Download or read book Recent Advances in Volatile Organic Compound Analysis as Diagnostic Biomarkers written by Natalia Drabińska and published by Mdpi AG. This book was released on 2022-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volatile organic compounds (VOCs) are a diverse group of carbon-based molecules that are volatile at ambient temperatures and are emitted by an organism as a result of metabolic processes of cells and associated microbiome. The qualitative and quantitative profile of VOCs in biological fluids can vary depending on the physiological changes. Therefore, the pattern of volatile metabolites may reflect the presence of several diseases. This has been intensively investigated in the last few decades, resulting in an increasing number of studies focused on new volatile biomarker discovery. This reprint aimed to summarize the recent findings related to VOCs detected in various biological fluids such as breath, urine and feces for biomedical applications. The content covers various topics, including but not limited to biomedical/medical application of VOC analysis, biomarker discovery, and novel approaches for sampling and analyzing VOCs.
Download or read book Volatile Biomarkers written by Cristina Davis and published by Elsevier. This book was released on 2013-05-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volatile organic compounds (VOCs) in exhaled breath, sweat or urine carry much information on the state of human health. The role of VOCs in clinical diagnosis and therapeutic monitoring is expected to become increasingly significant due to recent advances in the field. Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine includes the latest discoveries and applications for VOCs from the world's foremost scientists and clinicians working in this emerging analytic area.
Download or read book Volatile Biomarkers written by Cristina Davis and published by Newnes. This book was released on 2013-03-27 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volatile organic compounds (VOCs) in exhaled breath, sweat or urine carry much information on the state of human health. The role of VOCs in clinical diagnosis and therapeutic monitoring is expected to become increasingly significant due to recent advances in the field. Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine includes the latest discoveries and applications for VOCs from the world's foremost scientists and clinicians working in this emerging analytic area. Appeals to a multidisciplinary audience, including scientists, researchers, and clinicians with an interest in breath analysis Features the latest scientific research and technical breakthroughs in the diagnostic and therapeutic aspects of volatile organic compounds Includes case presentations documenting applications in multiple areas of human health and safety
Download or read book Volatile Organic Compound Analysis in Biomedical Diagnosis Applications written by Raquel Cumeras and published by CRC Press. This book was released on 2018-11-09 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a thought-provoking state-of-the-art picture of how volatile compounds are used in metabolomics, currently a hot topic in the metabolomics field. It provides a thorough description of what volatile organic compounds (VOCs) are, why they are important in biomedicine, and what the analytical platforms are used. It also looks at multivariate analysis and databases needs. Because VOCs are end-up compounds of metabolic processes, volatiles can be linked to different diseases or pathologies for both diagnosis and prognosis. The authors provide authoritative information and guidance on the analytical and statistical techniques used and how to identify, and they review the main current areas of application, which include breath metabolomics, cancer diagnosis, and microbial volatiles. Key Features: Presents a thorough overview of volatile research in biomedical applications Examines both gold standard techniques (metabolomics based) and artificial olfactory systems Reviews all aspects of volatile metabolites in biomedicine research, from origin to detection platforms Describes relevant diseases diagnosis and prognosis achievements, including cancer
Download or read book Recent Advances in Targeting Clinical Volatile Organic Compounds VOC written by Imadeddine Azzouz and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This chapter introduces the significance of exploring volatile organic compounds (VOC) in clinical samples. Because exhaled-breath is easy to collect, unlimited, and instruments are already commercially available, VOC analysis in exhaled breath seems to be a promising tool for non-invasive detection of many diseases including infections, respiratory diseases, and cancers. Here, we have focused on some appropriate technologies to extract, pre-concentrate, and evaluate VOC biomarkers in exhaled breath. The second part of this chapter discusses the comprehensive GC × GC in bio-VOCs analysis and illustrates the potential of using this analytical technique.
Download or read book Breathborne Biomarkers and the Human Volatilome written by Jonathan Beauchamp and published by Elsevier. This book was released on 2020-06-06 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breathborne biomarkers carry information on the state of human health, and their role in aiding clinical diagnosis or in therapeutic monitoring has become increasingly important as advances in the field are made. Breathborne Biomarkers and the Human Volatilome, Second Edition, provides a comprehensive update and reworking of the 2013 book Volatile Biomarkers, by Anton Amann and David Smith. The new editing team has expanded this edition beyond volatile organic compounds to cover the broad field of breath analysis, including the many exciting developments that have occurred since the first edition was published. This thoroughly revised volume includes the latest discoveries and applications in breath research from the world's foremost scientists, and offers insights into related future developments. It is an ideal resource for researchers, scientists, and clinicians with an interest in breath analysis. Presents recent advances in the field of breath analysis Includes an extensive overview of established biomarkers, detection tools, disease targets, specific applications, data analytics, and study design Offers a broad treatise of each topic, from basic concepts to a comprehensive review of discoveries, current consensus of understanding, and prospective future developments Acts as both a primer for beginners and a reference for seasoned researchers
Download or read book Volatile Biomarkers for Human Health written by Hossam Haick and published by Royal Society of Chemistry. This book was released on 2022-09-30 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volatile biomarkers play a significant signalling role in communication between biological cells living as individual entities or as mini-societies that sense, respond and adapt to changes in their environment. In this process, volatile biomarkers can leak into the blood, from which they can be secreted into most body fluids (blood, breath, skin, urine, saliva, feces, etc.), from which sensing devices can capture and interpret their chemical fingerprint to reflect any association with health disorders in a fast, easy, and minimally non-invasive manner. This book introduces the concept of biomarkers within the body in terms of basic and translational sciences. It starts with a comprehensive review of the expression and mechanistic pathways involving volatile biomarkers at single cell and (micro)organism levels, cell-to-cell and cell-to-organism communications, and their secretion into body fluids. It discusses several ways for discovering and detecting the secreted biomarkers using mass spectrometry and other spectroscopic techniques. This is followed by an appraisal and translation of the accumulating knowledge from the laboratory to the Point-of-Care phase, using selective sensors as well as desktop and wearable artificial sensing devices, e.g., electronic noses and electronic skins, in conjugation with AI-assisted data processing and healthcare decision-making in diagnostics. The book offers an outlook into the challenges in the continuing development of volatile biomarkers and their wider availability to healthcare, which can be substantially improved. It should appeal to research groups in universities, start-up and large-scale industries associated in all aspects of biomedicine.
Download or read book Volatile Organic Compounds in Environment written by Ki-Hyun Kim and published by MDPI. This book was released on 2018-04-06 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Volatile Organic Compounds in Environment" that was published in Environments
Download or read book Progress in Volatile Organic Compounds Research written by Igor Jerković and published by MDPI. This book was released on 2020-12-29 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volatile organic compounds (VOCs) have been intensively investigated in the last few decades. Their origins differ: plant secondary metabolites, food/beverages aromas, fungal/bacterial volatiles, and others. VOCs typically occur as complex mixtures of compounds (e.g., monoterpenes, sesquiterpenes, norisoprenoids, aliphatic/aromatic compounds, sulfur containing compounds, and others). They form through different biochemical pathways and can be modified or created during drying or maturation, thermal treatment, and others. Different conventional or modern methods of VOCs isolation, followed by the analysis with chromatographic and spectroscopic techniques, usually provide different chemical profiles and have been under constant modification and upgrading. The ecological interactions are mediated by VOCs (inter- and intra-organismic communication) and they can act as pheromones, attractants, or alleochemicals. Among them, chemical biomarkers of botanical origin or chemotaxonomic markers may be found. Many VOCs possess different biological activities, such as antioxidant, antimicrobial, antiviral, anticancer, and other activities. VOCs research from different sources is required to report their distribution and chemical profiles, and to discover new compounds. This Special Issue aims to attract up-to-date contributions on all aspects of VOCs chemistry, from challenges in their isolation to analysis, and on unlocking their biological activities or other useful properties
Download or read book Exhaled Biomarkers written by I. Horvath and published by European Respiratory Society. This book was released on 2010-09-01 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exhaled air contains numerous substances, often in extremely low concentrations. The development of sensitive detection techniques has made it possible to examine the composition of exhaled air in relation to a variety of airway diseases and other disorders. In this book, an overview of current cutting-edge breath analysis techniques and their clinical applications is provided for the clinician. The various contributions give a fascinating perspective of a future where new, highly sensitive methodologies will enable clinicians to diagnose and monitor a wide variety of diseases merely by taking.
Download or read book Progress in Volatile Organic Compounds Research written by Igor Jerković and published by . This book was released on 2020 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volatile organic compounds (VOCs) have been intensively investigated in the last few decades. Their origins differ: plant secondary metabolites, food/beverages aromas, fungal/bacterial volatiles, and others. VOCs typically occur as complex mixtures of compounds (e.g., monoterpenes, sesquiterpenes, norisoprenoids, aliphatic/aromatic compounds, sulfur containing compounds, and others). They form through different biochemical pathways and can be modified or created during drying or maturation, thermal treatment, and others. Different conventional or modern methods of VOCs isolation, followed by the analysis with chromatographic and spectroscopic techniques, usually provide different chemical profiles and have been under constant modification and upgrading. The ecological interactions are mediated by VOCs (inter- and intra-organismic communication) and they can act as pheromones, attractants, or alleochemicals. Among them, chemical biomarkers of botanical origin or chemotaxonomic markers may be found. Many VOCs possess different biological activities, such as antioxidant, antimicrobial, antiviral, anticancer, and other activities. VOCs research from different sources is required to report their distribution and chemical profiles, and to discover new compounds. This Special Issue aims to attract up-to-date contributions on all aspects of VOCs chemistry, from challenges in their isolation to analysis, and on unlocking their biological activities or other useful properties.
Download or read book The Detection of Biomarkers written by Sibel A. Ozkan and published by Academic Press. This book was released on 2021-12-05 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reliable, precise and accurate detection and analysis of biomarkers remains a significant challenge for clinical researchers. Methods for the detection of biomarkers are rather complex, requiring pre-treatment steps before analysis can take place. Moreover, comparing various biomarker assays and tracing research progress in this area systematically is a challenge for researchers. The Detection of Biomarkers presents developments in biomarker detection, including methods tools and strategies, biosensor design, materials, and applications. The book presents methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical, and therefore highly practical for use in clinical research scenarios. This volume situates biomarker detection in its research context and sets out future prospects for the area. Its 20 chapters offer a comprehensive coverage of biomarkers, including progress on nanotechnology, biosensor types, synthesis, immobilization, and applications in various fields. The book also demonstrates, for students, how to synthesize and immobilize biosensors for biomarker assay. It offers researchers real alternative and innovative ways to think about the field of biomarker detection, increasing the reliability, precision and accuracy of biomarker detection. Locates biomarker detection in its research context, setting out present and future prospects Allows clinical researchers to compare various biomarker assays systematically Presents new methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical Gives innovative biomarker assays that are viable alternatives to current complex methods Helps clinical researchers who need reliable, precise and accurate biomarker detection methods
Download or read book Volatile Organic Compound and Metabolite Signatures as Pathogen Identifiers and Biomarkers of Infectious Disease written by Elizabeth Hong-Geller and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Volatile organic compound (VOC)-based diagnostics have great potential to be the next generation of screening tools for pathogen identification and infectious disease management. VOCs are low molecular weight metabolic compounds that have high vapor pressures and low boiling points, both of which facilitate evaporation at ambient temperatures. There is increasing evidence that particular VOCs, or profiles of VOCs, are unique to various disease states. Different pathogenic species have been found to produce characteristic profiles of VOCs by virtue of their distinct metabolisms. The detection of these metabolite profiles from patient samples could provide an effective means of rapid, non-invasive pathogen identification, thus enabling early diagnosis and treatment. In this review, we will discuss the potential of VOC profiles to be utilized as biomarkers of pathogenic infection, with a focus on bacterial pathogens. Herein we describe the common methods for clinical VOC sample collection, provide an overview of the various instruments and techniques used for VOC detection and analysis, and summarize the key findings of recent studies that have investigated VOC biomarkers in various infectious diseases. We will also discuss the challenges associated with translating VOC analysis into a clinical diagnostic tool.
Download or read book Biosensing Technologies for the Detection of Pathogens written by Toonika Rinken and published by BoD – Books on Demand. This book was released on 2018-03-21 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid multiplex detection of pathogens in the environment and in our food is a key factor for the prevention and effective treatment of infectious diseases. Biosensing technologies combining the high selectivity of biomolecular recognition and the sensitivity of modern signal detection platforms are a prospective option for automated analyses. They allow rapid detection of single molecules as well as cellular substances. This book, including 12 chapters from 50 authors, introduces the principles of identification of specific pathogen biomarkers along with different biosensor-based technologies applied for pathogen detection.
Download or read book Wound Healing Tissue Repair and Regeneration in Diabetes written by Debasis Bagchi and published by Academic Press. This book was released on 2020-05-08 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wound Healing, Tissue Repair and Regeneration in Diabetes explores a wide range of topics related to wound healing, tissue repair and regeneration, putting a special focus on diabetes and obesity. The book addresses the molecular and cellular pathways involved in the process of wound repair and regeneration. Other sections explore a wide spectrum of nutritional supplements and novel therapeutic approaches, provide a comprehensive overview, present various types of clinical aspects related to diabetic wounds, including infection, neuropathy, and vasculopathy, provide an exhaustive review of various foods, minerals, supplements and phytochemicals that have been proven beneficial, and assess future directions. This book is sure to be a welcome resource for nutritionists, practitioners, surgeons, nurses, wound researchers and other health professionals. Explains diabetic wounds and their complications Assesses the role of nutraceuticals, herbal supplements and other modalities for use in treating diabetic wounds Provides protocols for diabetic wound management
Download or read book Development of Portable Collection and Detection Systems for Volatile Organic Compounds written by Alexander G. Fung and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Volatile organic compounds (VOCs) are present throughout the environment. They are emitted by all living organisms and can be used as biomarkers for health diagnostics for plants and humans. Additionally, a number of VOCs are toxic to humans and must be monitored to limit exposure and negative health effects. Different methods of collecting and detecting VOCs exist; however, with advances in microfabrication and computational power, new, improved techniques can be developed. This work presents the design and implementation of multiple devices that can be used for the collection and detection of VOCs. These devices range from integrating spirometry with chemical sensing, to developing new methods of collecting volatiles from the environment using solid phase microextraction fibers, to a wearable device that uses a micro preconcentrator to sample a person’s environmental chemical exposure. Finally, a mobile platform for a portable chemical sensor was developed and control of the peripherals was demonstrated.
Download or read book Wide Spectra of Quality Control written by Isin Akyar and published by BoD – Books on Demand. This book was released on 2011-11-09 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quality control is a standard which certainly has become a style of living. With the improvement of technology every day, we meet new and complicated devices and methods in different fields. Quality control explains the directed use of testing to measure the achievement of a specific standard. It is the process, procedures and authority used to accept or reject all components, drug product containers, closures, in-process materials, packaging material, labeling and drug products, and the authority to review production records to assure that no errors have occurred.The quality which is supposed to be achieved is not a concept which can be controlled by easy, numerical or other means, but it is the control over the intrinsic quality of a test facility and its studies. The aim of this book is to share useful and practical knowledge about quality control in several fields with the people who want to improve their knowledge.
