Download or read book Structural Studies on the DNA Replication Apparatus written by Brian Douglas Guenther and published by . This book was released on 1996 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structural Studies of a Protein Involved in DNA Replication written by Jeffrey Richard Salerno and published by . This book was released on 1999 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Themes in DNA Replication written by Lynne Suzanne Cox and published by Royal Society of Chemistry. This book was released on 2009 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by leading experts, this learned but accessible book highlights the latest work on eukaryotic DNA replication.
Download or read book Structural Studies of DNA Replication Proteins by X ray Crystallography and Molecular Dynamics written by Yanxiang Zhao and published by . This book was released on 2002 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structure and Function of the Genetic Apparatus written by Claudio Nicolini and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fourth Course of the International School of Pure and Applied Biostructure, a NATO Advanced Study Institute, was held September 18-31, 1983 at the Ettore Majorana Center for Scientific Culture in Erice, Sicily. The subject of the Fourth Course, which was co-sponsored by national and international agencies, was "Structure and Function of the Genetic "Appara tus. " Participants from 15 countries around the world attended the course. The study of the genetic apparatus is one of humanity's most challeng ing problems, and it has been approached in the tradition of the School from many different points of view, among them biochemistry, genetic eng ineering, cell biology, oncology, biophysics and other fields. It has been most difficult to confine such diverse points of view, as well as their pro ponents, within the four walls of one room, in front of one audience - es pecially since the heterogeneity of background and the inherent difficul ties encountered in communication could overshadow the true spirit of sci entific exchange. We are once again pleased to say the outcome of the 1983 Course has matched the success of the previous course held in Erice on the same subject five years ago. This book is the result of the 1983 Advanced Study Institute, and aims to present a cohesive, interdisciplinary view of the current knowledge on the structure and fuction of the genetic apparatus.
Download or read book Structural Studies of Protein nucleic Interactions in DNA Replication and Translation written by Ornchuma Itsathitphaisarn and published by . This book was released on 2012 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structural Studies of Bacterial DNA Replication Initiation written by Jan Peter Erzberger and published by . This book was released on 2005 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past thirty years, our understanding of the molecular processes that ensure the faithful duplication of genomic material has steadily evolved. Biochemical and structural studies of the enzymatic assemblies at the core of DNA replication have served as a paradigm for understanding how molecular machines composed of individual protein elements are able to carry out complex cellular functions. One such assembly regulates the process of DNA replication initiation, a critical juncture in the cell cycle of all organisms. This dissertation presents X-ray crystallographic studies of three DNA replication initiation factors from the thermophilic bacterium Aquifex aeolicus: The A&barbelow;TPases a&barbelow;ssociated with various a&barbelow;ctivities (AAA+) proteins DnaA and DnaC and the RecA-type helicase DnaB. My research has revealed the structures of two conformational states of the DnaA protein, the bacterial initiator responsible for the structural remodeling of DNA replication origins. The post-replicative, ADP-bound structure (ADP-DnaA), consists of a monomeric form of the protein, while the active, ATP-bound structure (ATP-DnaA), oligomerizes into a helical filamentous array. Specific conformational changes in DnaA, induced by ATP-binding, trigger the monomer to oligomer transition. The helical structure of ATP-DnaA represents a novel oligomeric arrangement within the AAA+ protein family and suggests possible solutions to some of the outstanding questions regarding the processing of DNA replication origins. The remodeling activity of DnaA sets the stage for the recruitment of the DnaBC complex and the deposition on origin DNA of the DnaB replicative helicase. In order to help understand this critical first step in replisome assembly, I have initiated structural studies of DnaB and the DnaBC complex and describe preliminary crystallization and x-ray diffraction studies of these proteins. The insights obtained from this research furthers our understanding of the mechanism of initiator action at origins of replication and, given the strong structural similarities between bacterial, archaeal and eukaryotic factors, open novel research avenues into the mechanistic details of all cellular initiators.
Download or read book Structural Studies of DNA Replication Machinery in Archaea written by and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biochemical and Structural Studies of Proteins and Nucleic Acids Regulating DNA Replication Initiation written by Yanyan Geng and published by . This book was released on 2017 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The DNA Replication Repair Interface written by Brandt Eichman and published by Elsevier. This book was released on 2021-11-16 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Replication-Coupled Repair, Volume 661 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including the Repair of replication-born DNA breaks by sister chromatid recombination, High resolution and high throughput DNA cyclization measurements to interrogate DNA bendability, A programmable detection method for genomic signatures: from disease diagnosis to genome editing, Characterization of the telomerase modulating activities of yeast DNA helicases, Eukaryotic DNA replication with purified budding yeast proteins, Single molecule studies of yeast Rad51 paralogs, Light activation and deactivation of Cas9 for DNA repair studies, and more. Other chapters explore MIDAS: Direct sequencing to map mitotic DNA synthesis and common fragile sites at high precision, Studying the DNA damage response in embryonic systems, GLASS-ChIP to map Mre11 cleavage sites in the human genome, New chemical biology approaches to trap reaction intermediates in living cells, Single-molecule imaging approaches for monitoring replication fork conflicts at genomic DNA G4 structures and R-loops in human cells, Monitoring the replication of structured DNA through heritable epigenetic change, Visualizing replication fork encounters with DNA interstrand crosslinks, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology series Includes the latest information on replication-coupled repair
Download or read book Crystallographic Studies of DNA Replication and Repair Proteins written by Stephen Joseph Tomanicek and published by . This book was released on 2005 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: The duplication of genomic information is central to the survival of organisms in all kingdoms of life. DNA replication and repair processes are essential for maintaining the fidelity and genomic stability required for life. Many proteins are involved directly in a number of coordinated interactions to ensure the accurate and efficient replication and repair of DNA. However, a number of these coordinated interactions during the replication and repair of DNA remain uncharacterized. Therefore, studying the nature of the various protein protein and protein substrate interactions can provide a more comprehensive understanding of both DNA replication and repair in all forms of life. Specifically, the fidelity of DNA replication is highly dependent on the function of the flap endonuclease (FEN 1) family of enzymes. The FEN-1 family of DNA replication associated DNA repair enzymes are structure specific 5' to 3' endonucleases that are members of the RAD2/RAD27 family of eukaryotic nucleases. The FEN 1 family of enzymes are also functionally related to both the bacteriophage and prokaryotic 5' to 3' exonucleases. Many of the enzymes in the RAD2/RAD27 family of nucleases are involved in the processing of Okazaki fragment primers during lagging-strand DNA synthesis and in processing strands displaced during DNA synthesis associated with repair. However, a comprehensive structural characterization of the structure specific substrate recognition of the FEN 1 family of enzymes has not yet been completed. This work was focused primarily on structural studies of the archaeal Aeropyrum pernix (Ape) FEN-1 enzyme and the T4 RNase H, a FEN 1 homologue in the bacteriophage T4. A number of X ray crystallographic studies were focused on understanding the molecular basis of nucleic acid substrate recognition and the role of divalent metal ions in the catalytic mechanism of these enzymes. These structural studies have provided a more complete understanding of how catalysis is facilitated by the structure specific substrate recognition of these essential enzymes in both DNA replication and repair.
Download or read book Initiation of DNA Replication in Bacillus Subtilis written by Eleyna Martin and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
Download or read book Structural DNA Nanotechnology written by Nadrian C. Seeman and published by Cambridge University Press. This book was released on 2015 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the founder of the field, this is a comprehensive and accessible introduction to structural DNA nanotechnology.
Download or read book Molecular Biology of the Gene written by James D. Watson and published by Benjamin-Cummings Publishing Company. This book was released on 2014 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now completely up-to-date with the latest research advances, the Seventh Edition retains the distinctive character of earlier editions. Twenty-two concise chapters, co-authored by six highly distinguished biologists, provide current, authoritative coverage of an exciting, fast-changing discipline.
Download or read book Anatomy of Gene Regulation written by Panagiotis A. Tsonis and published by Cambridge University Press. This book was released on 2003-01-13 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Table of contents
