Download or read book Innate Immunity to Pulmonary Infection written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2007-01-11 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the prestigious Novartis Foundation series, this volume uniquely addresses the use of innate immunity to treat or prevent infectious diseases of the lung. Innate Immunity to Pulmonary Infection: Provides a comprehensive overview of pulmonary infectious diseases, including basic pathology, current and potential therapies, and detailed consideration of the innate biological resistance mechanisms in the lung Thoroughly examines the major topic of innate immunity in immunology, which is now seen as key to the pathogenesis of and vaccination strategies for infectious diseases Describes the genetic and environmental factors which determine the outcome of infection, such as latency of Tuberculosis, blood stream invasion from local infection, and local target tissue damage Covers the roles of cells such as neutrophils, macrophages and dendritic cells and of molecular components such as Toll-like receptors Discusses the clinical applications of the new knowledge regarding innate immunity and how this can be used in both treatment and prevention (vaccination) strategies Includes contributions from an international and interdisciplinary group of experts Innate Immunity to Pulmonary Infection is an essential resource for researchers in both industry and academia. It is of interest for all those interested in the disciplines of immunology, virology, biology, biotechnology and genetics.
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Download or read book SARS MERS and other Viral Lung Infections written by David S. Hui and published by European Respiratory Society. This book was released on 2016-06-01 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral respiratory tract infections are important and common causes of morbidity and mortality worldwide. In the past two decades, several novel viral respiratory infections have emerged with epidemic potential that threaten global health security. This Monograph aims to provide an up-to-date and comprehensive overview of severe acute respiratory syndrome, Middle East respiratory syndrome and other viral respiratory infections, including seasonal influenza, avian influenza, respiratory syncytial virus and human rhinovirus, through six chapters written by authoritative experts from around the globe.
Download or read book Cell specific Innate Immunity in Lung Infection and Inflammation written by Adam Ahmad Anas and published by . This book was released on 2017 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Pneumonia and asthma affect millions of adults and children annually and are responsible for a significant amount of morbidity and mortality worldwide. Our airways are continuously exposed to pathogens and allergens inhaled through air that can potentially cause these serious illnesses. The innate immune system is initiated once the epithelial barrier fails. The net effect of the innate immunity is the result of complex cell-specific responses not yet fully understood. In this thesis, we studied these cell-specific contributions to host defense using genetically modified mice in which bacterial pneumonia and asthma were simulated. Cells present in the respiratory tract are able to recognize specific molecular patterns of pathogens or allergens because of the expression Toll-like receptors (TLRs). Correct functioning of TLRs is regulated by the chaperone glycoprotein 96 (gp96), and we found that host defense of mice with gp96 deficient macrophages was strongly impaired during pneumonia caused by Klebsiella pneumoniae. Next, we studied the cell-specific role of myeloid differentiation factor 88 (MyD88), the universal adaptor protein found downstream in the TLR signaling pathway. In a series of studies, we found that only myeloid MyD88, but not endothelial or epithelial MyD88, contributes significantly to protection against Klebsiella pneumonia, while in pneumonia induced by Pseudomonas Aeruginosa, antibacterial defense depends on epithelial but not myeloid MyD88. Finally, we examined the role of cell-specific MyD88 signaling in asthma, and found that general expression of MyD88 is essential for the development of asthma. Neither myeloid nor alveolar type II MyD88 affects asthma induced inflammatory response."--Samenvatting auteur.
Download or read book Lung Innate Immunity and Inflammation written by Scott Alper and published by Humana. This book was released on 2019-07-23 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book explores methods to isolate, characterize, and investigate key lung innate immune cells. Beginning with an overview, the volume then continues with methods for creating in vitro and in vivo model systems to study inflammatory lung diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Lung Innate Immunity and Inflammation: Methods and Protocols aims to be a guidebook and will be of value and interest to researchers investigating innate immunity and inflammation in the lung as well as other organs and tissues.
Download or read book Innate Immunity Resistance and Disease Promoting Principles written by G. Hartmann and published by Karger Medical and Scientific Publishers. This book was released on 2013-06-05 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the complex innate immune response is increasing rapidly. Its role in the protection against viral or bacterial pathogens is essential for the survival of an organism. However, it is equally important to avoid unregulated inflammation because innate immune responses can cause or promote chronic autoinflammatory diseases such as gout, atherosclerosis, type 2 diabetes or certain aspects of the metabolic syndrome. In this book leading international experts in the field of innate immunity share their findings, define the state of the art in this field and evaluate how insight into the molecular basis of these diseases could help in the design of new therapies. A tremendous amount of work on the innate immune response has been done over the last fifteen years, culminating in the 2011 Nobel Prize in Physiology/Medicine awarded for the discoveries of Toll genes in immunity in flies, membrane-bound Toll-like receptors in mammals, and dendritic cells as initiators of adaptive immunity.
Download or read book Yearbook of Intensive Care and Emergency Medicine 2010 written by Jean-Louis Vincent and published by Springer Science & Business Media. This book was released on 2010-06-28 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Yearbook compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.
Download or read book Update on the Immune Mechanisms Against Respiratory Pathogens written by Junkal Garmendía and published by Frontiers Media SA. This book was released on 2019-10-21 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Respiratory infections are leading causes of mortality and morbidity, with Tuberculosis and lower respiratory tract infections (LRTI) culminating in almost 5 million deaths per year. Respiratory tract infections pose a continuous threat to humans due to their easy dissemination via aerial transmission. Children under the age of five living in developing countries are the most susceptible hosts to a plethora of bacteria and viruses including Mycobacterium tuberculosis, Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Klebsiella pneumoniae, Bordetella pertussis, Pseudomonas aeruginosa, Mycoplasma pneumoniae, Influenza virus, Respiratory syncytial virus and metapneumovirus. Likewise, adult patients suffering from underlying chronic respiratory diseases such as Chronic Obstructive Pulmonary Disease (COPD), bronchiectasis or neutrophilic asthma are also highly targeted by LRTIs. Despite vaccination saving millions of lives, the growing emergence of antibiotic resistant strains is a major challenge for the coming years. In addition, some vaccines against particular respiratory pathogens are ineffective in providing long-term protection. Accordingly, an enhanced understanding of host immunity to respiratory infections is essential for developing new and more effective microbial- and host-directed therapeutics. This eBook will provide a comprehensive overview of the microbial factors and the host immune mechanisms that determine the control of lung infection and/or the development of lung diseases. Manuscripts included in this eBook are divided in four chapters and cover these aspects of immunology against respiratory pathogens: -Pathogen targets for immune recognition including membrane-anchored and secreted effector molecules. -Specific roles of immune cell subsets in response to respiratory infections spanning both innate and adaptive immunity. -Host factors involved in pathogen recognition in the respiratory system including cytosolic DNA sensors. -New prophylactic and/or therapeutic strategies against respiratory infections.
Download or read book Pulmonary Immunotoxicology written by Mitchell D. Cohen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pulmonary Immunotoxicology is a comprehensive exploration of the effects of various inhaled materials upon the immune system of the respiratory tract. It will be useful to investigators in the field of pulmonary toxicology and immunotoxicology, and to those involved in administration and regulation of matters related to inhaled materials. It can also serve as a textbook for a course in pulmonary immunotoxicology at graduate or advanced undergraduate level. Pulmonary Immunotoxicology comprises four sections. The first provides basic background concepts essential for understanding pulmonary immunotoxicology, including discussions of the normal structure and function of the respiratory system, its basic immunology, and the manner by which inhaled particles and gases are removed from the air and deposited upon respiratory tract surfaces. The second section provides an overview of the major types of pathological consequences which can arise from immunomodulation within the respiratory tract, including hypersensitivity and asthma, inflammation and fibrosis, as well as immunosuppression and autoimmunity. The third section, which comprises the largest portion of the book, deals specifically with major classes of airborne agents that are known to alter the immune function of the respiratory tract. These are arranged into major classes: organic agents, metals, gases, particles, biologics, and complex mixtures. The fourth and final section of the book explores the area of risk assessment, including discussions of the basic concepts of risk assessment as they apply specifically to immunotoxicologic effects upon the lungs, and the use of biomarkers as indices of potential pulmonary immunotoxic responses to inhaled materials.
Download or read book The Lung Microbiome written by Michael J. Cox and published by European Respiratory Society. This book was released on 2019-03-01 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studying the lung microbiome requires a specialist approach to sampling, laboratory techniques and statistical analysis. This Monograph introduces the techniques used and discusses how respiratory sampling, 16S rRNA gene sequencing, metagenomics and the application of ecological theory can be used to examine the respiratory microbiome. It examines the different components of the respiratory microbiome: viruses and fungi in addition to the more frequently studied bacteria. It also considers a range of contexts from the paediatric microbiome and how this develops to disease of all ages including asthma and chronic obstructive pulmonary disease, chronic suppurative lung diseases, interstitial lung diseases, acquired pneumonias, transplantation, cancer and HIV, and the interaction of the respiratory microbiome and the environment.
Download or read book Tuberculosis in Adults and Children written by Dorothee Heemskerk and published by Springer. This book was released on 2015-07-17 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Download or read book Current Trends in Immunity and Respiratory Infections written by Mieczyslaw Pokorski and published by Springer. This book was released on 2018-09-21 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to disseminate and deliberate on the latest knowledge concerning immunity and its role in protection and fight against microorganism invasion. The articles tackle both humoral and cellular immunity, and their interconnectivity. The former involves B cells that recognize invading pathogens and create the antibody-mediated response, which when memorized provides future immunity. The latter involves mostly T cells, exemplified by cytotoxic or killer cell destroying the pathogens, or helper cells stimulating B cells to produce antibodies to bind and neutralize the pathogens. T cells act through release of cytokines, interleukins, and other bioactive mediators. Neutrophils play a key role in innate immunity against bacterial infections. The process of NETosis is a recently unraveled sophisticated defense mechanism, consisting of the formation of neutrophil extracellular traps that catch, immobilize, and remove pathogens from the body. Dysfunction of immunity is indisputably conducive to the propensity for infections, particularly respiratory tract infections, as the airways are the first line of defense against invading pathogens. Pathogens can rapidly evolve and adapt to avoid detection by the immune system. The case in point is the influenza virus. The articles report on the epidemiology, diagnostics, serology, complications, and the process of acquired immunity due to vaccination against influenza and influenza-like infections in recent epidemic seasons. The book is a blend of medical research and practice. It is intended for academic scientists, research scholars, clinicians, family doctors, and healthcare professionals.
Download or read book Orchestration of an Immune Response to Respiratory Pathogens written by Andrea Sant and published by Frontiers Media SA. This book was released on 2019-07-25 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Came an East Wind written by Tori L. Jennings and published by . This book was released on 2010 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mouse Models of Innate Immunity written by Irving C. Allen and published by Humana. This book was released on 2016-08-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The innate immune system represents a critical arm of the immune response by providing immediate and robust host defense; however, human studies of its function are often limited by ethical, logistical, and technical obstacles. In Mouse Models of Innate Immunity: Methods and Protocols, experts in the field explore the design and execution of experiments used to thoroughly evaluate critical elements associated with the host innate immune response. The volume opens with methods that are essential for collecting and assessing various primary cells that are highly relevant to innate immunity, and it continues with in vivo protocols commonly used to evaluate the innate immune response in the mouse, including mouse models of respiratory infection, gastrointestinal inflammation, fungal and parasitic diseases, sepsis, and HIV-1 infection. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Mouse Models of Innate Immunity: Methods and Protocols will serve the research community by providing expert advice and protocols that allow both experienced and novice investigators to successfully plan, implement, and assess disease processes associated with the innate immune response.
