Download or read book Studies on the Pathogenesis of Non insulin dependent Diabetes Mellitus NIDDM in the Spontaneously Diabetic GK Goto Kakizaki Rat written by Samy M. Abdel-Halim and published by . This book was released on 1994 with total page 57 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New Concepts in the Pathogenesis of NIDDM written by Claes-Goran Östenson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM) has attracted the interest of our group during the last three decades. As early as 1969, a Nobel Symposium dealing with this topic was organized in Stockholm. This was followed in 1987 by a Nobel Conference devoted to the same subject. The main purpose of these meetings was to bring together the most distinguished scientists from all over the world and present theories on molecular and genetic mechanisms responsible for the development of glucose intolerance in NIDDM. This idea was followed also in the present symposium, "New Concepts in the Pathogenesis of NIDDM," organized with diabetologists from Toronto in Canada. Our purpose is to biannually organize international meetings covering important aspects of dia betes research, hoping that this type of interaction may result in new concepts and treat ment alternatives. For us, participating in this symposium in September 1992, the meeting in Stockholm was very stimulating and innovative. It is a special pleasure that almost all invited lecturers submitted manuscripts. Thus, the publication of the proceedings of the symposium makes it possible for all interested in diabetes research to share new ideas and findings presented at the meeting. Claes-G6ran Ostenson Suad Efendic Mladen V ranic v CONTENTS REGULATION OF INSULIN SECRETION Impaired Glucose-Induced Insulin Secretion: Studies in Animal Models with Spontaneous NIDDM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . C. -G. Ostenson, A. Khan, and S. Efendic Perturbation ofIslet Metabolism and Insulin Release in NIDDM. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 WJ. Malaisse 2 Regulation of Cytoplasmic Free Ca+ in Insulin-Secreting Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Download or read book Animal Models of Diabetes written by Eleazar Shafrir and published by CRC Press. This book was released on 2007-04-05 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the incidence of diabetes increases worldwide, the need for recommendations on how to prevent and treat the condition grows exponentially, and so does the need for an authoritative source for information on the appropriate models to study the condition. The new edition of Animal Models of Diabetes is that source. The book presents updated
Download or read book Experimental Models of Diabetes written by John H. McNeill and published by Routledge. This book was released on 2018-05-11 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: An extremely useful text for research Internationally renowned experts describe the models, provide data obtained with those models, and discuss the relative usefulness of models in relation to the diabetic syndrome in humans. The first section examines the most widely used model, the streptozotocin (STZ) rat, condensing a massive quantity of literature to present both the general effects of of STZ diabetes and the effects on individual organ systems. The second section discusses less well-known and more recent diabetic models, such as the BB rat, the NOD mouse and Zucker and Zucker Diabetic Fatty rat models. Genetic models of insulin dependent diabetes mellitus (IDDM) are examined and compared to chemically induced IDDM models.
Download or read book Lessons from Animal Diabetes VI written by Eleazar Shafrir and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genic constructs. Five articles are devoted to this topic ranging from the B-cell function in transgenic animals to the various effects on diabetes complications. The section on NIDDM, comprising of 10 articles, deals both with new and existing models, their particular widely varying pathogenesis, genetic character istics and complications. The animals reviewed include: spontaneously diabetic OLETF rats, Chinese hamsters, Goto-Kakizaki rats, db/db mice, rhesus monkeys, dogs and an article demonstrating the genetic link between the Zucker fa/fa and corpulent cp/cp obese interstrains. We wish to welcome the new members to our Editorial Board, Dr. Hubert Kolb from Dusseldorf, Dr. Alex Rabinovitch from Edmonton, Dr. Takayoshi Toyota from Sendai and Dr. Soroku Yagihashi from Hirosaki. At the same time we would like to thank Dr. Douglas L. Coleman from Bar Harbor and Dr. George Eisenbarth from Denver for their editorial contribution to the previous LAD Vol umes who have retired from the Editorial Board. With great sadness we have to mention Dr. Otho Michaelis IV from Beltsville, MD who suddenly passed away this year. Otho, or Mike as he was called by friends, made a significant contribution in developing and metabolically defin ing several strains of corpulent cp rats and was extremely helpful in the editor ial work of the LAD series. His contribution will remain in a lasting memory of all researchers of animal diabetes.
Download or read book Williams Textbook of Endocrinology E Book written by Shlomo Melmed and published by Elsevier Health Sciences. This book was released on 2011-05-12 with total page 1920 pages. Available in PDF, EPUB and Kindle. Book excerpt: The latest edition of Williams Textbook of Endocrinology edited by Drs. Shlomo Melmed, Kenneth S. Polonsky, P. Reed Larsen, and Henry M. Kronenberg, helps you diagnose and treat your patients effectively with up-to-the minute, practical know-how on all endocrine system disorders. Comprehensive yet accessible, this extensively revised 12th Edition updates you on diabetes, metabolic syndrome, obesity, thyroid disease, testicular disorders, and much more so you can provide your patients with the most successful treatments. Find scientific insight and clinical data interwoven in every chapter, reflecting advances in both areas of this constantly changing discipline, and presented in a truly accessible format. You’ll also access valuable contributions from a dynamic list of expert authors and nearly 2.000 full-color images to help you with every diagnosis. This title has everything you need to manage any and all the clinical endocrinopathies you may encounter. Rely on the one reference that integrates rapidly evolving basic and clinical science in a cohesive, user-friendly format, definitively addresses every topic in the field, and has remained a standard for more than half a century. Update your know-how and skills to diagnose and treat your patients most effectively with exhaustively revised content on diabetes, metabolic disease, thyroid cancer, fertility problems, testicular problems, weight issues, and much more. Apply reliable guidance on endocrine conditions of growing interest like hypothyroidism and testicular disorders, with dedicated new chapters that expound on the latest research findings. Overcome any clinical challenge with comprehensive and easy-to-use coverage of everything from hormone activity, diagnostic techniques, imaging modalities, and molecular genetics, to total care of the patient. Apply the latest practices with guidance from expert authors who contribute fresh perspectives on every topic.
Download or read book Humoral autoimmunity in the pathogenesis of insulin dependent diabetes mellitus written by and published by . This book was released on 1986 with total page 29 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies on the Aetiology Pathogenesis and Prevention of Insulin dependent Diabetes Mellitus IDDM in the Spontaneously Diabetic BB Edinburgh BB E Rat written by Robert Walker and published by . This book was released on 1989 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Williams Textbook of Endocrinology written by Shlomo Melmed, MBChB, MACP and published by Elsevier Health Sciences. This book was released on 2015-11-30 with total page 1944 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 65 years, Williams Textbook of Endocrinology has been the gold standard in the field, delivering authoritative guidance on every aspect of adult and pediatric endocrine system disorders. The 13th Edition has been thoroughly updated by Drs. Shlomo Melmed, Kenneth S. Polonsky, P. Reed Larsen, and Henry M. Kronenberg, to bring you state-of-the-art coverage of diabetes, metabolic syndrome, obesity, thyroid disease, testicular disorders, and much more, all designed to help you provide optimal care to every patient. Bridging the gap between basic science and clinical information, it is an essential, relevant resource for endocrinologists, endocrine surgeons, gynecologists, internists, and pediatricians - any clinician who needs the most reliable coverage available on the diverse features across the spectrum of endocrine disease. Obtain a better understanding of both scientific insight and clinical data from the classic reference that delivers the current information you need in a highly illustrated, user-friendly format. Stay up to date with expanded discussions of autoimmune thyroid diseases, mechanisms, and the appropriate treatment of the ophthalmopathy of Graves' disease; a new section on the interpretation of fine needle aspiration results in patients with thyroid nodules; and new coverage of when and when not to use radioiodine in the treatment of patients with thyroid cancer. Update your knowledge and skills with all-new chapters on Genetics of Endocrine Disease, Endocrinology of Population Health, and Laboratory Techniques for Recognition of Endocrine Disorders. Confidently manage any clinical endocrinopathy you may encounter thanks to new information on recent FDA-approved drugs for pituitary disorders, a new focus on pediatrics, and new content on diabetes, obesity, and appetite control. Benefit from the expertise of dynamic new contributors who offer fresh perspectives throughout.
Download or read book Pathogenesis of Non Insulin Dependent Diabetes Mellitus written by Valdemar Grill and published by . This book was released on 1988-01-01 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1989 with total page 1506 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Experimental Acupuncturology written by Jaung-Geng Lin and published by Springer. This book was released on 2018-11-02 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the use of acupuncture as a possible and alternative treatment in analgesia, drug addiction, depression, itchiness, peripheral nerve regeneration, stroke, diabetes, cognitive deficits and sleep regulation. Formal recognition by WHO and UNESCO concerning the use and efficacy of acupuncture science in modern medicine has encouraged high levels of investment and commitment to research and development activities into acupuncture science from several top-level health science research and treatment institutes in China Mainland, Taiwan, Japan, Korea, France and the USA. This book aims to provide direction and guidance on how the medical community can proceed with acupuncturology in modern medical treatment and precision medicine.
Download or read book Analysis of Transition from Pre diabetes to Diabetes in Two Animal Models and Evaluation of Anti diabetic Effects of Salsalate written by Wang, Xi and published by . This book was released on 2014 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Type 2 diabetes, once called non-insulin-dependent diabetes, is the most common form of diabetes worldwide. It is characterized by insulin resistance and progressive beta cell failure. This thesis aims at investigating the effects of the anti-inflammatory drug salsalate on type 2 diabetes in animal models and evaluating variations of type 2 diabetes disease progression in two diabetic animal models: non-obese Goto-Kakizaki (GK) rats and obese Zucker Diabetic Fatty (ZDF) rats. Salsalate is a non-steroidal anti-inflammatory drug, which is used to reduce pain and inflammation caused by conditions such as rheumatoid arthritis, osteoarthritis, and related rheumatic conditions. Recently, growing evidence has linked inflammation with type 2 diabetes. Therefore, in this thesis, we investigated the anti-diabetic effects and action mechanisms of salsalate on GK rats. The GK rat is a polygenetic spontaneous non-obese animal model for studies of type 2 diabetes. Both GK rats and non-diabetic control Wistar Kyoto (WKY) rats were treated with salsalate from the age of 4 weeks up until sacrifice at age 21 weeks. GK and WKY rats without salsalate treatment were included as the control groups. Physiological biomarkers and selective gene expression were measured during the time of salsalate treatment as well as at sacrifice. Results showed that salsalate ameliorated the hyperglycemia in GK rats and largely prevented type 2 diabetes disease progression by increasing the plasma adiponectin concentrations and suppressing certain inflammation related gene (interferon-induced protein with tetratricopeptide repeats 1, Ifit1; interferon inducible GTPase 1, Iigp1) expressions in adipose tissue. However, we have also noted differences in disease progression in two series of GK animals from Taconic USA. Development of hyperglycemia was more rapid in GKs derived in 2006 (Series 1) than those re-derived in 2010 (Series 2). A comparison between GK animals indicates that, although the hyperglycemic driving force was greater in Series 1 GKs, the sensitivity of beta cells to failure was higher in Series 2. A second animal model used in type 2 diabetes research is the leptin deficient ZDF rat. This model differs from the non-obese GK rat since it is hyperphagic and obese. We also documented that variations in disease manifestations occur in ZDF rats. In this case, not all ZDFs developed hyperglycemia relative to Zucker lean rats (ZLR). The difference was very clear between ZDFs that became hyperglycemic and those that did not. The ZDFs that became hyperglycemic with age lost the ability to produce insulin while non-hyperglycemic animals remained chronically hyperinsulinemic. Our analysis of gene expression related to inflammation and the effects of anti-inflammatory therapy suggest that inflammation was greater in both GK populations than ZDFs regardless of the development of diabetes. This comparison suggests the existence of different driving forces and etiology in these two models. The existing differences in diabetic animal models reflect the variability of disease progression in human type 2 diabetes. In summary, this dissertation provides insights regarding the anti-diabetic effects and molecular mechanisms of salsalate. Furthermore, our efforts validated two diabetic animal models and provide additional information to better understand the disease progression of type 2 diabetes.
Download or read book Molecular Mechanisms of Exocytosis written by Romano Regazzi and published by Springer Science & Business Media. This book was released on 2008-05-12 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the role of key components in the exocytotic process, not only in neuronal and endocrine cells but in a variety of other relevant cell systems. So far, because of the large number of components involved, understanding of the molecular basis of exocytosis has remained the privilege of a relatively small group of specialists. The book collects up-to-date reviews from the forefront of this fascinating and rapidly evolving field.
Download or read book Acta Histochemica Et Cytochemica written by and published by . This book was released on 2005 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Diabetic Kidney written by Pedro Cortes and published by Springer Science & Business Media. This book was released on 2007-11-06 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and authoritative survey of recent findings, ideas, and hypotheses about the causes and treatment of diabetic nephropathy. The authors cover both the basic pathogenic mechanisms of the disease, as well as many of its clinical aspects of identification, management, and new therapeutic approaches. Highlights include an entire section devoted to novel approaches to studying diabetic nephropathy with the most advanced molecular techniques, and complete descriptions of the most up-to-date views on the diagnosis and treatment of the disease. The Diabetic Kidney offers both researchers and practicing clinicians a clear understanding of the of the progress that has been made regarding the pathogenesis of diabetic nephropathy and of the therapeutic interventions needed to prevent its development or treat it.
Download or read book International Journal of Obesity written by and published by . This book was released on 1996 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:
