Download or read book Preimplantation Genetic Diagnosis written by Joyce C. Harper and published by John Wiley & Sons. This book was released on 2003-01-17 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preimplantation Genetic Diagnosis (PGD) is the detection and screening of genetic abnormality in gametes prior to fertilisation and embryos fertilised in vitro prior to implantation. This exciting new text provides an introduction and overview of the principles of PGD. An exciting fusion of prenatal diagnosis (PD) with in vitro fertilisation (IVF), this book is will appeal to both the prenatal diagnosis community, of clinical geneticists and foetal medicine specialists within obstetrics and gynaecology, and the IVF community within reproductive medicine. It is also an essential introduction to PD, clinical genetics and IVF for non-specialists. A concise introduction to the field of PGD Detailed explanations of the techniques and procedures used The law and ethical implications of PGD Future uses of PGD

Download or read book Preimplantation Genetic Testing written by Darren K. Griffin and published by CRC Press. This book was released on 2020-06-01 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preimplantation genetic testing (PGT) is now well established as a valuable treatment option for patients wishing to start or continue a family, for a range of indications from advanced maternal age to high risk of transmitting inherited disease. This text brings together contemporary thinking from international opinion leaders and will be an invaluable guide for practitioners in Reproductive Medicine wishing to keep pace with the latest developments and clinical data.

Download or read book Practical Preimplantation Genetic Diagnosis written by Yury Verlinsky and published by Springer Science & Business Media. This book was released on 2006-01-16 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the leaders in the field comes this new and completely up-to-date practical manual of the technique of preimplantation genetic diagnosis. Vital for all practitioners within the field of fertility and reproductive medicine and medical genetics, this will be the leading reference resource for anyone with a practical interest in this most controversial of areas.

Download or read book Practical Preimplantation Genetic Diagnosis written by Anver Kuliev and published by Springer Science & Business Media. This book was released on 2012-08-16 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although treatment remains the major goal in the control of genetic disease, this is not yet a reality for most inherited conditions. In the absence of radical treatment, preimplantation genetic diagnosis (PGD) offers the answer to the control of these inherited conditions by predicting reproductive outcome. PGD is now entering its third decade as an established procedure for genetic and assisted reproduction practices, with new and exciting developments changing the whole concept of prevention of congenital disorders. The availability of practical experience from tens of thousands of PGD cases makes it necessary to update the current information on its accuracy, reliability and safety. The Second Edition of this successful book updates the progress in prevention of genetic disorders to demonstrate the important place of PGD in primary preventive measures and its increasing role in providing the whole range of reproduction options to couples at risk. In addition, it provides an extensive review of the most recent developments within the field of PGD including, PGD for expanding indications such as de novo mutations, cancers, inherited cardiac diseases and combined PGD for single gene disorders, HLA typing and 24 chromosome testing in patients of advance reproductive age. This practical book is vital for all practitioners within the field of fertility, reproductive medicine and medical genetics. It will also be useful for those responsible for planning and organizing PGD services and provides a working manual for the establishment and performance of PGD in the framework of IVF and genetic practices.

Download or read book Preimplantation Genetics written by A. Kuliev and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Yury Verlinskyand Anver Kuliev Reproductive Genetics Institute, Illinois Masonic Medical Center, 836 W. Wellington chicago, IL 60657 Although introduction of a first trimester prenatal diagnosis by chorionic viIIus sampling (CVS) has considerably improved the possibility for prevention of genetic diseases, it requires a selective abortion in case of an affected fetus. Following the direction of an earlier prenatal diagnosis and to avoid the need for abortion, preimplantation genetic diagnosis has been initiated based on polar body removal and pre-embryo biopsy. The First International symposium on Preimplantation Genetics, Chicago, September 17-19, 1990, was organized to explore these important developments, to review the state of knowledge in the field, and to address existing problems to be solved for developing and improving current approaches for preimplantation diagnosis of genetic disorders. A growing interest in the subject was obvious from the wide attendance of the meeting: over 250 scientists from 19 countries participated. This was the first attempt to put together the advances in different areas of basic and applied research relevant to Preimplantation Genetic Diagnosis, with the multidisciplinary scientific program including the sessions on embryology, micromanipulation and biopsy, genetic analysis of gametes and pre-embryos, IVF, gene expression and gene therapy, and ethical and legal issues. The deliberations of the Symposium presented in the above mentioned sessions, which comprise the contents of correspond ing sections of the Proceedings, open a newarea in medical research based on the interaction of IVF and New Genetics.

Download or read book Preimplantation Diagnosis of Genetic Disease written by Yury Verlinsky and published by Wiley-Liss. This book was released on 1993 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preimplantation Diagnosis of Genetic Diseases A New Technique in Assisted Reproduction Editors: Yury Verlinsky and Anver M. Kuliev For individuals with hereditary genetic disorders such as cystic fibrosis, muscular dystrophy, or hemophilia, the decision to reproduce can be a profoundly difficult and emotional problem. For specialists in reproductive medicine, this situation can raise a myriad of complex—often conflicting—ethical questions. Recently, a revolutionary approach to screening for genetic disorders has emerged, offering unique possibilities for resolving this dilemma. Preimplantation Diagnosis of Genetic Diseases: A New Technique in Assisted Reproduction details the latest procedures for detecting congenital disease in gametes prior to fertilization or in embryos fertilized in vitro prior to uteral implantation. This book covers current methods used in oocyte and preembryo sampling as well as the latest techniques in DNA and cytogenetic analysis in preimplantation development. This text presents detailed, practical information on such crucial topics as: blastomere and blastocyst biopsy for preimplanation genetic analysis oocyte retrieval and embryo transfer for in vitro fertilization preparation of necessary media and micromanipulation tools polymerase chain reaction techniques for DNA analysis of polar bodies and preembryos preimplantation cytogenetic and enzymatic analyses ethical issues involved in preimplantation genetic screening. Serving as both a practical manual for current methods and a reference for future research and clinical applications, Preimplantation Diagnosis of Genetic Diseases: A New Technique in Assisted Reproduction provides a complete overview of this dramatic development in reproductive medicine. This book will be of interest to specialists in fertility medicine, obstetrics and gynecology, embryology, genetics, molecular biology, and cytogenetics whose work defines this new frontier in biomedical science.

Download or read book Preimplantation Genetic Diagnosis in Clinical Practice written by Tarek El-Toukhy and published by Springer Science & Business Media. This book was released on 2013-11-08 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preimplantation genetic diagnosis (PGD) is a rapidly advancing field of reproductive genetics. With the significant improvements achieved over the last few years in the understanding of many genetic diseases and in the techniques of molecular genetic testing, new genetic diseases are being added to the list of conditions amenable to PGD almost on a weekly basis. Therefore, the subject of PGD is becoming relevant to a much wider variety of medical disciplines and an increasing number of patients who may wish to know more about this treatment option. This unique book offers a comprehensive yet practical “user-friendly” guide to preimplantation genetic diagnosis (PGD). It provides understanding of and insight into the complete procedure, its recent clinical and laboratory developments and its future prospects, whilst offering an easy point of reference for patient enquiries. Concluding with perspectives on the ethical and social issues often encountered by healthcare professionals counselling patients with regards to PGD. Each chapter within Preimplantation Genetic Diagnosis in Clinical Practice is written by established authorities in their fields. An essential resource for PGD specialists and non-specialists, and for all practitioners working within the disciplines of fertility, reproductive medicine and medical genetics.

Download or read book Regulating Preimplantation Genetic Diagnosis in the United States written by M. Bayefsky and published by Springer. This book was released on 2015-01-20 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reproductive technology allows us to test embryos' genes before deciding whether to transfer them to a woman's uterus. Embryo selection raises many ethical questions but is virtually unregulated in the United States. This comprehensive study considers the ethical, medical, political, and economic aspects of developing appropriate regulation.

Download or read book Assessing Genetic Risks written by Institute of Medicine and published by National Academies Press. This book was released on 1994-01-01 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.

Download or read book Born and Made written by Sarah Franklin and published by Princeton University Press. This book was released on 2006-11-19 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Born and Made' examines the case of preimplantation genetic diagnosis (PGD), the procedure used to prevent serious genetic disease by embryo selection, and the so-called 'designer baby' method. It shows that far from being a runaway technology, the regulation of PGD provides an example of precaution and restraint.

Download or read book Genetic Steroid Disorders written by Maria I. New and published by Academic Press. This book was released on 2023-06-14 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Steroid Disorders, Second Edition targets adult and pediatric endocrinologists, clinical geneticists, genetic counselors, reproductive endocrinologists, neonatologists, urologists, and psychoendocrinologists. It is designed to assist these specialists in the diagnosis and treatment of steroid disorders. This revision includes a new chapter on "Gonadotropins, Obesity and Bone" and new research on non-invasive prenatal diagnosis with cell-free DNA. Chapters are thoroughly updated covering steroid disorders, the genetic bases for the disorder and case presentations, This definitive reference belongs in every medical library! - Presents a comprehensive, translational look at all aspects of genetic steroid disorders in one reference work - Provides a common language for endocrinologists, geneticists, molecular pathologists, and genetic counselors to discuss and diagnose genetic steroid disorders Saves clinicians and researchers time in quickly accessing the very latest details on genetic tests and diagnoses as opposed to searching through thousands of journal articles - Highlights significant discoveries with clinical relevance, presenting insight into which medications to use based on the genetic makeup of a patient - Teaches the best strategies and most effective use of genetic information in the patient counseling setting

Download or read book Practical Preimplantation Genetic Testing written by Anver Kuliev and published by Springer Nature. This book was released on 2020-05-29 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully revised and updated with the most current information, the third edition of this practical clinical text covers all aspects of the rapidly advancing field of preimplantation genetic testing (PGT). Although PGT has become an established procedure for genetics and assisted reproduction practices over the last decade, its wider application has occurred after the introduction of next generation technologies in the last few years, necessitating this much-needed new edition. This will include, first of all, an update on PGT accuracy, reliability and safety, to ensure improved access to PGT for those who may benefit greatly from this technology. New content will also present progress in the primary prevention of genetic disorders, which now discusses approaches for prospective identification of at-risk PGT couples through the application of the extended gene testing panels. In fact, because of dramatic technological improvements in all aspects of PGT, most of the sections have been updated, with the addition of new sections on next generation technologies and universal PGT with combined testing for single gene and chromosomal disorders, which has previously presented a challenge. The guiding PGT strategies for different genetic disorders are presented, with emphasis on the most complicated cases that might be of special utility in the wider application PGT technologies worldwide. Additionally, a new section will be devoted to borderline indications, which will include common adult-onset conditions with genetic predisposition and non-genetic indications, expanding PGT applications to heart disease and cancer and the use of PGT for stem cell transplantation treatment of genetic and acquired disorders, where unique outcome data has become available. Combining the latest research and the most cutting-edge practice, Practical Preimplantation Genetic Testing, 3e is an excellent resource for clinical reproductive medicine specialists, genetic counselors, researchers and analysts.

Download or read book An Atlas of Preimplantation Genetic Diagnosis written by Yury Verlinsky and published by CRC Press. This book was released on 2004-12-22 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensively illustrated, this atlas is a manual for the establishment and realization of PGD within the framework of assisted reproduction and genetics services. Fully revised and updated, the atlas includes descriptions of the authors' pioneering work on polar body based PGD for genetic and chromosomal disorders. The authors' novel experience of PGD for late-onset disorders with genetic predisposition will be of special interest. Their accumulated PGD experience for poor-prognosis IVF patients presents further evidence of the improvement of clinical outcome and the requirement for meiotic error testing for a higher accuracy of preselecting aneuploidy-free embryos for transfer.

Download or read book Genetic Disorders and the Fetus written by Aubrey Milunsky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technological advances continue to expand the number of genetic disorders that can be diagnosed in utero. Utilization of this new technology has de manded special expertise available in relatively few academic centers. As these new applications have become more widespread so have the realities of the medicolegal implications. Notwithstanding the laboratory challenges, most legal action, at least in the United States, has arisen from the physician's failure to inform a patient about the risks of a genetic disorder or the oppor tunities presented by prenatal diagnosis. Hence an extensive thorough reex amination of the subject seems appropriate and timely. The steady escalation in the number of prenatal genetic studies now being done in the western world makes it imperative for the physician to have a thorough comprehension of the subject in its entirety. I am, therefore, fortu nate in having colleagues who as acknowledged experts have shared their knowledge and experience in order to make this volume a major critical repository of facts and guidance about prenatal genetic diagnosis. The subject matter ranges from a consideration of required genetic counseling through the intricacies of establishing prenatal diagnoses. Special attention is focused on new advances using ultrasound, a-fetoprotein, fetoscopy, and first trimester diagnosis. Both ethical and legal implications are discussed in detail, as is the development of public policy.

Download or read book Reproductive Genetics written by Sean Kehoe and published by RCOG. This book was released on 2009-11 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the findings of the RCOG Study Group findings on genetics underlying reproductive function.

Download or read book Preconception and Preimplantation Diagnosis of Human Genetic Disease written by Robert G. Edwards and published by CUP Archive. This book was released on 1993-04-08 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of human in vitro fertilization and developments in molecular science have made it possible to diagnose genetic disease in fetuses at a very early stage of development. This book presents the most recent advances and developments in this new area of applied research. Experts in the field describe and discuss the latest technology, from micromanipulation of single cells to sophisticated methods of DNA analysis. The book considers the implications of this new technology for fetal screening and the prevention of genetic disease, as well as for the control and manipulation of the normal sex ratio. It draws together current knowledge and discusses the new clinical opportunities for disease prevention. The book begins with an overview of the genetics of some common inherited diseases and the historical development of prenatal screening. It then draws together the most recent advances in preimplantation diagnostic techniques, including tissue assays for specific genetic disorders, and methods for typing and separating spermatozoa. The practical aspects of the new methodologies are considered, along with the potential for developing safer, more reliable and less invasive methods of diagnosis. The ethical and legal implications of this diagnostic approach are also discussed.

Download or read book In Vitro Fertilization written by Kay Elder and published by Cambridge University Press. This book was released on 2010-12-02 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully updated new edition of a successful and popular practical guide is an indispensable account of modern in-vitro fertilization practice. Initial chapters cover theoretical aspects of gametogenesis and embryo development at the cellular and molecular level, while the latter half of the book describes the requisites for a successful IVF laboratory and the basic technologies in ART. Advanced techniques, including pre-implantation genetic diagnosis, vitrification and stem-cell technology, are comprehensively covered, providing up-to-date analyses of these groundbreaking technologies. This edition includes: • New practical techniques, including preservation of fertility for cancer patients, stem-cell biology/technology, vitrification and in-vitro maturation • A 'refresher' study review of fundamental principles of cell and molecular biology • The latest information available from animal and human research in reproductive biology Packed with a wealth of practical and scientific detail, this is a must for all IVF practitioners.