Download or read book Science and Engineering in High Throughput Biology Including a Theory on Parkinson s Disease written by Andr X. C. N. Valente and published by Lulu.com. This book was released on 2011-08 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology is shifting from its data-poor origins to a quantitative data, high-throughput regime. Accompanying this change is an increasing technical capacity to engineer biological constructs. This book is about theory in this new context for the Life Sciences. Three articles, each preceded by an explanatory introduction, are presented. They propose: * A framework for prediction in this new data-rich regime. * A theory on the systemic nature and hematopoietic origin of Parkinson's Disease. * An approach to engineering design in the biological context, in particular in Synthetic Biology.
Download or read book Novel Therapeutic Approaches to the Treatment of Parkinson s Disease written by Corey R. Hopkins and published by Springer. This book was released on 2016-06-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Download or read book Systems Biology of Parkinson s Disease written by Peter Wellstead and published by Springer Science & Business Media. This book was released on 2012-05-08 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Systems Biology of Parkinson’s Disease will be underpinned by new measurement techniques. This is particularly true of the pathology of Parkinson's Disease, where recent developments in brain imaging have offered new insights into the morphology of dopaminergic neurons that have profound implications for the special vulnerability and role of this class of neurons.
Download or read book A Molecular Biology Approach to Parkinson s Disease written by Peter Jenner and published by IOS Press. This book was released on 2000 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease is the only neurodegenerative disorder for which the major pathological and biochemical defects have been identified. But why dopamine-containing cells in the substantia nigra die in Parkinson's disease remains a mystery. Similarly, the changes in basal ganglia output pathways which lead to the onset of motor disability and the occurrence of L-DOPA induced dyskinesia remain unclear. While treatment for the symptoms of Parkinson's disease is available, nothing can presently be done to stop the disease progressing. A molecular approach to Parkinson's disease is unraveling genetic factors responsible for inducing the onset of nigral cell degeneration or for making individuals susceptible to other neutotoxic factors. Similarly, key findings in the area of mitochondrial dysfunction are now providing a new insight into the pathogenesis of Parkinson's disease. The application of molecular biochemistry to cell susceptibility and to the mechanisms of neuronal adapation occuring in basal ganglia are providing new clues to why motor abnormalities occur. Genetic engineering of cell lines, fibroblasts and viral vectors are providing means of replenishing dopamine production and introducing growth factors into the damaged basal ganglia. This book considers all these approaches and their implications for the future treatment of Parkinson's disease.
Download or read book Artificial Intelligence Theory Models and Applications written by P Kaliraj and published by CRC Press. This book was released on 2021-10-21 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the fundamentals and technologies of Artificial Intelligence (AI) and describes their tools, challenges, and issues. It also explains relevant theory as well as industrial applications in various domains, such as healthcare, economics, education, product development, agriculture, human resource management, environmental management, and marketing. The book is a boon to students, software developers, teachers, members of boards of studies, and researchers who need a reference resource on artificial intelligence and its applications and is primarily intended for use in courses offered by higher education institutions that strive to equip their graduates with Industry 4.0 skills. FEATURES: Gender disparity in the enterprises involved in the development of AI-based software development as well as solutions to eradicate such gender bias in the AI world A general framework for AI in environmental management, smart farming, e-waste management, and smart energy optimization The potential and application of AI in medical imaging as well as the challenges of AI in precision medicine AI’s role in the diagnosis of various diseases, such as cancer and diabetes The role of machine learning models in product development and statistically monitoring product quality Machine learning to make robust and effective economic policy decisions Machine learning and data mining approaches to provide better video indexing mechanisms resulting in better searchable results ABOUT THE EDITORS: Prof. Dr. P. Kaliraj is Vice Chancellor at Bharathiar University, Coimbatore, India. Prof. Dr. T. Devi is Professor and Head of the Department of Computer Applications, Bharathiar University, Coimbatore, India.
Download or read book Advances in Diagnostics and Treatment of Functional Neurological Disorders Neurogenomics Neuromodulation and Machine Learning written by Guohui Lu and published by Frontiers Media SA. This book was released on 2022-11-03 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Parkinson s Disease written by Patrik Verstreken and published by Academic Press. This book was released on 2016-12-19 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson’s Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson’s disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology. This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes. Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson’s. Written by experts in the field that focus on pathways and mechanisms implicated in Parkinson’s pathology Draws parallels between multidisciplinary discoveries in different model organisms using an array of technologies Provides a cross-methodology and cross-species approach to understanding the molecular biology of Parkinson’s disease Includes approximately 25 color Illustrations and diagrams to explain concepts and models Focuses on key pathways and mechanisms (as opposed to model organism or gene) to provide a multidisciplinary approach to Parkinson’s disease
Download or read book Experimental Models of Parkinson s Disease written by Yuzuru Imai and published by Humana. This book was released on 2022-06-11 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book focuses on cutting-edge methods for Parkinson’s disease (PD) research, such as the analysis of the prion-like properties of α-synuclein, mitochondrial functions related to the PINK1-Parkin pathway/CHCHD2, the endolysosome pathway related to LRRK2, VPS35, and ATP13A2 using cultured cells (including patient iPS cells), deep brain stimulation therapy, classic mitochondrial toxins related to PD, and genetic associations and screenings using mammalian and invertebrate genetic models of PD. The collection intends to serve as an introductory protocol book for basic research on PD pathogenesis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Experimental Models of Parkinson's Disease is an ideal guide for researchers continuing to work toward making PD risk predictable and surmountable.
Download or read book Systems Biology of Parkinson s Disease written by Peter Wellstead and published by Springer. This book was released on 2014-06-11 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Systems Biology of Parkinson’s Disease will be underpinned by new measurement techniques. This is particularly true of the pathology of Parkinson's Disease, where recent developments in brain imaging have offered new insights into the morphology of dopaminergic neurons that have profound implications for the special vulnerability and role of this class of neurons.
Download or read book Genetics Neurology Behavior and Diet in Parkinson s Disease written by Colin R. Martin and published by Academic Press. This book was released on 2020-08 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neuroscience of Parkinson's Disease: Diagnosis and Management provides a single source of material covering different scientific domains of neuropathology underlying this condition. It covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments and treatment regimens. It fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson's disease: from chemicals and cells to individuals. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field.
Download or read book Wiley Encyclopedia of Chemical Biology Volume 2 written by Tadhg P. Begley and published by Wiley-Blackwell. This book was released on 2009-02-03 with total page 820 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first major reference at the interface of chemistry, biology, and medicine Chemical biology is a rapidly developing field that uses the principles, tools, and language of chemistry to answer important questions in the life sciences. It has enabled researchers to gather critical information about the molecular biology of the cell and is the fundamental science of drug discovery, playing a key role in the development of novel agents for the prevention, diagnosis, and treatment of disease. Now students and researchers across the range of disciplines that use chemical biology techniques have a single resource that encapsulates what is known in the field. It is an excellent place to begin any chemical biology investigation. Major topics addressed in the encyclopedia include: Applications of chemical biology Biomolecules within the cell Chemical views of biology Chemistry of biological processes and systems Synthetic molecules as tools for chemical biology Technologies and techniques in chemical biology Some 300 articles range from pure basic research to areas that have immediate applications in fields such as drug discovery, sensor technology, and catalysis. Novices in the field can turn to articles that introduce them to the basics, whereas experienced researchers have access to articles exploring the cutting edge of the science. Each article ends with a list of references to facilitate further investigation. With contributions from leading researchers and pioneers in the field, the Wiley Encyclopedia of Chemical Biology builds on Wiley's unparalleled reputation for helping students and researchers understand the crucial role of chemistry and chemical techniques in the life sciences.
Download or read book Encyclopedia of Cardiovascular Research and Medicine written by and published by Elsevier. This book was released on 2017-11-27 with total page 2800 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Cardiovascular Research and Medicine offers researchers over 200 articles covering every aspect of cardiovascular research and medicine, including fully annotated figures, abundant color illustrations and links to supplementary datasets and references. With contributions from top experts in the field, this book is the most reputable and easily searchable resource of cardiovascular-focused basic and translational content for students, researchers, clinicians and teaching faculty across the biomedical and medical sciences. The panel of authors chosen from an international board of leading scholars renders the text trustworthy, contemporary and representative of the global scientific expertise in these domains. The book's thematic structuring of sections and in-depth breakdown of topics encourages user-friendly, easily searchable chapters. Cross-references to related articles and links to further reading and references will further guide readers to a full understanding of the topics under discussion. Readers will find an unparalleled, one-stop resource exploring all major aspects of cardiovascular research and medicine. Presents comprehensive coverage of every aspect of cardiovascular medicine and research Offers readers a broad, interdisciplinary overview of the concepts in cardiovascular research and medicine with applications across biomedical research Includes reputable, foundational content on genetics, cancer, immunology, cell biology and molecular biology Provides a multi-media enriched color-illustrated text with high quality images, graphs and tables.
Download or read book CMBEBIH 2019 written by Almir Badnjevic and published by Springer. This book was released on 2019-05-10 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume gathers the proceedings of the International Conference on Medical and Biological Engineering, which was held from 16 to 18 May 2019 in Banja Luka, Bosnia and Herzegovina. Focusing on the goal to ‘Share the Vision’, it highlights the latest findings, innovative solutions and emerging challenges in the field of Biomedical Engineering. The book covers a wide range of topics, including: biomedical signal processing, medical physics, biomedical imaging and radiation protection, biosensors and bioinstrumentation, bio-micro/nano technologies, biomaterials, biomechanics, robotics and minimally invasive surgery, and cardiovascular, respiratory and endocrine systems engineering. Further topics include bioinformatics and computational biology, clinical engineering and health technology assessment, health informatics, e-health and telemedicine, artificial intelligence and machine learning in healthcare, as well as pharmaceutical and genetic engineering. Given its scope, the book provides academic researchers, clinical researchers and professionals alike with a timely reference guide to measures for improving the quality of life and healthcare.
Download or read book Foundations of Regenerative Medicine written by Anthony Atala and published by Academic Press. This book was released on 2009-09-04 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interdisciplinary field of regenerative medicine holds the promise of repairing and replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Derived from the fields of tissue engineering, cell and developmental biology, biomaterials science, nanotechnology, physics, chemistry, physiology, molecular biology, biochemistry, bioengineering, and surgery, regenerative medicine is one of the most influential topics of biological research today. Derived from the successful Principles of Regenerative Medicine, this volume brings together the latest information on the advances in technology and medicine and the replacement of tissues and organs damaged by disease. Chapters focus on the fundamental principles of regenerative therapies that have crossover with a broad range of disciplines. From the molecular basis to therapeutic applications, this volume is an essential source for students, researchers, and technicians in tissue engineering, stem cells, nuclear transfer (therapeutic cloning), cell, tissue, and organ transplantation, nanotechnology, bioengineering, and medicine to gain a comprehensive understanding of the nature and prospects for this important field. Highlights the fundamentals of regenerative medicine to relate to a variety of related science and technology fields Introductory chapter directly addresses why regenerative medicine is important to a variety of researchers by providing practical examples and references to primary literature Includes new discoveries from leading researchers on restoration of diseased tissues and organs
Download or read book Principles of Regenerative Medicine written by Anthony Atala and published by Academic Press. This book was released on 2011-04-28 with total page 1473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. * Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology* The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine* New discoveries from leading researchers on restoration of diseased tissues and organs
Download or read book Volatile Biomarkers written by Cristina Davis and published by Newnes. This book was released on 2013-03-27 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volatile organic compounds (VOCs) in exhaled breath, sweat or urine carry much information on the state of human health. The role of VOCs in clinical diagnosis and therapeutic monitoring is expected to become increasingly significant due to recent advances in the field. Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine includes the latest discoveries and applications for VOCs from the world's foremost scientists and clinicians working in this emerging analytic area. Appeals to a multidisciplinary audience, including scientists, researchers, and clinicians with an interest in breath analysis Features the latest scientific research and technical breakthroughs in the diagnostic and therapeutic aspects of volatile organic compounds Includes case presentations documenting applications in multiple areas of human health and safety
Download or read book Expenditure Budget written by India and published by . This book was released on 2009 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:
