Download or read book Interdisciplinary Approaches for 4D Radiotherapy of Moving Lung Tumors Based on Nonlinear Dynamics Systems Theory written by and published by . This book was released on 2012 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intra-fractional tumor motion mainly due to respiratory motion necessitates enlarged treatment margins to provide full tumor coverage, thus limiting the dose that can be escalated for tumor control. Tumor motion and breathing irregularity are two major hurdles which stop us from achieving this apparently simple goal of dose escalation while sparing normal tissues. Delivery of radiation therapy using synchronization methodologies requires knowledge of real-time tumor position. All methodologies suffer from the problem of system latency which can be understood as a delay from the instant the tumor moves before the treatment system can make its corrective response. Predicting respiratory motion in real-time is challenging, due to the inherent chaotic nature of breathing patterns, i.e. sensitive dependence on initial conditions. In our previous work we established that respiratory system is 5-6 dimensional nonlinear, stationary and deterministic in nature albeit chaotic with sensitive dependence to initial conditions. In this thesis, we introduce nonlinear prediction algorithms based on state-space methodologies that have a larger prediction horizon than linear methods, A much larger prediction horizon can be achieved if patients can be coached to closely follow a regular breathing pattern. Patients revisit their breathing orbits arbitrarily closely and stay for a while before exponentially diverging from the orbit. These are called Unstable Periodic Orbits (UPOs) which can be used to intelligently coach the patients to maintain a comfortable breathing. This approach is called Chaos Control and its theoretical basis and preliminary results are elucidated in this thesis. However, many patients with high transients can be very challenging for both prediction and chaos control. We introduce a novel method, Recurrence quantification analysis (RQA) to classify patients breathing pattern to decide if a patient is a good candidate for Chaos control and prediction or just prediction bundled with 4D treatment.
Download or read book Accuracy Requirements and Uncertainties in Radiotherapy written by International Atomic Energy Agency and published by . This book was released on 2017-04-12 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accuracy requirements in radiation oncology have been defined in multiple publications; however, these have been based on differing radiation technologies. In the meantime, the uncertainties in radiation dosimetry reference standards have been reduced and more detailed patient outcome data are available. No comprehensive literature on accuracy and uncertainties in radiotherapy has been published so far. The IAEA has therefore developed a new international consensus document on accuracy requirements and uncertainties in radiation therapy, to promote safer and more effective patient treatments. This publication addresses accuracy and uncertainty issues related to the vast majority of radiotherapy departments including both external beam radiotherapy and brachytherapy. It covers clinical, radiobiological, dosimetric, technical and physical aspects.
Download or read book Medical Imaging Informatics written by Alex A.T. Bui and published by Springer Science & Business Media. This book was released on 2009-12-01 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical Imaging Informatics provides an overview of this growing discipline, which stems from an intersection of biomedical informatics, medical imaging, computer science and medicine. Supporting two complementary views, this volume explores the fundamental technologies and algorithms that comprise this field, as well as the application of medical imaging informatics to subsequently improve healthcare research. Clearly written in a four part structure, this introduction follows natural healthcare processes, illustrating the roles of data collection and standardization, context extraction and modeling, and medical decision making tools and applications. Medical Imaging Informatics identifies core concepts within the field, explores research challenges that drive development, and includes current state-of-the-art methods and strategies.
Download or read book PET MRI in Oncology written by Andrei Iagaru and published by Springer. This book was released on 2018-01-23 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, experts from premier institutions across the world with extensive experience in the field clearly and succinctly describe the current and anticipated uses of PET/MRI in oncology. The book also includes detailed presentations of the MRI and PET technologies as they apply to the combined PET/MRI scanners. The applications of PET/MRI in a wide range of oncological settings are well documented, highlighting characteristic findings, advantages of this dual-modality technique, and pitfalls. Whole-body PET/MRI applications and pediatric oncology are discussed separately. In addition, information is provided on PET technology designs and MR hardware for PET/MRI, MR pulse sequences and contrast agents, attenuation and motion correction, the reliability of standardized uptake value measurements, and safety considerations. The balanced presentation of clinical topics and technical aspects will ensure that the book is of wide appeal. It will serve as a reference for specialists in nuclear medicine and radiology and oncologists and will also be of interest for residents in these fields and technologists.
Download or read book Radiation Oncology Advances written by Søren M. Bentzen and published by Springer Science & Business Media. This book was released on 2007-09-20 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an up-to-date comprehensive overview of the exciting new developments shaping the current and future practice of radiation oncology. Advances in treatment planning and delivery, in biological targeted therapies combined with radiation and in functional and molecular imaging are all covered in a single volume. All of these advances are discussed by leading experts in the field and with a critical evaluation of their clinical relevance throughout.
Download or read book Image Guided Cancer Therapy written by Damian E. Dupuy and published by Springer. This book was released on 2013-08-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Image-Guided Cancer Therapy: A Multidisciplinary Approach provides clinicians with in-depth coverage of the growing, dynamic field of interventional oncology. Combining the knowledge of expert editors and authors into one powerhouse reference, this book looks at tumor ablation, HIFU, embolic therapies, emerging technologies, and radiation therapy throughout the body (liver, bone, breast, gynecologic and prostate cancers, to name just a few) , and includes discussion of different imaging modalities. In the words of Peter Mueller, MD, author of the book’s Foreword: “... The senior authors are all world renowned experts in interventional oncology, which is another example of the high quality authorship and experience that is brought to this book. The later chapters discuss therapies that are simply not covered in any other source. Everyone who is doing or wants to do ablation therapies and interventional oncology will face a time when they will be asked to use their expertise in less used and less investigated areas. There is nowhere else where the reader can get information on the prostate, breast, and gynecologic areas, and especially pediatrics....This book is an outstanding contribution to the literature and will become a ‘must read’ for all physicians who are interested in Interventional Oncology.”
Download or read book General System Theory written by Ludwig von Bertalanffy and published by George Braziller. This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The classic book on a major modern theory
Download or read book 4D Modeling and Estimation of Respiratory Motion for Radiation Therapy written by Jan Ehrhardt and published by Springer Science & Business Media. This book was released on 2013-05-30 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Respiratory motion causes an important uncertainty in radiotherapy planning of the thorax and upper abdomen. The main objective of radiation therapy is to eradicate or shrink tumor cells without damaging the surrounding tissue by delivering a high radiation dose to the tumor region and a dose as low as possible to healthy organ tissues. Meeting this demand remains a challenge especially in case of lung tumors due to breathing-induced tumor and organ motion where motion amplitudes can measure up to several centimeters. Therefore, modeling of respiratory motion has become increasingly important in radiation therapy. With 4D imaging techniques spatiotemporal image sequences can be acquired to investigate dynamic processes in the patient’s body. Furthermore, image registration enables the estimation of the breathing-induced motion and the description of the temporal change in position and shape of the structures of interest by establishing the correspondence between images acquired at different phases of the breathing cycle. In radiation therapy these motion estimations are used to define accurate treatment margins, e.g. to calculate dose distributions and to develop prediction models for gated or robotic radiotherapy. In this book, the increasing role of image registration and motion estimation algorithms for the interpretation of complex 4D medical image sequences is illustrated. Different 4D CT image acquisition techniques and conceptually different motion estimation algorithms are presented. The clinical relevance is demonstrated by means of example applications which are related to the radiation therapy of thoracic and abdominal tumors. The state of the art and perspectives are shown by an insight into the current field of research. The book is addressed to biomedical engineers, medical physicists, researchers and physicians working in the fields of medical image analysis, radiology and radiation therapy.
Download or read book Proton Therapy Physics written by Harald Paganetti and published by CRC Press. This book was released on 2016-04-19 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proton Therapy Physics goes beyond current books on proton therapy to provide an in-depth overview of the physics aspects of this radiation therapy modality, eliminating the need to dig through information scattered in the medical physics literature. After tracing the history of proton therapy, the book summarizes the atomic and nuclear physics background necessary for understanding proton interactions with tissue. It describes the physics of proton accelerators, the parameters of clinical proton beams, and the mechanisms to generate a conformal dose distribution in a patient. The text then covers detector systems and measuring techniques for reference dosimetry, outlines basic quality assurance and commissioning guidelines, and gives examples of Monte Carlo simulations in proton therapy. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. It also examines computerized treatment plan optimization, methods for in vivo dose or beam range verification, the safety of patients and operating personnel, and the biological implications of using protons from a physics perspective. The final chapter illustrates the use of risk models for common tissue complications in treatment optimization. Along with exploring quality assurance issues and biological considerations, this practical guide collects the latest clinical studies on the use of protons in treatment planning and radiation monitoring. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, the book helps readers understand the uncertainties and limitations of precisely shaped dose distribution.
Download or read book Principles of Environmental Physics written by John Monteith and published by Butterworth-Heinemann. This book was released on 1990-02-15 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly revised and up-dated edition of a highly successful textbook.
Download or read book Closing the Quality Gap written by Kaveh G. Shojania and published by . This book was released on 2004 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Branching Process Models of Cancer written by Richard Durrett and published by Springer. This book was released on 2015-06-20 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume develops results on continuous time branching processes and applies them to study rate of tumor growth, extending classic work on the Luria-Delbruck distribution. As a consequence, the author calculate the probability that mutations that confer resistance to treatment are present at detection and quantify the extent of tumor heterogeneity. As applications, the author evaluate ovarian cancer screening strategies and give rigorous proofs for results of Heano and Michor concerning tumor metastasis. These notes should be accessible to students who are familiar with Poisson processes and continuous time Markov chains. Richard Durrett is a mathematics professor at Duke University, USA. He is the author of 8 books, over 200 journal articles, and has supervised more than 40 Ph.D students. Most of his current research concerns the applications of probability to biology: ecology, genetics and most recently cancer.
Download or read book Supervised Learning with Quantum Computers written by Maria Schuld and published by Springer. This book was released on 2018-08-30 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantum machine learning investigates how quantum computers can be used for data-driven prediction and decision making. The books summarises and conceptualises ideas of this relatively young discipline for an audience of computer scientists and physicists from a graduate level upwards. It aims at providing a starting point for those new to the field, showcasing a toy example of a quantum machine learning algorithm and providing a detailed introduction of the two parent disciplines. For more advanced readers, the book discusses topics such as data encoding into quantum states, quantum algorithms and routines for inference and optimisation, as well as the construction and analysis of genuine ``quantum learning models''. A special focus lies on supervised learning, and applications for near-term quantum devices.
Download or read book Carbon Ion Radiotherapy written by Hirohiko Tsujii and published by Springer Science & Business Media. This book was released on 2013-12-25 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as a practical guide for the use of carbon ions in cancer radiotherapy. On the basis of clinical experience with more than 7,000 patients with various types of tumors treated over a period of nearly 20 years at the National Institute of Radiological Sciences, step-by-step procedures and technological development of this modality are highlighted. The book is divided into two sections, the first covering the underlying principles of physics and biology, and the second section is a systematic review by tumor site, concentrating on the role of therapeutic techniques and the pitfalls in treatment planning. Readers will learn of the superior outcomes obtained with carbon-ion therapy for various types of tumors in terms of local control and toxicities. It is essential to understand that the carbon-ion beam is like a two-edged sword: unless it is used properly, it can increase the risk of severe injury to critical organs. In early series of dose-escalation studies, some patients experienced serious adverse effects such as skin ulcers, pneumonitis, intestinal ulcers, and bone necrosis, for which salvage surgery or hospitalization was required. To preclude such detrimental results, the adequacy of therapeutic techniques and dose fractionations was carefully examined in each case. In this way, significant improvements in treatment results have been achieved and major toxicities are no longer observed. With that knowledge, experts in relevant fields expand upon techniques for treatment delivery at each anatomical site, covering indications and optimal treatment planning. With its practical focus, this book will benefit radiation oncologists, medical physicists, medical dosimetrists, radiation therapists, and senior nurses whose work involves radiation therapy, as well as medical oncologists and others who are interested in radiation therapy.
Download or read book Innovations in Biomedical Engineering written by Marek Gzik and published by Springer Nature. This book was released on 2022-05-31 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest developments in the field of biomedical engineering and includes practical solutions and strictly scientific considerations. The development of new methods of treatment, advanced diagnostics or personalized rehabilitation requires close cooperation of experts from many fields, including, among others, medicine, biotechnology and finally biomedical engineering. The latter, combining many fields of science, such as computer science, materials science, biomechanics, electronics not only enables the development and production of modern medical equipment, but also participates in the development of new directions and methods of treatment. The presented monograph is a collection of scientific papers on the use of engineering methods in medicine. The topics of the work include both practical solutions and strictly scientific considerations expanding knowledge about the functioning of the human body. We believe that the presented works will have an impact on the development of the field of science, which is biomedical engineering, constituting a contribution to the discussion on the directions of development of cooperation between doctors, physiotherapists and engineers. We would also like to thank all the people who contributed to the creation of this monograph—both the authors of all the works and those involved in technical works.
Download or read book Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design written by Sanjeev Kumar Singh and published by Springer Nature. This book was released on 2021-02-02 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents various computer-aided drug discovery methods for the design and development of ligand and structure-based drug molecules. A wide variety of computational approaches are now being used in various stages of drug discovery and development, as well as in clinical studies. Yet, despite the rapid advances in computer software and hardware, combined with the exponential growth in the available biological information, there are many challenges that still need to be addressed, as this book shows. In turn, it shares valuable insights into receptor-ligand interactions in connection with various biological functions and human diseases. The book discusses a wide range of phylogenetic methods and highlights the applications of Molecular Dynamics Simulation in the drug discovery process. It also explores the application of quantum mechanics in order to provide better accuracy when calculating protein-ligand binding interactions and predicting binding affinities. In closing, the book provides illustrative descriptions of major challenges associated with computer-aided drug discovery for the development of therapeutic drugs. Given its scope, it offers a valuable asset for life sciences researchers, medicinal chemists and bioinformaticians looking for the latest information on computer-aided methodologies for drug development, together with their applications in drug discovery.
Download or read book An Introduction to Medical Physics written by Muhammad Maqbool and published by Springer. This book was released on 2017-11-11 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book begins with the basic terms and definitions and takes a student, step by step, through all areas of medical physics. The book covers radiation therapy, diagnostic radiology, dosimetry, radiation shielding, and nuclear medicine, all at a level suitable for undergraduates. This title not only describes the basics concepts of the field, but also emphasizes numerical and mathematical problems and examples. Students will find An Introduction to Medical Physics to be an indispensible resource in preparations for further graduate studies in the field.
