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Book Progress in Polyamine Research

Download or read book Progress in Polyamine Research written by V. Zappia and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the scientific contributions presented at an International Symposium held in Sorrento, Italy, in June 1988 under the auspices of the University of Naples, the Italian Society of Biochemistry, and the National Research Council. The modern history of polyamines dates back to 1958 when the Tabors and Rosenthal first described the outlines of their biological synthesis. From then on, and particularly in the last ten years, a veri table explosion of Literature, characterized by thousands of papers, has witnessed the interest of the scientific community toward these molecules. Perhaps the old statement that "polyamines are molecules in search of a function" is no longer true today. A large number of effects exerted by these simple molecules are well known, and in many cases the mechanisms underlying these effects have been elucidated. The first section of the volume is entirely devoted to the enzymology and molecular biology of ornithine decarboxylase. Since its discovery by Gale more than forty years ago, this can be considered among the most widely studied enzymes in biology, and one of the most complex models in enzyme regulation. The mechanism of control of the enzyme activity at the transcriptional, post-transcriptional and post-translational levels, as well as the fine regulation by antizyme, are discussed in detail. The second group of contributions deals wi th AdoMet decarboxylase, propylamine transferase, polyamine oxidase and the other enzymes related to polyamine interconversion and regeneration.

Book Recent Progress in Polyamine Research

Download or read book Recent Progress in Polyamine Research written by L. Selmeci and published by . This book was released on 1985 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Progress in Polyamine Research

Download or read book Progress in Polyamine Research written by Vincenzo Zappia and published by . This book was released on 1988 with total page 779 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Advances in Polyamine Research

    Book Details:
  • Author : Advances in Polyamine Research Staff
  • Publisher :
  • Release :
  • ISBN : 9780783772745
  • Pages : 395 pages

Download or read book Advances in Polyamine Research written by Advances in Polyamine Research Staff and published by . This book was released on with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Advances in polyamine research

Download or read book Advances in polyamine research written by and published by . This book was released on 1983 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Advances in Polyamine Research

Download or read book Advances in Polyamine Research written by Robert A. Campbell and published by . This book was released on 1978 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Biogenic Polyamines  Advances in Research and Application  2011 Edition

Download or read book Biogenic Polyamines Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biogenic Polyamines: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Biogenic Polyamines in a compact format. The editors have built Biogenic Polyamines: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biogenic Polyamines in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Biogenic Polyamines: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Book The Physiology of Polyamines

Download or read book The Physiology of Polyamines written by Uriel Bachrach and published by CRC Press. This book was released on 1989-03-31 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: The state of the art in the area of polyamines is presented in this useful, two-volume publication. Basic information describing the role of polyamines in the processes of growth and differentiation is given. Also included are data on the regulation of polyamine biosynthesis and metabolism and their interactions with nucleic acids. Several chapters are devoted to the role of polyamines in various aspects of plant biology, with a special emphasis on their participation in the response of plants to extreme environments. Special attention is given to the use of inhibitors of polyamine biosynthesis as potential antitumor and antiproliferative agents. Additionally, recent progress in the molecular biology and genetic engineering of genes coding for polyamine biosynthetic enzymes is described. Cancer researchers, biologists, geneticists, biochemists, physiologists, and clinicians will find this volume indispensible. Contents VOLUME II: POLYAMINES IN MICROBES. Polyamines and the Growth of Bacteria and Viruses. Polyamines in Thermophiles. Propylamine Transfer Reactions in Thermophilic Archaebacteria: Enzymological Aspects and Comparative Biochemistry. Microbial Mutants Deficient in Polyamine Synthesis. Regulation of the Putrescine Biosynthetic Genes (SpeA, speB, and speC) in Escherichia coli. Utilization of L-Arginine, L-Ornithine, Agmatine, and Putrescine as the Major Source of Nitrogen and Its Control in Escherichia coli. POLYAMINES AND PLANTS. Polyamines and Plant Response to Stress. Polyamines and Plant Growth and Development. Polyamines and Plant Hormones. Polyamines in Plant Mutants. POLYAMINES AND DISEASES. Polyamines in Health and Disease. Polyamine Metabolism and Neoplastic Growth: A Programmed Deregulation? Polyamines as Markers of Malignancy. Polyamines as Indicators of Disease Activity and Response to Therapy in Cancer Patients. Inhibitors of Polyamine Biosynthesis as Therapeutic Agents. Clinical Studies of a- Difluoromethylornithine and a-Interferon in Cancer Patients. Changes in Polyamine Metabolism in Tumor-Bearing Hosts with Total Parenteral Nutrition and Intravenous Infusion of a-Difluoromethylornithine. Index. c. 328 pp., 7x10, due February 1989, ISBN-0-8493-6809-X.

Book Polyamine Metabolism in Disease and Polyamine Targeted Therapies

Download or read book Polyamine Metabolism in Disease and Polyamine Targeted Therapies written by Tracy Murray-Stewart and published by MDPI. This book was released on 2019-10-01 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyamines are ubiquitous polycations essential for all cellular life. The most common polyamines in eukaryotes, spermine, spermidine, and putrescine, exist in millimolar intracellular concentrations that are tightly regulated through biosynthesis, catabolism, and transport. Polyamines interact with, and regulate, negatively charged macromolecules, including nucleic acids, proteins, and ion channels. Accordingly, alterations in polyamine metabolism affect cellular proliferation and survival through changes in gene expression and transcription, translation, autophagy, oxidative stress, and apoptosis. Dysregulation of these multifaceted polyamine functions contribute to multiple disease processes, thus their metabolism and function have been targeted for preventive or therapeutic intervention. The correlation between elevated polyamine levels and cancer is well established, and ornithine decarboxylase, the rate-limiting biosynthetic enzyme in the production of putrescine, is a bona fide transcriptional target of the Myc oncogene. Furthermore, induced polyamine catabolism contributes to carcinogenesis that is associated with certain forms of chronic infection and/or inflammation through the production of reactive oxygen species. These and other characteristics specific to cancer cells have led to the development of polyamine-based agents and inhibitors aimed at exploiting the polyamine metabolic pathway for chemotherapeutic and chemopreventive benefit. In addition to cancer, polyamines are involved in the pathologies of neurodegenerative diseases including Alzheimer’s and Parkinson’s, parasitic and infectious diseases, wound healing, ischemia/reperfusion injuries, and certain age-related conditions, as polyamines are known to decrease with age. As in cancer, polyamine-based therapies for these conditions are an area of active investigation. With recent advances in immunotherapy, interest has increased regarding polyamine-associated modulation of immune responses, as well as potential immunoregulation of polyamine metabolism, the results of which could have relevance to multiple disease processes. The goal of this Special Issue of Medical Sciences is to present the most recent advances in polyamine research as it relates to health, disease, and/or therapy.

Book Advances in Polyamine Research

Download or read book Advances in Polyamine Research written by Robert A. Campbell and published by . This book was released on 1978 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Polyamines in Biomedical Research

Download or read book Polyamines in Biomedical Research written by Joseph M. Gaugas and published by John Wiley & Sons. This book was released on 1980 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book The Physiology of Polyamines  Volume I

Download or read book The Physiology of Polyamines Volume I written by Uriel Bachrach and published by CRC Press. This book was released on 2021-05-30 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: The area of polyamines is presented in this useful, two-volume publication. Basic information describing the role of polyamines in the processes of growth and differentiation is given. Also included are data on the regulation of polyamine biosynthesis and metabolism and their interactions with nucleic acids. Several chapters are devoted to the role of polyamines in various aspects of plant biology, with a special emphasis on their participation in the response of plants to extreme environments. Special attention is given to the use of inhibitors of polyamine biosynthesis as potential antitumor and antiproliferative agents. Additionally, progress in the molecular biology and genetic engineering of genes coding for polyamine biosynthetic enzymes is described. Cancer researchers, biologists, geneticists, biochemists, physiologists, and clinicians will find this volume indispensable.

Book Polyamine Cell Signaling

    Book Details:
  • Author : Jian-Ying Wang
  • Publisher : Springer Science & Business Media
  • Release : 2007-11-19
  • ISBN : 1597451452
  • Pages : 490 pages

Download or read book Polyamine Cell Signaling written by Jian-Ying Wang and published by Springer Science & Business Media. This book was released on 2007-11-19 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyamines are organic cations found in all eukaryotic cells and intimately involved in, and required for, distinct biological functions. An increasing body of evidence indicates that the regulation of cellular polyamines is a central convergence point for the multiple signaling pathways driving various cellular functions. Over the last decade, considerable progress has been made in und- standing the molecular functions of cellular polyamines. These significant findings provide a fundamental basis to not only define the exact role of polyamines in physiology, but also to develop new therapeutic approaches for cancers and other diseases. The major objective of this book is to provide a timely and long lasting guide for investigators in the fields of polyamines, physiology, pharmacology, and cancer research. It will provide a foundation based on research and address the potential for subsequent applications in clinical practice. Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research is divided into four main parts: Part I: Polyamines in Signal Transduction of Cell Proliferation Part II: Polyamines in Cellular Signaling of Apoptosis, Carcinogenesis, and Cancer Therapy Part III: Polyamines in Cell Motility and Cell–Cell Interactions Part IV: Polyamine Homeostasis and Transport This book not only covers the current state-of-the-art findings relevant to cellular and molecular functions of polyamines, but also provides the underlying conceptual basis and knowledge regarding potential therapeutic targeting of polyamines and polyamine metabolism. These points are addressed by int- nationally recognized experts in their contributions to this book.

Book Advances in Polyamine Research

Download or read book Advances in Polyamine Research written by Ralph Chayen and published by Lippincott Williams & Wilkins. This book was released on 1982-12 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book The Genus Yersinia

    Book Details:
  • Author : Robert D. Perry
  • Publisher : Springer Science & Business Media
  • Release : 2007-09-25
  • ISBN : 0387721231
  • Pages : 454 pages

Download or read book The Genus Yersinia written by Robert D. Perry and published by Springer Science & Business Media. This book was released on 2007-09-25 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 9th International Symposium on Yersinia was held in Lexington, Kentucky, USA on October 10-14, 2006. Over 250 Yersinia researchers from 18 countries gathered to present and discuss their research. In addition to 37 oral presentations, there were 150 poster presentations. This Symposium volume is based on selected presentations from the meeting and contains both reviews and research articles. It is divided into six topic areas: 1) genomics; 2) structure and metabolism; 3) regulatory mechanisms; 4) pathogenesis and host interactions; 5) molecular epidemiology and detection; and 6) vaccine and antimicrobial therapy development. Consequently, this volume covers a wide range of current research areas in the Yersinia field.

Book Polyamines

    Book Details:
  • Author : Anthony E. Pegg
  • Publisher : Humana Press
  • Release : 2011-04-06
  • ISBN : 9781617790355
  • Pages : 524 pages

Download or read book Polyamines written by Anthony E. Pegg and published by Humana Press. This book was released on 2011-04-06 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recently, important new findings in the polyamine field and a variety of new experimental systems have revolutionized the study of these ubiquitous cellular components, essential for normal growth and development. In Polyamines: Methods and Protocols, leading researchers contribute an extensive collection of up-to-date laboratory techniques for the further pursuit of polyamine study. The volume delves into vital subjects such as neoplasia studies with animal models and human patients, therapeutic roles for polyamine inhibitors and analogs, polyamine metabolism and oxidative damage, polyamines as regulators of critical ion channels, as well as polyamine transport systems and polyamine-responsive genes. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Polyamines: Methods and Protocols provides a key resource for all scientists pursuing the study of this dynamic and significant aspect of cellular biology.

Book RSC Drug Discovery  17

    Book Details:
  • Author : Patrick Woster
  • Publisher :
  • Release : 2011
  • ISBN :
  • Pages : 303 pages

Download or read book RSC Drug Discovery 17 written by Patrick Woster and published by . This book was released on 2011 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyamines are ubiquitous molecules that are involved in a number of important cellular processes. Aberrations in their function or metabolism play a role in diseases such as cancer and parasitic infection. A number of validated drug targets have been identified, including enzymes in the polyamine biosynthetic and catabolic pathways and the S-adenosylmethionine synthetic and salvage pathways. Polyamine Drug Discovery is the first comprehensive volume to cover all aspects of the design and development of potential therapeutics targeting polyamine metabolism. The book details research progress f.