Download or read book Osteochondral Tissue Engineering written by J. Miguel Oliveira and published by Springer. This book was released on 2018-05-07 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the most recent developments in the field of osteochondral tissue engineering (OCTE) and covers in detail the concepts and current challenges for bone and cartilage repair and regeneration. Specific topics include viscosupplementation, biologicals, tissue engineering approaches, in vitro and in vivo models, and technological advances with stem cells, bioreactors, and microfluidics. Osteochondral Tissue Engineering: Challenges, Current Strategies, and Technological Advances presents challenges and strategies in the field of osteochondral regeneration and serves as a core reference for biomedical engineering students and a wide range of established researchers and professionals working in orthopedics.

Download or read book Osteochondral Tissue Engineering written by J. Miguel Oliveira and published by Springer. This book was released on 2018-04-24 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the most recent developments in the field of osteochondral tissue engineering (OCTE) and presents challenges and strategies being developed that face not only bone and cartilage regeneration, but also establish osteochondral interface formation in order to translate it into a clinical setting. Topics include nanotechnology approaches and biomaterials advances in osteochondral engineering, advanced processing methodology, as well as scaffolding and surface engineering strategies in OCTE. Hydrogel systems for osteochondral applications are also detailed thoroughly. Osteochondral Tissue Engineering: Nanotechnology, Scaffolding-Related Developments and Translation is an ideal book for biomedical engineering students and a wide range of established researchers and professionals working in the orthopedic field.

Download or read book Articular Cartilage Tissue Engineering written by Kyriacos A. Athanasiou and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cartilage injuries in children and adolescents are increasingly observed, with roughly 20% of knee injuries in adolescents requiring surgery. In the US alone, costs of osteoarthritis (OA) are in excess of $65 billion per year (both medical costs and lost wages). Comorbidities are common with OA and are also costly to manage. Articular cartilage's low friction and high capacity to bear load makes it critical in the movement of one bone against another, and its lack of a sustained natural healing response has necessitated a plethora of therapies. Tissue engineering is an emerging technology at the threshold of translation to clinical use. Replacement cartilage can be constructed in the laboratory to recapitulate the functional requirements of native tissues. This book outlines the biomechanical and biochemical characteristics of articular cartilage in both normal and pathological states, through development and aging. It also provides a historical perspective of past and current cartilage treatments and previous tissue engineering efforts. Methods and standards for evaluating the function of engineered tissues are discussed, and current cartilage products are presented with an analysis on the United States Food and Drug Administration regulatory pathways that products must follow to market. This book was written to serve as a reference for researchers seeking to learn about articular cartilage, for undergraduate and graduate level courses, and as a compendium of articular cartilage tissue engineering design criteria. Table of Contents: Hyaline Articular Cartilage / Cartilage Aging and Pathology / In Vitro / Bioreactors / Future Directions

Download or read book The Soft Hard Tissue Junction written by Neil D. Broom and published by Cambridge University Press. This book was released on 2018-11-29 with total page 810 pages. Available in PDF, EPUB and Kindle. Book excerpt: Richly illustrated throughout with actual tissue images, this innovative book shows that the soft-hard tissue junction is best understood in a biomechanical context. The authors describe their pioneering experimental methods, providing an essential structure-function framework for computational modelling, and thereby encouraging the development of more realistic, predictive models of this important tissue junction. Covering the three main musculoskeletal junctions of cartilage-bone, disc-vertebra, and ligament/tendon-bone, the relevant soft tissues are examined with respect to both their own inherent structure and their mode of integration with the hard tissue. The soft-hard tissue interface is explored with a focus on structural damage resulting from overloading, and its associated pathologies. Adopting a multiscale approach, ranging in structural resolution from the macro to fibril levels, this is a must-have guide to the field and an ideal resource for researchers seeking new and creative approaches for studying the joint and spine tissues.

Download or read book Osteochondral Tissue Engineering for Total Joint Repair written by Doreen Hamann and published by . This book was released on 2008 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advances In Tissue Engineering written by Julia M Polak and published by World Scientific. This book was released on 2008-08-20 with total page 947 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Tissue Engineering is a unique volume and the first of its kind to bring together leading names in the field of tissue engineering and stem cell research. A relatively young science, tissue engineering can be seen in both scientific and sociological contexts and successes in the field are now leading to clinical reality. This book attempts to define the path from basic science to practical application. A contribution from the UK Stem Cell Bank and opinions of venture capitalists offer a variety of viewpoints, and exciting new areas of stem cell biology are highlighted. With over fifty stellar contributors, this book presents the most up-to-date information in this very topical and exciting field./a

Download or read book Scaffolding In Tissue Engineering written by Peter X. Ma and published by CRC Press. This book was released on 2005-08-19 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: The growing interest in scaffolding design and increasing research programs dedicated to regenerative medicine corroborate the need for Scaffolding in Tissue Engineering. While certain books and journal articles address various aspects in the field, this is the first current, comprehensive text focusing on scaffolding for tissue engineering.

Download or read book Biomimicked Biomaterials written by Heung Jae Chun and published by Springer Nature. This book was released on 2020-06-29 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the second of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. In this volume, which is devoted to biomimetic biomaterials, the opening section discusses bone regeneration by means of duck’s feet-derived collagen scaffold and the use of decellularized extracellular matrices. The role of various novel biomimetic hydrogels in regenerative medicine is then considered in detail. The third section focuses on the control of stem cell fate by biomimetic biomaterials, covering exosome-integrated biomaterials for bone regeneration, cellular responses to materials for biomedical engineering, and the regulation of stem cell functions by micropatterned structures. Finally, the use of nano-intelligent biocomposites in regenerative medicine is addressed, with discussion of, for example, recent advances in biphasic calcium phosphate bioceramics and blood-contacting polymeric biomaterials. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials.

Download or read book Development of Osteochondral Tissue Constructs Using a Gradient Generating Bioreactor written by Alexander Lee Rivera and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue engineering is viewed as a promising method for repair of articular cartilage injuries. While mesenchymal stem cell (MSC) based tissue engineering strategies have produced tissue constructs that display extracellular matrix similarities to articular cartilage, including glycosaminoglycan (GAG) and collagen type II synthesis, these constructs have failed to provide a clinical solution. One primary limitation is the lack of integration between the engineered construct and the native cartilage. Integration is very difficult to achieve due to the avascular nature of articular cartilage. The use of osteochondral constructs can allow for enhanced integration since the construct is anchored with the subchondral bone, a highly vascularized tissue that displays an intrinsic remodeling capability. We developed a gradient generating bioreactor for biphasic tissue fabrication and investigated the fabrication of osteochondral tissue constructs. We hypothesized that exposure of MSC-scaffold constructs to osteochondral gradients would allow for the production of an osteochondral tissue construct that transitions from a cartilage-like region to a bone-like mineralized region. The bioreactor developed within this dissertation utilizes two flow inlet streams of different compositions, which combine into a single flow channel to form a biomolecular gradient across three-dimensional cell-scaffold constructs. The bioreactor was characterized via COMSOL Multiphysics simulations and fluorescent/dye molecule tracer experiments and was then fabricated from Delrin. Osteochondral gradients were generated across human MSCs seeded within collagen-GAG scaffolds. The developed tissue constructs displayed two distinct regions: a cartilage-like region and a mineralized region. Mineralization was observed via von Kossa staining and energy dispersive x-ray spectroscopy. Production of collagen type II was visualized via immunohistochemistry and was highest in regions of the tissue construct exposed to higher concentrations of chondrogenic medium. GAG production was observed throughout the construct using Safranin O staining and a quantitative GAG/DNA assay. Via mechanical characterization, the osteogenic regions of these samples displayed higher aggregate modulus values compared to the chondrogenic regions. These results indicate the osteochondral tissue constructs displayed both biochemical properties and mechanical properties unique to each tissue region. The novel gradient generating bioreactor developed here to investigate osteochondral tissue construct fabrication serves as promising tool to study the engineering of biphasic tissues.

Download or read book Innovative Materials and Techniques for Osteochondral Repair written by Horea Rareș Ciprian Benea and published by Materials Research Forum LLC. This book was released on 2019-11-25 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents research in treating focal joint cartilage defects. Lipoaspirate fluid (LAF) cells have important applications in such areas as orthopedics, general surgery, plastic and repair or vascular surgery. Also discussed are cartilage tissue regeneration therapies using collagen scaffolds and multipotent mesenchymal cells; this offers the possibility of making real "biological arthroplasties". The regeneration of cartilage tissue by injecting stem cell concentrates gives hope to patients suffering from cartilage degradation. Keywords: Biomaterials, Osteochondral Repair, Lipoaspirate Fluid (LAF) Cells, Arthrosis, Focal Joint Cartilage Defects, Physiopathology of Cartilage Lesions, Diagnosis of Cartilage Lesions, Treatment of Cartilage Lesions, Plastic Surgery, Vascular Surgery, Repair Surgery, Orthopedics, Biological Arthroplasties.

Download or read book Advanced biomaterials for osteochondral regeneration written by Le Yu and published by Frontiers Media SA. This book was released on 2023-01-20 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Multizonal Scaffolds for Osteochondral Tissue Engineering written by Drew Clearfield and published by . This book was released on 2018 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteochondral tissue is a biphasic material comprised of articular cartilage integrated atop subchondral bone. Damage to this tissue is highly problematic, owing to its intrinsic inability to regenerate functional tissue in response to trauma or disease. Further, the function of the tissue is largely conferred by its compartmentalized zonal microstructure and composition. Current clinical treatments fail to regenerate new tissue that recapitulates this zonal structure. Consequently, regenerated tissue often lacks long-term stability. To address this growing problem, we propose the development of tissue engineered biomaterials that mimic the zonal collagen orientation and composition of osteochondral tissue. First, a unidirectional freeze casting platform was developed that facilitated the fabrication of highly-aligned porous collagen scaffolds to serve as the superficial zone of the multidirectional scaffold. Subsequently, a novel lyophilization bonding process, which seamlessly bonds scaffolds with different orientations and compositions together, forming a monolithic multidirectional collagen-based scaffolds that mimicked the structure and composition of the superficial, transition, calcified cartilage, and osseous zones of osteochondral tissues. The microstructure of multidirectional scaffolds was characterized and the ability of these scaffolds to promote osteochondral differentiation of progenitor cells was assessed using a novel transgenic multi- reporter cell platform. Zonal osteogenic differentiation of bone marrow stromal cells was confirmed by transition of pre-osteoblast marker BSP-GFPtopaz to late osteoblast/early osteocyte marker DMP1-RFPmCherry. Conventional histological and gene expression analysis corroborated fluorescence data. Zonal chondrogenesis of triple transgenic articular chondrocytes harboring reporters for fibrocartilage (Col3.6-GFPtopaz), articular cartilage (Col2a1-GFPcyan), and hypertrophic (Col10a1-RFPmCherry) lineages was assessed and corroborated in a similar manner. Though the majority of fluorescent cells (65%) remained of articular origin, there was a progression (28%) towards a pre-hypertrophic phenotype. Combined with fluorescent reporter information, gene expression, histological, and immunohistochemical analyses, subtle differences in zone-specific cellular phenotype and newly-formed tissue were identified. Upon ectopic implantation in mice for 8 weeks, pre- hypertrophic cell populations terminally matured into mineralized tissue. Together, these data suggest that multidirectional zonal scaffolds hold promise for clinical use in directing zonal osteochondral repair by articular chondrocytes.

Download or read book Bone Tissue Engineering written by Jeffrey O. Hollinger and published by CRC Press. This book was released on 2004-10-14 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t

Download or read book Regenerative Engineering of Musculoskeletal Tissues and Interfaces written by Syam Nukavarapu and published by Woodhead Publishing. This book was released on 2015-04-24 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: Repair and regeneration of musculoskeletal tissues is generating substantial interest within the biomedical community. Consequently, these are the most researched tissues from the regeneration point of view. Regenerative Engineering of Musculoskeletal Tissues and Interfaces presents information on the fundamentals, progress and recent developments related to the repair and regeneration of musculoskeletal tissues and interfaces. This comprehensive review looks at individual tissues as well as tissue interfaces. Early chapters cover various fundamentals of biomaterials and scaffolds, types of cells, growth factors, and mechanical forces, moving on to discuss tissue-engineering strategies for bone, tendon, ligament, cartilage, meniscus, and muscle, as well as progress and advances in tissue vascularization and nerve innervation of the individual tissues. Final chapters present information on musculoskeletal tissue interfaces. Comprehensive review of the repair and regeneration of musculoskeletal individual tissues and tissue interfaces Presents recent developments, fundamentals and progress in the field of engineering tissues Reviews progress and advances in tissue vascularization and innervation

Download or read book Biomedical Composites written by Luigi Ambrosio and published by Elsevier. This book was released on 2009-11-23 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biocomposites are widely used in the medical industry to repair and restore bone, tooth, cartilage skin and other tissues. Biomedical composites, provides a thorough review of the current status, recent progress and future trends in composites for biomedical applications. Part one discusses the fundamentals of biocomposites with chapters on natural composites, design and fabrication of biocomposites, and hard and soft tissue applications of biocomposites. Part two then reviews applications of biocomposites. Chapters discuss composites for bone repair, composite coatings for implants, composites for spinal implants, injectable composites and composites for tissue engineered scaffolds. Chapters in part three discuss the biocompatibility, mechanical behaviour and failure of biocomposites with such topics as cellular response, testing of biocomposites and tribology of biocomposites. Finally part four reviews the future for biocomposites with chapters on nano-structured biocomposites, developing biocomposites as scaffolds and biocomposites in tissue engineering and regenerative medicine. With its distinguished editor and team of international contributors, Biomedical composites is an essential reference to materials scientists and researchers in industry and academia, as well as all those concerned with this increasingly important field. Provides a thorough review of the current status, recent progress and future trends in composites for biomedical applications Discusses the fundamentals of biocomposites with chapters on natural composites, design and fabrication of biocomposites and their applications Chapters address composites for bone repair, spinal implants and various other applications and discuss biocompatability, mechanical behaviour and failure of biocomposites

Download or read book Stem Cell and Tissue Engineering written by Song Li and published by World Scientific. This book was released on 2011 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue engineering integrates knowledge and tools from biological sciences and engineering for tissue regeneration. A challenge for tissue engineering is to identify appropriate cell sources. The recent advancement of stem cell biology provides enormous opportunities to engineer stem cells for tissue engineering. The impact of stem cell technology on tissue engineering will be revolutionary. This book covers state-of-the-art knowledge on the potential of stem cells for the regeneration of a wide range of tissues and organs and the technologies for studying and engineering stem cells. It serves as a valuable reference book for researchers and students.

Download or read book Tissue Engineering of Cartilage and Bone written by Gregory R. Bock and published by John Wiley & Sons. This book was released on 2003-07-22 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue engineering takes advantages of the combined use of cultured living cells and three-dimensional scaffolds to reconstruct adult tissues that are absent or malfunctioning. This book brings together scientists and clinicians working on a variety of approaches for regenerating of damaged or lost cartilage and bone to assess the progress of this dynamic field. In its early days, tissue engineering was driven by material scientists who designed novel bio-resorbable scaffolds on which to seed cells and grow tissues. This ground-breaking work generated high expectations, but there have been significant stumbling blocks holding back the widespread use of these techniques in the clinic. These challenges, and potential ways of overcoming them, are given thorough coverage in the discussions that follow each chapter. The key questions addressed in this book include the following. How good must cartilage repair be for it to be worthwhile? What is the best source of cells for tissue engineering of both bone and cartilage? Which are the most effective cell scaffolds? What are the best preclinical models for these technologies? And when it comes to clinical trials, what sort of outcome measures should be used? With contributions from some of the leading experts in this field, this timely publication will prove essential reading for anyone with an interest in the field of tissue engineering.