Download or read book New Insights Into the Biology and Advances in the Management of Multiple Myeloma written by Jean Luc Harousseau and published by . This book was released on 2007 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New Insights into the Biology and Advances in the Management of Multiple Myeloma Best in Practice and Research Clinical Haematology vol 20 n4 December 2007 written by Jean Luc Harousseau and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Biology and Therapy of Multiple Myeloma written by Nikhil C. Munshi and published by Springer Science & Business Media. This book was released on 2012-12-09 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.
Download or read book Advances in Biology and Therapy of Multiple Myeloma written by Nikhil C. Munshi and published by Springer Science & Business Media. This book was released on 2012-11-15 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.
Download or read book Biology and Management of Multiple Myeloma written by James R. Berenson and published by Springer Science & Business Media. This book was released on 2004-05-14 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert physicians and clinical researchers summarize and explain all the recent advances in the biology and treatment of bone marrow-based malignancy. On the biological side, the authors show the characteristics of the malignant cell and describe the significant roles played by oncogenic changes, chromosomal anomalies, Kaposi's sarcoma herpes virus, and cytokines. New epidemiological findings and prognostic factors are also analyzed. On the clinical side, the authors provide a comprehensive review of conventional treatment regimens, as well as a discussion of newer experimental approaches involving immunologic targeting, inhibitors of drug resistance, and antitumor agents.
Download or read book Multiple Myeloma Cancer written by Ethan D. and published by Shuttle Systems. This book was released on 2024-03-11 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Multiple Myeloma Cancer: A Comprehensive Resource for Patients and Families" is an essential guide for anyone touched by multiple myeloma. This book offers a thorough understanding of this complex cancer, from its biology to the latest in treatments and research advancements, providing invaluable support for patients and their loved ones.Deep Dive into Multiple MyelomaStart your journey with an in-depth look at multiple myeloma, including its types, epidemiology, and the historical perspective on research. Gain crucial insights into the nature of plasma cells and the genetic and molecular factors that contribute to the development of this cancer.Understanding Risk Factors and Early DetectionLearn about the risk factors associated with multiple myeloma and the importance of early detection. This book covers screening methods and the significance of early diagnosis in improving treatment outcomes.Symptoms, Diagnosis, and StagingRecognize the symptoms of multiple myeloma and understand the diagnostic process, including tests and procedures. Grasp the staging system, its role in disease progression, and its impact on treatment and prognosis.Exploring Treatment OptionsNavigate the treatment landscape of multiple myeloma, from conventional chemotherapy and stem cell transplantation to cutting-edge targeted therapies and immunotherapies. This book provides comprehensive information to help make informed decisions about care and treatment.Managing Side Effects and ComplicationsUnderstand and manage the side effects and complications of treatment, including the impact on bone health and strategies for infection management.Nutrition and LifestyleDiscover the importance of nutrition and lifestyle changes in supporting overall health during and after treatment. Get practical advice on diet, exercise, and lifestyle adjustments.Psychological and Emotional SupportFind guidance on coping with the emotional and psychological impacts of multiple myeloma. Learn about the importance of support systems, counseling, and the role of community and support groups.Living with Multiple MyelomaAddress the day-to-day challenges of living with multiple myeloma, including chronic management, quality of life issues, and survivorship care.Advances in ResearchStay informed about the latest in multiple myeloma research and emerging treatments. This section highlights the importance of clinical trials and future possibilities in myeloma care.Special ConsiderationsGain insights into how multiple myeloma affects different populations, including considerations for younger and elderly patients, and the unique aspects of the disease in men and women.Advocacy and Community EngagementUnderstand the role of patient advocacy, find community resources, and learn how to engage in raising awareness about multiple myeloma.The Future of Myeloma CareLook ahead to the innovations and evolving landscape of myeloma therapy, offering hope and a vision for the future of myeloma care."Multiple Myeloma Cancer: A Comprehensive Resource for Patients and Families" is more than just a book; it's a companion and guide through the journey of multiple myeloma. It provides the knowledge, support, and resources needed to navigate this challenging path with confidence and hope.
Download or read book Multiple Myeloma Cancer written by Ethan D. Anderson and published by . This book was released on 2024-01-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Multiple Myeloma Cancer: A Comprehensive Resource for Patients and Families" is an essential guide for anyone touched by multiple myeloma. This book offers a thorough understanding of this complex cancer, from its biology to the latest in treatments and research advancements, providing invaluable support for patients and their loved ones. Deep Dive into Multiple Myeloma Start your journey with an in-depth look at multiple myeloma, including its types, epidemiology, and the historical perspective on research. Gain crucial insights into the nature of plasma cells and the genetic and molecular factors that contribute to the development of this cancer. Understanding Risk Factors and Early Detection Learn about the risk factors associated with multiple myeloma and the importance of early detection. This book covers screening methods and the significance of early diagnosis in improving treatment outcomes. Symptoms, Diagnosis, and Staging Recognize the symptoms of multiple myeloma and understand the diagnostic process, including tests and procedures. Grasp the staging system, its role in disease progression, and its impact on treatment and prognosis. Exploring Treatment Options Navigate the treatment landscape of multiple myeloma, from conventional chemotherapy and stem cell transplantation to cutting-edge targeted therapies and immunotherapies. This book provides comprehensive information to help make informed decisions about care and treatment. Managing Side Effects and Complications Understand and manage the side effects and complications of treatment, including the impact on bone health and strategies for infection management. Nutrition and Lifestyle Discover the importance of nutrition and lifestyle changes in supporting overall health during and after treatment. Get practical advice on diet, exercise, and lifestyle adjustments. Psychological and Emotional Support Find guidance on coping with the emotional and psychological impacts of multiple myeloma. Learn about the importance of support systems, counseling, and the role of community and support groups. Living with Multiple Myeloma Address the day-to-day challenges of living with multiple myeloma, including chronic management, quality of life issues, and survivorship care. Advances in Research Stay informed about the latest in multiple myeloma research and emerging treatments. This section highlights the importance of clinical trials and future possibilities in myeloma care. Special Considerations Gain insights into how multiple myeloma affects different populations, including considerations for younger and elderly patients, and the unique aspects of the disease in men and women. Advocacy and Community Engagement Understand the role of patient advocacy, find community resources, and learn how to engage in raising awareness about multiple myeloma. The Future of Myeloma Care Look ahead to the innovations and evolving landscape of myeloma therapy, offering hope and a vision for the future of myeloma care. "Multiple Myeloma Cancer: A Comprehensive Resource for Patients and Families" is more than just a book; it's a companion and guide through the journey of multiple myeloma. It provides the knowledge, support, and resources needed to navigate this challenging path with confidence and hope.
Download or read book Multiple Myeloma written by Shaji Kumar and published by Demos Medical Publishing. This book was released on 2010-08-24 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple Myeloma: The second issue of Emerging Cancer Therapeutics focuses on multiple myelomas also known as plasma cell myeloma, KahlerÃs Disease and myelomatosis. It is estimated that over 20,000 new cases are diagnosed each year with over 10,000 people dying from these malignancies. Multiple myelomas are highly treatable but rarely curable. Thus it is crucial for the practitioner to be up-to-date on the latest insights regarding their management. Management options and outcomes for individuals with multiple myelomas improved dramatically with the introduction of chemotherapy. Even further improvements in prognosis have occurred because of the introduction of newer therapies such as pulse corticosteroids, thalidomide, bortezomib, and autologous and allogeneic stem cell transplantation. With the increased number of therapeutic options to choose from, the clinician is better placed to offer effective therapy but at the same time is challenged to keep abreast of the rapidly changing treatment landscape and the newly emerging data that is shaping the treatment options today and in the future. Multiple Myeloma provides a comprehensive and in-depth review of this group of malignancies. This volume reviews the current literature, provides critical evaluations of the data and offers evidence-based recommendations. About the Series: Emerging Cancer Therapeutics is an invited review publication providing a through analysis of key clinical research related to cancer therapeutics, including a discussion and assessment of current evidence, current clinical best practice, and likely near future developments. There is an emphasis throughout on multidisciplinary approaches to the specialty, as well as on quality and outcomes analysis. Published three times a year Emerging Cancer Therapeutics provides authoritative, thorough assessments of advances in therapeutics in all major areas of oncology, both solid and hematologic malignancies, with a focus on advances in medical and biological therapies with emerging clinical impact and encompassing new technologies with implications for management such as molecular imaging. Features of Emerging Cancer Therapeutics include: Editorial board of nationally recognized experts across the spectrum of Cancer Therapeutics In-depth, up-to-date expert reviews and analysis of major new developments in all areas of Cancer Therapeutics Issues edited by an authority in specific subject area Focuses on major topics in Cancer Therapeutics with in-depth articles covering advances in clinical and translational research developments, as well as clinical applications and experience Emphasizes multidisciplinary approaches to research and practice "
Download or read book Multiple Myeloma written by Morie A. Gertz and published by Springer Science & Business Media. This book was released on 2013-10-01 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. Edited and written by a multidisciplinary group of recognized authorities from the Mayo Clinic, it presents clear guidelines on diagnosis and therapy and covers all aspects of multiple myeloma, from molecular classification and diagnosis, to risk stratification and therapy. Closely related plasma cell disorders such as solitary plasmacytoma, Waldenstrom macroglobulinemia, and light chain amyloidosis are discussed in detail as well. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care. Our understanding of this group of disorders is developing at an unprecedented rate, and Multiple Myeloma meets the need among oncologists and hematologists for a clear, timely, and authoritative resource on their biology, diagnosis, and treatment.
Download or read book Allogeneic Stem Cell Transplantation written by Hillard M. Lazarus and published by Springer Science & Business Media. This book was released on 2010-03-02 with total page 885 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.
Download or read book Myeloma Bone Disease written by G. David Roodman and published by Springer Science & Business Media. This book was released on 2010-04-28 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the forefront in the science and clinical management of myeloma bone disease. Coverage begins with sections on clinical presentation, imaging, and biochemical markers and goes on to discuss radiation, surgical, and medical therapies.
Download or read book Multiple Myeloma written by Thomas Moehler and published by Springer Science & Business Media. This book was released on 2011-04-21 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple myeloma is currently still an incurable disease, but during the past decade knowledge of its molecular pathogenesis has increased rapidly. This has led to remarkable progress in both diagnosis and therapy, including in particular the approval of novel and first-in-class drugs such as thalidomide, bortezomib, and lenalidomide. This book, written by internationally acknowledged experts, covers a wide range of topics relating to multiple myeloma, including history, epidemiology, pathophysiology, clinical features, staging, and prognostic systems. The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable. Individualized therapy and the variety of supportive treatment options, as described in this volume, will help in achieving this goal, as well as in reducing adverse events and improving quality of life.
Download or read book Update on Multiple Myeloma written by Khalid Ahmed Al-Anazi and published by . This book was released on 2019-02 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive overview of the recent developments in the clinical and research fields of multiple myeloma. It is divided into three main sections that cover a wide range of topics, including: epidemiology and pathogenesis of the disease, genetic targets and pathways, resistance to novel therapies, angiogenesis and anti-angiogenesis, hematopoietic stem cell transplantation, role of radiology and radiotherapy in myeloma, infectious complications, and management of multiple myeloma in resource-poor countries.
Download or read book Modern Hematology written by Reinhold Munker and published by Springer Science & Business Media. This book was released on 2007-11-06 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its second edition, Modern Hematology: Biology and Clinical Management reflects the major advances in the understanding, diagnosis, and treatment of blood disorders. It describes the latest clinical and scientific developments as well as details targeted and molecular therapies. The book brings together facts, concepts, and protocols important for the practice of hematology. In 23 chapters, all major blood diseases are covered, as well as rare diseases that are of scientific interest. As in the previous edition, each chapter is illustrated by tables, figures, and a selection of color plates.
Download or read book Toward Precision Medicine written by National Research Council and published by National Academies Press. This book was released on 2012-01-16 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.
Download or read book Personalized Therapy for Multiple Myeloma written by Saad Z. Usmani and published by Springer. This book was released on 2017-10-30 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the clinician with concise, practical guidance on risk stratification and therapeutic decision making in patients with multiple myeloma. In addition, the available clinical trial and research data are summarized into meaningful reviews and evidence-based recommendations for treatment are presented. The coverage encompasses all phases and forms of disease, including high-risk myeloma. Over recent decades, greater understanding of the biology of myeloma has fostered the development of new, more effective drugs, leading to remarkable improvements in survival. To continue this momentum, several recent prospective trials have aimed to identify further potential therapeutic targets or to evaluate various combinations of anti-myeloma agents. The increasing abundance of management options makes the decision making complex in different phases of the disease. This book will offer the clinician valuable assistance in the choice and sequencing of therapies, highlighting the need for a personalized approach that reflects the growing recognition that myeloma is not one uniform disease.
Download or read book Waldenstr m s Macroglobulinemia written by Véronique Leblond and published by Springer. This book was released on 2016-10-06 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book sheds new light on clinical, biological and therapeutic data on the rare disease Waldenström’s Macroglobulinemia (WM) with the participation of widely-recognized experts, involved in this field. It represents the efforts of physicians, scientists and patients, all around the world, to better understand and cure this rare disease. Considerable advances in the diagnosis, treatment indications, response criteria, prognostic factors and treatment options have been made since Dr Jan Waldenström first reported this “new syndrome“ 70 years ago. Particularly instrumental in advancing of our understanding of WM have been the eight international workshops devoted to this disease. New, exciting molecular data have recently been reported, allowing us to revisit the oncogenic events leading to WM B-cell proliferation and to use newly available compounds targeting oncogenic pathways.
