Download or read book Multivariate Spatial Modeling of HIV Risk written by Martiniano Jose Flores and published by . This book was released on 2018 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: We analyze data from the Los Angeles LGBT Center, a community-based healthcare organization. When patients visit the clinic, they are given a comprehensive risk-assessment questionnaire. We develop three methods that allow us to identify the risk factors associated with HIV seroconversion and predict who is most likely to become HIV positive. First, we construct a two-stage multivariate logistic regression model, where stage one models a patient's history of illicit drug use and their history of STIs other than HIV, and stage two models their risk of contracting HIV. Each stage of the model has ZIP code random effects that are correlated over space. We propose a statistic called the geometric mean ratio (GMR), which measures how much of the variability in the ZIP code random effects for HIV is explained by the stage one random effects. We find that the stage one random effects are negligible in the HIV model and that where a person lives is not predictive of their risk of contracting HIV. Next, we jointly model a patient's time until HIV seroconversion with their clinic visit frequency through shared frailties. We show that if clinic visit frequency is correlated with survival, then the censoring is informative. We examine how the informativeness of the censoring depends on the frailty distributions. We find that patients who visit the clinic more frequently tend to have a higher probability of contracting HIV, suggesting that patients are accurately assessing that they have a higher risk of disease. Finally, we reduce the items from the risk assessment questionnaire into a set of latent measures of patient riskiness with a factor analysis model. Because patients come to the clinic multiple times, we allow the factors to be correlated within a patient over time, and between patients over space. We then use the factor scores from one visit to predict whether or not a patient will seroconvert by their next visit. We show that this model is equivalent to a larger longitudinal factor model and that the factor scores are predictive of future risk of HIV.

Download or read book Modern Biostatistical Methods for Evidence Based Global Health Research written by Ding-Geng (Din) Chen and published by Springer Nature. This book was released on 2022-11-25 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the emerging topics in biostatistical theories and methods through their applications to evidence-based global health research and decision-making. It brings together some of the top scholars engaged in biostatistical method development on global health to highlight and describe recent advances in evidence-based global health applications. The volume is composed of five main parts: data harmonization and analysis; systematic review and statistical meta-analysis; spatial-temporal modeling and disease mapping; Bayesian statistical modeling; and statistical methods for longitudinal data or survival data. It is designed to be illuminating and valuable to both expert biostatisticians and to health researchers engaged in methodological applications in evidence-based global health research. It is particularly relevant to countries where global health research is being rigorously conducted.

Download or read book Analyzing and Modeling Spatial and Temporal Dynamics of Infectious Diseases written by Dongmei Chen and published by John Wiley & Sons. This book was released on 2014-12-08 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Features modern research and methodology on the spread of infectious diseases and showcases a broad range of multi-disciplinary and state-of-the-art techniques on geo-simulation, geo-visualization, remote sensing, metapopulation modeling, cloud computing, and pattern analysis Given the ongoing risk of infectious diseases worldwide, it is crucial to develop appropriate analysis methods, models, and tools to assess and predict the spread of disease and evaluate the risk. Analyzing and Modeling Spatial and Temporal Dynamics of Infectious Diseases features mathematical and spatial modeling approaches that integrate applications from various fields such as geo-computation and simulation, spatial analytics, mathematics, statistics, epidemiology, and health policy. In addition, the book captures the latest advances in the use of geographic information system (GIS), global positioning system (GPS), and other location-based technologies in the spatial and temporal study of infectious diseases. Highlighting the current practices and methodology via various infectious disease studies, Analyzing and Modeling Spatial and Temporal Dynamics of Infectious Diseases features: Approaches to better use infectious disease data collected from various sources for analysis and modeling purposes Examples of disease spreading dynamics, including West Nile virus, bird flu, Lyme disease, pandemic influenza (H1N1), and schistosomiasis Modern techniques such as Smartphone use in spatio-temporal usage data, cloud computing-enabled cluster detection, and communicable disease geo-simulation based on human mobility An overview of different mathematical, statistical, spatial modeling, and geo-simulation techniques Analyzing and Modeling Spatial and Temporal Dynamics of Infectious Diseases is an excellent resource for researchers and scientists who use, manage, or analyze infectious disease data, need to learn various traditional and advanced analytical methods and modeling techniques, and become aware of different issues and challenges related to infectious disease modeling and simulation. The book is also a useful textbook and/or supplement for upper-undergraduate and graduate-level courses in bioinformatics, biostatistics, public health and policy, and epidemiology.

Download or read book Statistical Models in Epidemiology the Environment and Clinical Trials written by M.Elizabeth Halloran and published by Springer Science & Business Media. This book was released on 1999-10-29 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This IMA Volume in Mathematics and its Applications STATISTICAL MODELS IN EPIDEMIOLOGY, THE ENVIRONMENT,AND CLINICAL TRIALS is a combined proceedings on "Design and Analysis of Clinical Trials" and "Statistics and Epidemiology: Environment and Health. " This volume is the third series based on the proceedings of a very successful 1997 IMA Summer Program on "Statistics in the Health Sciences. " I would like to thank the organizers: M. Elizabeth Halloran of Emory University (Biostatistics) and Donald A. Berry of Duke University (Insti tute of Statistics and Decision Sciences and Cancer Center Biostatistics) for their excellent work as organizers of the meeting and for editing the proceedings. I am grateful to Seymour Geisser of University of Minnesota (Statistics), Patricia Grambsch, University of Minnesota (Biostatistics); Joel Greenhouse, Carnegie Mellon University (Statistics); Nicholas Lange, Harvard Medical School (Brain Imaging Center, McLean Hospital); Barry Margolin, University of North Carolina-Chapel Hill (Biostatistics); Sandy Weisberg, University of Minnesota (Statistics); Scott Zeger, Johns Hop kins University (Biostatistics); and Marvin Zelen, Harvard School of Public Health (Biostatistics) for organizing the six weeks summer program. I also take this opportunity to thank the National Science Foundation (NSF) and the Army Research Office (ARO), whose financial support made the workshop possible. Willard Miller, Jr.

Download or read book Future Opportunities and Tools for Emerging Challenges for HIV AIDS Control written by and published by BoD – Books on Demand. This book was released on 2023-02-08 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews and discusses future opportunities and tools for emerging challenges in HIV/ADS control. Although significant progress has been made in the prevention, control, and care of HIV/AIDS, challenges continue to emerge. Over six sections, the book discusses a myriad of subjects, including obstacles to treatment, risk factors, demographics, testing, comorbidities, mental health, and much more.

Download or read book Advanced Techniques for Modelling Maternal and Child Health in Africa written by Ngianga-Bakwin Kandala and published by Springer Science & Business Media. This book was released on 2013-09-06 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents both theoretical contributions and empirical applications of advanced statistical techniques including geo-additive models that link individual measures with area variables to account for spatial correlation; multilevel models that address the issue of clustering within family and household; multi-process models that account for interdependencies over life-course events and non-random utilization of health services; and flexible parametric alternatives to existing intensity models. These analytical techniques are illustrated mainly through modeling maternal and child health in the African context, using data from demographic and health surveys. In the past, the estimation of levels, trends and differentials in demographic and health outcomes in developing countries was heavily reliant on indirect methods that were devised to suit limited or deficient data. In recent decades, world-wide surveys like the World Fertility Survey and its successor, the Demographic and Health Survey have played an important role in filling the gap in survey data from developing countries. Such modern demographic and health surveys enable investigators to make in-depth analyses that guide policy intervention strategies, and such analyses require the modern and advanced statistical techniques covered in this book. The text is ideally suited for academics, professionals, and decision makers in the social and health sciences, as well as others with an interest in statistical modelling, demographic and health surveys. Scientists and students in applied statistics, epidemiology, medicine, social and behavioural sciences will find it of value.

Download or read book Viral Sexually Transmitted Diseases Advances in Research and Treatment 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral Sexually Transmitted Diseases—Advances in Research and Treatment: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Viral Sexually Transmitted Diseases—Advances in Research and Treatment: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Viral Sexually Transmitted Diseases—Advances in Research and Treatment: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Multivariate Methods in Epidemiology written by Theodore R. Holford and published by Oxford University Press. This book was released on 2002-05-30 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: The basis for much of medical public health practice comes from epidemiological research. This text describes current statistical tools that are used to analyze the association between possible risk factors and the actual risk of disease. Beginning with a broad conceptual framework on the disease process, it describes commonly used techniques for analyzing proportions and disease rates. These are then extended to model fitting, and the common threads of logic that bind the two analytic strategies together are revealed. Each chapter provides a descriptive rationale for the method, a worked example using data from a published study, and an exercise that allows the reader to practice the technique. Each chapter also includes an appendix that provides further details on the theoretical underpinnings of the method. Among the topics covered are Mantel-Haenszel methods, rates, survival analysis, logistic regression, and generalized linear models. Methods for incorporating aspects of study design, such as matching, into the analysis are discussed, and guidance is given for determining the power or the sample size requirements of a study. This text will give readers a foundation in applied statistics and the concepts of model fitting to develop skills in the analysis of epidemiological data.

Download or read book Advanced Spatial Modeling with Stochastic Partial Differential Equations Using R and INLA written by Elias T. Krainski and published by CRC Press. This book was released on 2018-12-07 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modeling spatial and spatio-temporal continuous processes is an important and challenging problem in spatial statistics. Advanced Spatial Modeling with Stochastic Partial Differential Equations Using R and INLA describes in detail the stochastic partial differential equations (SPDE) approach for modeling continuous spatial processes with a Matérn covariance, which has been implemented using the integrated nested Laplace approximation (INLA) in the R-INLA package. Key concepts about modeling spatial processes and the SPDE approach are explained with examples using simulated data and real applications. This book has been authored by leading experts in spatial statistics, including the main developers of the INLA and SPDE methodologies and the R-INLA package. It also includes a wide range of applications: * Spatial and spatio-temporal models for continuous outcomes * Analysis of spatial and spatio-temporal point patterns * Coregionalization spatial and spatio-temporal models * Measurement error spatial models * Modeling preferential sampling * Spatial and spatio-temporal models with physical barriers * Survival analysis with spatial effects * Dynamic space-time regression * Spatial and spatio-temporal models for extremes * Hurdle models with spatial effects * Penalized Complexity priors for spatial models All the examples in the book are fully reproducible. Further information about this book, as well as the R code and datasets used, is available from the book website at http://www.r-inla.org/spde-book. The tools described in this book will be useful to researchers in many fields such as biostatistics, spatial statistics, environmental sciences, epidemiology, ecology and others. Graduate and Ph.D. students will also find this book and associated files a valuable resource to learn INLA and the SPDE approach for spatial modeling.

Download or read book Geospatial Health Data written by Paula Moraga and published by CRC Press. This book was released on 2019-11-26 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Geospatial health data are essential to inform public health and policy. These data can be used to quantify disease burden, understand geographic and temporal patterns, identify risk factors, and measure inequalities. Geospatial Health Data: Modeling and Visualization with R-INLA and Shiny describes spatial and spatio-temporal statistical methods and visualization techniques to analyze georeferenced health data in R. The book covers the following topics: Manipulate and transform point, areal, and raster data, Bayesian hierarchical models for disease mapping using areal and geostatistical data, Fit and interpret spatial and spatio-temporal models with the Integrated Nested Laplace Approximations (INLA) and the Stochastic Partial Differential Equation (SPDE) approaches, Create interactive and static visualizations such as disease maps and time plots, Reproducible R Markdown reports, interactive dashboards, and Shiny web applications that facilitate the communication of insights to collaborators and policy makers. The book features fully reproducible examples of several disease and environmental applications using real-world data such as malaria in The Gambia, cancer in Scotland and USA, and air pollution in Spain. Examples in the book focus on health applications, but the approaches covered are also applicable to other fields that use georeferenced data including epidemiology, ecology, demography or criminology. The book provides clear descriptions of the R code for data importing, manipulation, modeling and visualization, as well as the interpretation of the results. This ensures contents are fully reproducible and accessible for students, researchers and practitioners.

Download or read book Biostatistical Applications in Cancer Research written by Craig Beam and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biostatistics is defined as much by its application as it is by theory. This book provides an introduction to biostatistical applications in modern cancer research that is both accessible and valuable to the cancer biostatistician or to the cancer researcher, learning biostatistics. The topical areas include active areas of the application of biostatistics to modern cancer research: survival analysis, screening, diagnostics, spatial analysis and the analysis of microarray data. Biostatistics is an essential component of basic and clinical cancer research. The text, authored by distinguished figures in the field, addresses clinical issues in statistical analysis. The spectrum of topics discussed ranges from fundamental methodology to clinical and translational applications.

Download or read book Spatial Data Analysis written by Robert P. Haining and published by Cambridge University Press. This book was released on 2003-04-17 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spatial Data Analysis: Theory and Practice, first published in 2003, provides a broad ranging treatment of the field of spatial data analysis. It begins with an overview of spatial data analysis and the importance of location (place, context and space) in scientific and policy related research. Covering fundamental problems concerning how attributes in geographical space are represented to the latest methods of exploratory spatial data analysis and spatial modeling, it is designed to take the reader through the key areas that underpin the analysis of spatial data, providing a platform from which to view and critically appreciate many of the key areas of the field. Parts of the text are accessible to undergraduate and master's level students, but it also contains sufficient challenging material that it will be of interest to geographers, social and economic scientists, environmental scientists and statisticians, whose research takes them into the area of spatial analysis.

Download or read book Geographically Weighted Regression written by A. Stewart Fotheringham and published by John Wiley & Sons. This book was released on 2003-02-21 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Geographical Weighted Regression (GWR) is a new local modelling technique for analysing spatial analysis. This technique allows local as opposed to global models of relationships to be measured and mapped. This is the first and only book on this technique, offering comprehensive coverage on this new 'hot' topic in spatial analysis. * Provides step-by-step examples of how to use the GWR model using data sets and examples on issues such as house price determinants, educational attainment levels and school performance statistics * Contains a broad discussion of and basic concepts on GWR through to ideas on statistical inference for GWR models * uniquely features accompanying author-written software that allows users to undertake sophisticated and complex forms of GWR within a user-friendly, Windows-based, front-end (see book for details).

Download or read book Introduction to Spatial Econometrics written by James LeSage and published by CRC Press. This book was released on 2009-01-20 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although interest in spatial regression models has surged in recent years, a comprehensive, up-to-date text on these approaches does not exist. Filling this void, Introduction to Spatial Econometrics presents a variety of regression methods used to analyze spatial data samples that violate the traditional assumption of independence between observat

Download or read book Mixed Effects Models for Complex Data written by Lang Wu and published by CRC Press. This book was released on 2009-11-11 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although standard mixed effects models are useful in a range of studies, other approaches must often be used in correlation with them when studying complex or incomplete data. Mixed Effects Models for Complex Data discusses commonly used mixed effects models and presents appropriate approaches to address dropouts, missing data, measurement errors, censoring, and outliers. For each class of mixed effects model, the author reviews the corresponding class of regression model for cross-sectional data. An overview of general models and methods, along with motivating examples After presenting real data examples and outlining general approaches to the analysis of longitudinal/clustered data and incomplete data, the book introduces linear mixed effects (LME) models, generalized linear mixed models (GLMMs), nonlinear mixed effects (NLME) models, and semiparametric and nonparametric mixed effects models. It also includes general approaches for the analysis of complex data with missing values, measurement errors, censoring, and outliers. Self-contained coverage of specific topics Subsequent chapters delve more deeply into missing data problems, covariate measurement errors, and censored responses in mixed effects models. Focusing on incomplete data, the book also covers survival and frailty models, joint models of survival and longitudinal data, robust methods for mixed effects models, marginal generalized estimating equation (GEE) models for longitudinal or clustered data, and Bayesian methods for mixed effects models. Background material In the appendix, the author provides background information, such as likelihood theory, the Gibbs sampler, rejection and importance sampling methods, numerical integration methods, optimization methods, bootstrap, and matrix algebra. Failure to properly address missing data, measurement errors, and other issues in statistical analyses can lead to severely biased or misleading results. This book explores the biases that arise when naïve methods are used and shows which approaches should be used to achieve accurate results in longitudinal data analysis.

Download or read book Virus Dynamics Mathematical Principles of Immunology and Virology written by Martin Nowak and published by Oxford University Press, UK. This book was released on 2000-11-23 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This groundbreaking book describes the emerging field of theoretical immunology, in particular the use of mathematical models to describe the spread of infectious diseases within patients. It reveals fascinating insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. Structured around the examples of HIV/AIDS and hepatitis B, Nowak and May show how mathematical models can help researchers to understand the detailed dynamics of infection and the effects of antiviral therapy. Models are developed to describe the dynamics of drug resistance, immune responses, viral evolution and mutation, and to optimise the design of therapy and vaccines. - ;We know, down to the tiniest details, the molecular structure of the human immunodeficiency virus (HIV). Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreed understanding of the ultimate course and variability of the pathogenesis of AIDS. Gaps in our understanding like these impede our efforts towards developing effective therapies and preventive vaccines. Martin Nowak and Robert M May describe the emerging field of theoretical immunology in this accessible and well- written text. Using mathematical modelling techniques, the authors set out their ideas about how populations of viruses and populations of immune system cells may interact in various circumstances, and how infectious diseases spread within patients. They explain how this approach to understanding infectious diseases can reveal insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. The book is structured around the examples of HIV/AIDS and Hepatitis B virus, although the approaches described will be more widely applicable. The authors use mathematical tools to uncover the detailed dynamics of the infection and the effects of antiviral therapy. Models are developed to describe the emergence of drug resistance, and the dynamics of immune responses, viral evolution, and mutation. The practical implications of this work for optimisation of the design of therapy and vaccines are discussed. The book concludes with a glance towards the future of this fascinating, and potentially highly useful, field of study. - ;... an excellent introduction to a field that has the potential to advance substantially our understanding of the complex interplay between virus and host - Nature

Download or read book Emerging Infectious Diseases written by and published by . This book was released on 2012 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: