Download or read book Raman and SERS Investigations of Pharmaceuticals written by Monica Baia and published by Springer Science & Business Media. This book was released on 2008-06-11 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last several years it has become apparent to most researchers that interdisciplinary research is the key to success in the sciences’ future. The present book exemplifies such interdisciplinary work. Thus, some new derivatives have been prepared by chemists and consecutively analyzed by physicists in order to better understand their physical-chemical properties for future tests to be performed by pharmacists. The book consists of an introductory section and other eight chapters. First, the fundamentals of infrared, Raman and surface-enhanced Raman spectroscopy and those of the theoretical methods employed for the vibrational prediction modes are highlighted. The SERS investigations illustrated in the following chapters are focused on different kinds of drugs: tranquilizers and sedatives, anti-inflammatory drugs, vitamins, drugs with anti-bacterial properties, etc. Since there is an increased interest in designing highly effective and controllable SERS-active substrates, a few newly developed substrates that could contribute to a deeper understanding and knowledge of the adsorption behavior of various types of molecules of pharmaceutical and medical interest are also presented.
Download or read book Advanced Raman SERS and ROA Studies of Biomedical and Pharmaceutical Compounds in Solution written by Clare Levene and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The primary purpose of this study was to investigate the combination of experimental and computational methods in the search for reproducible colloidal surface-enhanced Raman scattering of pharmaceutical compounds. In the search for optimal experimental conditions for colloidal surface-enhance Raman scattering, the amphipathic [beta]-blocker propranolol was used as the target molecule. Fractional factorial designs of experiments were performed and a multiobjective evolutionary algorithm was used to find acceptable solutions, from the results, that were Pareto ranked. The multiobjective evolutionary algorithm suggested solutions outside of the fractional factorial design and the experiments were then performed in the laboratory. The results observed from the suggested solutions agreed with the solutions that were found on the Pareto front. One of the experimental conditions observed on the Pareto front was then used to determine the practical limit of detection of propranolol. The experimental conditions that were chosen for the limit of detection took into account reproducibility and enhancement, the two most important parameters for analytical detection using surface-enhanced Raman scattering. The principal conclusion to this study was that the combination of computational and experimental methods can reduce the need for experiments by > 96% and then selecting solutions from the Pareto front improved limit of detection by a factor of 24.5 when it was compared to the previously reported limit of detection for propranolol. Using the same experimental conditions that were used for the limit of detection, these experiments were extended to plasma spiked with propranolol in order to test detection of this pharmaceutical in biofluids. Concentrations of propranolol were prepared using plasma as the solvent and measured for detection using colloidal surface-enhanced Raman scattering. Detection was determined as
Download or read book Applications of Raman Spectroscopy to Biology written by M. Ghomi and published by IOS Press. This book was released on 2012-02-23 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Raman spectroscopy has been known and used as a technique for 80 years, originally for the study of inorganic substances. Recent advances in underlying technology, such as lasers, detectors, filters and components, have transformed the technique into a very effective modern tool for studying complex biological problems. Professor Mahmoud Ghomi (of the University of Paris XIII) has edited this book on the applications of Raman spectroscopy to biology, covering in a readily accessible way the area from basic studies to the diagnosis of disease. The early chapters provide background information on basic principles underlying the main Raman methods covered in the book, with information on Surface-Enhanced Raman Scattering (SERS) and Surface-Enhanced Fluorescence (SEF), as well as giving accounts of applications to biomolecular and cellular investigations. Among the topics covered are studies of drugs and their complexes with biomolecules on nanoparticles, application of SERS to blood analysis, studies of single cells and of applications to human cancer diagnostics.This will be a useful book for experimental scientists in academic, governmental, industrial and clinical environments and for those entering the field of biomolecular spectroscopy.
Download or read book Principles and Clinical Diagnostic Applications of Surface Enhanced Raman Spectroscopy written by Yuling Wang and published by Elsevier. This book was released on 2021-09-17 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles and Clinical Diagnostic Applications of Surface-Enhanced Raman Spectroscopy summarizes the principles of surface-enhanced Raman scattering/spectroscopy (SERS) and plasmonic nanomaterials for SERS, with a focus on SERS applications in clinical diagnostics. This book covers the key concepts from the fundamentals, materials, experimental aspects, and applications of SERS in clinical diagnostics with discussions on label-free/direct SERS assay, design and synthesis of SERS nanotags, SERS nanotags for point-of-care diagnostics, microfluidic SERS assay, and in vitro and in vivo sensing and imaging. Written by experts from around the world, this comprehensive volume showcases the recent progress of SERS applications in clinical diagnostics and helps readers understand when and how to use SERS in a clinical setting. Introduces the basics of SERS and suitable nanomaterials for SERS application Gives an overview of the cutting-edge research on SERS applications for clinical diagnosis, including the latest advances in our understanding of underlying principles to enable material design and clinical applications Gradually builds from the fundamental concepts to the applications of SERS for clinical diagnostics
Download or read book Principles of Surface Enhanced Raman Spectroscopy written by Eric Le Ru and published by Elsevier. This book was released on 2008-11-17 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: SERS was discovered in the 1970s and has since grown enormously in breadth, depth, and understanding. One of the major characteristics of SERS is its interdisciplinary nature: it lies at the boundary between physics, chemistry, colloid science, plasmonics, nanotechnology, and biology. By their very nature, it is impossible to find a textbook that will summarize the principles needed for SERS of these rather dissimilar and disconnected topics. Although a basic understanding of these topics is necessary for research projects in SERS with all its many aspects and applications, they are seldom touched upon as a coherent unit during most undergraduate studies in physics or chemistry. This book intends to fill this existing gap in the literature. It provides an overview of the underlying principles of SERS, from the fundamental understanding of the effect to its potential applications. It is aimed primarily at newcomers to the field, graduate students, researchers or scientists, attracted by the many applications of SERS and plasmonics or its basic science. The emphasis is on concepts and background material for SERS, such as Raman spectroscopy, the physics of plasmons, or colloid science, all of them introduced within the context of SERS, and from where the more specialized literature can be followed. Represents one of very few books fully dedicated to the topic of surface-enhanced Raman spectroscopy (SERS) Gives a comprehensive summary of the underlying physical concepts around SERS Provides a detailed analysis of plasmons and plasmonics
Download or read book Structure Investigations of Energetic and Pharmaceutical Nanoscale Composites Via AFM TERS and SERS written by Jakob Hübner and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tip Enhanced Raman Spectroscopy based on Atomic Force Microscopy (AFM-TERS) is applied to study the structure of diverse nanoscale energetic and pharmaceutical composites. AFM-TERS investigations of nanoscale CL-20/HMX co-crystals demonstrate that CL-20/HMX surfaces consist of a molecular layer of HMX. Experimental results are supported by an approximation of vibrational normal coordinates allowing to exclude the appearance of relatively strong HMX Raman intensities because of a specific arrangement between CL-20/HMX nano co crystals and the Raman scattering systems. Diverse nanoscale RDX and TNT mixtures differing in their weight percentage ratio are analyzed with AFM-TERS. The combination of far-field Raman spectroscopy and surface sensitive TERS enabled the identification of anisotropic RDX/TNT core/shell nanoparticles. Submicron Furosemide-PVP particles are investigated by confocal far-field Raman microscopy and Surface Enhanced Raman microscopy. Furosemide-PVP particles are directly sputtered with thin layers of silver. The comparison of far- and near-field Raman spectra reveals that shells of PVP encapsulate Furosemide cores.
Download or read book Surface Enhanced Raman Spectroscopy written by Marek Prochazka and published by Springer. This book was released on 2015-12-12 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives an overview of recent developments in RS and SERS for sensing and biosensing considering also limitations, possibilities and prospects of this technique. Raman scattering (RS) is a widely used vibrational technique providing highly specific molecular spectral patterns. A severe limitation for the application of this spectroscopic technique lies in the low cross section of RS. Surface-enhanced Raman scattering (SERS) spectroscopy overcomes this problem by 6-11 orders of magnitude enhancement compared with the standard RS for molecules in the close vicinity of certain rough metal surfaces. Thus, SERS combines molecular fingerprint specificity with potential single-molecule sensitivity. Due to the recent development of new SERS-active substrates, labeling and derivatization chemistry as well as new instrumentations, SERS became a very promising tool for many varied applications, including bioanalytical studies and sensing. Both intrinsic and extrinsic SERS biosensing schemes have been employed to detect and identify small molecules, nucleic acids and proteins, and also for cellular and in vivo sensing.
Download or read book Application of Raman Spectroscopy in Pharmaceuticals written by Anna Zarow and published by . This book was released on 2011 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental research on the use of Raman spectroscopy as an in- and on-line sensing tool and a complementary characterization technique for pharmaceutical applications is presented in this thesis. In the first chapter following a broad overview, the use of Raman spectroscopy, together with x-ray powder diffraction, scanning electron microscopy (SEM) and differential scanning calorimetry, for multilevel characterization of cryomilled powders, and the melt-grown amorphous phase of griseofulvin, a model active pharmaceutical ingredient (API), is presented and discussed in detail. A key feature was the observation of a broad inelastic background superimposed on the Raman spectra of cryomilled powders, which is attributed to lattice disorder and Mie scattering generated by mechanical processing and sub-micron particle interfaces. In the following chapter, polymorphs of another model API, acetaminophen (APAP), were studied by Raman spectroscopy with supporting information obtained from x-ray diffraction, SEM images and intrinsic dissolution profiles. An important result was the stabilization and characterization of the metastable type II orthorhombic phase of APAP which is highly desired for its unique tabletting properties which are important for pharmaceutical manufacturing. Stabilization of metastable type II APAP was achieved by micronizing or nanocoating stable monoclinic crystallites of type I APAP. In addition, as an Appendix to the thesis, micro-Raman spectroscopy of single crystal APAP as a function of crystal orientation and of temperature was measured to provide an understanding of the lattice properties of APAP for input into models to predict its behavior under mechanical milling conditions widely used in pharmaceutical processing. Molecular behavior obtained from the above studies guided simulated in-line and off-line characterization of griseofulvin as thin gel films made from micronized powders and nanosuspensions. By employing complementary near infrared and Raman imaging for newly developed films, it was possible to extract valuable information on the spatial distribution and crystallinity of the embedded particles in a polymeric matrix at different scales of scrutiny. Chemometrics processing of spectroscopic data for films and nanosuspensions allowed for qualitative and quantitative particle size determinations of the API’s in the films and nanosuspensions. In the final chapter a photonic crystal substrate for surface enhanced Raman spectroscopic (SERS) sensing was employed to detect and study griseofulvin and APAP down to 10-8 M levels with enhancement factors approaching 1099. Detection sensitivities of the aromatic griseofulvin and APAP molecules were also compared with those of less aromatic and non-aromatic energetic molecules in order to understand the Raman enhancement process.
Download or read book Pharmaceutical Applications of Raman Spectroscopy written by Slobodan Sasic and published by John Wiley & Sons. This book was released on 2007-10-23 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Raman spectroscopy has advanced in recent years with increasing use both in industry and academia. This is due largely to steady improvements in instrumentation, decreasing cost, and the availability of chemometrics to assist in the analysis of data. Pharmaceutical applications of Raman spectroscopy have developed similarly and this book will focus on those applications. Carefully organized with an emphasis on industry issues, Pharmaceutical Applications of Raman Spectroscopy, provides the basic theory of Raman effect and instrumentation, and then addresses a wide range of pharmaceutical applications. Current applications that are routinely used as well as those with promising potential are covered. Applications cover a broad range from discovery to manufacturing in the pharmaceutical industry and include identifying polymorphs, monitoring real-time processes, imaging solid dosage formulations, imaging active pharmaceutical ingredients in cells, and diagnostics.
Download or read book Detection of Drugs of Abuse by Surface Enhanced Raman Scattering SERS written by Karen Jade Faulds and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Surface Enhanced Vibrational Spectroscopy written by Ricardo Aroca and published by John Wiley & Sons. This book was released on 2006-05-01 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface Enhanced Vibrational Spectroscopy (SEVS) has reached maturity as an analytical technique, but until now there has been no single work that describes the theory and experiments of SEVS. This book combines the two important techniques of surface-enhanced Raman scattering (SERS) and surface-enhanced infrared (SEIR) into one text that serves as the definitive resource on SEVS. Discusses both the theory and the applications of SEVS and provides an up-to-date study of the state of the art Offers interpretations of SEVS spectra for practicing analysts Discusses interpretation of SEVS spectra, which can often be very different to the non-enhanced spectrum - aids the practicing analyst
Download or read book Surface Enhanced Raman Scattering written by Katrin Kneipp and published by Springer Science & Business Media. This book was released on 2006-06-21 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Almost 30 years after the first reports on surface-enhanced Raman signals, the phenomenon of surface-enhanced Raman scattering (SERS) is now well established. SERS gained particular interest after single-molecule Raman spectroscopy had been demonstrated. This book summarizes and discusses present theoretical approaches that explain the phenomenon of SERS and reports on new and exciting experiments and applications of the fascinating spectroscopic effect.
Download or read book Applications of Molecular Spectroscopy to Current Research in the Chemical and Biological Sciences written by Mark Stauffer and published by BoD – Books on Demand. This book was released on 2016-10-05 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this book is to present an overview of applications of molecular spectroscopy to investigations in organic and inorganic materials, foodstuffs, biosamples and biomedicine, and novel characterization and quantitation methods. This text is a compilation of selected research articles and reviews covering current efforts in various applications of molecular spectroscopy. Sections 1 and 2 deal, respectively, with spectroscopic studies of inorganic and organic materials. Section 3 provides applications of molecular spectroscopy to biosamples and biomedicine. Section 4 explores spectroscopic characterization and quantitation of foods and beverages. Lastly, Section 5 presents research on novel spectroscopic methodologies. Overall, this book should be a great source of scientific information for anyone involved in characterization, quantitation, and method development.
Download or read book Handbook of Raman Spectroscopy written by Ian R. Lewis and published by CRC Press. This book was released on 2001-08-08 with total page 1076 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work covers principles of Raman theory, analysis, instrumentation, and measurement, specifying up-to-the-minute benefits of Raman spectroscopy in a variety of industrial and academic fields, and how to cultivate growth in new disciplines. It contains case studies that illustrate current techniques in data extraction and analysis, as well as over 500 drawings and photographs that clarify and reinforce critical text material. The authors discuss Raman spectra of gases; Raman spectroscopy applied to crystals, applications to gemology, in vivo Raman spectroscopy, applications in forensic science, and collectivity of vibrational modes, among many other topics.
Download or read book Raman Spectroscopy and Applications written by Khan Maaz and published by BoD – Books on Demand. This book was released on 2017-02-15 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Raman spectroscopy has a number of applications in various fields including material science, physics, chemistry, biology, geology, and medicine. This book illustrates necessary insight and guidance in the field of Raman spectroscopy with detailed figures and explanations. This presents deep understanding of new techniques from basic introduction to the advance level for scientists and engineers. The chapters cover all major aspects of Raman spectroscopy and its application in material characterization with special emphasis on both the theoretical and experimental aspects. This book is aimed to provide solid foundation of Raman spectroscopy to the students, scientists, and engineers working in various fields as mentioned above.
Download or read book Modern Raman Spectroscopy written by Ewen Smith and published by John Wiley & Sons. This book was released on 2013-03-15 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reflects the dramatic increase in the number of Raman spectrometers being sold to and used by non-expert practitioners. It contains coverage of Resonance Raman and SERS, two hot areas of Raman, in a form suitable for the non-expert. Builds Raman theory up in stages without overloading the reader with complex theory Includes two chapters on instrumentation and interpretation that shows how Raman spectra can be obtained and interpreted Explains the potential of using Raman spectroscopy in a wide variety of applications Includes detailed, but concise information and worked examples
Download or read book Analysis of Pharmaceuticals by Raman Spectroscopy written by Fiona Carolynne Thorley and published by . This book was released on 2004 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: