Download or read book Cystogenesis written by Jong Hoon Park and published by Springer. This book was released on 2016-10-12 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Download or read book Podocytopathy written by Z.-H. Liui and published by Karger Medical and Scientific Publishers. This book was released on 2014-05-16 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.
Download or read book GENERATION ECCH written by Jason Cohen and published by Touchstone. This book was released on 1994-08-24 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Haunted by the spectre of the Beats and the Boomers, the Hippies and the Punks, today's twentysomethings are desperate for anything that gives them a generational self-image. This waggishly ironic book takes a riotous jab at the Generation X/twentysomething phenomenon and examines various aspects of their pop culture, including music, literature, and politics.
Download or read book Perspectives on Design and Digital Communication written by Nuno Martins and published by Springer Nature. This book was released on 2020-07-09 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book shares new research findings and practical lessons learned that will foster advances in digital design, communication design, web, multimedia and motion design, graphic design and branding, and other related areas. It gathers the best papers presented at the 3rd International Conference on Digital Design and Communication, DIGICOM 2019, held on November 15–16, 2019, in Barcelos, Portugal. The respective contributions highlight new theoretical perspectives and practical research directions in design and communication, aimed at promoting their use in a global, digital world. The book offers a timely guide and a source of inspiration for designers of all kinds (Graphic, Digital, Web, UI & UX Design and Social Media), for researchers, advertisers, artists, entrepreneurs, and brand or corporate communication managers, and for teachers and advanced students.
Download or read book Service Design Capabilities written by Nicola Morelli and published by Springer Nature. This book was released on 2020-08-27 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book discusses service design capabilities in innovation processes, and provides a framework that guides design students, practitioners and researchers towards a better understanding of operational aspects of service design processes. More specifically, it revisits service designers’ capabilities in light of the new roles that have opened up in innovation processes on different scales. After years of being inadequately defined, the professional profile of service designers is now taking shape. Today private and public institutions recognize service designers as essential contributors to their innovation and development processes. What are the capabilities that characterize a service designer? These essential capabilities are what service designers should acquire in their education and can sell when looking for a job.
Download or read book A Series of Plays in which it is Attempted to Delineate the Stronger Passions of the Mind Each Passion Being the Subject of a Tragedy and a Comedy written by Joanna Baillie and published by . This book was released on 1806 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Perspectives on Design and Digital Communication II written by Nuno Martins and published by Springer Nature. This book was released on 2021-05-29 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers new empirical findings fostering advances in the areas of digital and communication design, web, multimedia and motion design, graphic design, branding, and related ones. It includes original contributions by authoritative authors based on the best papers presented at the 4th International Conference on Digital Design and Communication, Digicom 2020, together with some invited chapters written by leading international researchers. They report on innovative design strategies supporting communication in a global, digital world, and addressing, at the same time, key individual and societal needs. This book is intended to offer a timely snapshot of technologies, trends and challenges in the area of design, communication and branding, and a bridge connecting researchers and professionals of different disciplines, such as graphic design, digital communication, corporate, UI Design and UX design. Chapter “Definition of a Digital Tool to Create Physical Artifacts: The Case of the Gamers4Nature Project” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Download or read book Mind and Places written by Anna Anzani and published by Springer Nature. This book was released on 2020-05-12 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the contributions of psychological, neuroscientific and philosophical perspectives to the design of contemporary cities. Pursuing an innovative and multidisciplinary approach, it addresses the need to re-launch knowledge and creativity as major cultural and institutional bases of human communities. Dwelling is a form of knowledge and re-invention of reality that involves both the tangible dimension of physical places and their mental representation. Findings in the neuroscientific field are increasingly opening stimulating perspectives on the design of spaces, and highlight how our ability to understand other people is strongly related to our corporeity. The first part of the book focuses on the contributions of various disciplines that deal with the spatial dimension, and explores the dovetailing roles that science and art can play from a multidisciplinary perspective. In turn, the second part formulates proposals on how to promote greater integration between the aesthetic and cultural dimension in spatial design. Given its scope, the book will benefit all scholars, academics and practitioners who are involved in the process of planning, designing and building places, and will foster an international exchange of research, case studies, and theoretical reflections to confront the challenges of designing conscious places and enable the development of communities.
Download or read book AWI 1 written by United States. Department of Agriculture and published by . This book was released on with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design for Ergonomics written by Francesca Tosi and published by Springer Nature. This book was released on 2019-11-21 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the global quality of the design of systems that people interact with during their work activities and daily lives; a quality that involves the globality of people’s experience – physical, sensory, cognitive and emotional. It presents a concise and structured overview of the ergonomic approach to planning, and of methodological and operational tools from ergonomic research that can more directly and concretely contribute to the design process. The book also explores physical ergonomics and cognitive ergonomics, which are essential components of design culture. The final section addresses the main design problems and intervention criteria regarding the design of environments, products and equipment, as well as the design of communication, training and learning interface systems based on digital technologies. The book is chiefly intended for designers and anyone interested in the methods, tools and opportunities for in-depth analysis and development that ergonomics can offer regarding the conception, production and testing of products, environments and services, whether physical or virtual. It also offers a learning resource for professionals and students in Industrial Design and Planning.
Download or read book In Spite of Myself written by Christopher Plummer and published by Vintage Canada. This book was released on 2009-10-06 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Canada’s most celebrated and acclaimed actor lets loose in a magnificent memoir that will delight and enchant readers across the country. A rollicking, rich self-portrait written by one of today’s greatest living actors. The story of a “young wastrel, incurably romantic, spoiled rotten” – his privileged Montreal background, rich in Victorian gentility, included steam yachts, rare orchid farms, music lessons in Paris and Berlin – “who tore himself away from the ski slopes to break into the big, bad world of theater not from the streets up but from an Edwardian living room down.” Plummer writes of his early acting days – on radio and stage with William Shatner and other fellow Canadians; of the early days of the Stratford Festival in southern Ontario; of his Broadway debut at twenty-four in The Starcross Story, starring Eva Le Gallienne (“It opened and closed in one night, but what a night!”); of joining Peter Hall’s Royal Shakespeare Company (its other members included Judi Dench, Vanessa Redgrave and Peter O’Toole); of his first picture, Stage Struck, directed by Sidney Lumet; and of The Sound of Music, which he affectionately dubbed “S&M.” He writes about his legendary colleagues: Dame Judith Anderson (“the Tasmanian devil from Down Under”); Sir Tyrone Guthrie; Sir Laurence Olivier; Elia Kazan (“this chameleon of chameleons might change into you, wear your skin, steal your soul”); and “that reprobate” Jason Robards, among many others. A revelation of the wild and exuberant ride that is the actor’s – at least this actor’s – life.
Download or read book Visualizing the Data City written by Paolo Ciuccarelli and published by Springer Science & Business Media. This book was released on 2014-02-17 with total page 79 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book investigates novel methods and technologies for the collection, analysis and representation of real-time user-generated data at the urban scale in order to explore potential scenarios for more participatory design, planning and management processes. For this purpose, the authors present a set of experiments conducted in collaboration with urban stakeholders at various levels (including citizens, city administrators, urban planners, local industries and NGOs) in Milan and New York in 2012. It is examined whether geo-tagged and user-generated content can be of value in the creation of meaningful, real-time indicators of urban quality, as it is perceived and communicated by the citizens. The meanings that people attach to places are also explored to discover what such an urban semantic layer looks like and how it unfolds over time. As a conclusion, recommendations are proposed for the exploitation of user-generated content in order to answer hitherto unsolved urban questions. Readers will find in this book a fascinating exploration of techniques for mining the social web that can be applied to procure user-generated content as a means of investigating urban dynamics.
Download or read book Inspire a Dream written by Steve Riach and published by . This book was released on 2000 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Football is built upon the dreams of players like Kurt Warner, who was told he didn't have what it takes to play at the professional level. It's about people like Mike Singletary, whowas told he was too small to ever make it big. It's about Steve Largent, who was told he was too slow to accel.These are men who have been inspired by a dream and, in turn, inspired other to dream with them and follow. They prove that true champions are not swayed by circumstances, labels, or past exzperiences, but rather are driven by a force within that pushes them to become something greater than they could have become by themselves.They are men who inspire us to push beyond our own limitations to reach our destiny.The dream is about what we are not yet, but can become.Highlighted by comments from some of the game's greatest players, a stunning collection of phototgraphs from Tom Henry, and the classic writing of author Steve Riach, this one-of-a-kind book reflect contemporary images and makes memories for tomorrow.
Download or read book A Nun s Story written by Sister Agatha and published by Metro Publishing. This book was released on 2017-01-05 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: THE SUNDAY TIMES BESTSELLER Shirley Leach lived in a world of extreme comfort, wealth and status. With every good thing life had to offer, she was due to marry the man she loved a man who, in turn, adored her. But all this was to change in a single moment. One happy day, in the midst of writing to her fiancée, her hand stopped writing unbidden; then it continued by itself, etching the words which would change her life forever:...but there's no point now, as I am going to be a nun.That bolt from the blue set events in motion that caused Shirley to lose her mother and sisters, her husband to be, her horses, her parties and life of ease. Within months, Shirley had become Sister Agatha. But her faith in her choice never faltered, despite years of great difficulty when her Convent was close to bankruptcy. Her belief took her to London to knock on the infamously intimidating and tight-fisted Sir Paul Getty's door to secure the money to ensure her community would not lose their home....and getting it. Now eighty-five, she looks back on an incredible life of love, loss and belief. This is at once a deeply poignant tale of doomed romance, and a heart-warming story of taking a leap of faith and finding a meaning in life beyond the wealth and comfort she was born into. Whether a believer or not, Sister Agatha's momentous life will touch and inspire, whilst reminding us that it is perhaps better to accept that not everything in the world is yet explained.
Download or read book Graphical Heritage written by Luis Agustín-Hernández and published by Springer Nature. This book was released on 2020-05-11 with total page 791 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the proceedings of the 18th International Conference on Graphic Design in Architecture, EGA 2020, focusing on heritage – including architectural and graphic heritage as well as the graphics of heritage. This first volume gathers selected contributions covering theories, and new technologies and findings to help shed light on current questions related to heritage. It features original documentation studies on historical archives, 3D and solid representation of architectural objects, as well as virtual graphic representation and applications of augmented reality, all documenting and/or reconstructing the present, past and future of architectural objects. As such, this book offers extensive and timely information to architectural and graphic designers, urban designers and engineers, and industrial designers and historians.
Download or read book The Chemical Muse written by D. C.A. Hillman, Ph.D. and published by Macmillan. This book was released on 2014-09-30 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The last wild frontier of classical studies." ---The Times (UK) The Chemical Muse uncovers decades of misdirection and obfuscation to reveal the history of widespread drug use in Ancient Rome and Greece. In the city-states that gave birth to Western civilization, drugs were an everyday element of a free society. Often they were not just available, but vitally necessary for use in medicine, religious ceremonies, and war campaigns. Their proponents and users existed in all classes, from the common soldier to the emperor himself. Citing examples in myths, medicine, and literature, D. C. A. Hillman shows how drugs have influenced and inspired the artists, philosophers, and even politicians whose ideas have formed the basis for civilization as we know it. Many of these ancient texts may seem well-known, but Hillman shows how timid, prudish translations have left scholars and readers in the dark about the reality of drug use in the Classical world. Hillman's argument is not simply "pro-drug." Instead, he appeals for an intellectual honesty that acknowledges the use of drugs in ancient societies despite today's conflicting social mores. In the modern world, where academia and university life are often politically charged, The Chemical Muse offers a unique and long overdue perspective on the contentious topic of drug use and the freedom of thought.
Download or read book Intellectual Property Design Innovation and Entrepreneurship written by Matthias Hillner and published by Springer Nature. This book was released on 2021-01-30 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on intellectual property (IP) in the context of product innovation and design-led start-up management. A distinguished feature is that it analyses innovation-related scenarios within their continuously changing contexts. IP is discussed in relation to the way in which its value changes over time as a venture matures. The book reveals how IP strategies can enhance a start-up’s survival prospects and its growth potential if they are connected systematically to other business development attributes. Being mainly addressed to enterprising designers, it may also support business administration programmes, innovation hubs, design educators, incubator managers, as well as business coaches and IP attorneys who support creatives and inventors. All in all, this book offers a unique and timely strategic guidance in the field of design and innovation management. “Design and design rights have long been overlooked in the plethora of studies on the links between IPR and innovation. Matthias Hillner’s thoughtful and eloquent journey provides a contemporary and meaningful analysis which will no doubt assist governments, economists, academics and designers’ better understanding of design in the context of successful business strategies and IPR. Given design’s significant contribution to global economies, I am confident it will offer much needed guidance.” Dids Macdonald OBE, founder CEO of Anticopying in Design (ACID) "This is an immensely practical book for designers and entrepreneurs who want to understand the issues of IP, product innovation, and business development. With clear explanations, many vivid examples, and strategically useful tips, it will be a valuable resource for creative minds at all levels of experience. A serious book but written with a sensitive touch on how to protect new ideas." Richard Buchanan, Professor of Design, Management, and Innovation, Weatherhead School of Management, Case Western Reserve University
