduate students with an interest beyond standard textbook materials. It covers the full spectrum of research on the retina - from the basic biochemistry of how nerve cells are created to information on neurotransmitters, comparisons of the structure and neuroscience of peripheral vision systems in different species, and all the way through to injury repair and other clinical applications. - The first single volume to integrate comparative studies into a comprehensive resource on the neuroscience of the retina - Chapters are carefully selected from the Encyclopedia of the Eye by one of the world's leading vision researchers - The best researchers in the field provide their conclusions in the context of the latest experimental results

Download or read book Genetically Engineered Mice Handbook written by John P. Sundberg and published by CRC Press. This book was released on 2016-04-19 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive book covers all aspects of the field of genetically engineered laboratory mice, including the creation of mutant mice through mouse models for developmental biology and the monitoring of laboratory mouse colonies. Written by leading biomedical investigators, pathologists, and clinicians, this book presents systematic approaches for analyzing mutant laboratory mice for specific medical applications. It provides a variety of methods for creating mutant mice, while covering legal aspects of mutant and inbred laboratory mice as well as the use and maintenance of international databases.

Download or read book Neuronal Calcium Sensor Proteins written by Pavel P. Philippov and published by Nova Publishers. This book was released on 2006 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium signalling is an astonishing example how a simple caption can trigger and regulate an enormous variety of cellular and physiological responses. Ca2+-signalling routes very often involve Ca2+-binding proteins that sense changes in intracellular [Ca2+] and trigger cellular responses by regulating specific targets. One fascinating group among these Ca2+-sensors are the neuronal calcium sensor (NCS) proteins, named for their localisation in neuronal tissue (although there are reports of their expression in non-neuronal tissues as well). While recent excellent reviews have covered key aspects of this protein group, the field expanded in recent years making it more and more difficult to represent every facet of this ongoing research endeavour. This book is intended to represent properties of NCS proteins.

Download or read book Axonopathy in Neurodegenerative Disease written by Samuel D. Crish and published by Frontiers Media SA. This book was released on 2019-02-05 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Axons are the major output processes of neurons, responsible for transmitting information to other neurons and tissues throughout the body. The 150,000+ kilometers of axons make up half of the brain's volume and require a large amount of energy. Normal axon function is the product of a massive number of intra- and extra-cellular mechanisms working in concert. Perhaps not surprisingly, the axon is a site of vulnerability during normal aging and in disease states, although this has only been recently appreciated. Axonopathy, broadly defined as functional or structural defects in the axon or its terminal, is common across a wide range of neurodegenerative conditions, including amyotrophic lateral sclerosis, Huntington’s, Parkinson’s, and Alzheimer’s diseases, glaucoma, and as a result of neurotoxin exposure or drug treatment. This Research Topic assembles a series of original research papers, reviews, and commentaries that will illustrate both the commonalities and important differences across neurodegenerative disorders. Though this collection cannot address all aspects of this topic, it is our hope that these manuscripts will educate other scientists and inspire new investigations into axon dysfunction and degeneration.

Download or read book Borish s Clinical Refraction E Book written by William J. Benjamin and published by Elsevier Health Sciences. This book was released on 2006-10-13 with total page 2711 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now updated and expanded to cover the latest technologies, this full-color text on clinical refraction uses an easy-to-read format to give optometry students and practitioners all the important information they need. Also covers a wide range of other aspects of the eye exam, including anterior and posterior segment evaluations, contact lens, ocular pharmacology, and visual field analysis. Four new chapters cover wavefront-guided refraction, optical correction with refractive surgeries, prosthetic devices, and patients with ocular pathology. - Offer precise, step-by-step how-to's for performing all of the most effective refractive techniques. - Presents individualized refractive approaches for the full range of patients, including special patient populations. - Contriubtors are internationally recognized, leading authorities in the field. - New full-color design with full-color images throughout. - Completely updated and expanded to include current technologies. - A new chapter on Optical Correction with Refractive Surgeries, including keratoplasty, traditional refractive surgeries (e.g. LASIK and PRK), crystalline lens extraction with and without pseudophakia, the new presbyopic surgery, etc. - A new chapter on Wavefront Guided Refraction provides information on the advantages and limitations the Hartmann-Shack Method for objective refraction plus aberrometry and the refraction and the use of in the correction of the eye with spectacles, contact lenses, and refractive surgery. - A new chapter on Patients with Ocular Pathology reflects the most current knowledge of patients with ocular pathologies. - Provides information on Optical Correction with Prosthetic Devices, including corneal onlays, stromal implants, phakic intraocular lenses, etc. - Includes new chapters and/or discussions on such topics as: Aberrations of the Eye, Refractive Consequences of Eye Pathology, Diagnosis and Treatment of Dry Eye, Diagnosis of Pathology of the Anterior Segment, Diagnosis of Glaucoma, and Diagnosis of Pathology of the Posterior Segment. - Visual Acuity chapter expanded to include the effect of refractive error on visual acuity and statistics on how much of a change in visual acuity is significant. - Objective Refraction, Corneal Topography, and Visual Field Analysis chapters include the addition of new electro-optical and computer techniques and equipment. - Chapters on Multifocal Spectacle Lenses and Contact Lenses now cover newer progressive addition lenses and contact lenses that are now on the market. - Electrodiagnosis chapter revised to take a more clinical approach.

Download or read book GENERAL ANATOMY written by NARAYAN CHANGDER and published by CHANGDER OUTLINE. This book was released on 2022-12-18 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: THE GENERAL ANATOMY MCQ (MULTIPLE CHOICE QUESTIONS) SERVES AS A VALUABLE RESOURCE FOR INDIVIDUALS AIMING TO DEEPEN THEIR UNDERSTANDING OF VARIOUS COMPETITIVE EXAMS, CLASS TESTS, QUIZ COMPETITIONS, AND SIMILAR ASSESSMENTS. WITH ITS EXTENSIVE COLLECTION OF MCQS, THIS BOOK EMPOWERS YOU TO ASSESS YOUR GRASP OF THE SUBJECT MATTER AND YOUR PROFICIENCY LEVEL. BY ENGAGING WITH THESE MULTIPLE-CHOICE QUESTIONS, YOU CAN IMPROVE YOUR KNOWLEDGE OF THE SUBJECT, IDENTIFY AREAS FOR IMPROVEMENT, AND LAY A SOLID FOUNDATION. DIVE INTO THE GENERAL ANATOMY MCQ TO EXPAND YOUR GENERAL ANATOMY KNOWLEDGE AND EXCEL IN QUIZ COMPETITIONS, ACADEMIC STUDIES, OR PROFESSIONAL ENDEAVORS. THE ANSWERS TO THE QUESTIONS ARE PROVIDED AT THE END OF EACH PAGE, MAKING IT EASY FOR PARTICIPANTS TO VERIFY THEIR ANSWERS AND PREPARE EFFECTIVELY.

Download or read book Pathology of Laboratory Rodents and Rabbits written by Dean H. Percy and published by John Wiley & Sons. This book was released on 2013-05-08 with total page 1096 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathology of Laboratory Rodents and Rabbits has become a standard text for both veterinary pathologists and veterinarians in laboratory animal medicine. Newly recognized infectious diseases continue to emerge and molecular methods for studying infectious agents are becoming widely used for the classification of these and previously known pathogens. With the ongoing development and perfection of genetic engineering techniques, the use of genetically engineered mice in the research laboratory continues to grow exponentially. This new edition features updates throughout with increased emphasis on timely topics such as infectious diseases in genetically engineered mice. Diseases covered include viral infections, bacterial infections, parasitic diseases, nutritional and metabolic disorders, behavioral disorders, aging and degenerative disorders, environment-related disease, and neoplasms. Organized by species, coverage includes mice, rats, hamsters, gerbils, guinea pigs, and rabbits. Veterinary pathologists, laboratory animal veterinarians, and students will appreciate the concise organization and easily accessible information on key diagnostic features, differential diagnoses, and significance of diseases.

Download or read book Fundamental Neuropathology for Pathologists and Toxicologists written by Brad Bolon and published by John Wiley & Sons. This book was released on 2011-08-08 with total page 661 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers pathologists, toxicologists, other medical professionals, and students an introduction to the discipline and techniques of neuropathology – including chemical and environmental, biological, medical, and regulatory details important for performing an analysis of toxicant-induced neurodiseases. In addition to a section on fundamentals, the book provides detailed coverage of current practices (bioassays, molecular analysis, and nervous system pathology) and practical aspects (data interpretation, regulatory considerations, and tips for preparing reports).

Download or read book Essentials of Veterinary Ophthalmology written by Kirk N. Gelatt and published by John Wiley & Sons. This book was released on 2013-03-25 with total page 823 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its second edition, Essentials of Veterinary Ophthalmology provides its readers with a practical introduction to the diagnosis and clinical management of the most frequently encountered eye diseases of domestic animals. Essentials of Veterinary Ophthalmology is distilled from the authoritative, two-volume, fourth edition of Veterinary Ophthalmology (Gelatt), drawing primarily on the clinically relevant sections to provide expert coverage in a more concise and quick-reference format – ideal for busy small animal or equine practitioners seeking rapid advice for a patient. The second edition includes more images, algorithms to speed the clinical problem-solving process, key points highlighted in bold, expanded appendices for convenient reference to therapeutic agents, recommended dosages, and possible side effects, and a brief glossary. Practical and accessible, the second edition of Essentials of Veterinary Ophthalmology is filled with reader-friendly features to provide veterinary students and practitioners with an indispensable resource for the fundamentals of clinical veterinary ophthalmology. Focuses on the most common eye diseases of small animals and horses Provides expert coverage in a concise, quick-reference format New edition includes more images, algorithms, key points in bold, expanded appendices and glossary Based on the two-volume definitive reference Veterinary Ophthalmology, 4th Edition (Gelatt)

Download or read book Regulation of inflammation and metabolism in retinal neurodegenerative disorders written by Henri Leinonen and published by Frontiers Media SA. This book was released on 2023-01-05 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Assessing Ocular Toxicology in Laboratory Animals written by Andrea B Weir and published by Springer Science & Business Media. This book was released on 2012-12-04 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes. The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.

Download or read book Hormones and Neural Aging Lessons From Experimental Models written by Isabel Varela-Nieto and published by Frontiers Media SA. This book was released on 2019-01-23 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: How can we slow the signs of aging? Although aging is a natural process for all living things, doing so without dramatic alterations of health and well-being is an important aim in health care. Understanding this gradual but continuous process is fundamental in order to avoid, or at least improve, aging associated illnesses and conditions. The reviews and studies compiled here address various aspects of the relationship between systemic and central changes during the aging process, with hormonal signals as the important liaison.