Download or read book Selenium and Selenoproteins in Cancer written by Francesco Galli and published by Academic Press. This book was released on 2017-10-19 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Selenium and Selenoproteins in Cancer, Volume 136, the latest release in the Advances in Cancer Research series, provides invaluable information on the fast-moving field of cancer research. This updated volume includes chapters on The epidemiology of selenium and human cancer, Selenium, epigenetics and cancer, Selenium status and cancer risk, Nutritional aspects of selenium and breast cancer risk: focus on cellular and molecular mechanisms, Selenoproteins in tumorigenesis and cancer progression, Selenoproteins and metastasis, The tumor microenvironment and inflammatory factors, and Selenium-dependent glutathione peroxidases during tumor development. This new release in the series presents original reviews on research regarding the prevention and treatment of cancer with selenium. - Provides information on cancer research and prevention - Offers outstanding and original reviews on a range of cancer research topics, with this volume focusing on the role of selenium and selenoproteins in cancer prevention - Serves as an indispensable reference for researchers and students alike
Download or read book Colitis Associated Cancer written by Masato Kusunoki and published by Springer. This book was released on 2015-10-01 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the number of patients with colitis-associated cancer (CAC) is on the increase, the purpose of this book is to review the latest topics concerning management of the disease. In recent years, the diagnostic power of endoscopy and molecular pathology has also grown tremendously, as a result of which they now have a far greater influence on the treatment of CAC. At the moment, appropriate monitoring programs for ulcerative colitis and Crohn’s disease remain uncertain. At the same time, the latest findings on DNA methylation and microRNAs hold the promise of making revolutionary changes in these areas. Moreover, recent drug advances in the treatment of inflammatory bowel diseases have changed surgical indications. On the other hand, the indication of mucosectomy on colorectal cancer in ulcerative colitis and prophylactic abdominoperineal resection for Crohn’s disease remain controversial. This book provides the latest information on the remaining issues of CAC from the point of view of expert surgeons.
Download or read book Selenium written by Dolph L. Hatfield and published by Springer Science & Business Media. This book was released on 2001 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: As discussed in this book, a large body of evidence indicates that selenium is a cancer chemopreventive agent. Further evidence points to a role of this element in reducing viral expression, in preventing heart disease, and other cardiovascular and muscle disorders, and in delaying the progression of AIDS in HIV infected patients. Selenium may also have a role in mammalian development, in male fertility, in immune function and in slowing the aging process. The mechanism by which selenium exerts its beneficial effects on health may be through selenium-containing proteins. Selenium is incorporated into protein as the amino acid selenocysteine. Selenocysteine utilizes a specific tRNA, a specific elongation factor, a specific set of signals, and the codeword, UGA, for its cotranslational insertion into protein. It is indeed the 21st naturally occurring amino acid to be incorporated into protein and marks the first and only expansion of the genetic code since the code was deciphered in the mid 1960s.
Download or read book Dietary Reference Intakes for Vitamin C Vitamin E Selenium and Carotenoids written by Institute of Medicine and published by National Academies Press. This book was released on 2000-08-27 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the newest release in the authoritative series of quantitative estimates of nutrient intakes to be used for planning and assessing diets for healthy people. Dietary Reference Intakes (DRIs) is the newest framework for an expanded approach developed by U.S. and Canadian scientists. This book discusses in detail the role of vitamin C, vitamin E, selenium, and the carotenoids in human physiology and health. For each nutrient the committee presents what is known about how it functions in the human body, which factors may affect how it works, and how the nutrient may be related to chronic disease. Dietary Reference Intakes provides reference intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for different groups based on age and gender, along with a new reference intake, the Tolerable Upper Intake Level (UL), designed to assist an individual in knowing how much is "too much" of a nutrient.
Download or read book Trace Elements and Minerals in Health and Longevity written by Marco Malavolta and published by Springer. This book was released on 2018-11-13 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the role of trace elements in health and longevity, pursuing a biogerontological approach. It offers essential information on the impact of trace elements on molecular and physiological processes of aging, and on their impact on health in connection with aging. The major topics covered in its 11 chapters, each dedicated to a specific trace element or mineral, are: a) Role of the element in species longevity, b) Recommended intake for longevity in animal species and in the elderly, c) Deficiency and age-related disease, d) Excess/toxicity and age-related disease, and e) Interactions with drugs prescribed in the elderly. Clinical, animal and other laboratory models of interest in aging are included, which enable a more in-depth analysis to be made. The respective chapters are a mixture of overviews and more in-depth reviews in which the mechanisms of aging are described from the point of view of their specific interactions with trace elements and minerals.
Download or read book Protein Sensors and Reactive Oxygen Species written by Helmut Sies and published by Academic Press. This book was released on 2002 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Methods in Enzymology is concerned with the rapidly developing field of selenoprotein synthesis and its related molecular genetics. Progressive information on the topics of proteins as redox sensors, selenoproteins, and the thioredoxin system is studied using methods such as bioinformatics, DNA chip technology, cell biology, molecular genetics, and enzymology. The information on novel selenoproteins identified from genomic sequence data, as well as current knowledge on glutathione peroxidases, selenoprotein P, iodothyronine deiodinases, and thioredoxin reductases, is presented in a method-based approach.
Download or read book New Prognostic and Predictive Markers in Cancer Progression written by Susan Costantini Alfredo Budillon and published by MDPI. This book was released on 2021-02-12 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers are of critical medical importance for oncologists, allowing them to predict and detect disease and to determine the best course of action for cancer patient care. Prognostic markers are used to evaluate a patient’s outcome and cancer recurrence probability after initial interventions such as surgery or drug treatments and, hence, to select follow-up and further treatment strategies. On the other hand, predictive markers are increasingly being used to evaluate the probability of benefit from clinical intervention(s), driving personalized medicine. Evolving technologies and the increasing availability of “multiomics” data are leading to the selection of numerous potential biomarkers, based on DNA, RNA, miRNA, protein, and metabolic alterations within cancer cells or tumor microenvironment, that may be combined with clinical and pathological data to greatly improve the prediction of both cancer progression and therapeutic treatment responses. However, in recent years, few biomarkers have progressed from discovery to become validated tools to be used in clinical practice. This Special Issue comprises eight review articles and five original studies on novel potential prognostic and predictive markers for different cancer types.
Download or read book Selenoprotein Structure and Function written by and published by Academic Press. This book was released on 2022-01-28 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Selenoprotein Structure and Function, Volume 662 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include Identification of Selenoprotein O substrates using a biotinylated ATP analog, Selenium-encoded isotopic signature targeted profiling, Designing tRNASec variants for efficient selenocysteine incorporation using Sec-specific reporters, Preparation of selenoprotein S by chemical ligation, Examining xCT-mediated selenium uptake and selenoprotein production capacity in cells, SecMS analysis of selenoprotein with selenocysteine insertion sequence and beyond, Selenocysteine substitutions in thiyl radical enzymes, and much more. Additional chapters cover Recombinant selenoprotein expression in E. coli based upon the redefinition of a UAG codon in an RF1-depleted host strain, Metabolic labeling with radioactive selenium in zebrafish, Low pH isoTOP-ABPP to identify selenocysteines, Expression of selenoproteins via genetic code expansion in mammalian cells, Alpha-methyl selenocysteine as a tool for the study of selenoproteins, Selective selenol fluorescent probes: design, synthesis, structural determinants, and biological applications, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Methods in Enzymology series - Updated release includes the latest information on Selenoprotein Structure and Function
Download or read book Selenium in Biology and Human Health written by Raymond F. Burk and published by Springer. This book was released on 2011-10-04 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Selenium plays a fascinating and still poorly understood role in the function of living cells and therefore in human health. Starting with investigations over 60 years ago into its role as a toxic agent in livestock disease, selenium studies have progressed rapidly with the application of tools from immunology and molecular biology. Selenium is now known to be important in human and animal nutrition, has been discovered as a structural component of so-called selenoproteins, and may play a number of physiological roles, ranging from cancer protection to hormone metabolism. Selenium in Biology and Human Health presents research syntheses on a range of topics involving selenium, written by specialists from around the world. It will be of interest to cell biologists and physiologists, nutritional scientists, and animal health researchers.
Download or read book Organoselenium Compounds in Biology and Medicine written by Vimal Kumar Jain and published by Royal Society of Chemistry. This book was released on 2017-10-03 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses organoselenium chemistry and biology in the context of its therapeutic potential, taking the reader through synthetic techniques, bioactivity and therapeutic applications
Download or read book Selenium Contamination in Water written by Pooja Devi and published by John Wiley & Sons. This book was released on 2021-05-12 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: The contamination of environment and water resources by Selenium (Se) and its oxyanions from various sources are emerging contaminants of significant health and environmental concern. The primary sources include agricultural drainage water, mine drainage, residues from fossil fuels, thermoelectric power plants, oil refineries, and metal ores. Various methods and technologies have been developed which focus on the treatment of selenium-containing waters and wastewater. High concentrations of selenium in water cause various adverse impact to human health, such as carcinogenic, genotoxic, and cytotoxic effects. But in the lower concentrations, it is a useful constituent of the biological system. The range between toxicity and deficiency of selenium is minimal (40 to 400 μg per day), due to its dual nature. Selenium Contamination in Water contains the latest status and information on selenium’s origin, its chemistry and its toxicity to humans. The book represents a comprehensive and advanced reference book for students, researchers, practitioners, and policymakers in working in the field of metalloids, in particular selenium. A special emphasis is given on its geological distribution, monitoring techniques, and remedial technologies. As such, the authors critically analyze the various techniques used for the monitoring and removal of selenium from water. Featuring chapters arranged according to the major themes of the latest research, with specific case-studies from industrial experiences of selenium detection and removal, Selenium Contamination in Water will be particularly valued by researchers, practitioners, and policymakers in working in the field of metalloids including selenium.
Download or read book Selenium written by Victor R Preedy and published by Royal Society of Chemistry. This book was released on 2015-08-10 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although toxic in large doses, selenium is an essential trace mineral in the animal diet and in some plants. It has a role in making antioxidant enzymes and a particular role in the functioning of the thyroid gland. This volume examines the chemical activity of selenium and its functional health effects eg towards cancers, in the heart and brain. It also covers other areas such as functional food enrichment, whole body metabolism, and the effects of selenium deficiency on health. Part of The Food and Nutritional Components in Focus series, this edited volume pools knowledge across scientific disciplines in a way that increases its applicability to a wide range of audiences. Victor Preedy’s own distinguished career in nutritional science has made him a prolific author of research articles and books in this area, and this project fills a gap in providing comprehensive synopses of food substances. Chemists, analytical scientists, forensic scientists, food scientists, as well as course lecturers will all benefit from this interdisciplinary title written by international experts in this area.
Download or read book Selenium in the Environment written by Frankenberger and published by CRC Press. This book was released on 1994-06-10 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses the biochemical and geological cycling of selenium (Se), its worldwide distribution, and the factors controlling its fate and transport within and between major environmental media, presenting a global assessment of selenium's complex environmental behaviour. The focus of this work is upon Se management and remediation strategies.
Download or read book Selenium and Selenoproteins in Brain Development Function and Disease written by Matthew William Pitts and published by Frontiers Media SA. This book was released on 2022-02-18 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nutraceuticals and Cancer Signaling written by Seid Mahdi Jafari and published by Springer Nature. This book was released on 2021-09-24 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today's consumers are looking for food products with health-promoting roles in addition to nutritional benefits. With current research showing that nutraceuticals and functional foods rich in specific bioactives may have chemopreventative effects, these products are increasingly popular. However, while much in the literature supports the health-promoting features of these foods, few texts focus on their bioactive agents and their mode of action in cancer signaling. Nutraceuticals and Cancer Signalling: Clinical Aspects and Mode of Action explains the link between nutraceuticals and cancer in terms of clinical trials and modes of action. This book gives an overview of common cancers and their mechanisms, and the most common functional foods and their bioactive components. Individual chapters focus on specific functional foods--including tomatoes, garlic, honey, tea, yoghurt, and many more--their prominent bioactive compounds, and their mode of action in cancer signaling and chemoprevention. Recent findings on cancer-prevention roles of different vitamins and minerals are also discussed. For food scientists, nutritionists, and pharmaceutical experts looking to understand how functional foods can play a role in fighting cancer, this text serves as a one-stop reference.
Download or read book Nutrition and Lifestyle for Pregnancy and Breastfeeding written by Peter D. Gluckman and published by . This book was released on 2015 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explaining the practical implications of new discoveries in 'life-course biology', Nutrition and Lifestyle for Pregnancy and Breastfeeding is an informed resource on factors that affect offspring development. The impact of parental lifestyle and behavioural choices influence not only fetal development and birth outcomes, but also postnatal development, yet guidance on appropriate diet, behaviour, and exposures during pregnancy is often confusing and contradictory. With accessible explanations of the latest scientific research, and clear summaries and recommendations, this book is a valuable and authoritative guide for all levels of health care providers. The authors provide an overview of the background evidence, highlighting the importance of lifestyle choices prior to and during pregnancy. In-depth discussions of nutritional and lifestyle factors that impact on pregnancy and offspring outcomes are based on the latest research and exploration of key scientific studies. Nutrition and Lifestyle for Pregnancy and Breastfeeding is a manual offering both scientific and clinical evidence to empower health care providers and ensure they have the information necessary to confidently care for prospective and new parents.
Download or read book Selenium in the Environment and Human Health written by Gary S. Banuelos and published by CRC Press. This book was released on 2013-11-29 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Selenium is arguably the naturally occurring trace element of greatest concern worldwide. In excessive amounts it can lead to toxicosis and teratogenesis in animals, while the impact of selenium deficiency can be even more significant. Contributors from 22 countries explored the connections and inter-relationships between selenium in the environmen
