Download or read book Pharmacokinetic differences of drugs and their regulatory mechanisms under dual status including normal and diseased organism written by Zipeng Gong and published by Frontiers Media SA. This book was released on 2023-01-06 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pharmacokinetic Pharmacodynamic Model of Drugs and Their Pharmacokinetic Differences between Normal and Disease States written by Zipeng Gong and published by Frontiers Media SA. This book was released on 2024-08-14 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the main frame of the above research topic, 16 contributions have been published including but not limited to the comparative pharmacokinetics between normal and disease status, the changes in the expression and function of drug-metabolizing enzymes and drug transporters in disease status and their related regulatory mechanisms, ADME/toxicity of drugs as well as their regulation, drug-drug interactions mediated by nuclear receptors, transporters and metabolic enzymes based on the methods and techniques of pharmacokinetics, transcriptomics, and metabolomics. However , the pharmacokinetic study is not only crucial in the development of new drugs, but also the study of pharmacokinetic-pharmacokinetic(PK-PD) model plays an important role in the process of new drug development. PK-PD model can reveal the internal relationship between drug concentration and effect, help to understand the dynamic characteristics of the drug action site in vivo and deduce the action site producing effect and drug concentration at the action site, which enables researchers to recognize the comprehensive characteristics of drug PK and PD processes in vivo. However, preclinical pharmacokinetic data are mainly derived from healthy animals, which is unreasonable. On the one hand, patients are the final consumers of drugs because drugs are mainly used to treat patients with diseases. On the other hand, whether the body is in a pathological state and the severity of the disease have different effects on the ADMEof drugs, which is closely related to whether the clinical drug is safe and effective. Therefore, studying the pharmacokinetics and PK-PD model in disease states is more meaningful and clinically relevant.
Download or read book Improving and Accelerating Therapeutic Development for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2014-02-06 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.
Download or read book Medicinal Chemistry Approaches to Personalized Medicine written by Karen Lackey and published by John Wiley & Sons. This book was released on 2013-11-22 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues. Numerous case studies from the first generation of "personalized drugs" are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas, such as neurosciences and inflammation, are also covered. With its careful balance of current and future approaches, this handbook is a prime knowledge source for every drug developer, and one that will remain up to date for some time to come. From the content: * Discovery of Predictive Biomarkers for Anticancer Drugs * Discovery and Development of Vemurafenib * Targeting Basal-Cell Carcinoma * G-Quadruplexes as Therapeutic Targets in Cancer * From Human Genetics to Drug Candidates: An Industrial Perspective on LRRK2 Inhibition as a Treatment for Parkinson's Disease * Therapeutic Potential of Kinases in Asthma * DNA Damage Repair Pathways and Synthetic Lethality * Medicinal Chemistry in the Context of the Human Genome and many more
Download or read book Toxicology Research Projects Directory written by and published by . This book was released on 1978 with total page 820 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
Download or read book Clinical Pharmacology Current Topics and Case Studies written by Markus Müller and published by Springer Science & Business Media. This book was released on 2011-02-04 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today we witness an eventful time in which the powerful new forces of genomics, information technology and economics are rapidly changing the science and art of medicine. This will require more specialization than ever before. However, there is also an increasing demand for an integrated approach, which is provided by the discipline of Clinical Pharmacology (CP). CP pursues a scientific goal by studying drug action in patients and volunteers, a clinical goal by administering appropriate drug therapy and a regulatory goal by assessing the risk/benefit ratio of drug candidates in drug development and reimbursement. This introduction to current topics of CP covers traditional topics of clinical drug research and trial methodology but also provides insight in current topics like genomics, imaging technology and issues in drug reimbursement. A number of concrete case studies in clinical drug research and development help to give a better understanding of the general principles of CP.
Download or read book Concepts and Principles of Pharmacology written by James E. Barrett and published by Springer Nature. This book was released on 2019-12-24 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.
Download or read book Drug Transporters written by Martin F. Fromm and published by Springer Science & Business Media. This book was released on 2010-11-19 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.
Download or read book Pharmacokinetics and Adverse Effects of Drugs written by Ntambwe Malangu and published by BoD – Books on Demand. This book was released on 2018-05-23 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a fruit of a collaborative work from several international scientists. It will be a useful resource for researchers, students, and clinicians. Each individual chapter could serve as a prescribed reading for postgraduate students and clinicians specializing in and practicing clinical pharmacology and toxicology, pharmacotherapy and pharmacotherapeutics, pharmacovigilance, and toxicovigilance, as well as those involved in clinical research, drug discovery, and development. Every chapter in this book discusses and provides illustrations on the theme discussed based on authors' understanding and experience while summarizing existing knowledge. In doing so, each chapter provides a new insight that would benefit a novice as well as a seasoned reader in understanding the pharmacokinetic mechanisms and risk factors involved in the occurrence of adverse effects of drugs.
Download or read book Mosby s Dictionary of Medicine Nursing and Health Professions Australian New Zealand Edition eBook written by Peter Harris and published by Elsevier Health Sciences. This book was released on 2014-09-08 with total page 2100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perfect for: Students of Nursing, Medicine and Health Professions. Clinicians in Nursing, Medicine and Health Professions. Educators in Nursing, Medicine and Health Professions. Benefits: The only Australian medical dictionary. Receive free access to the dictionary's online resources. Over 30 medical and health specialties covered. Over 39,000 entries, plus enyclopedic entries of significant terms. Over 50 new drug entries. High quality images and tables. Widely used by students, educators and professionals, Mosby’s Dictionary of Medicine, Nursing & Health Professions, 3rd Edition is the definitive reference text for Australian and New Zealand regions. Harris, Nagy and Vardaxis’ Mosby’s Dictionary, 3rd Edition delivers more than 1,100 new and revised definitions, more than 50 new drug entries, and a total of 74 new and updated tables for key reference information to complement definitions. As the only Australian medical dictionary, you also benefit from context-specific information written in local spelling conventions alongside phonetic pronunciation guides throughout Harris, Nagy and Vardaxis’ reference book. Enhance your knowledge base with an array of free online content, which supplements Mosby’s Dictionary of Medicine, Nursing & Health Professions, 3rd Edition. Make the most of the online regionalised spellchecker, five comprehensive appendices and an extensive image collection that can be viewed offline, including a printable colour atlas of human anatomy. over 39,000 clear, precise entries, plus encyclopaedic entries of significant terms over 2000 high quality images and the apt use of tables to demonstrate and clarify more than 30 medical and health specialties represented a detailed colour atlas of anatomy, enhancing the comprehension of anatomical terms local spelling conventions and phonetic pronunciation guides throughout fully revised etymologies comprehensive entries for numerous drugs valuable appendices, including normal laboratory values for adults and children, units of measurement, nutrition guidelines, assessment guides, immunisation schedules, infection control and herb-drug interactions Evolve Resources Online Features: free access to all online resources regionalised spellchecker printable colour atlas of human anatomy image collection offers all images for online viewing 5 comprehensive appendices over 50 new drug entries over 1,100 new and revised definitions a total of 74 new and updated tables providing key reference information to supplement definitions revised and updated materials throughout as well as many new terms, tables and illustrations to ensure currency and relevance updates of all appendices
Download or read book Oral Cephalosporins written by Robert C. Moellering and published by S Karger Ag. This book was released on 1995 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an excellent survey of the chemistry, microbiology, pharmacology and clinical use of the oral cephalosporins in general and the newer agents in particular. The cephalosporins have long provided satisfactory treatment for many disorders without causing serious side effects; and over the past fifty years forms with different antimicrobial, pharmacologic and toxicologic properties have been developed. Despite the broad spectrum of their activity against a large variety of gram-positive and gram-negative bacteria, the third-generation oral cephalosporins including the prodrug esters do not work against Pseudomonas aeruginosa, methicillin-resistant staphylococci, enterococci or Bacteroides species. Many, however, are suitable for treating infections of the respiratory and urinary tracts and of the skin and its structure, as well as certain sexually-transmitted diseases. Authors consider other possible uses, against multi-resistant Enterobacteriaceae for instance, but also point out the limitations of the oral cephalosporins. For those working in the fields of infectious disease, bacteriology, chemotherapy, pharmaceutics and pharmacokinetics, this book is a valuable source of authoritative information.
Download or read book Drug Metabolism written by Mino R. Caira and published by Springer Science & Business Media. This book was released on 2006-07-10 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.
Download or read book An Essay Concerning Human Understanding written by John Locke and published by . This book was released on 1894 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Clinical Precision Medicine written by Judy S. Crabtree and published by Academic Press. This book was released on 2019-11-15 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Precision Medicine: A Primer offers clinicians, researchers and students a practical, up-to-date resource on precision medicine, its evolving technologies, and pathways towards clinical implementation. Early chapters address the fundamentals of molecular biology and gene regulation as they relate to precision medicine, as well as the foundations of heredity and epigenetics. Oncology, an early adopter of precision approaches, is considered with its relationship to genetic variation in drug metabolism, along with tumor immunology and the impact of DNA variation in clinical care. Contributions by Stephanie Kramer, a Clinical Genetic Counselor, also provide current information on prenatal diagnostics and adult genetics that highlight the critical role of genetic counselors in the era of precision medicine. Includes applied discussions of chromosomes and chromosomal abnormalities, molecular genetics, epigenetic regulation, heredity, clinical genetics, pharmacogenomics and immunogenomics Features chapter contributions from leaders in the field Consolidates fundamental concepts and current practices of precision medicine in one convenient resource
Download or read book Mosby s Dictionary of Medicine Nursing Health Professions eBook written by Mosby and published by Elsevier Health Sciences. This book was released on 2016-04-28 with total page 2064 pages. Available in PDF, EPUB and Kindle. Book excerpt: Make sense of the complex world of health care with Mosby's Dictionary of Medicine, Nursing & Health Professions, 10th Edition! This one-stop reference includes detailed entries that help you communicate more effectively with colleagues in various disciplines. With over 56,000 definitions, 2,450 photographs and line drawings, and supporting reference appendixes and atlases, it is an indispensable reference for students and professionals alike. Over 56,000 entries offer detailed definitions, as well as the latest information on pathophysiology, treatment and interventions, and nursing care. More than 2,450 color photographs and line drawings demonstrate and explain complex conditions and abstract concepts. Strict, common-sense alphabetical organization makes it easy to find key terms and definitions. Detailed appendixes provide you with useful information on lab values, symbols and abbreviations, pharmacology, infection control standards, and more that can be used throughout your health career. NEW! Approximately 5,000 new and revised definitions reflect the latest developments in health care, drugs, and nursing terminology. NEW! Completely updated illustrations visually clarify key definitions to reflect current healthcare practice and equipment.
Download or read book Mosby s Medical Dictionary E Book written by Mosby and published by Elsevier Health Sciences. This book was released on 2016-04-29 with total page 2000 pages. Available in PDF, EPUB and Kindle. Book excerpt: Make sense of the complex world of health care with Mosby’s Medical Dictionary, 10th Edition! This one-stop reference includes detailed entries that help you communicate more effectively with colleagues in various disciplines. With over 56,000 definitions, 2,450 photographs and line drawings, and supporting reference appendixes and atlases, it is an indispensable reference for students and professionals alike. Over 56,000 entries offer detailed definitions, as well as the latest information on pathophysiology, treatment and interventions, and nursing care. More than 2,450 color photographs and line drawings demonstrate and explain complex conditions and abstract concepts. Strict, common-sense alphabetical organization makes it easy to find key terms and definitions. NEW! Approximately 5,000 new and revised definitions reflect the latest developments in health care, drugs, and nursing terminology. NEW! Updated illustrations visually clarify key definitions that reflect current health care practice and equipment.
