Download or read book Synthesis of Substituted 1 Thiocyanatobutadienes and Their Application in a i Diels Alder i 3 3 Sigmatropic Rearrangement Tandem Reaction written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis of 2 3 disubstituted 1 3 butadienes Via Organotin Precursors Sulfoxide and Selenoxide 2 3 Sigmatropic Rearrangements written by Kenneth Edward Yelm and published by . This book was released on 1984 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Application of the Novel Tandem Process i Diels Alder i Reaction i Ireland Claisen i Rearrangement to the Synthesis of i rac i Juvabione and i rac i Epijuvabione written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Synthesis of 2 aza 1 triethylsiloxybutadines and Their Application in Aza diels alder Reactions written by Iestyn Vernon Jones and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Application of Inverse Electron Demand Diels Alder Reactions in Total Synthesis of Nothapodytine B mappicine Phomazazarin and Ent roseophilin written by Jiyong Hong and published by . This book was released on 2001 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concise total syntheses of naturally occurring nothapodytine B (mappicine ketone) and ( - )-mappicine are detailed. The approach was based on the implementation of a room-temperature, inverse electron demand Diels-Alder reaction of an N-sulfonyl-1-aza-1,3-butadiene for assemblage of a pyridone D-ring precursor central to the structure. A Friedlander condensation was utilized for constructing the AB-ring system of nothapodytine B and ( - )-mappicine. An acid-catalyzed reaction sequence was used to accomplish a deprotection with subsequent ring-closure for introduction of the C-ring in a single step. A concise total synthesis of phomazarin is detailed enlisting a heterocyclic azadiene inverse electron demand Diels-Alder reaction (1,2,4-triazine [arrow right] pyridine) for preparation of the fully substituted and appropriately functionalized pyridine C-ring. Thus, [4+2] cycloaddition of triethyl 1,2,4-triazine-3,5,6-tricarboxylate with 1,1,2-trimethoxyethylene followed by conversion of the cycloadduct to the cyclic anhydride provided the phomazarin C-ring with the three carboxylates suitably differentiated. Linkage of the A- and C-rings through selective nucleophilic addition of an aryl lithium reagent to the least hindered carbonyl of the cyclic anhydride followed by Friedel-Crafts closure of the B-ring provided the fully functionalized phomazarin skeleton. The successful structural correlation of synthetic phomazarin with natural material and its derivatives confirmed the latest structural assignment for the natural product. An asymmetric total synthesis of ent-( - )-roseophilin, the unnatural enantiomer of a novel antitumor antibiotic, was accomplished based on an approach enlisting a room temperature heterocyclic azadiene inverse electron demand Diels-Alder reaction of dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate with an optically active enol ether bearing the C23 chiral center, followed by a reductive ring contraction reaction for formation of an appropriately functionalized pyrrole ring in a key 1,2,4,5-tetrazine [arrow right] 1,2-diazine [arrow right] pyrrole reaction sequence. A Grubbs' ring closing metathesis reaction was utilized to close the unusual 13-membered macrocycle prior to a subsequent 5- exo - trig acyl radical-alkene cyclization that was used to introduce the fused cyclopentanone and complete the preparation of the tricylic ansa-bridged azafulvene core. Condensation of the tricyclic core with the heterocyclic side chain followed by final deprotection provided (22S,23S)-roseophilin. Comparison of synthetic (22S,23S)-roseophilin ([[alpha]] [superscript]25 [subscript]D, CD) with natural roseophilin established that they were enantiomers and enabled the assignment of the absolute stereochemistry of the natural product as 22R,23R. Surprisingly, ent-( - )-roseophilin was found to be 2-10-fold more potent than natural (+)-roseophilin in cytotoxic activity.
Download or read book Synthesis and Asymmetric Diels Alder Reactions of Enantiopure 1 Methoxy 3 alkylsylfinyl 1 3 butadienes written by Paola Maria Bonaccorsi and published by . This book was released on 1996 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Toward the Synthesis of 1 aza 1 3 butadienes for Use in the Formation of Pyridoacridines written by Frederick Graham Leuschner and published by . This book was released on 1997 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The synthesis of 1-aza-1,3-butadienes and their subsequent reactions with dienophiles in Diels-Alder cycloadditions for use in the formation of the pyridoacridines meridine and amphimedine was investigated."--Abstract.
Download or read book Tandem Nucleophilic Addition Diels Alder Reaction of i N i Butadienyl i N O i Ketene Silyl Acetals with C sub 60 sub Stereoselective Formation of Bicyclic Octahydroquinolino 1 2 3 4 Tetrahydrobuckminsterfullerenes and Combined NMR Spectroscopic and Computational Evaluation of the Functionalization Reactions written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Asymmetric catalysis written by Michael P. Doyle and published by JAI Press(NY). This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second volume in a series covering research advances in the field of catalytic processes.
