Download or read book Drug Discovery and Development Volume 1 written by Mukund S. Chorghade and published by Wiley-Interscience. This book was released on 2006-06-16 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: From first principles to real-world applications -- here is the first comprehensive guide to drug discovery and development Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines--from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process. The only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview of the entire sequence of operations involved in drug discovery and development--from initial conceptualization to commercialization to clinicians and medical practitioners. Volume 1: Drug Discovery describes all the steps in the discovery process, including conceptualizing a drug, creating a library of candidates for testing, screening candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and modifying a drug as necessary. Volume 2: Drug Development delves into the nitty-gritty details of optimizing the synthetic route, drug manufacturing, outsourcing, and marketing--including drug coloring and delivery methods. Featuring contributions from a world-class team of experts, Drug Discovery and Development: * Features fascinating case studies, including the discovery and development of erythromycin analogs, Tagamet, and Ultiva (remifentanil) * Discusses the discovery of medications for bacterial infections, Parkinson's disease, psoriasis, peptic ulcers, atopic dermatitis, asthma, and cancer * Includes chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics Drug Discovery and Development is an indispensable working resource for industrialchemists, biologists, biochemists, and executives who work in the pharmaceutical industry.

Download or read book Puccini written by Julian Budden and published by Master Musicians. This book was released on 2005 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Julian Budden provides a look at the process of putting an opera together, the cut-and-slash of nineteenth-century Italian opera, -the struggle to find the right performers for the debut of La Boheme, Puccini's anxiety about completing Turandot (he in fact died of cancer before he did so), and his animosity toward his rival Leoncavallo (whom he called Leonasino or "lion-ass"). Budden provides an analysis of the operas themselves, examining the music act by act. He highlights, among other things, the influence of Wagner on Puccini--alone among his Italian contemporaries, Puccini followed Wagner's example in bringing the motif into the forefront of his narrative, sometimes voicing the singer's unexpressed thoughts, sometimes sending out a signal to the audience of which the character is unaware. And Budden also paints a portrait of Puccini the man--talented but modest, a man who had friends from every walk of life: shopkeepers, priests, wealthy landowners, fellow artists. --From publisher's description.

Download or read book Freedom and Taboo written by Richard S. Randall and published by Univ of California Press. This book was released on 1989 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Richard Randall reinterprets pornography both as a part of the human psyche and a public policy issue. He explores the pornographic imagination in art and literature, offers a wide-ranging assessment of major empirical findings on the effects of pornography, and draws on historical and anthropological data to show how social rules and institutions have mirrored the ambivalence we feel toward sexual expression. Freedom and Taboo argues that pornography is likely to be a major, continuing public issue for democratic society.

Download or read book Index of Patents Issued from the United States Patent Office written by and published by . This book was released on 1982 with total page 2252 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Index of Patents Issued from the United States Patent and Trademark Office written by and published by . This book was released on 1982 with total page 2252 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Fibrosis Research written by John Varga and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading investigators review the highlights of current fibrosis research and the experimental methodologies used uncover the mechanisms that drive it. In their discussion of research methodologies utilizing cultured cells to model various aspects of the fibrotic response in vitro, the authors describe the isolation, characterization, and propagation of mesenchymal cells, and highlight the similarities and differences between methods that are appropriate for different types of fibroblasts. Approaches for studying collagen gene regulation and TGF-b production are also discussed, along with experimental methodologies utilizing animal models to study the pathogenesis of fibrosis. The protocols follow the successful Methods in Molecular MedicineTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.

Download or read book Community Acquired Pneumonia written by Norbert Suttorp and published by Birkhäuser. This book was released on 2009-09-03 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Community-acquired pneumonia (CAP) is a disease associated with high morbidity and mortality. The goal of this volume is to present state-of-the-art knowledge on epidemiology, clinical presentation, immunology, pathology, and diagnosis of CAP including the identification of "new pathogens". Therapeutic approaches, antibiotics resistance, disease management and vaccination strategies are also covered.

Download or read book Real time PCR in Microbiology written by and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The editor and authors have produced an excellent book that will be extremely useful for all microbiologists. A recommended book for all microbiology laboratories.

Download or read book Clinical Hepatology written by G. Csomos and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatology has come of age in the last decades. Biology of the liver has flour ished long before. As the largest homogeneous organ of the body the liver served as useful model in the development of biochemistry and related discip lines. Only gradually were these biological investigations applied to the clinical study of liver disease. This was particularly stimulated by the recognition that in the greater part of the world, the developing countries and what we now call the Third World, liver disease represents a major threat to overall public health. It leads to morbidity and mortality of persons in their productive years from liver cancer, cirrhosis and parasitic disease, particularly, schistosomiasis. Moreover, the growing emphasis on the social impact of diseases focused on disorders of the liver because malnutrition, poverty, and drug addiction contrib ute greatly to their spread. This is compounded by the increase of alcohol abuse, recently on the rise even in the developing countries. Concern with envi ronmental pollution has also raised the interest in liver diseases, in part because the liver acts as a guardian against polluting chemicals and in part because it is considered, possibly to an exaggerated degree, a vulnerable target of such chemicals.

Download or read book Acute Surgical Management written by Nian Chih Hwang and published by World Scientific. This book was released on 2004 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute surgical emergencies constitute one of the main clinical aspects that a doctor in hospital practice is expected to handle and manage. This book addresses some of the important and common acute surgical conditions, and has been written from an Asian perspective, with extensive experimental input from practices that are more common in Europe and America. Various aspects of surgical emergencies, ranging from clinical condition to diagnosis and management, are discussed.Acute Surgical Management will be suitable for institutional clinicians and medical students, and should be especially useful to those who have some contact with patients with surgical conditions. This would include surgeons (and basic or advanced surgical trainees), emergency specialists, anaesthetists and intensivists, as well as various surgical sub-specialists.This book has been selected for coverage in: ? CC / Clinical Medicine? Index to Scientific Book Contents? (ISBC

Download or read book Tai Chi Chuan written by Youlian Hong and published by Karger Medical and Scientific Publishers. This book was released on 2008 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of current scientific research reflects the characteristics and beneficial effects of tai chi chuan in the fields of biomechanics and physiology, sensory motor control and fall prevention, psychology and social aspects, as well as in clinical application of Parkinson's disease, Alzheimer's disease, coronary heart disease, chronic heart failure, breast cancer, rheumatoid arthritis and diabetes.

Download or read book Industrial Dyes written by Klaus Hunger and published by John Wiley & Sons. This book was released on 2007-09-24 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: What would life be like without color? Ever since one can think back, color has always accompanied mankind. Dyes - originally obtained exclusively from natural sources - are today also produced synthetically on a large scale and represent one of the very mature and traditional sectors of the chemical industry. The present reference work on Industrial Dyes provides a comprehensive review of the chemistry, properties and applications of the most important groups of industrial dyes, including optical brighteners. It also outlines the latest developments in the area of functional dyes. Renowned experts in their respective fields have contributed to the chapters on chemical chromophores, synthesis and application of the various dye classes, textile dyeing and non-textile dyeing. The book is aimed at all professionals who are involved in the synthesis, production, manufacture or application of dyes and will prove to be an indispensable guide to all chemists, engineers and technicians in dye science and industry.

Download or read book Total Synthesis of Natural Products written by Stephen Hanessian and published by . This book was released on 1986 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advanced Electronic Packaging Volume 968 written by Vasudeva P. Atluri and published by . This book was released on 2007-04-09 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microelectronic packaging architecture evolutions are being driven by silicon technology advancements and new form factors, used models and emerging technologies. High-performance mobile computer and communication systems will require higher I/O counts, greater density, lower cost, lighter weight and improved performance in the electronic package. The book focuses on silicon technology dimension scaling and performance improvement, Pb-free or 'green' assembly, and system-in-package (SIP) technologies. It explores the key thermomechanical failure modes and mitigating solutions associated with integration of silicon with weak interlayer dielectrics during the assembly process, under bump metallurgy integrity with lead-free assembly, and the impact of stress on die-cracking and transistor performance in 3D thin-die stacking. The interaction of these failures with silicon and assembly materials, processes and design features is covered and includes: system in package; advanced packaging/nanotechnology in packaging; physical behavior and mechanical behavior in packaging; electromigration and thermal behavior in packaging and thin films and adhesives in packaging.

Download or read book Mechanical Engineering and Materials written by Wen Jin and published by Trans Tech Publications Ltd. This book was released on 2012-01-24 with total page 2080 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume is indexed by Thomson Reuters CPCI-S (WoS). The present papers, drawn from both academia and industry, reflect the international flavour of this event; devoted to the topics of: Materials Science and Engineering, Materials Properties, Measuring Methods and Applications, Methodology of Research and Analysis and Modelling, Materials Manufacturing and Processing, Nanoscience and Nanotechnology, Mechanical Engineering, Design and Manufacturing, etc.

Download or read book Design and Strategy in Organic Synthesis written by Stephen Hanessian and published by Wiley-VCH. This book was released on 2013-09-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This long-awaited graduate level book, written by one of the world's leading organic chemists in collaboration with two of his former and present coworkers, adopts a refreshingly unique approach to synthesis planning and execution. Following an introductory look at the concept of synthesis, the authors discuss the Why, What, and How of organic synthesis as they apply to natural products. Although emphasis is on the Chiron Approach utilizing amino-acids, carbohydrates, hydroxy acids, terpenes, lactones and other naturally occurring small molecules as starting materials, catalytic asymmetric methods are also included as a corollary whenever relevant. A must-have source of first class information for everyone working in organic synthesis, be it in academia or industry. With a foreword by Larry E. Overman and David W. C. MacMillan

Download or read book Advanced Biology written by Michael Roberts and published by Nelson Thornes. This book was released on 2000 with total page 814 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major new course text has been written by experienced authors to provide coverage of the Advanced Subsidiary (AS) and Advanced GCE Biology and Human Biology specifications in a single book. Advanced Biology provides clear, well-illustrated information, which will help develop a full understanding of biological structure and function and of relevant applications. The topics have been carefully organised into parts, which give a logical sequence to the book. This new text has been developed to replace the best-selling titles Biology: Principles and Processes and Biology, A Functional Approach. Features include: full-colour design with clear diagrams and photographs; up-to-date information on biotechnology, health, applied genetics and ecology; clearly written text using the latest Institute of Biology terminology; a useful summary and a bank of practice questions at the end of every chapter; support boxes help bridge the gap from GCSE or equivalent courses; extension boxes providing additional depth of content - some by guest authors who are experts in their field; and a comprehensive index so you can quickly locate information with ease. There is also a website providing additional support that you can access directly at www.advancedbiolgy.co.uk.