Download or read book Synthesis and Coordination Chemistry of Tripodal Thioether pyrazole Ligands and Their Applications to Modeling Reactivity of Zinc Thiolate Enzymes written by Show-Jen Chiou and published by . This book was released on 2004 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2004 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Studies of the Coordination Chemistry with Catalytic Applications of Tripodal Ligands Based on Nitrogen Oxygen and Sulfur Donors written by Mandeep K. Sidhu and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comprehensive Coordination Chemistry II written by J. A. McCleverty and published by Elsevier Science. This book was released on 2004 with total page 1352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Coordination Chemistry II (CCC II) is the sequel to what has become a classic in the field, Comprehensive Coordination Chemistry, published in 1987. CCC II builds on the first and surveys new developments authoritatively in over 200 newly comissioned chapters, with an emphasis on current trends in biology, materials science and other areas of contemporary scientific interest.
Download or read book The Synthesis Coordination Chemistry and Reactivity of Tripodal Schiff Base Ligands written by Claire Margaret Strange and published by . This book was released on 1996 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design of New Tripodal Ligands to Advance the Biomimetic Zinc Chemistry written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this work was the synthesis of a ligand system which coordinates zinc with the same features as those showed by the enzymes. This ligand was to be water soluble, was to form a hydrophobic cavity around zinc and was to provide additional functional groups with hydrogen bonding properties. Several zinc complexes of three new tripodal ligands that deal with these aspects have been synthesised. First, a water soluble tripodal ligand, (2-pyridylmethylamino)-3-(3,5-dimethylpyrazol-1-yl)-propionic acid (L1H) was synthesised. With this amino acid ligand seven zinc complexes were isolated and characterised. Two new water soluble zinc aqua complexes provided structural models for several hydrolytic zinc enzymes. The hydrolytic cleavage of tris(p-nitrophenylphosphate) promoted by the hydroxide complex L1Zn-OH appeared to be accelerated by increasing the water content of the reaction solution. Thus, the rate constant k2 in a 50% water/DMSO solution is 0.912 s-1M-1, while in a 75% water/DMSO solution it is 4.02 s-1M-1. Second, the ligand system N, N, N-Tris{2-[((4-nitrophenyl)methyl)amino]ethyl}amine (L2) with a big hydrophobic cavity was synthesised. With this TREN based ligand seven zinc complexes were isolated and characterised. Two new zinc aqua complexes provided structural models for the resting state of the enzyme carbonic anhydrase. These complexes could be deprotonated and the resulting hydroxide species reacted with CO2 producing two new carbonate complexes. The ability of the thiocyanate anion to inhibit this process was demonstrated by the isolation of the thiocyanate complex. Third, the new ligand system potassium hydrotris(3-(2'-furyl)-5-methylpyrazol-1-yl)borate (KL3) has been synthesised. With this ligand twenty-eight new zinc complexes were isolated and characterized. The reactions of the hydroxide complex L3Zn-OH in methanolic solutions have demonstrated that the L3Zn-methanolate complex present in the equilibrium mixture is the reactive species. The.
Download or read book Syntheis and Studies of the Coordination Chemistry with Catalytic Applications of Tripodal Ligands Based on Nitrogen Oxygen and Sulfur Donors written by Mandeep K. Sidhu and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Coordination Chemistry of a New Tridentate Thioehter i e Thioether Ligand written by Hing Wan Yim and published by . This book was released on 2001 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: ABSTRACT: A new tridentate thioether ligand, methyltris[(methylthio)methyl]silane MeSi(CH2SMe)3, has been synthesized with the goal of investigating the coordination chemistry of acyclic polythioethers. This ligand represents the first member of a new family of face-capping, tridentate thioether ligands which are related to the well known macrocyclic thioether 1,4,7-trithiacyclononane and also to the anionic tetrakis[(methylthio)methyl]borates. Initial reactivity studies of the newly synthesized thioether ligand resulted in the successful isolation and structural characterization of the complete series of group 6 carbonyl derivatives ([eta symbol3]-MeSi(CH2SMe)3)M(CO)3(M = Cr, Mo, W). The copper(I) coordination polymers Cu3(MeSi(CH2SMe)3)2X3(X = Cl, Br) and [(MeSi(CH2SMe)3)Cu(NCMe)]Y (Y = OSO2CF3, BF4, PF6) were isolated by reacting CuX or [Cu(NCMe)4]Y, respectively, with the ligand. The reaction of the ligand in a 1:1 molar ratio with CuI yielded (MeSi(CH2SMe)3)CuI, which has been structurally characterized and found to form a dimer in the solid state. Related silver(I) derivatives based on the thioether ligand were also synthesized and characterized. The investigation of the behavior of these complexes in acetonitrile solution was conducted using electrospray ionization mass spectrometry (ESI-MS). Reactions of the ligand with BiX3(X = Cl, Br) afforded complexes of stoichiometry Bi2(MeSi(CH2SMe)3)2X6 and the chloride derivative was also found to be polymeric.
Download or read book The Synthesis and Coordination Chemistry of Tripodal Triamides written by Eugenie Alexandra Martin and published by . This book was released on 1998 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Coordination Chemistry of Tripodal Tetraamine Ligands Incorporating Pyrazolyl Donors written by John Randoph Cubanski and published by . This book was released on 2013 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: A family of novel tripodal, tetraamine (N4) ligands incorporating three heterocyclic donors and inequivalent donor arms has been synthesized and characterized. All of the ligands incorporate at least one pyrazolyl or 3,5-(dimethyl)pyrazolyl donor, and many include either a pyridyl, imidazolyl, or 1,2,3-triazolyl ring. Additionally, these ligands have been complexed with cobalt, copper or zinc and crystallographically characterized.
Download or read book New Peptide type Tripodal Ligands and Their Metal Complexes written by Ágnes Dancs and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most important directions of modern bioinorganic research is the development of artificial enzymes. One pathway of enzyme modeling strategy is the study of amino acid sequences present in the active centers of metalloenzymes. Linear peptides, however, have their limitations in reconstituting the active centers of metalloenzymes, since they do not possess the well-defined three dimensional structure, therefore their structure is vulnerable towards amide nitrogen coordination/hydrolysis. Improvement of metal binding capabilities of linear peptides can be obtained by e.g. their functionalization with tripodal ligands. Tripodal compounds may provide a rigid, less flexible platform for the coordinating amino acid side chains, creating pre-organized metal binding sites. In my thesis, I present synthesis and characterization of histidine containing tripodal peptide ligands and their complex formation in presence of copper(II) and zinc(II). Solution equilibrium was studied with pH potentiometric measurements, and several spectroscopic methods were used for structural characterization (UV-Vis, CD, ESR, NMR and MS methods). Beside thermodynamic and structural characterization, enzyme mimicking catalytical properties of the complexes have also been investigated (catechol oxidation, superoxide dismutation). Our results demonstrated that tripodal peptide ligands are capable of enhancing the stability of metal-peptide complexes, and they may provide convenient structures to efficiently mimic the catalytic functions of enzymes. With thorough and systematical solution equilibrium and spectroscopic studies, we uncovered the driving forces of metal coordination, and established the impact of the tripodal structure in stability, structure and catalytic properties of the forming complexes. Our findings confirm the beneficial effect of tripodal scaffolds in peptide-type ligand-metal complexes, and emphasize the possibilities lying within tripodal peptides in the field of enzyme mimicking.
Download or read book Synthesis of Tripodal Bis imidazole thioether and Tris imidazole Ligands and the Derived Copper Complexes written by Lei Zhou and published by . This book was released on 2008 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design and Synthesis of Meso and Macrocyclic Tripodal Triamine Ligands and Investigations Into Their Coordination Chemistry written by Andrew Ure and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Copper I Coordination Chemistry of Tris mercaptoimidazolyl Mesitylenes written by Javier Ulises Pacheco and published by . This book was released on 2010 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: To study the functional properties of copper proteins several copper(I) complexes have been used for modeling biological sites. A new family of neutral tris(thione) ligands, the tris(mercaptoimidazolyl)mesitylenes R3TmmesMe (R = H, Me, Et) have been synthesized. The ligand system presented good solubility in organic solvents and stability. The corresponding copper(I) complexes were synthesized and characterized in the search for potential synthetic analogues of the metal center in copper enzymes. The effect of the alkyl substituent on the aromatic ring showed to have an unexpected effect on the reactivity of these ligands towards copper(I) ions. Reactivity studies of these complexes were done with different donor ligands like thiolates, tetramethylthiourea, triphenylphosphine and pyridine. Reactions with silver(I) and cobalt(II) were also tried to study the relationship of the ligand system with biologically relevant metals. The data and structures obtained is compared and discussed in the context of obtaining a mononuclear complex.
Download or read book Coordination Chemistry of Noncyclic and Macrocyclic Thioether diazine Polydentate Ligands written by Liqin Chen and published by . This book was released on 1993 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Reactivity of BIS PYRIDYL and BIS PICOLYL Mercaptoimidazoles written by Jessica Marie Hanley and published by . This book was released on 2012 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mixed-donor ligands are particularly attractive in inorganic chemistry due to their steric and electronic versatility and the multiple coordination modes they may exercise when bound to metal centers. Although pyridines are arguably the most common nitrogen-donor ligands and the coordination chemistry of heterocyclic thiones is well-established, the reactivity of simple tridentate ligands containing a combination of such functionalities is virtually unknown. The synthesis and reactivity of two new mixed-donor ligands, the bis(pyridyl)mercaptoimidazole (2-py)2m, and the bis(picolyl)mercaptoimidazole (2-pic)2m, have been developed. Several coordination complexes of (2-py)2m and (2-pic)2m have been prepared and fully characterized, including the complete series of group 12 metal compounds {(2-py)2m}MX2 and {(2-pic)2m}MX2 (M = Zn, Cd, Hg; X = CI, Br, I). In addition, an investigation of the coordination of these two N2S donor ligands with copper(I) was pursued because one of the key goals of this project is the preparation of synthetic analogues of methanobactin (mb), a small protein responsible for the uptake and delivery of copper(I) ions to various copper-dependent enzymes such as the particulate form of methane monooxygenase (pMMO). The copper(I) derivatives {(2-py)2m}CuX (X = Br, I) and {(2-pic)2m}CuX (X.
Download or read book The Synthesis of Thiolate Ligands for Modeling the Active Sties of Metalloenzymes written by Christopher Gordon Oliveri and published by . This book was released on 2003 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
