Download or read book Retinal Prosthesis System for Advanced Retinitis Pigmentosa written by and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods We performed a systematic search of the literature for studies examining the effects of the Argus II retinal prosthesis system in patients with advanced retinitis pigmentosa, and appraised the evidence according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) Working Group criteria, focusing on visual function, functional outcomes, quality of life, and adv [...] This pass-through payment status covers the placement of a subconjunctival retinal prosthesis receiver and pulse generator, and the implantation of intraocular retinal electrode array with vitrectomy.8 In addition, the new technology add-on payment provides inpatient payment for the Argus II system.9 Research Questions What is the clinical effectiveness and safety of the Argus II retinal prosthe [...] What is the cost-effectiveness of the Argus II retinal prosthesis system compared with standard care in treating patients with retinitis pigmentosa in the context of the Ontario Ministry of Health and Long-Term Care? [...] What is the budget impact of implementing the Argus II system over the next 5 years from the perspective of the Ontario Ministry of Health and Long-Term Care? [...] Statistical Analysis We did not pool the results of the studies, because of the small number of studies included and the heterogeneous outcomes reported.

Download or read book Retinal Prosthesis System for Advanced Retinitis Pigmentosa written by and published by . This book was released on 2016 with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Retinitis pigmentosa is a group of genetic disorders that involves the breakdown and loss of photoreceptors in the retina, resulting in progressive retinal degeneration and eventual blindness. The Argus II Retinal Prosthesis System is the only currently available surgical implantable device approved by Health Canada. It has been shown to improve visual function in patients with severe visual loss from advanced retinitis pigmentosa. The objective of this analysis was to examine the clinical effectiveness, cost-effectiveness, budget impact, and safety of the Argus II system in improving visual function, as well as exploring patient experiences with the system."--Abstract.

Download or read book Retinal Prosthesis System for Advanced Retinitis Pigmentosa written by and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: However, the committee also recommended that Health Quality Ontario re-evaluate the evidence in 1 year, because new evidence about the effectiveness of the system was emerging.2 This health technology assessment update looked at new evidence on the clinical benefits and harms, cost-effectiveness, and patient experiences of the Argus II system in patients with bare to no light perception from advan [...] Since the publication of the 2016 health technology assessment1 and the related Ontario Health Technology Advisory Committee recommendation,2 the Argus II system has received the following funding and reimbursement approvals: In November 2016, the United States Centers for Medicare and Medicaid Services finalized its reimbursement of the payment for the surgical procedure and the cost of the Arg [...] Statistical Analysis We did not pool the results of the studies because of the small number of studies included and the heterogeneous outcomes reported. [...] The role of the expert advisor was to provide advice on research questions, review methods and results, and contextualize the evidence for the effectiveness and safety of the Argus II retinal prosthesis system. [...] The study design and inclusion criteria are described in the 2016 health technology assessment.1 One study presented the 5-year follow-up results for the predefined efficacy and safety outcomes.19 Two studies described the 3-year follow-up results for observer-rated functional vision8 and vision-related quality of life.20 One study described the performance of real-world functional vision tasks ov.

Download or read book Retinal Prosthesis written by Mark S. Humayun and published by Springer. This book was released on 2018-01-17 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intended as a useful and practical guide primarily oriented toward ophthalmic practitioners involved in retinal prosthesis implantation and post-operative visual rehabilitation, this book focuses on the Argus II Retinal Prosthesis and its revolutionary incorporation into the practice. The reader will get an update on patient selection, expected visual outcomes, surgical implantation techniques, and post-operative visual rehabilitation. Retinal Prosthesis - A Clinical Guide to Successful Implementation is written in a clear and concise manner and includes diagrams and high quality photographs to demonstrate best practices in surgical techniques and desired outcomes. Covering topics such as history of retinal prostheses, bioengineering considerations, clinical therapies, and other therapies and future directions, this book is written for practicing ophthalmologists, residents, and medical students interested in retinal implants.

Download or read book Visual Prosthesis written by Jeffrey N. Weiss and published by Springer Nature. This book was released on 2022-08-22 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the millions of people with untreatable blindness the thought of a visual prosthesis that would allow them to live a normal life has always been a distant hope. There have been intermittent bright spots that periodically fan that hope such as when Dr. Dobelle’s visual prosthesis patient drove a car in an empty parking lot. This book will serve as an update of the work in developing a visual prosthesis. Chapters discuss the physiologic and engineering issues, alternative strategies, and patents, as well as recent research studies. Visual Prosthesis - A Concise Guide is a must-have resource for ophthalmologists, neurologists, engineers and physicists.

Download or read book Artificial Sight written by Mark S. Humayun and published by Springer Science & Business Media. This book was released on 2007-09-30 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes advances in implantable neural stimulation technology to restore partial sight to people who are blind from retinal degnerative diseases such as age-related macular degeneration and retintis pigmentosa. Many scientific, engineering, and surgical challenges must be surmounted before widespread practical applications can be realized. The book summarizes the state of research and clinical practice in the field and reviews the current ideas and approaches of its leading researchers and practitioners.

Download or read book Artificial Vision written by Veit Peter Gabel and published by Springer. This book was released on 2016-11-24 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents and analyses the most recent research dedicated to restoring vision in individuals who are severely impaired or blind from retinal disease or injury. It is written by the leading groups worldwide who are at the forefront of developing artificial vision. The book begins by discussing the difficulties in comparing and interpreting functional results in the area of very low vision and the principal prospects and limitations of spatial resolution with artificial tools. Further on, chapters are included by researchers who stimulate the surface or the pigment epithelial side of the retina and by experts who work on stimulating the optic nerve, the lateral geniculate body and the superficial layers of the visual cortex. Artificial Vision: A Clinical Guide collates the most recent work of key artificial vision research groups to explain in a comparable and stringent order their varying approaches, the clinical or preclinical outcomes and their achievements during the last years. Senior ophthalmic fellows and academic practitioners will find this guide to be an indispensable resource for understanding the current status of artificial vision.

Download or read book Visual Prosthesis and Ophthalmic Devices written by Joyce Tombran-Tink and published by Springer Science & Business Media. This book was released on 2007-12-08 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details the latest technology in treating eye injuries and infections. It provides insight into the most up-to-date and established treatment options. The volume focuses on what can currently be achieved with a variety of ocular prostheses as well as what the future holds. Coverage reviews issues such as intraocular lens implants, biocompatibility of materials, retinal implants, testing models, and software designs.

Download or read book Webvision written by Helga Kolb and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Visual Prosthetics written by Gislin Dagnelie and published by Springer Science & Business Media. This book was released on 2011-02-19 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Visual Prosthetics provides an in-depth analysis of the principles of operation, current state, anticipated developments, and functional aspects of visual prosthetics restoring sight to visually impaired individuals. This volume uniquely describes the human visual system in health and disease in a pedagogical and didactic manner, fitting to professionals and researchers with a bioengineering background. Readers will find a balanced overview of electrical, molecular chemical and synthetic chromophore stimulation, in addition to the biophysics and psychological aspects of vision restoration. Unlike competitive texts, this introduction also includes the need and methods for functional evaluation and rehabilitation. Professionals in the field of biomedical engineering and graduate and postgraduate researchers will find Visual Prosthetics a valuable reference.

Download or read book Retinal Implant 26 Success Secrets 26 Most Asked Questions on Retinal Implant What You Need to Know written by Tammy Forbes and published by Emereo Publishing. This book was released on 2014-02 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: A retinal implant is a Biomedical implant technics at the moment being elaborated by a numeral of undisclosed businesses and study establishments international. The implant is denoted to partly reinstate practical apparition to folks whoever have missed their apparition expected to degenerative eye states such like retinitis pigmentosa either macular deterioration. There has never been a Retinal implant Guide like this. It contains 26 answers, much more than you can imagine; comprehensive answers and extensive details and references, with insights that have never before been offered in print. Get the information you need--fast! This all-embracing guide offers a thorough view of key knowledge and detailed insight. This Guide introduces what you want to know about Retinal implant. A quick look inside of some of the subjects covered: Neurostimulation - Visual Prosthesis, Visual prosthetic - Photovoltaic Retinal Prosthesis, Retinal implant - Advantages, Neurostimulation - Stimulation Microelectrode Technologies, Retinal implant - Design Principles, Neurochip - Applications, Retinitis pigmentosa - Research, Retinal implant - Clinical Studies, Retinal implant - Types of Retinal Implants, Retinal implant - Candidates, Retinal implant - Spatial Resolution, Retinal implant - Disadvantages, Retinitis pigmentosa - Treatment, Foundation Fighting Blindness - Research and Clinical Trials, Argus Retinal Prosthesis - Design, Visual prosthesis - Photovoltaic Retinal Prosthesis, Cyborg - In medicine, Brain-computer interface - BCI versus neuroprosthetics, Visual prosthetic - Tuuml;bingen MPDA Project Alpha IMS, Retinal implant - History, and much more...

Download or read book Handbook of Neuroengineering written by Nitish V. Thakor and published by Springer Nature. This book was released on 2023-02-02 with total page 3686 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook serves as an authoritative reference book in the field of Neuroengineering. Neuroengineering is a very exciting field that is rapidly getting established as core subject matter for research and education. The Neuroengineering field has also produced an impressive array of industry products and clinical applications. It also serves as a reference book for graduate students, research scholars and teachers. Selected sections or a compendium of chapters may be used as “reference book” for a one or two semester graduate course in Biomedical Engineering. Some academicians will construct a “textbook” out of selected sections or chapters. The Handbook is also meant as a state-of-the-art volume for researchers. Due to its comprehensive coverage, researchers in one field covered by a certain section of the Handbook would find other sections valuable sources of cross-reference for information and fertilization of interdisciplinary ideas. Industry researchers as well as clinicians using neurotechnologies will find the Handbook a single source for foundation and state-of-the-art applications in the field of Neuroengineering. Regulatory agencies, entrepreneurs, investors and legal experts can use the Handbook as a reference for their professional work as well.​

Download or read book Implantable Electronic Medical Devices written by Dennis Fitzpatrick and published by Elsevier. This book was released on 2014-11-05 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Implantable Electronic Medical Devices provides a thorough review of the application of implantable devices, illustrating the techniques currently being used together with overviews of the latest commercially available medical devices. This book provides an overview of the design of medical devices and is a reference on existing medical devices. The book groups devices with similar functionality into distinct chapters, looking at the latest design ideas and techniques in each area, including retinal implants, glucose biosensors, cochlear implants, pacemakers, electrical stimulation therapy devices, and much more. Implantable Electronic Medical Devices equips the reader with essential background knowledge on the application of existing medical devices as well as providing an introduction to the latest techniques being used. A catalogue of existing implantable electronic medical devices Up-to-date information on the design of implantable electronic medical devices Background information and reviews on the application and design of up-to-date implantable electronic medical devices

Download or read book High Resolution Photovoltaic Retinal Prosthesis written by James Loudin and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Age-related blindness has become a critical issue as life expectancies continue to rise. Age-related Macular Degeneration (AMD) is the leading cause of blindness in the developed world, with an incidence of 1:500 in patients age 55-64, and 1:8 in patients over 85. Retinitis Pigmentosa (RP) is the leading cause of inherited blindness, occurring in about 1 in every 4000 births. This disease afflicts patients starting in their early 20s, leaving them blind for the most productive period of their lives. Both diseases are characterized by the degeneration of the "image capturing" photoreceptor layer of the retina, while neurons in the "image processing" inner retinal layers are relatively well preserved. AMD progression can be delayed, but not prevented, while there is currently no effective treatment for RP. Visual prostheses seek to restore visual sensation to patients suffering from these diseases by electrically stimulating surviving retinal nerve cells via chronically implanted electrode arrays, in the visual analog of the successful cochlear implant. Several existing technologies have been evaluated in laboratory settings and in patients, but like the cochlear implant, all are tethered to implanted wire coil systems which deliver power to the neural stimulators. To date the most successful prostheses have enabled blind patients to read large fonts. However, the perceptual resolution of current systems is quite low - less than 10 pixels/mm2, geometrically corresponding to visual acuity below 20/1200. The presented work describes the design and initial testing of a high resolution, photovoltaic retinal prosthesis in which power and data are directly delivered to photodiodes within each pixel using pulsed, near-infrared light. This direct optical data delivery maintains the natural link between eye movements and visual stimulus, while the lack of a separate power delivery system greatly simplifies the implantation of an array of such pixels, thereby decreasing the risk of surgical complications. All pixels operate autonomously, obviating the need for a wiring array and allowing separate arrays to be independently placed in different areas of the subretinal space. A goggles-mounted camera captures images of the visual scene, which are processed by a pocket computer before being projected onto the pixel array by a near-to-eye projection system. This projection system is similar to commercially available video goggles, but approximately 1000 times brighter, requiring the use of novel laser projection and de-speckling techniques. The charge injection characteristics of several dozen different circuit designs and electrode geometries were measured, before were selecting two for fabrication with 16, 64, and 256 pixels/mm2. Initial tests have been performed with both single and three-diode pixels. Previous work on blind rats implanted with subretinal photodiode arrays has recorded neural activity in response to an infrared flash. However, these recordings were made from electrodes in the superior colliculus region of the brain, and therefore yield little insight into the retinal stimulation dynamics. To probe this space, we have measured photovoltaic stimulation responses from ex vivo rat retinas sandwiched between 512-microelectrode recording array and a photovoltaic stimulating array. Stimulated ganglion cell spikes were observed with latencies in the 1-100ms range, and with peak irradiance stimulation thresholds varying from 0.1 to 1.0 mW/mm2. The elicited response disappeared upon the addition of synaptic blockers, indicating that stimulation is mediated by the inner retina rather than the ganglion cells directly, and raising hopes that a subretinal photovoltaic prosthesis will preserve some of the retina's natural signal processing.

Download or read book The Argus II Retinal Prosthesis System written by Edward Bloch and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of retinal prosthetics has seen significant advances in the past 3 decades. Encouraging results from different groups have shown coarse objective functional improvement, using a range of technological and surgical approaches. The Argus II retinal prosthesis system was the first of its kind to receive regulatory approval for commercial use in Europe and the USA. The device is designed to replicate the function of photoreceptors in converting visual information into electrical neural signals in patients with profound visual loss secondary to degenerative retinal disease. Results from a phase II study of 30 patients have demonstrated improved performance in basic tests of visual function, object recognition, letter reading, prehension, orientation and mobility tasks. It is now the most widely implanted retinal prosthetic device worldwide. This chapter provides an overview of the requirements of a retinal prosthetic system, the results from the Argus II device to date, and an insight into some of the challenges and future directions of visually restorative therapies.

Download or read book Implantable Devices for a Retinal Prosthesis Design and Electromagnetic and Thermal Effects written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A retinal prosthesis, wherein electrical stimulation is provided to the retina of a person inflicted with outer retinal degenerative diseases such as Retinitis Pigmentosa and Age-related Macular degeneration, has been clinically tested and has succeeded in providing limited vision; such as shape recognition. It is hoped that an increased electrode count will improve visual acuity. The retinal prosthesis considered in this work is a dual-unit system with an external (outside the human body) unit and an internal (inside the body) unit with a wireless link for power and data transfer between them. Such a system poses possible health risks due to the incident electromagnetic energy of the wireless link and the power dissipated by the internal components, particularly the processing chip which drives the electrodes responsible for eliciting a neural response from the retina. Tissue damage via heating is one the primary concerns for such a system making it necessary to obtain via simulation and in-vivo and in-vitro experiments, accurate estimates of thermal elevation due to the operation of the such devices. In this work, numerical methods have been developed to compute temperature increases and electromagnetic effects due to the prosthesis components in anatomically correct human head models. The explicit and the Alternating-Direction Implicit (ADI) Finite-Difference Time-Domain (FDTD) have been used. Further, a hybrid explicit-ADI method was developed for the heat equation which provided simulation speedup of more than 10x over conventional methods for the models considered. FDTD methods were employed to compute the induced current densities and Specific Absorption Rate (SAR) in the human head due the inductive link comprising the primary coil (external) and a secondary coil (internal). Different orientations of the primary coil were considered in a frequency range of 1 MHz-20 MHz to provide guidelines for choosing eventual frequency and power parameters to conform to i.

Download or read book Towards a Completely Implantable Light Sensitive Intraocular Retinal Prosthesis written by and published by . This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: An electronic retinal prosthesis is under development to treat retinitis pigmentosa and age-related macular degeneration, two presently incurable diseases of the outer retina that afflict millions world-wide. Previous studies have established the feasibility of the retinal prosthesis. Short-term tests in blind humans have shown that degenerated retina will respond to light in a way that is consistent with form vision. Postmortem analysis of human eyes with RP and AMD show a significant survival of inner retinal cells despite near complete degeneration of the photoreceptors in the outer retina. Long-term implants have demonstrated that the retina can tolerate the physical presence of an electrode array without degenerating due to pressure or other mechanical affects.