Download or read book Spectral Tailoring for Boron Neutron Capture Therapy written by Victor Alexander Nievaart and published by IOS Press. This book was released on 2007 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first clinical trials on Boron Neutron Capture Therapy in the 1950s, BNCT research has been mainly focussed on the treatment of (deep-seated) brain tumours, in particular, glioblastoma multiforme. Promising work to treat other cancers at other locations and even other diseases are in progress. Therefore, the chemists, medical doctors, physicists and biologists involved in BNCT are not only continuing to investigate and improve the (brain) clinical results, but are also investigating the new applications in BNCT. The work presented in this thesis is in the field of physics and deals, from three different viewpoints, with obtaining the optimal source neutron energy to optimise BNCT. The optimal source neutron energy is defined such as to obtain as many as possible (n, a)-absorptions due to 10B in the tumours and as low as possible total neutron dose in the healthy tissues and organs at risk

Download or read book Neutron Capture Therapy written by Wolfgang A.G. Sauerwein and published by Springer Science & Business Media. This book was released on 2012-11-05 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.

Download or read book Neutrons in Research and Industry written by George Vourvopoulos and published by SPIE-International Society for Optical Engineering. This book was released on 1997 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Neutron Beam Design Development and Performance for Neutron Capture Therapy written by Otto K. Harling and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: For this Workshop, the organizers have attempted to invite experts from all known centers which are engaged in neutron beam development for neutron capture therapy. The Workshop was designed around a series of nineteen invited papers which dealt with neutron source design and development and beam characterization and performance. Emphasis was placed on epithermal beams because they offer clinical advantages and are more challenging to implement than thermal beams. Fission reactor sources were the basis for the majority of the papers; however three papers dealt with accelerator neutron sources. An additional three invited papers provided a summary of clinical results of Ncr therapy in Japan between 1968 and 1989 and overviews of clinical considerations for neutron capture therapy and of the status of tumor targeting chemical agents for Ncr. Five contributed poster papers dealing with NCT beam design and performance were also presented. A rapporteurs' paper was prepared after the Workshop to attempt to summarize the major aspects, issues, and conclusions which resulted from this Workshop. Many people contributed to both the smooth functioning of the Workshop and to the preparation of these proceedings. Special thanks are reserved for Ms. Dorothy K.

Download or read book Cancer Neutron Capture Therapy written by Y. Mishima and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 893 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many human cancers which actively synthesize specific characteristic proteins such as melanomas, thyroid cancer and squamous cell carcinoma. Many cancer researchers have of course tried to utilize this specific activity as a key for the selective treatment of cancers. In the past for example, the molecular hybrid compound of DOPA, a substrate of melanin, and nitrogen mustard N-oxide hydrochloride, a ctyotoxic anti-tumor drug, was synthesized as Melphalan and used to treat malignant melanoma. A major problem arose though in that it was soon found to be highly suppressive toward bone marrow and quite toxic while not being remarkably effective. Thus, malignant melanoma could not be cured by it. Such failure led us to develop a novel bimodal therapeutic system which includes the use of non-toxic potentially cytocidal chemicals which selectively accumulate within the cancer cells and which are converted by a controllable modality into an actively cytocidal element in situ. We can now non-surgically cure malignant melanoma and glioblastoma with our selective cancer treatment, neutron capture therapy (NCT); as can be found in this volume. Included are 124 papers on the latest breaking developments discussed at the Sixth International Symposium on NCT for Cancer held in Kobe during the late autumn of 1994.

Download or read book Neutron Spectrum Measurement for Boron Neutron Capture Therapy written by Jameel Hefne and published by . This book was released on 1996 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Frontiers in Neutron Capture Therapy written by M. Frederick Hawthorne and published by Springer. This book was released on 2013-11-11 with total page 1389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Neutron Capture Therapy contains current research results originally presented at the Eighth International Symposium on Neutron Capture Therapy for Cancer in La Jolla, CA. This comprehensive collection of peer-reviewed manuscripts is showcased in two volumes covering all aspects of the development of this multidisciplinary approach to cancer therapy. Volume I of this work includes clinical results and current progress in treatment planning, neutron sources and dosimetry, while Volume II presents the synthesis, pharmacology and tissue-targeting design of boron compounds, including work on preclinical dosimetry and radiobiology. Intended for researchers and clinicians involved with or interested in new modes of cancer therapy, this volume will also serve as a useful guideline for scientists, students, and practitioners in the field.

Download or read book Analysis of Accelerator Based Neutron Spectra for BNCT Using Proton Recoil Spectroscopy written by and published by . This book was released on 1998 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: Boron Neutron Capture Therapy (BNCT) is a promising binary treatment modality for high-grade primary brain tumors (glioblastoma multiforme, GM) and other cancers. BNCT employs a boron-10 containing compound that preferentially accumulates in the cancer cells in the brain. Upon neutron capture by 1°B energetic alpha particles and triton released at the absorption site kill the cancer cell. In order to gain penetration depth in the brain Fairchild proposed, for this purpose, the use of energetic epithermal neutrons at about 10 keV. Phase 1/2 clinical trials of BNCT for GM are underway at the Brookhaven Medical Research Reactor (BMRR) and at the MIT Reactor, using these nuclear reactors as the source for epithermal neutrons. In light of the limitations of new reactor installations, e.g. cost, safety and licensing, and limited capability for modulating the reactor based neutron beam energy spectra, alternative neutron sources are being contemplated for wider implementation of this modality in a hospital environment. For example, accelerator based neutron sources offer the possibility of tailoring the neutron beams, in terms of improved depth-dose distributions, to the individual and offer, with relative ease, the capability of modifying the neutron beam energy and port size. In previous work new concepts for compact accelerator/target configuration were published. In this work, using the Van de Graaff accelerator the authors have explored different materials for filtering and reflecting neutron beams produced by irradiating a thick Li target with 1.8 to 2.5 MeV proton beams. However, since the yield and the maximum neutron energy emerging from the Li-7(p, n)Be-7 reaction increase with increase in the proton beam energy, there is a need for optimization of the proton energy versus filter and shielding requirements to obtain the desired epithermal neutron beam. The MCNP-4A computer code was used for the initial design studies that were verified with benchmark experiments using a proton recoil spectroscopy detection system. Comparison was also made between in phantom 1°BF3 readings made at the BMRR and those made at the RARAF accelerator facility.

Download or read book Determination and Production of an Optimal Neutron Energy Spectrum for Boron Neutron Capture Therapy written by Darren Leo Bleuel and published by . This book was released on 2003 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Personalized and Precision Nanomedicine for Cancer Treatment written by Mohammad Azhar Aziz and published by Springer Nature. This book was released on with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Transactions of the American Nuclear Society written by American Nuclear Society and published by . This book was released on 2000 with total page 922 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Spectral Tailoring for Fusion Radiation damage Studies written by and published by . This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Oak Ridge Research Reactor is currently being used to irradiate an experiment (MFE-4A) to simulate in stainless steel-316 the He to DPA ratio of 14 appM He/DPA expected at the first wall of a fusion reactor. The experimental design criterion is to remain within +- 20% of this ratio after an initial irradiation period of approx. 1.2 years. At present (March 31, 1981) the experiment has been in the reactor for 19 cycles corresponding to 131,543 Mwh, 4.05 x 1025 n/m2 in thermal fluence, 1.21 x 1026 n/m2 in total fluence, 3.1 DPAs and 21.0 appM He. The current He to DPA ratio is 6.8. This paper summarizes some of the analysis calculations for this experiment and presents the current status of this work. The analysis calculations utilize the codes VENTURE, ANISN, GAS, UNFOLD, etc. and the obtained results include gas production, DPA, and heating rates, and neutron spectral modifications resulting from different reactor fuel loadings and core piece compositions.

Download or read book Boron Neutron Capture Therapy written by United States. Congress. Senate. Committee on Energy and Natural Resources and published by . This book was released on 1994 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book An Interactive Computer Model for Neutron Spectrum Tailoring written by Rida Y. Nuwayhid and published by . This book was released on 1980 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Reactor Dosimetry State Of The Art 2008 Proceedings Of The 13th International Symposium written by Wim Voorbraak and published by World Scientific. This book was released on 2009-08-19 with total page 761 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives the state of the art in the field of reactor dosimetry as applied in nuclear power plants and research reactors. Surveillance programs are presented for nuclear power plants in Europe, including Russia and Ukraine, USA, Argentina and Korea. New cross-section measurements from most of the European, American and Japanese research reactors are reported. The latest developments in computer code development for radiation transport and shielding calculations, and radiation measurement techniques are also highlighted.

Download or read book The Engineering Index Bioengineering and Biotechnology Abstracts written by and published by . This book was released on 1990 with total page 930 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book TID written by and published by . This book was released on 1978 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: