Download or read book Mechanisms of Secondary Brain Damage written by A. Baethmann and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: A distinction between primary and secondary brain damage of vari ous origin, particularly in acute lesions, such as head injury and ische mia is not entirely new. The concept is of practical significance, be cause it is the foremost intention of all clinical efforts to prevent, or at least attenuate the development of secondary sequelae. Primary dam age to nervous elements usually cannot be influenced by treatment. Its prevention is the objective of prophylactic measures. The current volume gathered prominent scientists and clinicians from various fields to pro vide a competent introduction and survey of the various aspects involved in secondary brain damage. It was attempted to provide criteria for the distinction between the primary and secondary phenomena on a morpho logical and functional level, on the basis of the kinetics involved and, most importantly, regarding the different specific manifestations, such as disturbances of microcirculation, aspects of the blood-brain barrier, and of cellular structure and function at a molecular level. Although it was not expected that a grand unifying hypothesis will be reached recon cilable with the many, occasionally opposing views on such a complex subject, nevertheless, the present volume attains an appropriate result. It can best be described as a mosaic of many different pieces which only as an ensemble reflect the current state of the art.
Download or read book Mechanisms of Secondary Brain Damage from Trauma and Ischemia written by A. Baethmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Top level clinical and laboratory scientists present their most recent clinical and experimental findings and concepts. The well balanced contributions illustrate the enormous significance of the dialogue between both laboratory and clinic, ultimately for the benefit of the patients, and contribute to a better understanding of secondary brain damage from trauma and ischemia as basis to develop more effective treatment including drugs.
Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2015-12-01 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.
Download or read book Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma written by Alexander Baethmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: The publication of the Vth International Symposium 1995 on "Mechanisms of Secondary Brain Damage" in Mauls/ltaly is a collection of focused reviews reaching from novel molecular- and cell biological findings to aspects of clinical management in head injury and cerebral ischemia. A specific purpose of these series of meetings introduced in 1984 is for an exchange on problems of mutual interest by international high ranking experts from the basic sciences and related clinical disciplines, such as intensive care medicine, neurology, or neurosurgery. The present volume covers three major areas: (a) Molecular and cell biological mechanisms including inflammation (b) Novel findings on mechanisms and treatment in cerebral ischemia (c) Secondary processes in head injury, regeneration and treatment Molecular-and cell biology is currently attracting attention towards activation of genomic processes associated with the demise of cells referred to as "programmed cell death" and "apoptosis" which, actually, might be distinguished from each other. Thus, the phenomenon of delayed neuronal death in selectively vulnerable brain areas following brief interruption of blood flow is scrutinized as to the contribution of the activation of suicide genes. The physiological role of such a response, among others, is removal of surplus neurons during ontogenesis of the brain. Yet, evidence is accumulating that similar mechanisms playa role in cerebral ischemia, probably also trauma, where nerve-and other cells demonstrate features of apoptosis. Observations on protection of neurons by administration of protein synthesis inhibitors in cerebral ischemia provide more direct support.
Download or read book Current Progress in the Understanding of Secondary Brain Damage from Trauma and Ischemia written by A. Baethmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Information is provided from the basic and clinical sciences on the mechanisms damaging the brain from trauma or ischemia. New aspects involve the endoplasmic reticulum, mitochondrial failure, pathobiology of axonal injury, molecular signals activating glial elements, or the emerging therapeutical role of neurotrophins. Experimental issues involve a better analysis of the ischemic penumbra, the salvagable tissue. Therapeutic contributions reach from the environmental influence to gene expression, including neuroprotection, such as hibernation – mother nature’s experiment – or hypothermia which is reported to induce cell swelling. Treatment issues deal also with thrombolysis and combination therapies, or with the clearance of adverse blood components – LDL/fibrinogen – by a novel procedure using heparin. Other highlights are discussing the specificities of pediatric vs. adult brain trauma, or the evolving role of the Apolipoprotein-E e4 gene in severe head injury. An update is also provided on an online assessment of the patient management during the pre- and early hospital phase in Southern Bavaria. The empirical observation of neuroworsening is analyzed in further details, whether this is a specificity autonomously driving the posttraumatic course. Finally, the unsolved question why drug trials in severe head injury have failed so far in view of the promising evidence from the laboratory is subjected to an expert analysis.
Download or read book Nutrition and Traumatic Brain Injury written by Institute of Medicine and published by National Academies Press. This book was released on 2011-07-01 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) accounts for up to one-third of combat-related injuries in Iraq and Afghanistan, according to some estimates. TBI is also a major problem among civilians, especially those who engage in certain sports. At the request of the Department of Defense, the IOM examined the potential role of nutrition in the treatment of and resilience against TBI.
Download or read book Mechanisms of secondary brain damage from trauma and ischemia written by A. Baethmann and published by . This book was released on 2004 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanisms of Secondary Brain Damage from Trauma and Ischemia written by and published by . This book was released on 2004 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pediatric Head Trauma written by Kenneth Shapiro and published by Wiley-Blackwell. This book was released on 1983 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanisms of Secondary Brain Damage written by Alexander Baethmann and published by . This book was released on 1992-12-23 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Top level clinical and laboratory scientists present their most recent clinical and experimental findings and concepts. The well balanced contributions illustrate the enormous significance of the dialogue between both laboratory and clinic, ultimately for the benefit of the patients, and contribute to a better understanding of secondary brain damage from trauma and ischemia as basis to develop more effective treatment including drugs.
Download or read book Brain Neurotrauma written by Firas H. Kobeissy and published by CRC Press. This book was released on 2015-02-25 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
Download or read book Traumatic Brain Injury written by Nikolai Gorbunov and published by BoD – Books on Demand. This book was released on 2018-05-09 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) syndrome has emerged as a serious health concern worldwide due to the severity of outcomes and growing socioeconomic impacts of the diseases, e.g., high cost of long-term medical care and loss of quality of life. This book focuses on the TBI pathobiology as well as on the recent developments in advanced diagnostics and acute management. The presented topics encompass personal experience and visions of the chapter contributors as well as an extensive analysis of the TBI literature. The book is addressed to a broad audience of readers from students to practicing clinicians.
Download or read book Acute Ischemic Stroke written by R. Gilberto González and published by Springer Science & Business Media. This book was released on 2010-10-05 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated second edition of Acute Ischemic Stroke: Imaging and Intervention provides a comprehensive account of the state of the art in the diagnosis and treatment of acute ischemic stroke. The basic format of the first edition has been retained, with sections on fundamentals such as pathophysiology and causes, imaging techniques and interventions. However, each chapter has been revised to reflect the important recent progress in advanced neuroimaging and the use of interventional tools. In addition, a new chapter is included on the classification instruments for ischemic stroke and their use in predicting outcomes and therapeutic triage. All of the authors are internationally recognized experts and members of the interdisciplinary stroke team at the Massachusetts General Hospital and Harvard Medical School. The text is supported by numerous informative illustrations, and ease of reference is ensured through the inclusion of suitable tables. This book will serve as a unique source of up-to-date information for neurologists, emergency physicians, radiologists and other health care providers who care for the patient with acute ischemic stroke.
Download or read book Diseases of the Brain Head and Neck Spine 2020 2023 written by Juerg Hodler and published by Springer Nature. This book was released on 2020-02-14 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.
Download or read book Intracerebral Hemorrhage Research written by John Zhang and published by Springer Science & Business Media. This book was released on 2011-07-05 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volume includes 75 papers which were presented at the Third International Conference on Intracerebral Hemorrhage, held in Rancho Mirage, California, in March 2010. The topics treated include animal models, pathophysiology of cerebral hemorrhage, experimental treatment for cerebral hemorrhage, cerebral hemorrhage clinical manifestations, prognosis of cerebral hemorrhage, and clinical management. The articles represent the recent advances in hemorrhagic brain injury research presented by highly respected laboratories around the world.
Download or read book Evaluation of the Disability Determination Process for Traumatic Brain Injury in Veterans written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-05-20 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Veterans Benefits Administration (VBA) provides disability compensation to veterans with a service-connected injury, and to receive disability compensation from the Department of Veterans Affairs (VA), a veteran must submit a claim or have a claim submitted on his or her behalf. Evaluation of the Disability Determination Process for Traumatic Brain Injury in Veterans reviews the process by which the VA assesses impairments resulting from traumatic brain injury for purposes of awarding disability compensation. This report also provides recommendations for legislative or administrative action for improving the adjudication of veterans' claims seeking entitlement to compensation for all impairments arising from a traumatic brain injury.
Download or read book Imaging Acute Neurologic Disease written by Massimo Filippi and published by Cambridge University Press. This book was released on 2014-09-11 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive survey of best practice in using diagnostic imaging in acute neurologic conditions. The symptom-based approach guides the choice of the available imaging tools for efficient, accurate, and cost-effective diagnosis. Effective examination algorithms integrate neurological and imaging concepts with the practical demands and constraints of emergency care.
