Download or read book Molecular Bases of Endometriosis written by Giovana Gonçalves and published by BoD – Books on Demand. This book was released on 2019-09-04 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: What are the objectives of the genetic study of individuals? There is great interest from the medical community and also much concern from the lay press about the potential benefits and harms of genetic screening, gene therapy, and even the possibility of cloning individuals. The current use of genetic tests for the detection and treatment of endometriosis is still at an early stage but very important. The determination of susceptibility markers will be increasingly explored in clinical studies and their uses will be much more defined. Still, it seems increasingly likely that major changes will occur over the next decade in how we evaluate and treat our patients. In particular, surgeons and clinicians will have the opportunity to use a number of new tests to predict the future appearance of endometriosis in patients still free of the disease. They may have the power to explore the best therapeutic modality for a particular patient according to his/her genetic makeup. And they will be able to more specifically target prevention measures for family members of people already affected by the disease. It should be understood that molecular diagnosis, especially in asymptomatic individuals, does not mean disease but an increased risk of developing a disease. Ethical implications exist and should not be underestimated. Patients should be advised about the likely implications of such tests, not only after but especially before the achievement of these. A major step has already been overcome and we currently have the basic tools for a new leap in understanding human pathologies responsible for much of the world's mortality. Bridging the great barrier that still separates this basic knowledge and clinical practice is quite a significant challenge.
Download or read book Molecular Basis of Endometriosis written by Priyanka Rai and published by LAP Lambert Academic Publishing. This book was released on 2015-04-02 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endometrium, a heterogeneous tissue lining the uterus, is highly dynamic and exhibits marked cyclic changes during the menstrual cycle. Any aberration in endometrial physiology would lead to diseases like endometriosis, endometrial polyps, hyperplasia and endometrial cancer. The pathogenesis of endometriosis includes the proliferation of heterogeneous endometrial cells and their invasion into ectopic sites within the peritoneal cavity. This may be due to abnormalities of the eutopic endometrium itself, predisposing the cells to survive and implant ectopically. Several studies were carried out to have a better understanding of the endometrium per se as well to have an insight in the pathogenesis of endometriosis. However, the pathogenesis of endometriosis is still poorly understood. This work is designed to identify the proteins that are differentially expressed in different stages of endometriosis and establish the role of candidate protein(s) in endometriosis.
Download or read book Molecular Research of Endometrial Pathophysiology written by Paola Viganò and published by MDPI. This book was released on 2019-10-14 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endometrium has been the subject of intense research in a variety of clinical settings, because of its importance in the reproductive process and its role in women’s health. In the past 15 years, significant efforts have been invested in defining the molecular phenotype of the receptive phase endometrium as well as of various endometrial pathologies. Although this has generated a wealth of information on the molecular landscape of human endometrium, there is a need to complement this information in light of the novel methodologies and innovative technical approaches. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms of endometrium and endometrium-related disorders. The progress made in the molecular actions of steroids, in the metabolism of steroids and intracrinology, in endometrial intracellular pathways, in stem cells biology, as well as in the molecular alterations underlying endometrium-related pathologies has been the focus of the reviews and papers included.]
Download or read book Molecular and Cellular Advances in Endometriosis Research written by Antonio Simone Laganà and published by . This book was released on 2022 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endometriosis is defined as the presence of endometrial-like endometrial cells, glands, and stroma outside the uterus, causing a strong inflammatory-like microenvironment in the affected tissue. The exact prevalence of endometriosis is unknown, but estimates range from 2%-10% of women of reproductive age to 50% of infertile women. The etiopathogenesis of endometriosis remains controversial--immune, hormonal, genetic, and epigenetic factors may all be involved, and several theories have been proposed to explain it.This book aims to summarize some of the most recent advancements in basic and translational science (immunology, cell biology, genetics, and epigenetics) in the field of endometriosis that may create new scenarios and change our perspective of the topic.
Download or read book Molecular and Cellular Advances in Endometriosis Research written by Antonio Simone Lagana and published by Mdpi AG. This book was released on 2022-02-17 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endometriosis is defined as the presence of endometrial-like endometrial cells, glands, and stroma outside the uterus, causing a strong inflammatory-like microenvironment in the affected tissue. The exact prevalence of endometriosis is unknown, but estimates range from 2%-10% of women of reproductive age to 50% of infertile women. The etiopathogenesis of endometriosis remains controversial-immune, hormonal, genetic, and epigenetic factors may all be involved, and several theories have been proposed to explain it. This book aims to summarize some of the most recent advancements in basic and translational science (immunology, cell biology, genetics, and epigenetics) in the field of endometriosis that may create new scenarios and change our perspective of the topic.
Download or read book The Human Endometrium written by Carlo Bulletti and published by . This book was released on 1994 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structural, biochemical and clinical events related to menstruation, implantation, parturition, endometriosis, abnormal uterine bleeding and endometrial cancer are discussed in this comprehensive volume on the biological functions of the endometrium. New topics, such as the biochemical and molecular mechanisms regulating maternal embryonic interaction, are explored, and gynecologic endoscopy and therapeutic tools are discussed. The proceedings of the first conference is also available from the Academy, as volume 622 of The Annals of The New York Academy of Science.
Download or read book Chronic Pelvic Pain written by Richard E. Blackwell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: A clinically oriented, multi-disciplinary approach to the diagnosis, treatment, and management of chronic pelvic pain in women -- one of the most common problems encountered in the practice setting. The editors present this challenging and often vexing subject in a user-friendly, highly illustrated text, with chapters on: physiology of pain; pain associated with endometriosis; pain associated with fibroids; surgical management; the role of office based surgery; the role of the psychiatrist in pain management; pelvic pain of urinary origin; pelvic pain of gastrointestinal origin. Designed to be part of everyday practice, this is a must for all clinicians in obstetrics-gynaecology, as well as for any physician involved in the health care of women.
Download or read book Endometriosis written by Christopher Sutton and published by Cambridge University Press. This book was released on 2004-05-01 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endometriosis affects a huge number of women throughout the world. It has been estimated that between 1% and 15% of women who are examined for pelvic pain and infertility may have endometriosis; the true prevalence is unknown because diagnosis can only be made with any accuracy by laparoscopic examination of the pelvis. This book provides clinicians with all the information they need in a succinct and clear text, with colour illustrations. Chapters cover: epidemiology and aetiology; diagnosis; investigation; medical treatment; and surgical treatment.
Download or read book The Endometrium written by Stanley R. Glasser and published by CRC Press. This book was released on 2002-05-16 with total page 1079 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Endometrium is devoted to a comprehensive multi-disciplinary account of the uterine endometrium. This book is the first to define the regulatory biological interrelationships between epithelial and stromal cell phenotypes, endothelial cells, extracellular matrix and immunobiological elements. It highlights their relevance to clinical conditions
Download or read book The Role of the Molecular Genetic Approach in the Pathogenesis of Endometriosis written by Alfredo Borges and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in cytogenetic, molecular genetic, and molecular cytogenetic techniques have provided convincing evidence in favor of a genetic basis for endometriosis and corroborating the higher prevalence of the disease in first-degree relatives of affected women. The regulatory mechanisms involved in the morphological and biochemical differentiation of the uterine endometrium are obviously complex, but consistent somatic genetic alterations have been identified. A higher percentage of aberrant metaphases showing aneuploidy, dicentric chromosomes, endomitosis, and chromosomal spraying have been detected in several trials. These results were further amplified by multicolored fluorescent in situ hybridization (FISH) analysis demonstrating the presence of alterations, where at least chromosomes 1, 16, 17, and 22 show structural aberrations containing genes that could play a role in the development and/or progression of endometriosis. Overall, the non-random distribution along with the subchromosomal location of the genetic alterations strongly supports the idea that these anomalies are relevant and are associated with the endometriotic process.
Download or read book Clinical Gynecology written by Eric J. Bieber and published by Cambridge University Press. This book was released on 2015-04-23 with total page 1127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.
Download or read book Biomarkers for Endometriosis written by Thomas D'Hooghe and published by Springer. This book was released on 2017-09-22 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine. The value of existing and emerging systems biology technologies for biomarker development is addressed in several chapters on genetics, microarrays, proteomics and metabolomics. Although tests with high sensitivity and acceptable specificity have been developed, sometimes validated in independent populations and seem promising, more research is needed to translate these data into clinical benefit for patients and coordinate efforts internationally to standarize analysis, reports and operating procedures. The gold standard to diagnose endometriosis is currently through laparoscopic inspection with histological confirmation, a surgical procedure with rare but significant potential risks for the patients. A non-invasive test for endometriosis would be critical for the early detection of endometriosis of symptomatic women with pelvic pain and/or subfertility with normal ultrasound. This would include nearly all cases of minimal-mild endometriosis, some cases of moderate-severe endometriosis without a clearly visible ovarian endometrioma and cases with pelvic adhesions and/or other pelvic pathology, who might benefit from surgery to improve pelvic pain and/or subfertility. Such a test would also be useful in symptomatic women with ultrasound imaging suspicious for endometriosis, since it may be difficult to differentiate an ovarian endometrioma from other ovarian cysts and since the quality of ultrasound imaging is highly variable worldwide.
Download or read book Endometrial Gene Expression written by Joanne Kwak-Kim and published by Springer. This book was released on 2020-11-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endometrium goes through cyclical changes under the influence of hormones, and immune effectors in the endometrium change their populations cyclically as well. Dynamic changes in immune effectors determine endometrial cytokine and chemokine milieus and, consequently, the endometrial immune response. Endometrial immune responses have been shown to be important for trophoblast invasion and early pregnancy. Indeed, dysregulated endometrial inflammatory immune responses are associated with reproductive failures, such as recurrent pregnancy losses, repeated implantation failure, and gynecological diseases with oncogenic potential. Hence, the investigation of endometrial gene expression may predict infertility, gynecological and oncological conditions. This book presents the state of the art in endometrial gene expression as well as recent developmental findings relating to reproduction and reproductive disorders. It begins with a review of the genetic regulation of urogenital tract formation and molecular mechanism underlying the physiology of menstrual cycle before moving on to the current and emerging technological advances in molecular biology. Endometrial gene expressions of immune inflammatory conditions, viral infection, metabolic and nutritional conditions, and reproductive disorders are then presented in following chapters. Examples of the use and interpretation of gene expression in clinical scenarios including recurrent pregnancy losses, infertility and multiple implantation failures are presented with currently available endometrial gene analysis. Utilizing the latest evidence and clinical guidelines, Endometrial Gene Expression will be a cutting-edge resource for gynecologist, reproductive immunologist, reproductive endocrinologists, obstetrician, maternal fetal medicine specialist and other health care providers in the field of reproductive medicine.
Download or read book Endometriosis written by Togas Tulandi and published by CRC Press. This book was released on 2003-12-09 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addresses new concepts and theories in disease control and provides the latest treatment modalities. Dedicated to new developments in the medical and surgical treatment of endometriosis, this reference delves into current management controversies, examines emerging therapeutic strategies, and assists specialists in the design of new investigations and research paths for the study of this common condition.
Download or read book Molecular genetic analysis of endometriosis written by Xiuxian Jiang and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Endometriosis in Adolescents written by Ceana H. Nezhat and published by Springer Nature. This book was released on 2020-11-13 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adolescent endometriosis is a previously overlooked disease in children, the true prevalence of which is still unknown but has been estimated between 19-73%. There are numerous initial challenges faced by adolescents suffering from delayed or undiagnosed endometriosis apart from experiencing chronic pain, such as: school/work absenteeism, false diagnoses/treatments, erroneous physician referrals, unnecessary radiological studies, radiation exposure, and emergency room visits as well as early exposure to narcotic pain medications and subsequent drug tolerance, resistance or even addiction. This text presents a clear history of physician and patient understanding and awareness of endometriosis in adolescents. It lays the groundwork for this condition with background information on endometriosis in general followed by a more focused look at endometriosis in adolescents. Leading experts in the field provide chapters on the different locations where endometriotic lesions can present in adolescents as well as identified risk factors and concomitant diseases of which it is important to be aware. In addition to the clinical presentation, this book also provides information on breaking down existing barriers, such as stigma, and current activism and awareness of this condition. Adolescent Endometriosis is a first-of-its-kind text that focuses exclusively on endometriosis in the adolescent population. Written by experts in the field, this book is a comprehensive resource for clinicians in all medical disciplines that treat adolescent age girls.
Download or read book Endometriosis written by Camran R. Nezhat and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endometriosis is one of the most common diseases of women. This book provides a practical, clinical and thorough examination of both the medical and surgical treatment of this disease. A world renowned group of contributors address basic issues, management approaches and selected special topics, emphasizing the latest advanced operative techniques. Topics include: - minimally invasive and advanced laparoscopic surgical technique in the treatment of endometriosis - treatment of endometriosis of the ovaries, cul-de-sac, gastrointestinal and urinary tracts, and extragenital sites - management of recurrent endometriosis - treatment of infertility and pelvic pain associated with endometriosis - guidelines for medical management and combined medical-surgical management.
