Download or read book Irreversible Electroporation written by Boris Rubinsky and published by Springer Science & Business Media. This book was released on 2009-11-25 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-thermal irreversible electroporation is a new minimally invasive surgical p- cedure with unique molecular selectivity attributes – in fact it may be considered the first clinical molecular surgery procedure. Non-thermal irreversible electro- ration is a molecular selective mode of cell ablation that employs brief electrical fields to produce nanoscale defects in the cell membrane, which can lead to cell death, without an effect on any of the other tissue molecules. The electrical fields can be produced through contact by insertion of electrode needles around the undesirable tissue and non-invasively by electromagnetic induction. This new - dition to the medical armamentarium requires the active involvement and is of interest to clinical physicians, medical researchers, mechanical engineers, che- cal engineers, electrical engineers, instrumentation designers, medical companies and many other fields and disciplines that were never exposed in their training to irreversible electroporation or to a similar concept. This edited book is designed to be a comprehensive introduction to the field of irreversible electroporation to those that were not exposed or trained in the field before and can also serve as a reference manual. Irreversible electroporation is broad and interdisciplinary. Therefore, we have made an attempt to cover every one of the various aspects of the field from an introductory basic level to state of the art.

Download or read book Irreversible Electroporation in Clinical Practice written by Martijn R. Meijerink and published by Springer. This book was released on 2017-12-27 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the clinical use of irreversible electroporation (IRE) – better known by its commercial name, NanoKnife – which is one of the most exciting new needle-guided cancer treatments. The coverage includes the history of IRE, general technique, preclinical research, applications in clinical practice and early clinical results, and future perspectives. Contraindications, treatment planning, potential complications, follow-up imaging, and other practical aspects are fully discussed, with highlighting of useful tips and tricks. Through the delivery of short but highly intense electrical pulses, IRE results in tumor cell membrane permeabilization, causing cells to go into apoptosis. The minimally invasive nature of IRE, combined with the prospect of completely eradicating tumors while preserving delicate structures in the ablation zone, makes IRE the object of worldwide clinical research. This book will be of value for practitioners and trainees in interventional and diagnostic radiology, surgery, medical oncology, HPB and gastroenterology, urology, and radiation oncology.

Download or read book Electroporation in Veterinary Oncology Practice written by Joseph A. Impellizeri and published by Springer Nature. This book was released on 2021-11-20 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first edited collection on veterinary applications of electroporation. Written by an international team of experts, this book presents worldwide emerging therapy options for cancer treatments in veterinary oncology practice. Electroporation offers a precision tool to target cancer cells without destroying surrounding tissue structures. The opening of tumor cell membranes facilitates local control of solid tumors either through the delivery of chemotherapeutics or by direct ablation of tissues using electric fields. In addition, transfer of gene-based products into the cancer cells can be used for genetic vaccination to achieve systemic responses and cancer control. Readers will discover valuable reference texts for practitioner education, including chapters on electrodes for unique anatomical access and treatment planning for deep-seated tumors, different immunotherapy applications with gene electrotransfer, calcium electroporation, irreversible electroporation applications and combinations with other common treatments such as surgery, radiation therapy and chemotherapy. Therapy options with electroporation are gaining interest around the world in both human and veterinary oncology, making this book valuable for oncologists, surgeons, primary care veterinarians, residents, interns and students at veterinary schools, where teaching of Electrochemotherapy will become part of the curriculum. Featuring cross-disciplinary authorship, this work further contributes to advances in comparative medicine and translation research in support of the One Health concept.

Download or read book Interventional Urology written by Ardeshir R. Rastinehad and published by Springer Nature. This book was released on 2021-11-17 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated text provides a concise yet comprehensive and state-of-the-art review of evolving techniques in the new and exciting subspecialty of interventional urology. Significant advances in imaging technologies, diagnostic tools, fusion navigation, and minimally invasive image-guided therapies such as focal ablative therapies have expanded the interventional urologists’ clinical toolkit over the past decade. Organized by organ system with subtopics covering imaging technologies, interventional techniques, recipes for successful practice, pitfalls to shorten the learning curves for new technologies, and clinical outcomes for the vast variety of interventional urologic procedures, this second edition includes many more medical images as well as helpful graphics and reference illustrations. The second edition of Interventional Urology serves as a valuable resource for clinicians, interventional urologists, interventional radiologists, interventional oncologists, urologic oncologists, as well as scientists, researchers, students, and residents with an interest in interventional urology.

Download or read book Handbook of Electroporation written by Damijan Miklavčič and published by Springer. This book was released on 2017-09-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This major reference work is a one-shot knowledge base on electroporation and the use of pulsed electric fields of high intensity and their use in biology, medicine, biotechnology, and food and environmental technologies. The Handbook offers a widespread and well-structured compilation of 156 chapters ranging from the foundations to applications in industry and hospital. It is edited and written by most prominent researchers in the field. With regular updates and growing in its volume it is suitable for academic readers and researchers regardless of their disciplinary expertise, and will also be accessible to students and serious general readers. The Handbook's 276 authors have established scholarly credentials and come from a wide range of disciplines. This is crucially important in a highly interdisciplinary field of electroporation and the use of pulsed electric fields of high intensity and its applications in different fields from medicine, biology, food processing, agriculture, process engineering, energy and environment. An Editorial Board of distinguished scholars from across the world has selected and reviewed the various chapters to ensure the highest quality of this Handbook. The book was edited by an international team of Section Editors: P. Thomas Vernier, Boris Rubinsky, Juergen Kolb, Damijan Miklavcic, Marie-Pierre Rols, Javier Raso, Richard Heller, Gregor Serša, Dietrich Knorr, and Eugene Vorobiev.

Download or read book Electroporation Based Therapies for Cancer written by Raji Sundararajan and published by Elsevier. This book was released on 2014-08-28 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electroporation-Based Therapies for Cancer reviews electroporation-based clinical studies in hospitals for various cancer treatments, including melanomas, head and neck cancers, chest wall breast carcinomas, and colorectal cancers, as well as research studies in the lab using cell lines, primary cells, and animals. Cancer kills about one American per minute, amounting to over 500,000 deaths in the United States and millions, worldwide, each year. There is a critical need for safe, effective, and affordable alternative treatment modalities, especially for inoperable, recurring, and chemo-resistant cancers, that do not respond well to current treatment regimen. An electrical-pulse-mediated, enhanced drug delivery technique known as electroporation is one way to effectively treat these patients. This technique is especially suitable for low- and middle-income countries, where lack of infrastructure and resources leads to cancer diagnoses at late stages. This quick, safe, effective, economical, out-patient-based technique is a boon to these patients for palliative and other care with enhanced quality of life. This book features discussions by interdisciplinary authors—including practicing oncological surgeons, medical professionals, and academic and other researchers—of the basics and clinical medical applications of electroporation. Provides novel and recent clinical applications of electrochemotherapy for various cancers, including melanomas, sarcomas, superficial extreme melanoma, chest wall breast carcinoma, and colorectal cancers Extensive study of a number of cell lines, including human breast cancer, lung cancer, cervical cancer, leukemia, and mouse breast cancer using both reversible and irreversible electroporation techniques In vitro study of delivery of various commonly prescribed/administered breast cancer chemo and hormone drugs, such as Doxorubicin, Paclitaxel, Bleomycin, and Tamoxifen

Download or read book Clinical Aspects of Electroporation written by Stephen T. Kee and published by Springer Science & Business Media. This book was released on 2011-04-06 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electroporation is the forefront in tumor ablation. This book presents the basic principles and clinical applications of electroporation, including the latest research results and patient data. A comprehensive approach to the basic science behind the development of this ground-breaking technique and its introduction into clinical practice, the book discusses the entire spectrum of currently available reversible treatments, the emerging irreversible applications, and their impact on patient care. Clinical Aspects of Electroporation is the first book intended for clinicians on this extremely important and rapidly developing field.

Download or read book Advanced Electroporation Techniques in Biology and Medicine written by Andrei G. Pakhomov and published by CRC Press. This book was released on 2010-06-02 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: A reflection of the intense study of the effects of electromagnetic fields on living tissues that has taken place during the last decades, Advanced Electroporation Techniques in Biology and Medicine summarizes most recent experimental findings and theories related to permeabilization of biomembranes by pulsed electric fields. Edited by experts and

Download or read book Bioelectrics written by Hidenori Akiyama and published by Springer. This book was released on 2016-09-19 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on bioelectrics, a new multidisciplinary field encompassing engineering and biology with applications to the medical, environmental, food, energy, and biotechnological fields. At present, 15 universities and institutes in Japan, the USA and the EU comprise the International Consortium of Bioelectrics, intended to advance this novel and important research field. This book will serve as an introductory resource for young scientists and also as a textbook for use by both undergraduate and graduate students – the world’s first such work solely devoted to bioelectrics.

Download or read book XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010 written by Nicolas Pallikarakis and published by Springer Science & Business Media. This book was released on 2010-05-28 with total page 1070 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past three decades, the exploding number of new technologies and applications introduced in medical practice, often powered by advances in biosignal processing and biomedical imaging, created an amazing account of new possibilities for diagnosis and therapy, but also raised major questions of appropriateness and safety. The accelerated development in this field, alongside with the promotion of electronic health care solutions, is often on the basis of an uncontrolled diffusion and use of medical technology. The emergence and use of medical devices is multiplied rapidly and today there exist more than one million different products available on the world market. Despite the fact that the rising cost of health care, partly resulting from the new emerging technological applications, forms the most serious and urgent problem for many governments today, another important concern is that of patient safety and user protection, issues that should never be compromised and expelled from the Biomedical Engineering research practice agenda.

Download or read book Bioengineering In Wound Healing A Systems Approach written by Yarmush Martin L and published by World Scientific. This book was released on 2017-03-24 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: What is a wound, how does it heal, and how can we prevent scarring? The concept of wound healing has puzzled humans even before the advent of modern medicine. In recent years, bioengineering has tackled the problems of cancer, tissue engineering and molecular manufacturing. The broad spectrum of technologies developed in these fields could potentially transform the wound care practice. However, entering the world of wound healing research is challenging — a broad spectrum of knowledge is required to understand wounds and improve healing. This book provides an essential introduction of the field of wound healing to bioengineers and scientists outside the field of medicine. Written by leading researchers from various fields, this book is a comprehensive primer that gives readers a holistic understanding of the field of wound biology, diagnostics and treatment technologies. Contents:Scarless Tissue Regeneration (Alexander Golberg)Anatomy of the Human Skin and Wound Healing (Amit Sharma, Labib R Zakka and Martin C Mihm Jr)Deprived and Enriched Environments: How Sensory Stimulation Affects Wound Healing (Jonathan G Fricchione and John B Levine)Models of Ischemic and Vascular Wounds (Michael T Watkins and Hassan Albadawi)Developmental Biology of Skin Wound Healing: On Pathways and Genes Controlling Regeneration Versus Scarring (Sarah Susan Kelangi and Marianna Bei)Nutrition, Metabolism, and Wound Healing Process (Yong-Ming Yu and Alan J Fischman)Polarization Sensitive Optical Coherence Tomography for Imaging of Wound Repair (Martin Villiger and Brett E Bouma)Functional Imaging of Wound Metabolism (Jake Jones, Vasily Belov and Kyle P Quinn)Functional Skin Substitutes — The Intersection of Tissue Engineering and Biomaterials (Kevin Dooley, Julie Devalliere and Basak Uygun)Biomaterial-Based Systems for Pharmacologic Treatment of Wound Repair (Mara A Pop, Julia B Sun and Benjamin D Almquist)Laser Tissue Welding in Wound Healing and Surgical Repair (Russell Urie, Tanner Flake and Kaushal Rege)Bioprinting for Wound Healing Applications (Aleksander Skardal, Sean Murphy, Anthony Atala and Shay Soker)Electroporation Applications in Wound Healing (Laure Gibot, Tadej Kotnik and Alexander Golberg) Readership: Bioengineers, scientists, researchers and graduate students outside the field of medicine.

Download or read book Hepatocellular Carcinoma written by Yujin Hoshida and published by Springer. This book was released on 2019-08-05 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.

Download or read book Guide to Electroporation and Electrofusion written by Donald Chang and published by Academic Press. This book was released on 1991-12-11 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Guide to Electroporation and Electrofusion is designed to cover all relevant topics pertaining to both electroporation and electrofusion. Divided into four major parts, the book covers fundamental aspects, as well as more advance aspects of the electroporation-electrofusion relationship. The book first covers the basic principles and fundamentals by presenting the most recent theoretical and experimental studies from various fields, such as physics, chemistry, and biology. Next, the book tackles the applications of electroporation and electrofusion in biology, such as transferring, manipulating, and transforming genetic materials. In the third section, the book discusses experimental protocols to serve as a guide when performing experiments using electroporation and electrofusion. The final section discusses the instruments needed to effectively perform an experiment that involves electroporation and electrofusion. This book will be of great used to both novice and advanced researchers whose work involves electroporation and electrofusion, as it provides comprehensive information regarding these topics.

Download or read book Clinical Pancreatology for Practising Gastroenterologists and Surgeons written by Juan Enrique Dominguez-Munoz and published by John Wiley & Sons. This book was released on 2021-03-17 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Pancreatology Since the book Clinical Pancreatology for Practising Gastroenterologists and Surgeons was first published sixteen years ago, the knowledge and clinical management of pancreatic diseases have developed markedly. Thanks to the development of the translational research and the from bench to bedside concept, much progress from the lab has been applied to clinical practice. In addition, several highly relevant clinical trials published over the last years have resulted in the update and optimisation of clinical guidelines. A new and validated classification of severity and complications of acute pancreatitis is firmly rooted in clinical practice and has been the basis for the development of minimally invasive approaches to pancreatic necrosis. The etiopathogenic knowledge of chronic pancreatitis and other pancreatopaties, like that associated with diabetes mellitus, has developed significantly. Especially important has been the development of the field of cystic pancreatic tumours, which has been reflected in the publication of several guidelines and consensus reports over the last few years. Most research efforts have focused on pancreatic cancer, which have led and will further lead to a significant increase in the therapeutic armamentarium against this devastating disease. Finally, many newly published studies have changed the concept, causes, clinical relevance, diagnosis and treatment of exocrine pancreatic insufficiency. This new edition of Clinical Pancreatology for Practising Gastroenterologists and Surgeons has enjoyed the collaboration of the world’s leading experts in each of the areas of clinical pancreatology with the aim of facilitating gastroenterologists, surgeons, oncologists, internists, nutritionists, diabetologists, paediatricians, radiologists, pathologists and other specialists in their decision making when facing patients with pancreatic diseases in their daily clinical practice. All in all, this book supplies an indispensable update of the relevant aspects of clinical pancreatology.

Download or read book Electroporation and Electrofusion in Cell Biology written by C.A. Jordan and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells can be funny. Try to grow them with a slightly wrong recipe, and they turn over and die. But hit them with an electric field strong enough to knock over a horse, and they do enough things to justify international meetings, to fill a sizable book, and to lead one to speak of an entirely new technology for cell manipulation. The very improbability of these events not only raises questions about why things happen but also leads to a long list of practical systems in which the application of strong electric fields might enable the merger of cell contents or the introduction of alien but vital material. Inevitably, the basic questions and the practical applications will not keep in step. The questions are intrinsically tough. It is hard enough to analyze the action of the relatively weak fields that rotate or align cells, but it is nearly impossible to predict responses to the cell-shredding bursts of electricity that cause them to fuse or to open up to very large molecular assemblies. Even so, theoretical studies and systematic examination of model systems have produced some creditable results, ideas which should ultimately provide hints of what to try next.

Download or read book Prostate Cancer written by Adam P. Dicker, MD, PhD and published by Demos Medical Publishing. This book was released on 2014-12-17 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book admirably covers prostate cancer. It is written in an easily digestible manner for non-experts and emphasizes the importance of a team approach to treatment of patients with this disease."--Doody's Reviews With an emphasis on multidisciplinary collaboration and decision-making, this practical resource reflects the extraordinary advances in the treatment of prostate cancer during the past five years. Approximately thirty international, leading-edge investigators describe the most current evidence-based approaches to prostate cancer treatment. The book provides a comprehensive view of the entire spectrum of prostate cancer management from initial screening through novel and experimental treatments that have the potential for a major impact on practice. The book first reviews fundamental issues including epidemiology, screening, risk reduction, diagnosis and pathologic characterization, staging, and imaging. This includes strategies for improving the accuracy of PSA screening and an update on controversies surrounding the ISUP Modified Gleason Score. The book covers novel molecular and genotype profiling in prostate cancer, including morphometric and systems pathology. Detailed information is provided on radiographic imaging for diagnosis and staging. The treatment sections of the book correspond to the staging of disease. The treatment of localized disease addresses the range of multidisciplinary management options including a discussion of prostate cancer's impact on the quality of life. A detailed review of multimodal therapies (medical, surgical, and radiologic) addresses the treatment of localized advanced disease, and coverage of advanced metastatic prostate cancer reviews current management options including a range of promising novel and experimental agents. The book also discusses counseling the high-risk patient. Several chapters incorporate models of care delivery, patient navigation for multidisciplinary care, genomic and risk assessment, and comparative effects of research in treatment decision-making. The book is designed as a management text for all health care professionals who provide care for prostate cancer patients as well as patients, families, and advocates. Extensive references offer opportunities for additional study. Key Features: Delineates a practical, concise approach to multidisciplinary management of prostate cancer Provides a wide range of perspectives and expertise Written and edited by an international, multidisciplinary team of prostate cancer specialists Focuses on such key issues as special populations, screening controversies, patient counseling, and quality of life Includes discussion of important emerging topics such as gene profiling and targeted therapies and comparative effectiveness data

Download or read book Pancreatic Cancer and Periampullary Neoplasms An Issue of Surgical Clinics of North America E Book written by Jeffrey M. Hardacre and published by Elsevier Health Sciences. This book was released on 2016-11-21 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Surgical Clinics of North America, guest edited by Dr. Jeffrey M. Hardacre, is devoted to Pancreatic Cancer and Periampullary Neoplasms. He has assembled expert authors to review the following topics: Genetics of Pancreatic Cancer and its Implication on Therapy; Familial Pancreatic Cancer and Screening of High-risk Individuals; Imaging Evaluation of Pancreatic Cancer; Endoscopic Evaluation in the Work-up of Pancreatic Cancer; Definition and Management of Borderline Resectable Pancreatic Cancer; Techniques of Vascular Resection and Reconstruction in Pancreatic Cancer Surgery; Surgical Therapy for Pancreatic and Periampullary Cancer; Post-Pancreatectomy Complications and Management; Adjuvant and Neoadjuvant Therapy for Resectable Pancreatic and Periampullary Cancer; Management of Locally Advanced Pancreatic Cancer; Management of Metastatic Pancreatic Cancer; Management of Pancreatic Neuroendocrine Tumors; Management of Intraductal Papillary Mucinous Neoplasms; Palliative Care and Surgery in Pancreatic Cancer; Enhanced Recovery Pathways in Pancreatic Cancer; and more!