Download or read book Surgical neuropathology of focal epilepsies written by Ingmar Blümcke and published by John Libbey Eurotext. This book was released on 2015-10-29 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: The need for neuropathology reviews in epilepsy surgery tissues steadily increases. However, textbooks and case presentations highlighting and focusing on this specific topic are rare. The authors of this book reviewed their professional experience in surgical and post-mortem neuropathology studies to compile a coherent summary of: clinico-pathological findings, current classification schemes, useful protocols research data for major histopathological entities of brain lesions encountered in modern epilepsy surgery programs, which is hippocampal sclerosis, brain tumours associated with early epilepsy onset, malformations of cortical development, brain inflammation and malformative vascular lesions. They did not intend to be exhaustive but rather representative of the main lesions and pathologies encountered. Thirty-two illustrated cases constitute the core of this book and will be very helpful in current practice.
Download or read book Neuropathology of Focal Epilepsies written by Reiner Lahl and published by John Libbey Eurotext. This book was released on 2003 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interdisciplinary co-operation between epileptologists, neuroradiologists, psychologists and neurosurgeons is the most fundamental prerequisite for localising and performing targeted resections of epileptogenic foci from patients with focal therapy resistant epilepsy. Worldwide there has been a steady increase in the number of epilepsy surgery centres, and in the number of operations performed on children and babies. A systematic neuropathological description is presented here involving macroscopic and histological findings. In this book, a systematic documentation of characteristic as well as rarer alterations is presented involving 444 patients who had been operated on in Germany between 1990 and 1997 at the Bethel Epilepsy Centre in Bielefeld. It includes 257 patients with temporal lobes (TLE) and 187 patients with extratemporal epilepsy (ETE).
Download or read book Neuropathology of Focal Epilepsies written by R. Lahl and published by . This book was released on 2003 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Epilepsies written by Chrysostomos P. Panayiotopoulos and published by Springer. This book was released on 2005 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives an exhaustive account of the classification and management of epileptic disorders. It provides clear didactic guidance on the diagnosis and treatment of epileptic syndromes and seizures through thirteen chapters, complemented by a pharmacopoeia and CD ROM of video-EEGs.
Download or read book Neuropathology of Epilepsy written by Francesco Scaravilli and published by World Scientific. This book was released on 1998 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Health Onlineturns a computer into your most important health tool. For newcomers, it makes going online easy by explaining e-mail and showing what’s on the big commercial online services. Later chapters explore Internet mailing lists, newsgroups, and World Wide Web pages. Even online veterans will benefit from the book’s listings of hundreds of health resources, especially self-help support groups.Health Onlinefinds the healing power of electronic networks not in technology or data, but in the worldwide community of people helping each other.
Download or read book Benign Focal Epilepsies written by N. Fejerman and published by John Libbey Eurotext. This book was released on 2007 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pediatric Neurology Part I written by Harvey B. Sarnat and published by Elsevier Inc. Chapters. This book was released on 2013-04-24 with total page 51 pages. Available in PDF, EPUB and Kindle. Book excerpt: The preoperative study of patients who are candidates for epilepsy surgery often classifies their epileptic foci as “lesional” or “non-lesional” based upon evidence from neuroimaging. Many lesions not detected by MRI are found by microscopic examination of the resected tissue. Advances have been made in neuropathological techniques to study resected brain tissue and to specify the types of focal cortical dysgeneses and other lesions by extending microscopic findings by applying immunocytochemical markers that identify specific types and distributions of neurons and glial cells that denote tissue architecture. There may be etiological differences between focal and extensive cortical dysplasias involving many gyri or entire lobes of cerebral cortex. Of additional importance in pediatric brain resections is that these modern techniques also denote cellular maturation and can identify abnormal cells with mixed lineage. α-B-crystallin can serve as a metabolic tissue marker of epileptic activity, regardless of the presence or absence of a “structural” lesion by MRI or by conventional histopathology. Satellitosis may contribute to epileptogenic neurons and later to death of those neurons. The classification of malformations of the brain is a process requiring continuous updates that include genetics, neuroimaging, and neuropathology as new data emerge, but should not be exclusive to one region of the brain, such as cerebral cortex or cerebellum. Standardization in neuropathological terminology enhances scientific communication. The ILAE recently published a useful consensus classification of focal cortical dysplasias that is flexible to enable future revisions and changes as new data become available.
Download or read book Atlas of Epilepsies written by S.R. Benbadis and published by Springer Science & Business Media. This book was released on 2010-09-20 with total page 1966 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atlas of Epilepsies is a landmark, all-encompassing, illustrated reference work and hands-on guide to the diagnosis, management and treatment of epilepsy in all its forms and across all age groups. The premier text in the field with over one thousand images, the Atlas’s highly illustrative approach tackles the difficult subject of epileptic seizures and epileptic syndromes, accompanied by sequential photographs of each management step. Intraoperative photographs are accompanied by detailed figure legends describing nuances, subtleties, and the thought processes involved in each step, providing a fuller understanding of each procedure. The Atlas draws on the expertise of over 300 internationally-renowned experts, and is liberally interspersed with clinical insights and personal vignettes that offer helpful tips, technical advice and critical knowledge to the clinician and scholar. The thorough and complete table of contents includes dedicated sections or chapters on important topics such as neonatal and pediatric seizures; imitators of epilepsy; EEG and neuroimaging; psychiatric and quality of life aspects of epilepsy; and a complete guide to treatment options including current and up-to-date chapters on pharmaceuticals, surgical procedures, and additional and alternative treatments. No other publication addresses epilepsies as thoroughly and completely as the Atlas of Epilepsies. Exhaustive and illustrative, convenient and current, this reference is sure to be the premier text on epilepsy for many years to come.
Download or read book Introduction to Epilepsy written by Gonzalo Alarcón and published by Cambridge University Press. This book was released on 2012-04-26 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers all aspects of epilepsy, from basic mechanisms to diagnosis and management, as well as legal and social considerations.
Download or read book Pediatric Neurology Part I written by André Palmini and published by Elsevier Inc. Chapters. This book was released on 2013-04-24 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malformations of cortical development (MCD) are now well established as a most prevalent and relevant etiology of medically refractory epilepsies in children and adolescents. Focal cortical dysplasia (FCD) and hemimegalencephalies (HMG) occupy a special status because their focality (or in the case of HMG, their unihemispheric distibution) makes them amenable to surgical treatment to attempt seizure control. Since interictal epileptiform discharges and frequent seizures can lead to abnormal development because of brain plasticity during early childhood, the aim of surgical treatment is not only seizure control but also the redirection of development toward more physiological paths. In this review, we propose an “imaging-semiological organization” including (1) patients whose dysplastic lesion surrounds the fronto-rolandic cortex with increased signal and a transmantle sign, (2) multilobar hemispheric lesions, predominating in the anterior or posterior quadrants with large areas of abnormal gyration, increased cortical thickness, and gray–white blurring, (3) anterior temporal dysplasias usually featuring volume reduction combined with blurring of the underlying white matter in the temporal pole, and (4) a very relevant group of patients with refractory seizures, normal or roughly normal intellect, and normal MRI, later shown to harbor microscopic “nidus” of dysplastic cells. Classification takes into account the cortical disorganization, the presence of aberrant cellular elements, and the association with other lesion types.
Download or read book Genetics of Focal Epilepsies written by Samuel F. Berkovic and published by John Libbey Eurotext. This book was released on 1999 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains contributions on genetic aspects of a wide range of focal epilepsies. It is based on an international workshop held in Avignon, France in September 1996. Topics covered include: idiopathic age-related focal epilepsies; idiopathic iocal epilepsies in infancy; autosomal dominant focal epilepsies; molecular biology; animals models; and case reports.
Download or read book Pediatric Neurology Part I written by Federico Vigevano and published by Elsevier Inc. Chapters. This book was released on 2013-04-24 with total page 41 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this chapter we include a series of epilepsies with onset in pediatric age characterized by focal seizures, idiopathic etiology, normal psychomotor development, and a benign course related to the spontaneous remission of seizures without sequelae. These entities are age-dependent and seizures tend to disappear spontaneously. For these reasons often the drug treatment is not necessary. On the basis of genetic assessment idiopathic focal epilepsies can be divided into two groups: nonautosomal dominant and autosomal dominant. In the group of nonautosomal entities we include benign epilepsy with centro-temporal spikes, Panayiotopoulos syndrome, idiopathic childhood occipital epilepsy described by Gastaut, and benign idiopathic midline spikes epilepsy. Seizures are rare, sometimes prolonged, as autonomic status in Panayiotopoulos syndrome. A common feature is the presence of peculiar EEG interictal paroxysmal abnormalities. In the group with an autosomal dominant mode of inheritance we include benign familial infantile seizures and benign familial neonatal–infantile seizures. These entities are characterized by partial seizures in cluster, self-limited in a brief period during the first months of life. There are no typical interictal EEG abnormalities. In some families a mutation in SCN2A, the gene coding for the 2α subunit of the voltage-gated sodium channel, has been described.
Download or read book A Clinical Guide to Epileptic Syndromes and their Treatment written by C. P. Panayiotopoulos and published by Springer Science & Business Media. This book was released on 2010-05-10 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: Affecting 4 percent of children and 1-2 percent of the general population, epilepsy is one of the most common neurological disorders. The 1st edition of this guide proved to be the only one of its kind, covering many important aspects of diagnosis and treatment. Due to the continued advances being made in the subject, and building on the sell-out success of the 1st edition this thorough revision reflects the latest report of the ILAE classification core group and the significant progress made in the diagnosis, classification and treatment of the epilepsies.
Download or read book Understanding Epilepsy written by Vibhangini S. Wasade and published by Cambridge University Press. This book was released on 2019-11-21 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, accessible synthesis of current information on epilepsy for medical trainees and physicians preparing for board certification.
Download or read book Jasper s Basic Mechanisms of the Epilepsies written by Jeffrey Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Download or read book The Causes of Epilepsy written by Simon Shorvon and published by Cambridge University Press. This book was released on 2019-05-02 with total page 1013 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanded and revised, this unique book provides concise descriptions of the many causes of epilepsy, for use in clinical practice.
Download or read book Pediatric Neurology Part I written by Ahsan N.V. Moosa and published by Elsevier Inc. Chapters. This book was released on 2013-04-24 with total page 49 pages. Available in PDF, EPUB and Kindle. Book excerpt: The spectrum of focal epileptogenic lesions and their clinical manifestations in children differ substantially from those seen in adults. In adults, mesial temporal sclerosis is the common lesion in surgical series; but in children, MTS is uncommon, and when it does occur, it exists frequently as dual pathology. The most common lesions in pediatric epilepsy surgery candidates are malformations of cortical development, developmental tumors, or encephalomalacia from infarction, hypoxia, trauma, or infection. Careful analysis of the lesion characteristics on brain MRI is sufficiently predictive of pathology in most cases. Histopathological evaluation remains the gold standard for diagnosis of mass lesions. The electroclinical phenotype of epilepsy in adults is largely determined by the anatomical location of the lesion and its connectivity. In children, in addition to the location of the lesion, the age at onset of the lesion and the age at onset of epilepsy have a major impact on the electroclinical phenotype. Children with congenital or early acquired lesions may manifest with generalized features on EEG and seizure semiology. Experience from various centers has demonstrated that a subset of these children benefit from epilepsy surgery despite a generalized epilepsy phenotype. All children with medically refractory epilepsy and a focal lesion should undergo evaluation for potential epilepsy surgery irrespective of the EEG findings and seizure semiology.
