Download or read book Structural Studies on Proteins of the Bacterial Phosphotransferase System written by Christian Siebold and published by . This book was released on 2002 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Bacterial Phosphotransferase System PTS written by Jean-Marc Jeckelmann and published by . This book was released on 2009 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Bacterial Phosphotransferase System written by Milton H. Saier and published by Garland Science. This book was released on 2002-06-13 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following it's discovery in E.coli by Kundig, Ghosh and Rosema thirty seven years ago, a wealth of information has accumulated on the bacterial Phosphotransferase system (PTS). Since then the PTS has been found in a wide variety of different bacteria where it has been recognised to play a pivotal role in numerious aspects of bacterial cellular physiology. While the primary functions of this system involve sugar reception, transport and phosphorylation, the secondary functions include the regulation, both directly and indirectly, of important metabolic pathways. In this book, Internationally recognised authors review the current research on the PTS, discuss the multifaceted structural and functional aspects of the system and attempt to provide a realistic forecast of future discoveries. Study of this important system will contribute to our understanding of prokaryotic physiology and pathogenesis, will allow major advances in biotechnology, and will result in the development of agents capable of effectively combating harmful microorganisms.
Download or read book Structural Studies on Proteins from Pathogenic Bacteria written by Richard Michael Salmon and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Burkholderia pseudomallei is a Class III bacterial pathogen of humans and the causative agent of melioidosis, a disease endemic to South East Asia and Australia. This work describes X-ray crystallographic and biochemical studies of the BPSL1204 protein from B. pseudomallei. The amino acid sequence of BPSL1204 possesses an N-terminal glyceryl-cysteine lipid-anchoring motif for covalent association with a membrane. After genetic truncation of the anchoring sequence, the BPSL1204 truncate was cloned, over-expressed and purified from E. coli before being subjected to crystallisation trials. The 1.05 Å resolution crystal structure of BPSL1204 was solved by Selenomethionine MAD and revealed a two-domain fold similar to that of [beta]-Lactamase Inhibitory Protein I (BLIP-I). Like BLIP-I, the BPSL1204 structure consists of two similar domains. However TEM1 [beta]-lactamase assays showed BPSL1204 to lack the general inhibitory activity of BLIP-I. Pull-down assays to uncover biological binding partners of the BPSL1204 homologue BCAL2351 from the paraphyletic Class II B. cenocepacia were undertaken. Although a methionyl-tRNA synthetase was isolated, no complex was seen to form between pure samples of the proteins. Antibodies raised against pure BPSL1204 were used to locate the BCAL2351 homologue in fractionated B. cenocepacia. BCAL2351 was found exclusively in the purified outer membrane by immunoblot analysis. Some evidence of binding of antibodies to whole B. cenocepacia cells was observed by fluorescence microscopy, indicative of external BCAL2351 and BPSL1204. However, other slides containing samples from the same culture showed no such binding, suggestive of internal or absent protein. Surface presence may be cell-cycle dependant. However, no immune response was found when BPSL1204 was challenged with anti-B. mallei human sera. Thus by a cross-disciplinary approach to investigating the structure and function of a protein of unknown function from the pathogenic B. pseudomallei, it was concluded that BPSL1204 is a protein with a BLIP-like fold potentially located on either the periplasmic or possibly outer face of the outer membrane of the bacterium.
Download or read book Structural Studies of Bacterial Infection Proteins written by and published by . This book was released on 2011 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structural Studies of Specialized Bacterial Surface Proteins written by Jakob Jensen Ulstrup and published by . This book was released on 2014 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Functional and Structural Studies on Bacterial and Archaeal Membrane Proteins written by Mirko Stauffer and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structural Studies of PTS Proteins written by Andreas Zurbriggen and published by . This book was released on 2008 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bacterial Physiology and Metabolism written by Byung Hong Kim and published by Cambridge University Press. This book was released on 2008-02-21 with total page 934 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent determination of genome sequences for a wide range of bacteria has made in-depth knowledge of prokaryotic metabolic function essential in order to give biochemical, physiological, and ecological meaning to the genomic information. Clearly describing the important metabolic processes that occur in prokaryotes under different conditions and in different environments, this advanced text provides an overview of the key cellular processes that determine bacterial roles in the environment, biotechnology, and human health. Prokaryotic structure is described as well as the means by which nutrients are transported into cells across membranes. Glucose metabolism through glycolysis and the TCA cycle are discussed, as well as other trophic variations found in prokaryotes, including the use of organic compounds, anaerobic fermentation, anaerobic respiratory processes, and photosynthesis. The regulation of metabolism through control of gene expression and control of the activity of enzymes is also covered, as well as survival mechanisms used under starvation conditions.
Download or read book Mechanisms and Regulation of Carbohydrate Transport in Bacteria written by Milton H. Saier and published by . This book was released on 1985 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms and Regulation of Carbohydrate Transport in Bacteria reviews the developments in the study of the mechanisms and regulation of carbohydrate transport in prokaryotic organisms. The book presents the progress made in the understanding of transport and regulation of carbohydrates in bacteria in the molecular level. Aspects on the important structural and topographical features of several sugar permeases in Escherichia coli are elucidated; the energy-coupling processes are clearly delineated for most (but not all) types of bacterial carbohydrate permease systems; and mechanistic details ...
Download or read book Bacterial Cell Walls and Membranes written by Andreas Kuhn and published by Springer. This book was released on 2019-06-18 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an up-to-date overview of the architecture and biosynthesis of bacterial and archaeal cell walls, highlighting the evolution-based similarities in, but also the intriguing differences between the cell walls of Gram-negative bacteria, the Firmicutes and Actinobacteria, and the Archaea. The recent major advances in this field, which have brought to light many new structural and functional details, are presented and discussed. Over the past five years, a number of novel systems, e.g. for lipid, porin and lipopolysaccharide biosynthesis have been described. In addition, new structural achievements with periplasmic chaperones have been made, all of which have revealed amazing details on how bacterial cell walls are synthesized. These findings provide an essential basis for future research, e.g. the development of new antibiotics. The book’s content is the logical continuation of Volume 84 of SCBI (on Prokaryotic Cytoskeletons), and sets the stage for upcoming volumes on Protein Complexes.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein protein Complexes written by Martin Zacharias and published by World Scientific. This book was released on 2010 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge be used to predict and design protein-protein interactions (interaction regions and complex structures)? What methods are currently employed to design protein-protein interactions, and how can we influence protein-protein interactions by mutagenesis and small-molecule drugs or peptide mimetics?The book consists of about 15 review chapters, written by experts, on the characterization of protein-protein interfaces, structure determination of protein complexes (by NMR and X-ray), theory of protein-protein binding, dynamics of protein interfaces, bioinformatics methods to predict interaction regions, and prediction of protein-protein complex structures (docking and homology modeling of complexes, etc.) and design of protein-protein interactions. It serves as a bridge between studying/analyzing protein-protein complex structures (interfaces), predicting interactions, and influencing/designing interactions.
Download or read book Prokaryotic Metabolism and Physiology written by Byung Hong Kim and published by Cambridge University Press. This book was released on 2019-05-16 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensive and up-to-date review of key metabolic processes in bacteria and archaea and how metabolism is regulated under various conditions.
Download or read book Biomedical Index to PHS supported Research pt A Subject access A H written by and published by . This book was released on 1992 with total page 1064 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bacterial Signaling written by Reinhard Krämer and published by John Wiley & Sons. This book was released on 2009-12-09 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a comprehensive insight into cellular signaling processes in bacteria with a special focus on biotechnological implications, this is the first book to cover intercellular as well as intracellular signaling and its relevance for biofilm formation, host pathogen interactions, symbiotic relationships, and photo- and chemotaxis. In addition, it deals in detail with principal bacterial signaling mechanisms -- making this a valuable resource for all advanced students in microbiology. Dr. Krämer is a world-renowned expert in intracellular signaling and its implications for biotechnology processes, while Dr. Jung is an expert on intercellular signaling and its relevance for biomedicine and agriculture.
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
