Download or read book Interactions of Non heme Ferrous Active Sites with Substrates written by Jyllian Nicole Kemsley and published by . This book was released on 2003 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Iron Containing Enzymes written by Samuel P de Visser and published by Royal Society of Chemistry. This book was released on 2011-08-04 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many mononuclear iron containing enzymes in nature that utilize molecular oxygen and transfer one or both oxygen atoms of O2 to substrates. These enzymes catalyze many processes including the biosynthesis of hormones, the metabolism of drugs, DNA and RNA base repair and, the biosynthesis of antibiotics. Therefore, mononuclear iron containing enzymes are important intermediates in bioprocesses and have great potential in the commercial biosynthesis of specific products since they often catalyze reactions regioselectively or stereospecifically. Understanding their mechanism and function is important and will assist in searches for commercial exploitation. In recent years, advances in experimental as well as theoretical methodologies have made it possible to study the mechanism and function of these enzymes and much information on their properties has been gained. This book highlighting recent developments in the field is, therefore, a timely addition to the literature and will interest a broad readership in the fields of biochemistry, inorganic chemistry and computational chemistry. The Editors, leaders in the field of nonheme and heme iron containing monoxygenases, have filled the book with topical review chapters by leaders in the various sub-disciplines.
Download or read book Spectroscopic Definition of the Non heme Ferrous Active Sites in Bleomycin and Phenylalanine Hydroxylase written by Kelly Elise Loeb and published by . This book was released on 1997 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Non heme Iron Enzymes Structures and Mechanisms written by and published by Academic Press. This book was released on 2019-09-28 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonheme Iron Enzymes: Structures and Mechanisms, Volume 117, highlights new advances in the field, with this new volume presenting new and interesting chapters on the topics. Each chapter is written by an international board of authors. - Targeted to a very wide audience of specialists, researchers and students - Contains timely chapters written by well-renowned authorities in their field - Includes a number of high quality illustrations, figures and tables
Download or read book Spectroscopic Probes of the Non heme Iron Active Sites written by Yan Zhang and published by . This book was released on 1992 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Drug Metabolism Third Edition written by Paul G. Pearson and published by CRC Press. This book was released on 2019-05-20 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments. It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecules disposition, stereo-selectivity in drug metabolism, drug transporters and metabolic activation of drugs. Some chapters have been prepared by new authors who have emerged as subject area experts in the decade that has passed since publication of the first edition.
Download or read book Spectroscopic Studies of Mononuclear Non heme Iron Sites in Lipoxygenases Clavaminate Synthase 2 and 1 aminocyclopropane 1 carboxylate Oxidase written by Jing Zhou and published by . This book was released on 2000 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook on Metalloproteins written by Ivano Bertini and published by CRC Press. This book was released on 2001-06-29 with total page 1225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook on Metalloproteins focuses on the available structural information of proteins and their metal ion coordination spheres. It centers on the metal ions indispensable for life but also considers metal ions used as substitution probes in studies of metalloproteins. Emphasizing the structure-function relationship, the book covers the commo
Download or read book Mononuclear Non heme Iron Dependent Enzymes written by and published by Elsevier. This book was released on 2024-09-10 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mononuclear Non-heme Iron Dependent Enzymes, Volume 703 focuses on methods for studying, characterizing, and leveraging the chemistry of mononuclear non-heme iron dependent enzymes. Chapters in this new release include Photoreduction for Rieske oxygenase chemistry, Insights into the Mechanisms of Rieske Oxygenases from Studying the Unproductive Activation of Dioxygen, Non-heme iron and 2-oxoglutarate enzymes catalyze cyclopropane and azacyclopropane formations, Obtaining precise metrics of substrate positioning in Fe(II)/2OG dependent enzymes using Hyperfine Sublevel Correlation Spectroscopy, Xe-pressurization studies for revealing substrate-entrance tunnels, and much more.Additional chapters cover A tale of two dehydrogenases involved in NADH recycling, Rieske oxygenases and/or their partner reductase proteins, Expression, assay and inhibition of 9-cis-epoxycarotenoid dioxygenase (NCED) from Solanum lycopersicum and Zea mays, Biocatalysis and non-heme iron enzymes, In vitro analysis of the three-component Rieske oxygenase cumene dioxygenase from Pseudomonas fluorescens IP01, Structure and function of carbazole 1,9a-dioxygenase, Characterization of a Mononuclear Nonheme Iron-dependent Mono-oxygenase OzmD in Oxazinomycin Biosynthesis, and much more. - Provides detailed articles regarding how to study the structures and mechanisms of mononuclear non-heme iron dependent enzymes - Guides readers on how to use partner proteins in non-heme iron enzyme catalysis - Includes strategies to employ mononuclear non-heme iron enzymes in biocatalytic applications
Download or read book Cytochrome P450 2D6 written by Shufeng Zhou and published by CRC Press. This book was released on 2018-09-03 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytochromes are proteins that catalyze electron transfer reactions of well-known metabolic pathways and are classified in various superfamilies. The CYP, or P450, superfamily accounts for 90% of the oxidative metabolism of clinical drugs. One member of this superfamily, P450 2D6 (or CYP2D6), singlehandedly metabolizes about 25% of all medications in the human liver. Cytochrome P450 2D6: Structure, Function, Regulation, and Polymorphism reviews the current knowledge of CYP2D6 as well as the maturing body of evidence indicating its significance to clinical and pharmacological researchers and practitioners. This book focuses on the critical role CYP2D6 plays in the human liver. It examines the genetic, epigenetic, physiological, pathological, and structural factors of the gene that govern the highly variable metabolism of a number of drugs in clinical use. It highlights the impact of the functional roles of CYP2D6 on clinical practice and drug development and also discusses implications for precise medicine, strategies to avoid adverse drug reactions, and paths for future research. Cytochrome P450 2D6 is a unique, valuable book focusing on a single but immensely powerful human gene. It provides the first single source of comprehensive information on CYP2D6 that serves as an important reference for medical, biomedical, pharmaceutical, and nursing researchers, practitioners, and students.
Download or read book Automation in Proteomics and Genomics written by Gil Alterovitz and published by John Wiley & Sons. This book was released on 2009-03-16 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade DNA sequencing costs have decreased over a magnitude, largely because of increasing throughput by incremental advances in tools, technologies and process improvements. Further cost reductions in this and in related proteomics technologies are expected as a result of the development of new high-throughput techniques and the computational machinery needed to analyze data generated. Automation in Proteomics & Genomics: An Engineering Case-Based Approach describes the automation technology currently in the areas of analysis, design, and integration, as well as providing basic biology concepts behind proteomics and genomics. The book also discusses the current technological limitations that can be viewed as an emerging market rather than a research bottleneck. Topics covered include: molecular biology fundamentals: from ‘blueprint’ (DNA) to ‘task list’ (RNA) to ‘molecular machine’ (protein); proteomics methods and technologies; modelling protein networks and interactions analysis via automation: DNA sequencing; microarrays and other parallelization technologies; protein characterization and identification; protein interaction and gene regulatory networks design via automation: DNA synthesis; RNA by design; building protein libraries; synthetic networks integration: multiple modalities; computational and experimental methods; trends in automation for genomics and proteomics new enabling technologies and future applications Automation in Proteomics & Genomics: An Engineering Case-Based Approach is an essential guide to the current capabilities and challenges of high-throughput analysis of genes and proteins for bioinformaticians, engineers, chemists, and biologists interested in developing a cross-discipline problem-solving based approach to systems biology.
Download or read book X ray Absorption Spectroscopic Investigations of Non heme Iron Active Sites written by Erik Christopher Wasinger and published by . This book was released on 2003 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metalloenzymes written by Claudiu T. Supuran and published by Elsevier. This book was released on 2023-08-30 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metalloenzymes: From Bench to Bedside offers a thorough overview of metalloenzymes, spanning biochemical and structural features, pharmacology, and biotechnological applications. After a brief overview, international experts in the field discuss a wide range of magnesium, calcium, zinc, manganese, nickel, iron, copper, cadmium, molybdenum, and tungsten enzymes, along with catalytic roles within their active sites. With a uniform approach throughout, each chapter includes the structure and function of the enzyme, physiologic and pathologic roles, inhibitors and activators of the enzyme (and their design), and clinical agents or compounds applied in medicine and drug discovery. This book enables scientists across academia and industry to adopt ongoing metalloenzyme research, and continuous discovery of novel metalloenzymes, in new life science studies and clinical applications. - Examines a range of metalloenzymes, from biochemistry to pharmacology and drug design - Each chapter examines enzyme structure and function, physiologic and pathologic roles, inhibitors and activators, and clinical application - Features chapter contributions from international experts in the field
Download or read book Peroxidases in Chemistry and Biology written by Johannes Everse and published by CRC Press. This book was released on 1990-10-24 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second of two relatively independent volumes on the chemistry and biology of peroxidases. Volumes 2 covers the peroxidases isolated from plants and microorganisms, and includes detailed discussions of some of the unique reactions catalyzed by these enzymes. Volume one covered the peroxidases isolated from animal sources, as well as the "pseudo- peroxidase activity" of prostaglandin H synthase and of myoglobin and hemoglobin. Acidic paper. Annotation copyrighted by Book News, Inc., Portland, OR
Download or read book Biochemistry of Nonheme Iron written by Anatoly Bezkorovainy and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atomic biology has come of age. Interest in the role of chemical elements in life processes has captured the imagination of a wide spectrum of research scientists-ranging from the nutritionist to the biochemist, the inorganic chemist, and even to some biophysicists. This series, Biochemistry of the Elements, is a recognition of this increasing interest. When complete, the books will assemble the hard facts concerning the biochemistry of each element-singly or in a logical grouping. The series will provide a permanent reference for this active and growing field. Each volume shall represent an integrated effort by one or several authors to describe the current knowledge of an element(s) or the methods by which it is studied. Iron is the only element to which we have devoted two volumes, because its biological and chemical role is so versatile and complex. These two volumes will treat the two main structural categories of iron: heme and nonheme iron. In this volume on nonheme iron, the first in the series, Anatoly Bezkorovainy provides what we believe is the most comprehensive treatment of this important topic.
Download or read book Hayes Principles and Methods of Toxicology written by A. Wallace Hayes and published by CRC Press. This book was released on 2023-07-03 with total page 2143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. Key Features: The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals. Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered. All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary. The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology"). This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.
Download or read book Inorganic Reaction Mechanisms written by and published by Academic Press. This book was released on 2017-06-30 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inorganic Reaction Mechanisms, Volume 70 is the latest volume in the Advances in Inorganic Chemistry series that presents timely summaries of current progress in inorganic chemistry, ranging from bio-inorganic to solid state studies. Topics covered in this updated volume include The Kinetics and Mechanism of Complex Redox Reactions in Aqueous Solution: The Tools of the Trade, O-O Bond Activation in Cu and Fe-Based Coordination Complexes: Breaking it Makes the Difference, μ-Nitrido Diiron Phthalocyanine and Porphyrin Complexes: Unusual Structures With Interesting Catalytic Properties, and The Role of Nonheme Transition Metal-Oxo, -Peroxo and -Superoxo Intermediates in Enzyme Catalysis and Reactions of Bioinspired Complexes. This acclaimed serial features reviews written by experts in the field, serving as an indispensable reference to advanced researchers. Each volume contains an index and chapters are fully referenced. Features comprehensive reviews on the latest developments in inorganic reaction mechanisms, a subfield of inorganic chemistry Includes contributions from leading experts in the field of inorganic reaction mechanisms Serves as an indispensable reference to advanced researchers in inorganic reaction mechanisms
