Download or read book Pituitary Adenylate Cyclase Activating Polypeptide PACAP written by Dora Reglodi and published by Springer. This book was released on 2016-10-08 with total page 818 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive book to cover all aspects of the last 25 years of PACAP (pituitary adenylate cyclase activating polypeptide) research, this book contains contributions from virtually all the leading researchers in the field, and addresses some of the following topics: evolutionary aspects of PACAP, distribution and occurrence of PACAP and its receptors, hormonal effects of PACAP, intracellular signaling, effects on cellular proliferation and differentiation, protective effects of PACAP, behavioral effects of PACAP, developmental aspects of PACAP, other physiological effects of PACAP (cardiovascular, thermoregulatory), human studies, drug design, metabolism and transport. This compendium can serve as an important reference for researchers and students in PACAP research and can also be a thorough introduction for those in related fields.
Download or read book Pituitary Adenylate Cyclase Activating Polypeptide written by Hubert Vaudry and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pituitary Adenylate Cyclase-Activating Polypeptide is the first volume to be written on the neuropeptide PACAP. It covers all domains of PACAP from molecular and cellular aspects to physiological activities and promises for new therapeutic strategies. Pituitary Adenylate Cyclase-Activating Polypeptide is the twentieth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.
Download or read book Pituitary Adenylate Cyclase Activating Peptide PACAP written by Kristian Moller and published by . This book was released on 1997 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Novel Therapeutic Potential for Pituitary Adenylate Cyclase Activating Polypeptide PACAP Vasoactive Intestinal Peptide VIP and related peptides in cognition deficits written by Lucia Ciranna and published by Frontiers Media SA. This book was released on 2021-11-01 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanisms of Pituitary Adenylate Cyclase Activating Peptide PACAP evoked Release of Norepinephrine in Primary Cultures of Chick Sympathetic Neurons written by Dmitry V. Leontiev and published by . This book was released on 1998 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pituitary Adenylate Cyclase Activating Peptide written by Yanzhen Zhang and published by . This book was released on 1996 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Vasoactive Intestinal Peptides Pituitary Adenylate Cyclase Activating Polypeptide And Related Regulatory Peptides From Molecular Biology To Clinical Applications written by G Rosselin and published by World Scientific. This book was released on 1994-06-21 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the most up-to-date information on the ever-growing class of peptides with high biological activity, which function as hormones or neurotransmitters and have analogous structures. These peptides include the Vasoactive Intestinal Peptide (VIP), the Pituitary Adenylate Cyclase-Activating Polypeptides (PACAP 38 and PACAP 27), the Peptide Histidyl-Isoleucylamide and the Histidyl-Methionine Peptide (PHI and PHM), Helodermin, Helospectin, the Growth Hormone Releasing Factor (GRF), Glucagon, the Glucagon-like Peptides I and II, Oxyntomodulin, Glicentin and Secretin.Selection, organization and special subject matter: The contributors to this volume who are leading experts in their fields, present a valuable synopsis of the significant research in the transduction of the peptide signals, and how it helps to maintain the essential environment for cellular functions and adaptation. Contributions are organized around the molecular systems involved in the normal and altered functions of the central nervous system, the endocrine systems and cellular proliferation. In addition, the book identifies potential sites to be targeted for drug design and therapeutic development in the domain of biosynthesis, inflammation and cardiovascular and digestive diseases.This book draws together information from widely-scattered literature and thus obviates the need for time-consuming research on the part of the readers. It is aimed at an international audience of pharmacologists, physiologists, clinical investigators, biochemists and researchers.
Download or read book Peptides for Health Benefits 2019 written by Blanca Hernández-Ledesma and published by . This book was released on 2020-06-23 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book VIP PACAP and Related Peptides written by Wolf-Georg Forssmann and published by . This book was released on 1998 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume of papers research findings on vasoactive intestinal peptide (VIP), pituitary adenylate cyclase activating peptide (PACAP), and related peptides are presented. The authors provide information on the biology, biochemistry, molecular biology, physiology, signal transduction mechanisms, and pharmacology of these peptides. Their roles in neurobiology, cell proliferation and tumorogenesis, inflammation and tissue injury, endocrinology, gastrointestinal function, and other topics are discussed, along with clinical and potential therapeutic implications.
Download or read book Studies of Pituitary Adenylate Cyclase activating Polypeptide PACAP and Vasoactive Intestinal Peptide VIP and Their Effects on Pituitary Hormone Secretion in the Ewe written by Kitja Sawangjaroen and published by . This book was released on 1997 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Stress Physiology Biochemistry and Pathology written by George Fink and published by Academic Press. This book was released on 2019-01-12 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stress impacts the daily lives of humans and all species on Earth. Physiology, Biochemistry, and Pathology, the third volume of the Handbook of Stress series, covers stress-related or induced physiology, biochemistry, and pathology. Integrated closely with new behavioral findings and relevance to human conditions, the concepts and data in this volume offer readers cutting-edge information on the physiology of stress. A sequel to Elsevier’s Encyclopedia of Stress (2000 and 2007), this Handbook of Stress series covers the many significant advances made since then and comprises self-contained volumes that each focus on a specific area within the field of stress. Targeted at scientific and clinical researchers in neuroendocrinology, neuroscience, biomedicine, endocrinology, psychology, psychiatry, the social sciences, and stress and its management in the workplace, this volume and series are ideal for graduate students, post-doctoral fellows, and faculty interested in stress and its consequences. Chapters offer impressive scope, with topics addressing stress-related or induced physiology, biochemistry, and pathology Articles carefully selected by eminent stress researchers and prepared by contributors representing outstanding scholarship in the field, with each chapter fully vetted for reliable expert knowledge Richly illustrated with explanatory figures and tables Each chapter has a boxed “Key points call out section The volume is fully indexed All chapters are electronically available via ScienceDirect Affordably priced, self-contained volume for readers specifically interested in the physiology, biochemistry and pathology of stress, avoiding the need to purchase the whole Handbook series
Download or read book P A C A P written by CHRISTINE.. OUSTRIC and published by . This book was released on 1996 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Structural Analysis of Pituitary Adenylate Cyclase Activating Polypeptide Pacap Type I Receptor written by Yong-Jiang Cao and published by . This book was released on 1996 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Characterisation of Human Pituitary Adenylate Cyclase Activating Polypeptide PACAP PAC1 Receptor Null and Hop 1 Intracellular Loop 3 Isoforms written by Chantevy Pou and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pituitary Adenylate Cyclase Activating Polypeptide PACAP written by Guo, Xi and published by . This book was released on 1996 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuropeptides in Neuroprotection and Neuroregeneration written by Fred Nyberg and published by CRC Press. This book was released on 2012-06-19 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the genomic era is no longer in its infancy, the life sciences are still facing questions about the role of endogenous proteins and peptides in homeostasis and pathologies. Delving into one of the most current fields of interest in biology and medicine, Neuropeptides in Neuroprotection and Neuroregeneration describes the impact of neuropeptides on neuroprotection and neuroregeneration. The book begins with chapters describing important features of the endogenous neuropeptide systems related to their formation, receptor signaling, and inactivation. It includes chapters focused on the design and development of peptide-like drugs (peptidomimetics). In addition, the book covers: General aspects regarding the biosynthesis, structures, and distribution of neuroactive peptides and their receptors Basic mechanisms for neuropeptide action, metabolism, as well as techniques for their detection and aspects essential for the cellular mechanisms underlying brain pathology Neuropeptides known for their impact in neurodegenerative and neuroprotective processes Fundamental aspects as well as recent progress in the development of peptidomimetics of neuroprotective and cognition-enhancing peptides
Download or read book Targeted Disruption of the Gene for Pituitary Adenylate Cyclase activating Polypeptide PACAP in Mouse Results in Metabolic Dysfunction written by Sarah Louise Gray and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A recently discovered peptide hormone, pituitary adenylate cyclase-activating polypeptide (PACAP) regulates several endocrine systems affecting essential physiological processes such as metabolism, growth, reproduction, and the stress response. PACAP acts as a hypophysiotropic factor, is a potent secretogogue of insulin, regulates production and release of catecholamines from the adrenal medulla and acts as a neuromodulator in the sympathetic and parasympathetic nervous system. The primary structure of PACAP has been highly conserved during the evolution of chordates suggesting it plays an important physiological role. The objective of my thesis was to identify PACAP's primary physiological function and to determine if it is essential for survival by generating a mouse line deficient in PACAP through targeted disruption of the PACAP gene locus. Postnatal PACAP expression was examined to determine sites of peripheral PACAP production. In addition, several splice variants of the PACAP gene with alternate 5'untranslated regions were identified suggesting a complex system for regulating expression of the mouse PACAP gene. A targeting vector that allows tissue specific or developmental stage specific knockout of the PACAP gene was constructed in the event that PACAP gene deletion resulted in embryonic lethality. PACAP null mice were generated from homologously recombined embryonic stem cells. Initial characterization of the PACAP null mice determined that in the absence of PACAP, mice died within the first two postnatal weeks with abnormal lipid metabolism. Lipid accumulation was present in liver, heart and skeletal muscle and serum lipids were high. Mitochondrial dysfunction in the liver was not the cause of the lipid accumulation, as P-oxidative function was normal. I conclude that PACAP null mice are unable to regulate lipid release from white adipose tissue stores, resulting in a flood of lipids to non-adipose tissues. The abnormal distribution of lipids observed in the PACAP null mice is characteristic of diabetes type 2, yet classical insulin resistance is not observed. Thus, elevated insulin levels were accompanied by low blood glucose levels and the response to a glucose challenge was normal. The uncontrolled release of free fatty acids may result if glucose that is taken up by cells can not be utilized and an alternate energy source is required or if white adipocytes only are insulin resistant. The PACAP null mice were temperature sensitive, in that when raised at 21"C they exhibited metabolic dysfunction and died by two weeks of age. At 24°C most (85%) of the mice survived to adulthood with no obvious signs of metabolic dysfunction. We have determined that the inability of the PACAP null pups to thermoregulate normally when exposed to a lower environmental temperature may be associated with decreased norepinephrine levels to the brown adipose tissue. PACAP may be important for the production and release of catecholamines in the adrenal gland or within the sympathetic nervous system in times of prolonged stress. A mechanistic connection between the lipid abnormalities and the temperature sensitivity in the PACAP null pups has yet to be made. Catecholamines affect a wide range of tissues and the problems associated with insulin regulation within the PACAP null mice may be due to the imbalance in catecholamine production. As one of two main stress response systems, the sympathetic nervous system elicits a vital coping mechanism in times of stress and PACAP's ability to regulate this system may explain why the primary structure of PACAP has remained so highly conserved. PACAP is a wide acting hormone and therefore the metabolic problems seen in the PACAP null mice may result from altered regulation of several endocrine systems at once. Targeted disruption of the PACAP gene in mouse has revealed a role for PACAP in the regulation of lipid metabolism and in the sympathetic control of thermoregulation.
